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  1. Article ; Online: Contrast-Enhanced Ultrasound Follow-Up for Acute Pyelonephritis Patients

    Andrea Boccatonda / Stefano Venerato / Damiano D’Ardes / Giulio Cocco / Cosima Schiavone / Susanna Vicari

    Healthcare, Vol 11, Iss 21, p

    2023  Volume 2899

    Abstract: Contrast-enhanced ultrasound (CEUS) is increasingly used in clinical practice as the first diagnostic method in patients with suspected pyelonephritis rather than abdominal CT with contrast medium, especially in young subjects. We performed a ... ...

    Abstract Contrast-enhanced ultrasound (CEUS) is increasingly used in clinical practice as the first diagnostic method in patients with suspected pyelonephritis rather than abdominal CT with contrast medium, especially in young subjects. We performed a retrospective analysis on patients in for whom a CEUS examination was utilized as a follow-up method after acute pyelonephritis as normal clinical practice. Through evaluating all patients, in terms duration between CEUS examination and normalization (healing) of the renal disease, we found that the mean duration is 25.9 days. Our ultrasound findings did not induce any therapeutic modifications, not even in the cases in which the examination was repeated several times. Therefore, setting up a CEUS follow-up examination after 25 days from the first diagnosis can reduce the number of repeated tests, benefitting patients and the healthcare system in terms of reducing costs.
    Keywords kidney ; CEUS ; ultrasound ; pyelonephritis ; infection ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Selective serotonin reuptake inhibitors related bleeding risk

    Andrea Boccatonda / Damiano D'Ardes / Maria Teresa Guagnano / Francesco Cipollone / Francesca Santilli

    Emergency Care Journal (2023)

    case report and review of literature

    2023  

    Abstract: Gastrointestinal bleedings are relevant side effects in patients during anticoagulant therapy for atrial fibrillation. Direct oral anticoagulants (DOACs) are less correlated with major bleeding events than vitamin K antagonists (VKAs), but concerns are ... ...

    Abstract Gastrointestinal bleedings are relevant side effects in patients during anticoagulant therapy for atrial fibrillation. Direct oral anticoagulants (DOACs) are less correlated with major bleeding events than vitamin K antagonists (VKAs), but concerns are present about the relative risk of gastrointestinal bleeding. Here we report the case of a patient with atrial fibrillation and dementia on DOAC treatment who developed a SSRI-associated thrombocytopenia with subsequent life-threatening bleeding. Physicians should be aware of the possible correlation between SSRI-induced thrombocytopenia and concomitant use of anticoagulant and/or antiplatelet drugs, thus preventing life-threatening bleedings.
    Keywords SSRI ; bleeding ; platelet ; thrombocytopenia ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: From NAFLD to MAFLD

    Andrea Boccatonda / Lorenzo Andreetto / Damiano D’Ardes / Giulio Cocco / Ilaria Rossi / Susanna Vicari / Cosima Schiavone / Francesco Cipollone / Maria Teresa Guagnano

    Biomedicines, Vol 11, Iss 883, p

    Definition, Pathophysiological Basis and Cardiovascular Implications

    2023  Volume 883

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic liver disease characterized by excessive fat accumulation in the liver without another obvious cause (no excessive alcohol consumption, hepatotoxic medications, toxins, viral infections, ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic liver disease characterized by excessive fat accumulation in the liver without another obvious cause (no excessive alcohol consumption, hepatotoxic medications, toxins, viral infections, genetic hepatic diseases), therefore it is an exclusion diagnosis. The term NAFLD literally refers to non-alcohol related hepatopathy and does not adequately correlate with metabolic dysfunction and related cardiovascular risks. Therefore, researchers and scientific societies have moved towards changing the terminology. The novel nomenclature for a metabolic-associated fatty liver disease (MAFLD) has been proposed in 2020 by a group of experts to overcome the issues related to the old terminology. The diagnosis of MAFLD is based on the presence of hepatic steatosis and at least one between these three conditions: type 2 diabetes mellitus (T2DM), obesity or metabolic dysregulation. MAFLD has been shown to be an independent risk factor for cardiovascular diseases and atherosclerosis. It is better related to the main risk factors for atherosclerosis and cardiovascular diseases than NAFLD, such as dyslipidemia, T2DM and hypertension. The aim of this review is to highlight the reasons why the term NAFLD is moving to the term MAFLD, what are the conceptual basis of this choice and its clinical implications, particularly in the cardiovascular field.
    Keywords MAFLD ; NAFLD ; cardiovascular ; diabetes ; NASH ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Gender, Obesity, Fat Distribution and 25-Hydroxyvitamin D

    Maria Teresa Guagnano / Damiano D’Ardes / Pamela Di Giovanni / Ilaria Rossi / Andrea Boccatonda / Marco Bucci / Francesco Cipollone

    Medicina, Vol 59, Iss 1123, p

    2023  Volume 1123

    Abstract: Background and Objectives : Obesity is a worldwide disease associated with systemic complications. In recent years, there has been growing interest in studying vitamin D but data related to obese subjects are still poor. AIM: The aim of this study was to ...

    Abstract Background and Objectives : Obesity is a worldwide disease associated with systemic complications. In recent years, there has been growing interest in studying vitamin D but data related to obese subjects are still poor. AIM: The aim of this study was to evaluate the relationship between obesity degree and 25-hydroxyvitamin D [25(OH)D] levels. Materials and Methods : We recruited 147 Caucasian adult obese patients (BMI > 30 Kg/m 2

    49 male; median age 53 years), and 20 overweight subjects as control group (median age 57 years), who had been referred to our Obesity Center of Chieti (Italy) between May 2020 and September 2021. Results : The median BMI was 38 (33–42) kg/m 2 for obese patients and 27 (26–28) kg/m 2 for overweight patients. 25(OH)D concentrations were lower in the obese population compared to the overweight population (19 ng/mL vs. 36 ng/mL; p < 0.001). Considering all obese subjects, a negative correlation was observed between 25(OH)D concentrations and obesity-related parameters (weight, BMI, waist circumference, fat mass, visceral fat, total cholesterol, LDL cholesterol) and glucose metabolism-related parameters. 25(OH)D was also negatively correlated with blood pressure. Conclusions : Our data confirmed the inverse relationship between obesity and blood concentration of 25(OH)D and highlighted how 25(OH)D levels decrease in the presence of glucose and lipid metabolism alterations.
    Keywords 25-hydroxyvitamin D ; gender ; obesity ; adipose tissue ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome in Women

    Maria Teresa Guagnano / Damiano D'Ardes / Rossi Ilaria / Francesca Santilli / Cosima Schiavone / Marco Bucci / Francesco Cipollone

    Journal of Clinical Medicine, Vol 11, Iss 2759, p

    Effects of Lifestyle Modifications

    2022  Volume 2759

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most widespread liver disease, characterized by fatty acids liver accumulation and subsequent fibrosis. NAFLD prevalence ranges from 80% to 90% in obese subjects and is estimated to be around 50% in ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is the most widespread liver disease, characterized by fatty acids liver accumulation and subsequent fibrosis. NAFLD prevalence ranges from 80% to 90% in obese subjects and is estimated to be around 50% in patients with metabolic syndrome. In this clinical scenario, diet and lifestyle modifications can play an important role. There are several imaging techniques that can accurately diagnose fatty liver. Recently, ultrasound has acquired a leading role in the diagnosis and follow-up of fatty liver disease. Furthermore, elastosonography represents a valid alternative to liver biopsy. Shear wave elastosonography evaluates the elastic and mechanical properties of liver tissue. The aim is to evaluate the effects of lifestyle and nutritional interventions and a loss of body weight during hepatic steatosis through ultrasonographic and elastosonographic techniques. Thirty-two female subjects with metabolic syndrome were subjected to clinical, anthropometric, and laboratory assessments, as well as abdominal ultrasonographic/elastosonographic measurements taken from enrollment time (T0) and after 3 months (T1) of lifestyle modifications. After 3 months of lifestyle changes, significant weight loss was observed, with a marked improvement in all adiposity indices. The laboratory parameters at T1 showed significant decreases in total and LDL cholesterol, triglycerides, basal blood glucose, 120 min glycaemia, basal insulin and HOMA Index ( p < 0.001). A similar improvement was observed at T1 for steatosis degree ( p < 0.01) and elastosonographic measurements (Kpa p < 0.001). The linear regression analysis of the baseline conditions documented that the size of the liver positively correlated with body weight, BMI, neck and waist circumferences, waist to height ratio (WhtR), insulin and HOMA Index, fat mass and visceral fat, and steatosis grade. After 3 months, the liver size showed improvement with positive correlations to all previous variables. Hepatic stiffness (Kpa) ...
    Keywords NAFLD ; metabolic syndrome ; diet ; obesity ; lifestyle modifications ; ultrasound ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Mondor's Disease in SARS-CoV-2 Infection

    Gianfranco Lessiani / Andrea Boccatonda / Damiano D'Ardes / Giulio Cocco / Giuseppe Di Marco / Cosima Schiavone

    European Journal of Case Reports in Internal Medicine (2020)

    A Case of Superficial Vein Thrombosis in the Era of COVID-19

    2020  

    Abstract: SARS-CoV-2 causes blood hypercoagulability and severe inflammation resulting in an increased risk of thrombosis. Consequently, COVID-19 patients with cardiovascular disease seem to be at higher risk of adverse events. Mondor’s disease is a rare, ... ...

    Abstract SARS-CoV-2 causes blood hypercoagulability and severe inflammation resulting in an increased risk of thrombosis. Consequently, COVID-19 patients with cardiovascular disease seem to be at higher risk of adverse events. Mondor’s disease is a rare, generally self-limiting, thrombosis of the penis. The pathogenesis of Mondor’s disease is unknown, and it is usually diagnosed through clinical signs and with Doppler ultrasound evaluation. We describe the case of a young man with COVID-19 infection who manifested Mondor’s disease.
    Keywords covid-19 ; sars-cov-2 ; vein thrombosis ; mondor’s disease ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Perioperative Management of Antithrombotic Therapy in Patients Who Undergo Dental Procedures

    Andrea Boccatonda / Alessio Frisone / Felice Lorusso / Calogero Bugea / Maristella Di Carmine / Cosima Schiavone / Giulio Cocco / Damiano D’Ardes / Antonio Scarano / Maria Teresa Guagnano

    International Journal of Environmental Research and Public Health, Vol 20, Iss 5293, p

    A Systematic Review of the Literature and Network Meta-Analysis

    2023  Volume 5293

    Abstract: Background: The surgical dental treatment of subjects admitted for anticoagulants therapy represents a consistent risk for peri-operative bleeding. The aim of the present study was to investigate the clinical findings of dental surgery operative ... ...

    Abstract Background: The surgical dental treatment of subjects admitted for anticoagulants therapy represents a consistent risk for peri-operative bleeding. The aim of the present study was to investigate the clinical findings of dental surgery operative management of the patients under anticoagulants drugs protocol. Methods: The literature screening was performed using Pubmed/Medline, EMBASE and Cochrane library, considering only randomized clinical trials (RCTs) papers. No limitations about the publication’s period, follow-up time or clinical parameters were considered. Results: A total of eight RCTs were included for the qualitative synthesis. No thromboembolic complications were reported in any studies. Several bleeding episodes associated with anticoagulant drugs in dental surgery were mild and generally happened on the first day after the treatment. Conclusions: The use of local haemostatic measures is generally effective for bleeding control with no further pharmacological drug management or suspension.
    Keywords tooth extraction ; oral surgery ; haemostasis ; oral haemorrhage ; anticoagulants ; antiplatelet therapy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The case of a liver adenoma that looked like a hemangioma

    Andrea Boccatonda, MD / Damiano D'Ardes, MD / Giulio Cocco, MD / Susanna Vicari, MD / Francesco Cipollone, PhD / Cosima Schiavone, PhD / Maria Teresa Guagnano, PhD

    Radiology Case Reports, Vol 18, Iss 3, Pp 1024-

    2023  Volume 1028

    Abstract: Benign focal liver lesions are among the most frequent findings on ultrasound. Liver hemangiomas are often easily recognizable on ultrasound examination and are characterized by a clear benign prognosis. In some cases, hemangiomas display an atypical ... ...

    Abstract Benign focal liver lesions are among the most frequent findings on ultrasound. Liver hemangiomas are often easily recognizable on ultrasound examination and are characterized by a clear benign prognosis. In some cases, hemangiomas display an atypical appearance both on B-mode and on contrast-enhanced ultrasound, thus raising concerns for differential diagnosis both with adenomas and with lesions of malignant nature. We report here the case of a patient who presented with a liver lesion with all signs suggestive for hemangioma on B-mode, but it showed atypical features on contrast-enhanced ultrasound examination and final diagnosis of liver adenoma.
    Keywords Ultrasound ; Adenoma ; Hemangioma ; Liver ; CEUS ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Gastrointestinal Ultrasound in Emergency Setting

    Andrea Boccatonda / Damiano D’Ardes / Viola Tallarico / Susanna Vicari / Elena Bartoli / Gianpaolo Vidili / Maria Teresa Guagnano / Giulio Cocco / Francesco Cipollone / Cosima Schiavone / Esterita Accogli

    Journal of Clinical Medicine, Vol 12, Iss 799, p

    2023  Volume 799

    Abstract: Acute bowel diseases are responsible for more than one third of subjects who were referred to the emergency department for acute abdominal pain and gastrointestinal evaluation. Gastrointestinal ultrasound (GIUS) is often employed as the first imaging ... ...

    Abstract Acute bowel diseases are responsible for more than one third of subjects who were referred to the emergency department for acute abdominal pain and gastrointestinal evaluation. Gastrointestinal ultrasound (GIUS) is often employed as the first imaging method, with a good diagnostic accuracy in the setting of acute abdomen, and it can be an optimal diagnostic strategy in young females due to the radiation exposure related to X-ray and computed tomography methods. The physician can examine the gastrointestinal system in the area with the greatest tenderness by ultrasound, thus obtaining more information and data on the pathology than the standard physical examination. In this comprehensive review, we have reported the most relevant indications and advantages to using ultrasound in the investigation of abdominal acute pain.
    Keywords ultrasound ; bowel ; emergency ; inflammation ; abdomen ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Risk Factors and Immunoinflammatory Mechanisms Leading to Atherosclerosis

    Riccardo Mattia Ricciardi / Alessia Cipollone / Damiano D’Ardes / Davide Di Giacomo / Pamela Pignatelli / Francesco Cipollone / Maria Cristina Curia / Paolo Magni / Marco Bucci

    Microorganisms, Vol 11, Iss 1479, p

    Focus on the Role of Oral Microbiota Dysbiosis

    2023  Volume 1479

    Abstract: Cardiovascular diseases (CVD), including myocardial infarction and stroke, are currently the leading cause of morbidity, disability and mortality worldwide. Recently, researchers have focused their attention on the alterations of the gut and oral ... ...

    Abstract Cardiovascular diseases (CVD), including myocardial infarction and stroke, are currently the leading cause of morbidity, disability and mortality worldwide. Recently, researchers have focused their attention on the alterations of the gut and oral microbiota, investigating the possible role of their dysbiosis in the pathogenesis and/or progression of CVD. In this regard, it has been shown that endothelial dysfunction, a major feature of CVD, can also be induced by chronic periodontal infection, due to a systemic pro-inflammatory condition, as suggested by increased plasma levels of acute phase proteins, IL-6 and fibrinogen. Moreover, proatherogenic dysfunctions can also be promoted by direct bacterial invasion of the endothelium. This review reports the current evidence about the possible role of oral microbiota dysbiosis and the related immunoinflammatory components in the pathophysiology of atherosclerosis and associated CVD. It is concluded that integration of oral microbiota sampling into clinical practice may result in a more accurate assessment of CV risk in patients and even modify their prognosis.
    Keywords atherosclerosis ; Porphyromonas gingivalis ; Fusobacterium nucleatum ; cardiovascular disease ; heterozygous familial hypercholesterolemia ; secondary cardiovascular prevention ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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