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  1. Article: Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review.

    Civino, Adele / Diomeda, Federico / Giordano, Luca / Damasio, Maria Beatrice / Perrone, Sandra / Gallizzi, Romina / Ravelli, Angelo / Piscitelli, Prisco / Maggio, Maria Cristina

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and ... ...

    Abstract Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and frequent initial misdiagnoses, with pictures that can mimic inflammatory monoarthritis. We aimed to describe a case series, and to provide a literature review of this uncommon and misleading tumor location.
    Methods: We performed a retrospective analysis of patients referred to three pediatric rheumatology centers, with a final diagnosis of articular osteoid osteoma. A review of the literature was additionally conducted.
    Results: We included 10 patients with a mean age of 14 years. All patients with unusual sites (olecranon fossa, lumbar vertebra, distal phalanx of the toe, fibula) had a misdiagnosis, and cases with initial suspicion of monoarthritis had the longest diagnostic delay, up to 24 months. The literature review confirms the significant risk of misdiagnosis, and an average time from symptom onset to diagnosis ranging from 0.4 to 1.8 years.
    Conclusions: Articular osteoid osteoma may mimic arthritis, especially in adolescence. Knowledge of the atypical forms of presentation, and of the clinical and radiological pitfalls, reduces the risk of diagnostic error.
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10050829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinical and Microbiological Characteristics of Deep Neck Abscesses in Pediatrics: Analysis of a Case Series from a 3rd Level Pediatric Hospital.

    Mariani, Marcello / Saffioti, Carolina / Mesini, Alessio / Palmero, Candida / D'Agostino, Roberto / Garofolo, Sabrina / Rossi, Andrea / Damasio, Maria Beatrice / Castagnola, Elio

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: As there is currently no consensus on managing deep neck infections in pediatric populations, we report a case series from a large pediatric hospital. Clinical data of patients discharged from Istituto Gaslini-Children's Hospital from January 2014 to ... ...

    Abstract As there is currently no consensus on managing deep neck infections in pediatric populations, we report a case series from a large pediatric hospital. Clinical data of patients discharged from Istituto Gaslini-Children's Hospital from January 2014 to June 2020 with peritonsillar, parapharyngeal, or retropharyngeal abscess diagnoses were collected. A total of 59 patients were identified. Patients underwent surgical drainage in 47% of cases. Streptococcus mitis/oralis was the most isolated pathogen. Surgically treated patients did have larger abscesses compared to others, but there were no differences in the duration of hospitalization. Children who received NSAIDs at home had significant delays in diagnosis (median 4 vs. 1.5 days,
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10091506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical and Radiological Features of

    Ricci, Erica / Bartalucci, Claudia / Russo, Chiara / Mariani, Marcello / Saffioti, Carolina / Massaccesi, Erika / Pierri, Filomena / Brisca, Giacomo / Moscatelli, Andrea / Caorsi, Roberta / Bruzzone, Bianca / Damasio, Maria Beatrice / Marchese, Anna / Mesini, Alessio / Castagnola, Elio

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 4

    Abstract: Background: Pneumocytis jirovecii: Description of cases: All PJP cases in non-HIV/AIDS patients diagnosed at Istituto Giannina Gaslini Pediatric Hospital in Genoa (Italy) from January 2012 until October 2022 were retrospectively evaluated. Nine cases ...

    Abstract Background: Pneumocytis jirovecii
    Description of cases: All PJP cases in non-HIV/AIDS patients diagnosed at Istituto Giannina Gaslini Pediatric Hospital in Genoa (Italy) from January 2012 until October 2022 were retrospectively evaluated. Nine cases were identified (median age: 8.3 years), and of these, 6/9 underwent prophylaxis with trimethoprim/sulfamethoxazole (TMP/SMX; five once-a-week schedules and one three times-a-week schedule), while 3/9 did not receive this. PJP was diagnosed by real-time PCR for
    Discussion: Due to the difficulty in obtaining biopsy specimens, PJP diagnosis is usually considered probable in most cases. Moreover, the severity of the clinical presentation often leads physicians to start TMP/SMX treatment empirically. BDG proved to be a useful tool for diagnosis, and CT showed good accuracy in identifying typical patterns. In our center, single-day/week prophylaxis was ineffective in high-risk patients; the three-day/week schedule would, therefore, seem preferable and, in any case, should be started promptly in all patients who have an indication of pneumonia.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10040276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Update on imaging recommendations in paediatric uroradiology: the European Society of Paediatric Radiology workgroup session on voiding cystourethrography.

    Damasio, Maria Beatrice / Donati, Francesco / Bruno, Costanza / Darge, Kassa / Mentzel, Hans-Joachim / Ključevšek, Damjana / Napolitano, Marcello / Ozcan, H Nursun / Riccabona, Michael / Smets, Anne M / Sofia, Carmelo / Stafrace, Samuel / Petit, Philippe / Ording Müller, Lil-Sofie

    Pediatric radiology

    2024  Volume 54, Issue 4, Page(s) 606–619

    Abstract: Voiding cystourethrography (VCUG) is a fluoroscopic technique that allows the assessment of the urinary tract, including the urethra, bladder, and-if vesicoureteral reflux (VUR) is present-the ureters and the pelvicalyceal systems. The technique also ... ...

    Abstract Voiding cystourethrography (VCUG) is a fluoroscopic technique that allows the assessment of the urinary tract, including the urethra, bladder, and-if vesicoureteral reflux (VUR) is present-the ureters and the pelvicalyceal systems. The technique also allows for the assessment of bladder filling and emptying, providing information on anatomical and functional aspects. VCUG is, together with contrast-enhanced voiding urosonography (VUS), still the gold standard test to diagnose VUR and it is one of the most performed fluoroscopic examinations in pediatric radiology departments. VCUG is also considered a follow-up examination after urinary tract surgery, and one of the most sensitive techniques for studying anatomy of the lower genitourinary tract in suspected anatomical malformations. The international reflux study in 1985 published the first reflux-protocol and graded VUR into five classes; over the following years, other papers have been published on this topic. In 2008, the European Society of Paediatric Radiology (ESPR) Uroradiology Task Force published the first proposed VCUG Guidelines with internal scientific society agreement. The purpose of our work is to create a detailed overview of VCUG indications, procedural recommendations, and to provide a structured final report, with the aim of updating the 2008 VCUG paper proposed by the European Society of Paediatric Radiology (ESPR). We have also compared VCUG with contrast-enhanced VUS as an emergent alternative. As a result of this work, the ESPR Urogenital Task Force strongly recommends the use of contrast-enhanced VUS as a non-radiating imaging technique whenever indicated and possible.
    MeSH term(s) Child ; Humans ; Infant ; Ultrasonography/methods ; Urinary Bladder/diagnostic imaging ; Urination ; Vesico-Ureteral Reflux/diagnostic imaging ; Urethra/diagnostic imaging ; Radiology ; Contrast Media
    Chemical Substances Contrast Media
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-024-05883-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response to "Re Hydronephrosis and crossing vessels in children: Optimization of diagnostic-therapeutic pathway and analysis of color Doppler ultrasound and magnetic resonance urography diagnostic accuracy".

    Wong, Michela Cing Yu / Damasio, Maria Beatrice / Piaggio, Giorgio / Mattioli, Girolamo

    Journal of pediatric urology

    2018  Volume 14, Issue 2, Page(s) 204

    MeSH term(s) Child ; Humans ; Hydronephrosis ; Magnetic Resonance Spectroscopy ; Ultrasonography, Doppler, Color ; Urography
    Language English
    Publishing date 2018-02-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2017.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 Pneumomediastinum: Possible Role of Transesophageal Echo in Bedside Percutaneous Bicaval Double-Lumen ECMO Cannulation in Children. A Case Report.

    Moscatelli, Andrea / Pezzato, Stefano / Buratti, Silvia / Lampugnani, Elisabetta / Di Mascio, Alberto / Damasio, Maria Beatrice / Caorsi, Roberta / Gattorno, Marco / Castagnola, Elio

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 740853

    Abstract: COVID-19 is generally uneventful in children. Only 8% of severe acute respiratory distress syndrome corona virus 2 pediatric patients require intensive care; of these, 1% may need extracorporeal membrane oxygenation. Preexisting medical conditions are an ...

    Abstract COVID-19 is generally uneventful in children. Only 8% of severe acute respiratory distress syndrome corona virus 2 pediatric patients require intensive care; of these, 1% may need extracorporeal membrane oxygenation. Preexisting medical conditions are an independent risk factor for pediatric intensive care unit admission. We describe the case of an 11-year-old girl with adenosine deaminase 2 deficiency who presented severe COVID-19 acute respiratory distress syndrome, complicated by a massive air leak syndrome. The respiratory failure, refractory to conventional support, required veno-venous extracorporeal membrane oxygenation. To prevent viral diffusion, bicaval double-lumen cannulation was performed percutaneously at the bedside under exclusive echo guidance. Because of pneumomediastinum, pneumothorax, and subcutaneous emphysema, ultrasound visualization of the heart was possible only with transesophageal echo. To our knowledge, this is the first description of a transesophageal echo guided bedside percutaneous bicaval double-lumen extracorporeal membrane oxygenation cannulation in a pediatric patient. Pitfalls of the technique are highlighted.
    Language English
    Publishing date 2021-10-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.740853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Diffusion-Weighted MRI in the Evaluation of Renal Parenchymal Involvement during Febrile Urinary Tract Infections in Children: Preliminary Data.

    Anfigeno, Lorenzo / Sertorio, Fiammetta / Basso, Luca / Fontana, Andrea / Bodria, Monica / Pistorio, Angela / Ghiggeri, Gian Marco / Damasio, Maria Beatrice

    Journal of clinical medicine

    2021  Volume 10, Issue 11

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10112239
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  8. Article ; Online: Magnetic resonance urography of congenital abnormalities - what the radiologist needs to know.

    Campo, Irene / Sertorio, Fiammetta / Wong, Michela / Anfigeno, Lorenzo / Bertolotto, Michele / Mattioli, Girolamo / Damasio, Maria Beatrice

    Pediatric radiology

    2021  Volume 52, Issue 5, Page(s) 985–997

    Abstract: Congenital abnormalities of the kidney and urinary tract include a wide range of malformations ranging from asymptomatic to life-threatening conditions. Although pediatric urogenital system imaging is based on the use of US (pre- and postnatal), voiding ... ...

    Abstract Congenital abnormalities of the kidney and urinary tract include a wide range of malformations ranging from asymptomatic to life-threatening conditions. Although pediatric urogenital system imaging is based on the use of US (pre- and postnatal), voiding cystourethrography and scintigraphic study, magnetic resonance (MR) urography plays a fundamental role in the classification and management of congenital abnormalities of the kidney and urinary tract, giving an overview of the different clinical pictures, thanks to its panoramicity and high anatomical detail. In fact the anomalies of the urinary tract are phenotypically variable because they can affect simultaneously several segments of different embryonic derivation, with complex clinical pictures; they can appear both as isolated phenotypes or as complex malformative conditions, involving renal parenchyma, collecting system and bladder. A deep knowledge of this complex embryogenesis and its possible phenotypic patterns allows a correct interpretation of MR urography images. We describe the embryology and pathophysiology of congenital abnormalities of the kidney and urinary tract as well as MR urography technique and findings. Congenital abnormalities of the kidney and urinary tract are classified into four groups: (1) obstruction (proximal, middle and distal), (2) budding with respect to the Wolffian duct (site and number of ureter), (3) ascent and rotation (ectopia, malrotation and fusion of kidney) and (4) anomaly of metanephric differentiation (dysplasia, megapolicalycosis).
    MeSH term(s) Child ; Humans ; Kidney/abnormalities ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Radiologists ; Urinary Tract/diagnostic imaging ; Urography/methods
    Language English
    Publishing date 2021-11-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05233-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Whole-body MRI: non-oncological applications in paediatrics.

    Damasio, Maria Beatrice / Magnaguagno, Francesca / Stagnaro, Giorgio

    La Radiologia medica

    2016  Volume 121, Issue 5, Page(s) 454–461

    Abstract: Whole-body magnetic resonance imaging (WBMRI) is a fast and accurate method for detecting and monitoring of diseases throughout the entire body without exposure to ionizing radiation. Among emerging non-oncological potential applications of WBMRI, ... ...

    Abstract Whole-body magnetic resonance imaging (WBMRI) is a fast and accurate method for detecting and monitoring of diseases throughout the entire body without exposure to ionizing radiation. Among emerging non-oncological potential applications of WBMRI, rheumatological diseases play an important role. Rheumatological WBMRI applications include the evaluation of chronic multifocal recurrent osteomyelitis, dermatomyositis, fever of unknown origin, arthritis, and connective tissue diseases. Aim of this review is to give an overview of the use of WBMRI in rheumatological field.
    MeSH term(s) Adolescent ; Arthritis, Juvenile/diagnosis ; Arthritis, Rheumatoid/diagnosis ; Child ; Connective Tissue Diseases/etiology ; Dermatomyositis/diagnosis ; Fever of Unknown Origin/etiology ; Humans ; Magnetic Resonance Imaging/methods ; Osteomyelitis/diagnosis ; Predictive Value of Tests ; Rheumatic Diseases/diagnosis ; Rheumatology ; Sensitivity and Specificity ; Whole Body Imaging/methods
    Language English
    Publishing date 2016-05
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-015-0619-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Early treatment of type II SMA slows rate of progression of scoliosis.

    Coratti, Giorgia / Lenkowicz, Jacopo / Pera, Maria Carmela / D'Amico, Adele / Bruno, Claudio / Gullì, Consolato / Brolatti, Noemi / Pedemonte, Marina / Antonaci, Laura / Ricci, Martina / Capasso, Anna / Cicala, Gianpaolo / Cutrona, Costanza / de Sanctis, Roberto / Carnicella, Sara / Forcina, Nicola / Cateruccia, Michela / Damasio, Maria Beatrice / Labianca, Luca /
    Manfroni, Francesca / Leone, Antonio / Bertini, Enrico / Pane, Marika / Patarnello, Stefano / Valentini, Vincenzo / Mercuri, Eugenio

    Journal of neurology, neurosurgery, and psychiatry

    2024  Volume 95, Issue 3, Page(s) 235–240

    Abstract: Background: Type II spinal muscular atrophy (SMA) often leads to scoliosis in up to 90% of cases. While pharmacological treatments have shown improvements in motor function, their impact on scoliosis progression remains unclear. This study aims to ... ...

    Abstract Background: Type II spinal muscular atrophy (SMA) often leads to scoliosis in up to 90% of cases. While pharmacological treatments have shown improvements in motor function, their impact on scoliosis progression remains unclear. This study aims to evaluate potential differences in scoliosis progression between treated and untreated SMA II patients.
    Methods: Treatment effect on Cobb's angle annual changes and on reaching a 50° Cobb angle was analysed in treated and untreated type II SMA patients with a minimum 1.5-year follow-up. A sliding cut-off approach identified the optimal treatment subpopulation based on age, Cobb angle and Hammersmith Functional Motor Scale Expanded at the initial visit. Mann-Whitney U-test assessed statistical significance.
    Results: There were no significant differences in baseline characteristics between the untreated (n=46) and treated (n=39) populations. The mean Cobb angle variation did not significantly differ between the two groups (p=0.4). Optimal cut-off values for a better outcome were found to be having a Cobb angle <26° or an age <4.5 years. When using optimal cut-off, the treated group showed a lower mean Cobb variation compared with the untreated group (5.61 (SD 4.72) degrees/year vs 10.05 (SD 6.38) degrees/year; p=0.01). Cox-regression analysis indicated a protective treatment effect in reaching a 50° Cobb angle, significant in patients <4.5 years old (p=0.016).
    Conclusion: This study highlights that pharmacological treatment, if initiated early, may slow down the progression of scoliosis in type II SMA patients. Larger studies are warranted to further investigate the effectiveness of individual pharmacological treatment on scoliosis progression in this patient population.
    MeSH term(s) Humans ; Child, Preschool ; Scoliosis/diagnostic imaging ; Scoliosis/therapy ; Spinal Muscular Atrophies of Childhood ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-332084
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