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  1. Article ; Online: Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update.

    Bellal, Mathieu / Malherbe, Jolan / Damaj, Gandhi / Du Cheyron, Damien

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 69

    Abstract: Background: Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are ...

    Abstract Background: Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU.
    Objective: The aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues.
    MeSH term(s) Adult ; Humans ; Receptors, Chimeric Antigen/therapeutic use ; B-Lymphocytes ; Critical Care ; Hematologic Neoplasms/therapy ; T-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04851-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  2. Article ; Online: Be ever cautious until the truth is proven.

    Chantepie, Sylvain / Yakoub-Agha, Ibrahim / Damaj, Gandhi

    American journal of hematology

    2019  Volume 94, Issue 4, Page(s) E106

    MeSH term(s) Bendamustine Hydrochloride ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma ; Transplantation, Autologous
    Chemical Substances Bendamustine Hydrochloride (981Y8SX18M)
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25410
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  3. Article ; Online: Combining baseline TMTV and gene profiling for a better risk stratification in diffuse large B cell lymphoma.

    Aide, Nicolas / Lasnon, Charline / Damaj, Gandhi

    European journal of nuclear medicine and molecular imaging

    2018  Volume 45, Issue 5, Page(s) 677–679

    MeSH term(s) Humans ; Lymphoma, Large B-Cell, Diffuse ; Risk
    Language English
    Publishing date 2018-02-17
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-018-3966-7
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    Zs.A 1227: Show issues Location:
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  4. Article ; Online: Évaluation de la disparité de prise en charge des patients avec une leucémie lymphoïde chronique en France.

    Rateau, Yann / Harbouche, Michael / Damaj, Gandhi / Troussard, Xavier

    Bulletin du cancer

    2018  Volume 105, Issue 12, Page(s) 1147–1156

    Abstract: Environmental factors have an impact on the effectiveness of treatments for chronic lymphocytic leukemia: vulnerability, organization of the supply of care and proximity of the patient to health professionals. The disparity of care was assessed; ... ...

    Title translation Evaluation of management disparity in patients with chronic lymphocytic leukemia in France.
    Abstract Environmental factors have an impact on the effectiveness of treatments for chronic lymphocytic leukemia: vulnerability, organization of the supply of care and proximity of the patient to health professionals. The disparity of care was assessed; vulnerability by the European index of deprivation, the provision of care by values of localized potential accessibility to general practitioners, nurses and pharmacists and hospital supply by the density of hematologists and time access to the center. The data, extracted from the public databases for each grouped island for statistical information, were cross-referenced to apply a principal component analysis and group them into 4 clusters. Cluster 1 has an average EDI, easy access to city professionals, remote access to the referral center, and a good density of hematologists. Cluster 2 has low EDI, satisfactory access to professionals, satisfactory proximity to the referral center and average density of hematologists. Cluster 3 has good EDI, access to professionals is difficult, access to the reference center is long, and the density of hematologists remains average. Cluster 4 has a good EDI, with access to professionals easier than in Cluster 3 but still difficult. The access time to the reference center is better than that of cluster 3 but remains elongated, the density of hematologists remaining average. Mapping is a tool for hospitals and institutions to evaluate care and compare it to other territories.
    MeSH term(s) Adult ; Aged ; Europe ; Female ; France ; Geographic Mapping ; Health Services Accessibility/statistics & numerical data ; Healthcare Disparities/statistics & numerical data ; Hematology/statistics & numerical data ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Male ; Middle Aged ; Socioeconomic Factors ; Time Factors
    Language French
    Publishing date 2018-11-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2018.08.014
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  5. Article: Immunophenotypic Analysis of Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia-like (HCL-like) Disorders.

    Maitre, Elsa / Cornet, Edouard / Salaün, Véronique / Kerneves, Pauline / Chèze, Stéphane / Repesse, Yohan / Damaj, Gandhi / Troussard, Xavier

    Cancers

    2022  Volume 14, Issue 4

    Abstract: Hairy cell leukemia (HCL) is characterized by abnormal villous lymphoid cells that express CD103, CD123, CD25 and CD11c. HCL-like disorders, including hairy cell leukemia variant (vHCL) and splenic diffuse red pulp lymphoma (SDRPL), have similar ... ...

    Abstract Hairy cell leukemia (HCL) is characterized by abnormal villous lymphoid cells that express CD103, CD123, CD25 and CD11c. HCL-like disorders, including hairy cell leukemia variant (vHCL) and splenic diffuse red pulp lymphoma (SDRPL), have similar morphologic criteria and a distinct phenotypic and genetic profile. We investigated the immunophenotypic features of a large cohort of 82 patients: 68 classical HCL, 5 vHCL/SDRPL and 9 HCL-like NOS. The HCL immunophenotype was heterogeneous: positive CD5 expression in 7/68 (10%), CD10 in 12/68 (18%), CD38 in 24/67 (36%), CD23 in 22/68 (32%) and CD43 in 19/65 (31%) patients. CD26 was expressed in 35/36 (97%) of HCL patients, none of vHCL/SDRPL and one of seven HCL-like NOS (14%). When adding CD26 to the immunologic HCL scoring system (one point for CD103, CD123, CD25, CD11c and CD26), the specificity was improved, increasing from 78.6% to 100%. We used unsupervised analysis of flow cytometry raw data (median fluorescence, percentage of expression) and the mutational profile of
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14041050
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  6. Article ; Online: Low total gamma globulin level discovery at diffuse large B-cell lymphoma diagnosis predicts high risk of infection-related death: data from a monocentric retrospective study.

    Nguyen, Alexandre / Martin-Silva, Nicolas / de Boysson, Hubert / Deshayes, Samuel / Gac, Anne-Claire / Reboursière, Emilie / Damaj, Gandhi / Aouba, Achille

    Swiss medical weekly

    2022  Volume 152, Page(s) w30143

    Abstract: Objective: Diffuse large B-cell lymphoma can complicate the course of B-cell primary immunodeficiencies or induce lowering of total gamma globulin levels, whose clinical status as an effective secondary immunodeficiency remains unspecified. This study ... ...

    Abstract Objective: Diffuse large B-cell lymphoma can complicate the course of B-cell primary immunodeficiencies or induce lowering of total gamma globulin levels, whose clinical status as an effective secondary immunodeficiency remains unspecified. This study aimed to assess the frequency, and clinical and prognostic relevance of the low total gamma-globulin levels discovered at diagnosis of diffuse large B-cell lymphoma.
    Results: In a 2-year monocentric retrospective study, 96 patients diagnosed with diffuse large B-cell lymphoma who had a serum electrophoresis were included. Patients were divided into those with lower (L-TGL and higher (H-TGL) total gamma-globulin levels (total gamma-globulin levels ≤5.5 g/l and >5.5 g/l) and compared for outcomes, including fatal infectious events. Twelve (12.5%; 8 males; age median 68 years, range 55-82 years) exhibited L-TGL. There was no difference between the both groups regarding demographics, Ann Arbor lymphoma stage, inflammatory parameters or chemotherapy regimen. However, overall death rates (10/12, 83.3% versus 22/96, 26.2%; p = 0.03) and infection-related death rates (10/12, 83% versus 6/96, 6.2%; p <0.001) were significantly higher in the L-TGL group.
    Conclusion: We demonstrate for the first time the strong negative impact of L-TGL on overall and infection-related mortality in diffuse large B-cell lymphoma. Prospective studies should distinguish immunodeficiencies secondary to the lymphoma from pre-existing humoral primary immunodeficiencies, using biomolecular testing and post-treatment total gamma-globulin level monitoring, to determine the best management strategy for infectious risk during diffuse large B-cell lymphoma treatment in the context of L-TGL.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Retrospective Studies ; gamma-Globulins/therapeutic use
    Chemical Substances gamma-Globulins ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2022.w30143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.152: Show issues Location:
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  7. Article ; Online: Efficacy of ruxolitinib in the treatment of relapsed/refractory large granular lymphocytic leukaemia.

    Marchand, Tony / Pastoret, Cédric / Damaj, Gandhi / Lebouvier, Angélique / Herbaux, Charles / Moignet, Aline / Pavlosky, Miguel / Pavlosky, Astrid / Blouet, Anaise / Eloit, Martin / Launay, Vincent / Lebreton, Pierre / Stamatoullas, Aspasia / Nilsson, Christer / Ochmann, Marlène / Prola, Juliette / Lamy, Thierry

    British journal of haematology

    2024  

    Abstract: Large granular lymphocytic (LGL) leukaemia is a rare chronic lymphoproliferative disorder characterized by an expansion of cytotoxic T or NK cells. Despite a usually indolent evolution, most patients will require a treatment over the course of the ... ...

    Abstract Large granular lymphocytic (LGL) leukaemia is a rare chronic lymphoproliferative disorder characterized by an expansion of cytotoxic T or NK cells. Despite a usually indolent evolution, most patients will require a treatment over the course of the disease because of cytopenia or symptomatic associated autoimmune disorders. First-line treatment is based on immunosuppressive agents, namely cyclophosphamide, methotrexate and ciclosporin. However, relapses are frequent, and there is no consensus on the management of relapsed/refractory patients. The implication of the JAK/STAT pathway in the pathogenesis of this disease has prompted our group to propose treatment with ruxolitinib. A series of 21 patients who received this regimen is reported here. Ten patients (47.6%) were refractory to the three main immunosuppressive drugs at the time of ruxolitinib initiation. Ruxolitinib yielded an overall response rate of 86% (n = 18/21), including 3 complete responses and 15 partial responses. With a median follow-up of 9 months, the median response duration was 4 months. One-year event-free survival and 1-year overall survival were 57% and 83% respectively. Mild side effects were observed. Biological parameters, notably neutropenia and anaemia, improved significantly, and complete molecular responses were evidenced. This study supports ruxolitinib as a valid option for the treatment of relapsed/refractory LGL leukaemia.
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19476
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  8. Article ; Online: Successful allogeneic hematopoietic stem cell transplantation in a child with angioimmunoblastic T-cell lymphoma: A case report.

    Delehaye, Fanny / Deparis, Marianna / Buchbinder, Nimrod / Bodet, Damien / Minard, Véronique / Jean-Jacques, Bastien / Marie-Laure, Quintyn / Gaulard, Philippe / Sako, Nouhoum / Robe, Cyrielle / Bardet, Hippolyte / Damaj, Gandhi / Rouger, Jérémie

    Pediatric blood & cancer

    2023  Volume 70, Issue 10, Page(s) e30497

    MeSH term(s) Humans ; Child ; Hematopoietic Stem Cell Transplantation ; Lymphoma, T-Cell, Peripheral/therapy ; Transplantation, Autologous
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30497
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    Zs.A 1131: Show issues Location:
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  9. Article: [

    Barré, Louisa / Hovhannisyan, Narinée / Bodet-Milin, Caroline / Kraeber-Bodéré, Françoise / Damaj, Gandhi

    Frontiers in medicine

    2019  Volume 6, Page(s) 77

    Abstract: With the emergence of PET/CT ... ...

    Abstract With the emergence of PET/CT using
    Language English
    Publishing date 2019-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2019.00077
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  10. Article: Comprehensive analysis of the influence of G-CSF on the biodistribution of

    Oliveira, Magno / Lasnon, Charline / Nganoa, Catherine / Gac, Anne-Claire / Damaj, Gandhi / Aide, Nicolas

    EJNMMI research

    2019  Volume 9, Issue 1, Page(s) 79

    Abstract: Aims: (1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of : Materials and methods: Retrospectively included were 74 consecutive diffuse large B cell ... ...

    Abstract Aims: (1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of
    Materials and methods: Retrospectively included were 74 consecutive diffuse large B cell lymphoma (DLBCL) patients referred for baseline and interim examinations and receiving immunochemotherapy with various G-CSF regimens. A comprehensive evaluation considering baseline metabolic active tumour volume (MATV), factors affecting liver uptake, the type of G-CSF, and the time elapsed between chemotherapy/G-CSF and interim PET/CTs was performed.
    Results: Mean (± SD) percentage variations between baseline and interim PET/CTs (i-PET/CT) for bone marrow (%Variation_
    Conclusions: Neither the type of G-CSF used nor the time elapsed between its last injection and i-PET/CT examination independently influences bone, hepatic, or splenic uptakes at i-PET/CT. The major determinant for the occurrence of a bone or spleen hypermetabolism on i-PET/CT is the time elapsed between the chemotherapy and the examination, which should be maintained above 15 days. Inversion of the liver to spleen ratio appeared to be due to increased spleen hypermetabolism on i-PET/CT, making unlikely an impact on the Deauville scoring.
    Language English
    Publishing date 2019-08-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-019-0546-1
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