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  1. Article: Autonomic Nervous System and Cognitive Impairment in Older Patients: Evidence From Long-Term Heart Rate Variability in Real-Life Setting.

    Dalise, Anna Maria / Prestano, Raffaele / Fasano, Renata / Gambardella, Antonio / Barbieri, Michelangela / Rizzo, Maria Rosaria

    Frontiers in aging neuroscience

    2020  Volume 12, Page(s) 40

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2020-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2020.00040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cirrhosis and frailty assessment in elderly patients: A paradoxical result.

    Federico, Alessandro / Caprio, Giuseppe Gerardo / Dalise, Anna Maria / Barbieri, Michelangela / Dallio, Marcello / Loguercio, Carmelina / Paolisso, Giuseppe / Rizzo, Maria Rosaria

    Medicine

    2020  Volume 99, Issue 2, Page(s) e18501

    Abstract: The frailty represents a key determinant of elderly clinical assessment, especially because it allows the identification of risk factors potentially modifiable by clinical and therapeutic interventions. The frailty assessment in elderly patients usually ... ...

    Abstract The frailty represents a key determinant of elderly clinical assessment, especially because it allows the identification of risk factors potentially modifiable by clinical and therapeutic interventions. The frailty assessment in elderly patients usually is made by using of Fried criteria. However, to assess the frailty in cirrhotic patients, multiple but different tools are used by researchers. Thus, we aimed to compare frailty prevalence in elderly patients with well-compensated liver cirrhosis and without cirrhosis, according to Fried criteria.Among 205 elderly patients screened, a total of 148 patients were enrolled. The patients were divided into 2 groups according to the presence/absence of well-compensated liver cirrhosis.After clinical examination with conventional scores of cirrhosis, all patients underwent anthropometric measurements, nutritional, biochemical, comorbidity, and cognitive performances. Frailty assessment was evaluated according to Fried frailty criteria.Unexpectedly, according to the Fried criteria, non-cirrhotic patients were frailer (14.2%) than well-compensated liver cirrhotic patients (7.5%). The most represented Fried criterion was the unintentional weight loss in non-cirrhotic patients (10.1%) compared to well-compensated liver cirrhotic patients (1.4%). Moreover, cumulative illness rating scale -G severity score was significantly and positively associated with frailty status (r = 0.234, P < .004). In a multivariate linear regression model, only female gender, body mass index and mini nutritional assessment resulted associated with frailty status, independently of other confounding variables.Despite the fact that elderly cirrhotic patients are considered to be frailer than the non-cirrhotic elderly patient, relying solely on "mere visual appearance," our data show that paradoxically non-cirrhotic elderly patients are frailer than elderly well-compensated liver cirrhotic patients. Thus, clinical implication of this finding is that frailty assessment performed in the well-compensated liver cirrhotic patient can identify those cirrhotic patients who may benefit from tailored interventions similarly to non-cirrhotic elderly patients.
    MeSH term(s) Aged ; Body Mass Index ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Comorbidity ; Cross-Sectional Studies ; Female ; Frailty/epidemiology ; Hepacivirus/isolation & purification ; Hepatitis C/complications ; Hepatitis C/epidemiology ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/epidemiology ; Male ; Nutrition Assessment ; Prevalence ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000018501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Serum adiponectin levels are associated with worse cognitive function in postmenopausal women.

    De Franciscis, Pasquale / Barbieri, Michelangela / Leo, Stefania / Dalise, Anna Maria / Sardu, Celestino / Marfella, Raffaele / Colacurci, Nicola / Paolisso, Giuseppe / Rizzo, Maria Rosaria

    PloS one

    2017  Volume 12, Issue 12, Page(s) e0186205

    Abstract: Introduction: Adiponectin may be a biomarker of cognitive impairment stage, and its clinical progression. In this study we aimed to evaluate the relationship between serum adiponectin levels and cognitive performances in menopausal women, and whether ... ...

    Abstract Introduction: Adiponectin may be a biomarker of cognitive impairment stage, and its clinical progression. In this study we aimed to evaluate the relationship between serum adiponectin levels and cognitive performances in menopausal women, and whether serum adiponectin levels may be differently associated with cognitive performances as compared to overweight/obese subjects.
    Methods: We enrolled 188 post-menopausal women, divided into two groups: obese/overweight group (n = 96) and normal weight group (n = 92). After a clinical examination, and laboratory measurements, we assessed cognitive functions by Montreal Cognitive Assessment test (MoCA).
    Results: A significant and greater decrease in executive/visuo-spatial and in attention functions occurred in obese/overweight group as compared to normal weight group (p< 0.001). A significant positive relationship between serum adiponectin levels, and MoCA Global cognitive function was found. MoCA executive, and MoCA attention functions significantly and positively correlated with serum adiponectin levels. BMI, WHR, and serum adiponectin levels were independently associated with MoCA Global cognitive function, but only serum adiponectin levels were independently associated with MoCA attention.
    Conclusion: A significant positive association may exist between serum adiponectin levels, and better cognitive function in postmenopausal status. The major determinant of attentional capacity was just serum adiponectin levels, and dosage of serum adiponectin levels may be early serum marker of cognitive decline. Therefore, serum adiponectin level has to be used, as early biomarker, to detect cognitive decline, and to support an early prevention.
    MeSH term(s) Adiponectin/blood ; Biomarkers/blood ; Case-Control Studies ; Cognition Disorders/blood ; Cognition Disorders/complications ; Female ; Humans ; Middle Aged ; Obesity/blood ; Obesity/complications ; Postmenopause
    Chemical Substances Adiponectin ; Biomarkers
    Language English
    Publishing date 2017-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0186205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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