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Artikel ; Online: Letter: Bif195 for aspirin-induced gastric mucosal damage - More to do in further research. Authors' reply.

Løn, Nina / Engel, Sara / Damholt, Anders / Wellejus, Anja / Knop, Filip K

2024 Band 59, Heft 10, Seite(n) 1306–1307

Mesh-Begriff(e)	Humans ; Aspirin/adverse effects ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Chemische Substanzen	Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents, Non-Steroidal
Sprache	Englisch
Erscheinungsdatum	2024-04-23
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.18002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Editorial: The microbiome and gastric mucosal protection in aspirin users-Authors' reply.

Løn, Nina / Engel, Sara / Damholt, Anders / Wellejus, Anja / Knop, Filip K

Alimentary pharmacology & therapeutics

2024 Band 59, Heft 4, Seite(n) 577–578

Mesh-Begriff(e)	Humans ; Microbiota ; Gastric Mucosa/drug effects ; Aspirin/adverse effects
Chemische Substanzen	Aspirin (R16CO5Y76E)
Sprache	Englisch
Erscheinungsdatum	2024-01-21
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17826
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Efficacy and dose response of

Martoni, Christopher J / Srivastava, Shalini / Damholt, Anders / Leyer, Gregory J

World journal of gastroenterology

2023 Band 29, Heft 28, Seite(n) 4451–4465

Abstract: Background: Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D); however, the certainty of evidence is low. Well-powered randomized controlled dose-ranging trials are warranted on promising ... ...

Abstract	Background: Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D); however, the certainty of evidence is low. Well-powered randomized controlled dose-ranging trials are warranted on promising single-strain candidates. Aim: To investigate the clinical efficacy of Methods: This is a randomized, double-blind, placebo-controlled, multi-center, and dose-ranging study. Three hundred and seven adults, 18-70 years of age, with IBS-D, according to Rome IV criteria, were allocated (1:1:1) to receive placebo or Results: IBS-SSS was significantly reduced, after 8 wk, in participants receiving Conclusion: L. plantarum
Mesh-Begriff(e)	Adult ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/drug therapy ; Quality of Life ; Diarrhea/etiology ; Diarrhea/complications ; Treatment Outcome ; Abdominal Pain/diagnosis ; Abdominal Pain/drug therapy ; Abdominal Pain/etiology ; Double-Blind Method
Sprache	Englisch
Erscheinungsdatum	2023-07-27
Erscheinungsland	United States
Dokumenttyp	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v29.i28.4451
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Safety of

Engel, S / Mortensen, B / Wellejus, A / Vera-Jimenez, N / Struve, C / Brummer, R J / Damholt, A / Woods, T / Shanahan, F

Beneficial microbes

2022 Band 13, Heft 3, Seite(n) 243–252

Abstract: We have previously shown that the ... ...

Abstract	We have previously shown that the probiotic
Mesh-Begriff(e)	Adult ; Bifidobacterium breve ; Cytokines ; Double-Blind Method ; Female ; Humans ; Intestines ; Lactulose ; Male ; Permeability ; Probiotics
Chemische Substanzen	Cytokines ; Lactulose (4618-18-2)
Sprache	Englisch
Erscheinungsdatum	2022-07-22
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	2561259-1
ISSN	1876-2891 ; 1876-2883
ISSN (online)	1876-2891
ISSN	1876-2883
DOI	10.3920/BM2021.0173
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Effects of a 10-Strain Oral Probiotic on Parameters of Vaginal Health and Microbial Community: A Pilot Clinical Study.

Martoni, Christopher J / Frederiksen, Amalie Kruse Sigersted / Damholt, Anders / Leyer, Gregory

International journal of women's health

2022 Band 14, Seite(n) 29–39

Abstract: Objective: To investigate the clinical effects of a 10-strain probiotic on parameters of vaginal health in a pilot, open label study in women with intermediate Nugent score (NS) or vaginal pH >4.5.: Methodology: A total of 43 healthy premenopausal ... ...

Abstract	Objective: To investigate the clinical effects of a 10-strain probiotic on parameters of vaginal health in a pilot, open label study in women with intermediate Nugent score (NS) or vaginal pH >4.5. Methodology: A total of 43 healthy premenopausal women, ages 18 to 50 years, with NS of 4-6 or vaginal pH >4.5 were enrolled. Participants consumed a probiotic formulation (Feminine Support™), containing 8 lactobacilli and 2 bifidobacteria strains, with a daily dose of 2.5×10 Results: A total of 36 participants were included in the analysis set, with 24 and 12 participants included in subgroups 1 and 2, respectively. In the analysis set, there was a significant reduction in vaginal pH, from baseline, at day 28 (mean change=-0.19, P = 0.047). Participants in subgroup 1 achieved a significant reduction in vaginal pH from baseline, at day 28 (mean change=-0.23, P = 0.029) and day 42 (mean change=-0.29, P = 0.008), while participants in subgroup 2 achieved a significant and quantitatively greater reduction in vaginal pH from baseline to day 42 (mean change=-0.64, P = 0.008). No significant changes in NS were reported, due in part to highly diverse baseline levels. Vaginal microbial abundance exhibited a majority lactobacilli abundance at baseline, which was maintained over the study period. Vaginal pH was inversely associated with lactobacilli abundance throughout the study (P < 0.005). The product was well tolerated with high compliance. Two participants reported adverse events with suspected causality, which were mild and resolved during the study. Conclusion: This 10-strain probiotic formulation was well tolerated and helped reduce vaginal pH in women with intermediate NS or elevated vaginal pH. The study product warrants a randomized controlled trial to further assess efficacy.
Sprache	Englisch
Erscheinungsdatum	2022-01-18
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ZDB-ID	2508161-5
ISSN	1179-1411
ISSN	1179-1411
DOI	10.2147/IJWH.S341046
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Seeding the Infant Gut in Early Life-Effects of Maternal and Infant Seeding with Probiotics on Strain Transfer, Microbiota, and Gastrointestinal Symptoms in Healthy Breastfed Infants.

Melsaether, Cathrine / Høtoft, Diana / Wellejus, Anja / Hermes, Gerben D A / Damholt, Anders

Nutrients

2023 Band 15, Heft 18

Abstract: We investigated the effects of two dosing regimens of two multi-strain probiotic products on the gut microbiota of breastfed infants, including the transfer of the dosed strains and clinical outcomes. In forty-seven dyads, infants were either exposed ... ...

Abstract	We investigated the effects of two dosing regimens of two multi-strain probiotic products on the gut microbiota of breastfed infants, including the transfer of the dosed strains and clinical outcomes. In forty-seven dyads, infants were either exposed through maternal intake (MS) of
Mesh-Begriff(e)	Female ; Humans ; Infant ; Breast Feeding ; RNA, Ribosomal, 16S/genetics ; Probiotics ; Microbiota ; Lactobacillus acidophilus ; Feces/microbiology ; Bifidobacterium animalis ; Bifidobacterium longum subspecies infantis/genetics
Chemische Substanzen	RNA, Ribosomal, 16S
Sprache	Englisch
Erscheinungsdatum	2023-09-15
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15184000
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Lacticaseibacillus rhamnosus GG DSM 33156 effects on pathogen defence in the upper respiratory tract: a randomised, double-blind, placebo-controlled paediatric trial

Damholt, A. / Keller, M.K. / Baranowski, K. / Brown, B. / Wichmann, A. / Melsaether, C. / Eskesen, D. / Westphal, V. / Arltoft, D. / Habicht, A. / Gao, Q. / Crawford, G.

Beneficial microbes. 2022 Feb. 28, v. 13, no. 1

2022

Abstract: Acute upper respiratory tract infections (URTIs) are caused by numerous viruses and bacteria. URTIs can be a cause of morbidity and are among the most common reasons for visiting healthcare practitioners and prescribing antibiotics to children in ... ...

Abstract	Acute upper respiratory tract infections (URTIs) are caused by numerous viruses and bacteria. URTIs can be a cause of morbidity and are among the most common reasons for visiting healthcare practitioners and prescribing antibiotics to children in addition to causing absenteeism from school and work. Oral intake of Lacticaseibacillus rhamnosus GG DSM 33156 has shown beneficial health effects in several clinical trials, primarily relating to immune function and gastrointestinal health in children and adults. It has also been suggested that oral intake of L. rhamnosus GG DSM 33156 can reduce the incidence rate and alleviate symptoms of URTIs in children. We here report the results of a randomised, double-blind, placebo-controlled trial of 619 children aged 2-6 years conducted at a single centre in Scotland. The children, who were in day care or primary school, were followed over a 16-week intervention period with 309 randomised in the active group and 310 in the placebo group. The parents or guardians reported a daily healthcare status and any presumed episodes of URTI, which were subsequently confirmed by a general practitioner. The investigational product was well tolerated in the trial. Although a general trend towards a beneficial effect was observed, this trial did not demonstrate that L. rhamnosus GG DSM 33156 significantly reduced the incidence of URTIs, diagnosed by a general practitioner according to prespecified criteria (primary endpoint). Moreover, none of the secondary efficacy endpoints were met. Applying a Ward’s hierarchical clustering, two separate clusters, focussing on four quality of life-related endpoints, were identified. Cluster 1 was associated with more severe URTI characteristics than cluster 2. Cluster 2 was significantly enriched with children who consumed the product, indicating that the symptoms children experience during an URTI are alleviated by the intake of L. rhamnosus GG DSM 33156. The study is registered at ClinicalTrials.gov ID: NCT03636191.
Schlagwörter	elementary schools ; gastrointestinal system ; health services ; immune response ; morbidity ; pathogens ; placebos ; respiratory system ; Scotland
Sprache	Englisch
Erscheinungsverlauf	2022-0228
Umfang	p. 13-23.
Erscheinungsort	Wageningen Academic Publishers
Dokumenttyp	Artikel
ZDB-ID	2561259-1
ISSN	1876-2891 ; 1876-2883
ISSN (online)	1876-2891
ISSN	1876-2883
DOI	10.3920/BM2021.0065
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Bifidobacterium breve Bif195 ameliorates aspirin-induced gastric mucosal damage: A randomised, double blind, placebo-controlled crossover trial.

Løn, Nina / Engel, Sara / Damholt, Anders / Mortensen, Brynjulf / Haaber, Anne B / Wellejus, Anja / Knop, Filip K

Alimentary pharmacology & therapeutics

2023 Band 59, Heft 3, Seite(n) 341–349

Abstract: Background: Gastric and duodenal ulcerations are common during multiple-dosing aspirin treatment, such as for prevention of cardiovascular disease. On capsule endoscopy, oral administration of the bacterial strain Bifidobacterium breve Bif195 (DSM 33360) ...

Abstract	Background: Gastric and duodenal ulcerations are common during multiple-dosing aspirin treatment, such as for prevention of cardiovascular disease. On capsule endoscopy, oral administration of the bacterial strain Bifidobacterium breve Bif195 (DSM 33360) reduced the risk of aspirin-induced small intestinal damage, without affecting cyclo-oxygenase-2 (COX-2) inhibition. Aim: To evaluate endoscopically the effect of Bif195 on aspirin-induced stomach and duodenal mucosal damage METHODS: Twenty-five healthy volunteers underwent two intervention periods in a randomised, double-blind, placebo-controlled crossover design including four gastroduodenoscopies and 6 weeks washout. Each intervention was a 4-week oral co-treatment of aspirin 300 mg daily and Bif195 (≥10 Results: All 25 participants (56% females); age 27.3 (±4.8) years; BMI 23.2 (±3.4) kg/m Conclusions: Bif195 reduces aspirin-induced gastric mucosal damage and may serve as a safe supplement during multiple-dosing aspirin treatment.
Mesh-Begriff(e)	Female ; Humans ; Adult ; Male ; Aspirin/pharmacology ; Bifidobacterium breve ; Cross-Over Studies ; Anti-Ulcer Agents/adverse effects ; Duodenal Ulcer/chemically induced ; Duodenal Ulcer/drug therapy ; Duodenal Ulcer/prevention & control ; Gastric Mucosa ; Double-Blind Method
Chemische Substanzen	Aspirin (R16CO5Y76E) ; Anti-Ulcer Agents
Sprache	Englisch
Erscheinungsdatum	2023-11-30
Erscheinungsland	England
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17817
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Corrigendum to "The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10-12 months, a randomized clinical trial." [Journal of Dentistry 135 (2023) 104599].

Pørksen, Camilla Juhl / Keller, Mette Kirstine / Damholt, Anders / Frederiksen, Amalie Kruse Sigersted / Ekstrand, Kim Rud / Markvart, Merete / Larsen, Tove / Bakhshandeh, Azam

Journal of dentistry

2023 Band 141, Seite(n) 104807

Sprache	Englisch
Erscheinungsdatum	2023-12-16
Erscheinungsland	England
Dokumenttyp	Published Erratum
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2023.104807
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10-12 months, a randomized clinical trial.

Pørksen, Camilla Juhl / Keller, Mette Kirstine / Damholt, Anders / Frederiksen, Amalie Kruse Sigersted / Ekstrand, Kim Rud / Markvart, Merete / Larsen, Tove / Bakhshandeh, Azam

Journal of dentistry

2023 Band 135, Seite(n) 104599

Abstract: Objectives: To investigate the effect of daily use of a lozenge containing arginine and probiotics for 10-12 months on caries increment, gingivitis- and plaque occurrence in children aged 5-9 years.: Methods: In this placebo-controlled, double- ... ...

Abstract	Objectives: To investigate the effect of daily use of a lozenge containing arginine and probiotics for 10-12 months on caries increment, gingivitis- and plaque occurrence in children aged 5-9 years. Methods: In this placebo-controlled, double-blinded, parallel-grouped randomized clinical trial, 343 children were randomly assigned to one of the study arms (1:1). The intervention group (n = 172) received a lozenge containing Lacticaseibacillus rhamnosus, LGG® (DSM33156), Lactobacillus paracasei subsp. paracasei, L. CASEI 431® (DSM33451) and prebiotic (arginine 2%). The placebo group (n = 171) received an identical lozenge without arginine or probiotics. Primary canines and molars, and permanent first molars were examined clinically (d/D= ICDAS Results: The study was completed by 288 children. The dropout rate was 15%. The increase in ∆mean d Conclusion: Daily consumption of a lozenge containing prebiotic arginine and two strains of probiotics showed safe use and statistically significantly reduction in caries incrementbut no effect on the mean plaque or gingivitis occurrence in children. The use of a lozenge with arginine and probiotics combined has a promising potential as a supplementary tool for future management of caries. www. Clinicaltrials: gov (NCT03928587). Clinical significance: The combination of prebiotic arginine and probiotics shows clinical potential as a supplementary approach to toothbrushing with fluoride toothpaste in managing caries increment in children. A new era in the management of caries may be emerging.
Mesh-Begriff(e)	Humans ; Prebiotics ; Dental Caries Susceptibility ; Dental Caries/prevention & control ; Probiotics/therapeutic use ; Dental Plaque ; Gingivitis
Chemische Substanzen	Prebiotics
Sprache	Englisch
Erscheinungsdatum	2023-06-24
Erscheinungsland	England
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2023.104599
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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