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Article ; Online: Interview with Professor Angus Dalgleish.

Dalgleish, Angus

Immunotherapy

2016 Volume 8, Issue 11, Page(s) 1271–1276

Abstract: Angus Dalgleish is the Foundation Professor of Oncology at St. George's University of London and Principal of the Institute for Cancer Vaccines and Immunotherapy. ...

Abstract	Angus Dalgleish is the Foundation Professor of Oncology at St. George's University of London and Principal of the Institute for Cancer Vaccines and Immunotherapy.
MeSH term(s)	Allergy and Immunology/history ; Australia ; Cancer Vaccines/immunology ; HIV/physiology ; HIV Infections/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Immunotherapy/methods ; Male ; Neoplasms/immunology ; Neoplasms/therapy ; United Kingdom
Chemical Substances	Cancer Vaccines
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Autobiography ; Historical Article ; Interview
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2016-0120
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Article ; Online: Reverse total shoulder arthroplasty for acute proximal humeral fracture has comparable 10-year outcomes to elective indications: results from the New Zealand Joint Registry.

Bolam, Scott M / Wells, Zoe / Tay, Mei Lin / Frampton, Chris M A / Coleman, Brendan / Dalgleish, Adam

Journal of shoulder and elbow surgery

2024

Abstract: Hypothesis and background: Recently, the indication of reverse total shoulder arthroplasty (RTSA) has expanded beyond rotator cuff arthropathy to include treatment of complex acute proximal humeral fracture (PHF). Limited previous studies have compared ... ...

Abstract	Hypothesis and background: Recently, the indication of reverse total shoulder arthroplasty (RTSA) has expanded beyond rotator cuff arthropathy to include treatment of complex acute proximal humeral fracture (PHF). Limited previous studies have compared the long-term clinical and functional outcomes of patients undergoing RTSA for PHF vs. elective indications for degenerative conditions. The purpose of this study was to compare implant survivorship, reasons for revision and functional outcomes in patients undergoing RTSA for acute PHF with those undergoing elective RTSA in a population-based cohort study. Methods: Prospectively collected data from the New Zealand Joint Registry from 1999 to 2021 and identified 6862 patients who underwent RTSA. Patients were categorized by preoperative indication, including PHF (10.8%), rotator cuff arthropathy (RCA) (44.5%), osteoarthritis (OA) (34.1%), rheumatoid arthritis (RA) (5.5%), and old traumatic sequelae (5.1%). Revision-free implant survival and functional outcomes (Oxford Shoulder Scores [OSSs] at the 6-month, 5-year, and 10-year follow-ups) were adjusted by age, sex, American Society of Anesthesiologists class, and surgeon experience and compared. Results: Revision-free implant survival at 10 years for RTSA for PHF was 97.3%, compared with 96.1%, 93.7%, 92.8%, and 91.3% for OA, RCA, RA and traumatic sequelae, respectively. When compared with RTSA for PHF, the adjusted risk of revision was significantly higher for traumatic sequelae (hazard ratio = 2.3, P = .023) but not for other elective indications. The most common reason for revision in the PHF group was dislocation or instability (42.9%), which was similar to the OA (47.6%) and traumatic sequelae (33.3%) groups. At 6 months post-surgery, OSSs were significantly lower for the PHF group compared with the RCA, OA, and RA groups (31.1 vs. 35.6, 37.7, and 36.5, respectively, P < .001), and similar to traumatic sequelae (31.7, P = .431). At 5 years, OSSs were only significantly lower for PHF compared with OA (37.4 vs. 41.0, P < .001) and there was no difference between the PHF and other groups. At 10 years, there were no significant differences between groups. Conclusions: RTSA for PHF demonstrated reliable long-term survivorship and functional outcomes compared with elective indications. Despite lower functional outcomes in the early postoperative period for the PHF group, implant survivorship was similar in patients undergoing RTSA for the primary indication of acute PHF compared with RCA, OA, and RA and superior compared to the primary indication of traumatic sequelae.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2024.01.024
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Article ; Online: Releasing the restraints of Vγ9Vδ2 T-cells in cancer immunotherapy.

Ridgley, Laura A / Caron, Jonathan / Dalgleish, Angus / Bodman-Smith, Mark

Frontiers in immunology

2023 Volume 13, Page(s) 1065495

Abstract: Objectives: Vγ9Vδ2 T-cells are a subset of T-cells with a crucial role in immunosurveillance which can be activated and expanded by multiple means to stimulate effector responses. Little is known about the expression of checkpoint molecules on this cell ...

Abstract	Objectives: Vγ9Vδ2 T-cells are a subset of T-cells with a crucial role in immunosurveillance which can be activated and expanded by multiple means to stimulate effector responses. Little is known about the expression of checkpoint molecules on this cell population and whether the ligation of these molecules can regulate their activity. The aim of this study was to assess the expression of both activatory and inhibitory receptors on Vγ9Vδ2 T-cells to assess potential avenues of regulation to target with immunotherapy. Methods: Expression of various activatory and inhibitory receptors was assessed on Vγ9Vδ2 T-cells by flow cytometry following activation and expansion using zoledronic acid (ZA) and Bacillus Calmette-Guérin (BCG). Expression of these markers and production of effector molecules was also examined following co-culture with various tumour cell targets. The effect of immune checkpoint blockade on Vγ9Vδ2 T-cells was also explored. Results: Vγ9Vδ2 T-cells expressed high levels of activatory markers both at baseline and following stimulation. Vγ9Vδ2 T-cells expressed variable levels of inhibitory checkpoint receptors with many being upregulated following stimulation. Expression of these markers is further modulated upon co-culture with tumour cells with changes reflecting activation and effector functions. Despite their high expression of inhibitory receptors when cultured with tumour cells expressing cognate ligands there was no effect on Vδ2+ T-cell cytotoxic capacity or cytokine production with immune checkpoint blockade. Conclusions: Our work suggests the expression of checkpoint receptors present on Vγ9Vδ2 T-cells which may provide a mechanism with the potential to be utilised by tumour cells to subvert Vγ9Vδ2 T-cell cytotoxicity. This work suggests important candidates for blockade by ICI therapy in order to increase the successful use of Vγ9Vδ2 T-cells in immunotherapy.
MeSH term(s)	Humans ; T-Lymphocytes ; Immune Checkpoint Inhibitors/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Lymphocyte Activation ; Immunotherapy ; Neoplasms/therapy ; Neoplasms/metabolism
Chemical Substances	Immune Checkpoint Inhibitors ; Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1065495
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Article ; Online: Bacillus Calmette-Guerin (BCG) induces superior anti-tumour responses by Vδ2+ T cells compared with the aminobisphosphonate drug zoledronic acid.

Fenn, J / Ridgley, L A / White, A / Sarfas, C / Dennis, M / Dalgleish, A / Reljic, R / Sharpe, S / Bodman-Smith, M

Clinical and experimental immunology

2022 Volume 208, Issue 3, Page(s) 301–315

Abstract: Vδ2+ T cells can recognize malignantly transformed cells as well as those infected with mycobacteria. This cross-reactivity supports the idea of using mycobacteria to manipulate Vδ2+ T cells in cancer immunotherapy. To date, therapeutic interventions ... ...

Abstract	Vδ2+ T cells can recognize malignantly transformed cells as well as those infected with mycobacteria. This cross-reactivity supports the idea of using mycobacteria to manipulate Vδ2+ T cells in cancer immunotherapy. To date, therapeutic interventions using Vδ2+ T cells in cancer have involved expanding these cells in or ex vivo using zoledronic acid (ZA). Here, we show that the mycobacterium Bacillus Calmette-Guérin (BCG) also causes Vδ2+ T-cell expansion in vitro and that resulting Vδ2+ cell populations are cytotoxic toward tumour cell lines. We show that both ZA and BCG-expanded Vδ2+ cells effectively killed both Daudi and THP-1 cells. THP-1 cell killing by both ZA and BCG-expanded Vδ2+ cells was enhanced by treatment of targets cells with ZA. Although no difference in cytotoxic activity between ZA- and BCG-expanded Vδ2+ cells was observed, BCG-expanded cells degranulated more and produced a more diverse range of cytokines upon tumour cell recognition compared to ZA-expanded cells. ZA-expanded Vδ2+ cells were shown to upregulate exhaustion marker CD57 to a greater extent than BCG-expanded Vδ2+ cells. Furthermore, ZA expansion was associated with upregulation of inhibitory markers PD-1 and TIM3 in a dose-dependent manner whereas PD-1 expression was not increased following expansion using BCG. Intradermal BCG vaccination of rhesus macaques caused in vivo expansion of Vδ2+ cells. In combination with the aforementioned in vitro data, this finding suggests that BCG treatment could induce expansion of Vδ2+ T cells with enhanced anti-tumour potential compared to ZA treatment and that either ZA or BCG could be used intratumourally as a means to potentiate stronger anti-tumour Vδ2+ T-cell responses.
MeSH term(s)	Animals ; BCG Vaccine ; Lymphocyte Activation ; Macaca mulatta/metabolism ; Mycobacterium bovis ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocytes ; Zoledronic Acid/pharmacology
Chemical Substances	BCG Vaccine ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell, gamma-delta ; Zoledronic Acid (6XC1PAD3KF)
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1093/cei/uxac032
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Book: The link between inflammation and cancer

Dalgleish, Angus G.

wounds that do not heal

(Cancer treatment and research ; 130)

2006

Author's details	ed. by Angus G. Dalgleish
Series title	Cancer treatment and research ; 130
Collection
Keywords	Krebs ; Entzündung ; Carcinogenese ; Nuklearfaktor Kappa B
Subject	Nuclearer Faktor Kappa B ; NF-Kappa B ; NF-kB ; Nuklearer Faktor Kappa B ; Nuclearfaktor Kappa B ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Inflammatio ; Entzündungsreaktion
Language	English
Size	XII, 254 S. : graph. Darst.
Publisher	Springer
Publishing place	New York, NY
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT014608844
ISBN	0-387-26282-2 ; 978-0-387-26282-6 ; 0387262830 ; 9780387262833
Database	Catalogue ZB MED Medicine, Health

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2006 A 431	order for loan	Magazin

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Article: Challenges for European investors in Asia

Dalgleish, Alan

Indirect real estate investments , p. 112-117

2014 , Page(s) 112–117

Author's details	Alan Dalgleish
Keywords	Gewerbeimmobilien ; Kapitalanlage ; Investitionsentscheidung ; Australien ; Japan ; Singapur ; Greater China
Language	English
Size	graph. Darst.
Publisher	SECA, Swiss Private Equity & Corporate Finance Association [u.a.]
Publishing place	Zug
Document type	Article
ISBN	978-3-905977-07-3 ; 3-905977-07-9
Database	ECONomics Information System

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Article: Editorial: Immunotherapy for Prostate Cancer - turning the immunological desert into an oasis of hope.

Galustian, Christine / Dalgleish, Angus / Bodman-Smith, Mark / Kusmartsev, Sergei / Dasgupta, Prokar

Frontiers in oncology

2022 Volume 12, Page(s) 1021870

Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1021870
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Article ; Online: The importance for immunoregulation for long-term cancer control.

Fusi, Alberto / Dalgleish, Angus

Future oncology (London, England)

2017 Volume 13, Issue 18, Page(s) 1619–1632

Abstract: Immune checkpoint blockades have recently emerged as a breakthrough treatment for solid tumors showing high response rates and long durability. In melanoma, the combination of ipilimumab with nivolumab showed high efficacy. However, still half the ... ...

Abstract	Immune checkpoint blockades have recently emerged as a breakthrough treatment for solid tumors showing high response rates and long durability. In melanoma, the combination of ipilimumab with nivolumab showed high efficacy. However, still half the patients do not respond to this treatment. In order to increase the therapeutic ratio in melanoma and other cancers, different approaches are under evaluation. Three relevant questions are at the moment driving the research community: how to maximize benefit while minimizing toxicity; how to better identify patients who are more likely to benefit from immunotherapy; how to convert nonresponders into responders. In this review we summarize the most recent findings and we outline the most likely future challenges.
MeSH term(s)	Animals ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Clinical Trials as Topic ; Combined Modality Therapy ; Humans ; Immunomodulation/drug effects ; Immunotherapy/methods ; Molecular Targeted Therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/mortality ; Neoplasms/therapy ; Treatment Outcome
Chemical Substances	Antineoplastic Agents, Immunological ; Biomarkers, Tumor
Language	English
Publishing date	2017-08-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2184533-5
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2017-0085
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Article ; Online: Mycobacterial immunotherapy for prostate cancer: where can we go from here?

Stavrinides, Vasilis / Dalgleish, Angus / Copier, John P / Moore, Caroline M

Nature reviews. Urology

2020 Volume 17, Issue 4, Page(s) 189–190

MeSH term(s)	Bacterial Vaccines/therapeutic use ; Cancer Vaccines/therapeutic use ; Humans ; Immunotherapy ; Male ; Mycobacterium ; Prostatic Neoplasms/therapy
Chemical Substances	Bacterial Vaccines ; Cancer Vaccines ; SRL172 (1H3FW8MP4J) ; IMM-101 (IZT740JY57)
Language	English
Publishing date	2020-01-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-020-0283-2
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Article: The relevance of non-linear mathematics (chaos theory) to the treatment of cancer, the role of the immune response and the potential for vaccines.

Dalgleish, A

QJM : monthly journal of the Association of Physicians

1999 Volume 92, Issue 6, Page(s) 347–359

Abstract: Non-linear mathematics or 'chaos' theory was first applied in the prediction of complex systems such as the weather. Chaotic systems exhibit not only apparently random unpredictability, but also a degree of determinism, in that randomness remains ... ...

Abstract	Non-linear mathematics or 'chaos' theory was first applied in the prediction of complex systems such as the weather. Chaotic systems exhibit not only apparently random unpredictability, but also a degree of determinism, in that randomness remains confined within specific parameters. Biological systems manifest many of the features of chaotic systems, including the inherent repetition of self, fractal structure, and the existence of strange attractors. In this article, the interaction between a tumour and the immune system is examined with regard to the capacity for immunotherapy to influence these two complex systems beneficially. It is postulated that judicious immunization may lead to profound changes in the stability of this interaction, in the favour of the immune system's ability to recognize tumour cells.
MeSH term(s)	Antibody Formation ; Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Nonlinear Dynamics
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines
Language	English
Publishing date	1999-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 1460-2725 ; 0033-5622
ISSN (online)	1460-2393
ISSN	1460-2725 ; 0033-5622
DOI	10.1093/qjmed/92.6.347
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