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Book ; Thesis: Public Health im Berliner Gesundheitswesen

Damm, Sabine

eine qualitative Untersuchung zu Praxis und Perspektiven

2000

Author's details	vorgelegt von Sabine Damm
Language	German
Size	IV, 212, 12 S., 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Freie Univ., Diss.--Berlin, 2000
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Public Health im Berliner Gesundheitswesen

Damm, Sabine

eine qualitative Untersuchung zu Praxis und Perspektiven

2000

Author's details	vorgelegt von Sabine Damm
Language	German
Size	IV, 212, 12 S., 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Freie Univ., Diss.--Berlin, 2000
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Primary lung tumour visualised by transthoracic echocardiography

Valind Sven / Damm Sabine / Cronberg Carin / Dencker Magnus / Wadbo Monica

Cardiovascular Ultrasound, Vol 6, Iss 1, p

2008 Volume 60

Abstract: Abstract We present images of a rare case where a primary lung tumour was visualised by transthoracic echocardiography. The patient was a 78-year-old male where Chest X-ray had revealed a tumour-suspected structure in the left lung. Both transthoracic ... ...

Abstract	Abstract We present images of a rare case where a primary lung tumour was visualised by transthoracic echocardiography. The patient was a 78-year-old male where Chest X-ray had revealed a tumour-suspected structure in the left lung. Both transthoracic echocardiography and combined PET/CT images showed a large tumour located close to the heart. Fine-needle biopsy showed non-small cell lung cancer.
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro

Bernhart, Eva / Damm, Sabine / Wintersperger, Andrea / DeVaney, Trevor / Zimmer, Andreas / Raynham, Tony / Ireson, Christopher / Sattler, Wolfgang

Experimental cell research. 2013 Aug. 1, v. 319, no. 13

2013

Abstract: Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which, despite combined modality treatment, reoccurs and is invariably fatal for affected patients. Recently, a member of the serine/threonine protein kinase D (PRKD) family, PRKD2, ... ...

Abstract	Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which, despite combined modality treatment, reoccurs and is invariably fatal for affected patients. Recently, a member of the serine/threonine protein kinase D (PRKD) family, PRKD2, was shown to be a potent mediator of glioblastoma growth. Here we studied the role of PRKD2 in U87MG glioblastoma cell migration and invasion in response to sphingosine-1-phosphate (S1P), an activator of PRKD2 and a GBM mitogen. Time-lapse microscopy demonstrated that random cell migration was significantly diminished in response to PRKD2 silencing. The pharmacological PRKD family inhibitor CRT0066101 decreased chemotactic migration and invasion across uncoated or matrigel-coated Transwell inserts. Silencing of PRKD2 attenuated migration and invasion of U87MG cells even more effectively. In terms of downstream signaling, CRT0066101 prevented PRKD2 autophosphorylation and inhibited p44/42 MAPK and to a smaller extent p54/46 JNK and p38 MAPK activation. PRKD2 silencing impaired activation of p44/42 MAPK and p54/46 JNK, downregulated nuclear c-Jun protein levels and decreased c-JunS73 phosphorylation without affecting the NFκB pathway. Finally, qPCR array analyses revealed that silencing of PRKD2 downregulates mRNA levels of integrin alpha-2 and -4 (ITGA2 and -4), plasminogen activator urokinase (PLAU), plasminogen activator urokinase receptor (PLAUR), and matrix metallopeptidase 1 (MMP1). Findings of the present study identify PRKD2 as a potential target to interfere with glioblastoma cell migration and invasion, two major determinants contributing to recurrence of glioblastoma after multimodality treatment.
Keywords	brain ; cell movement ; chemotaxis ; gene expression regulation ; integrins ; messenger RNA ; microscopy ; mitogen-activated protein kinase ; patients ; phosphorylation ; quantitative polymerase chain reaction ; serine ; threonine ; transcription factor NF-kappa B ; u-plasminogen activator
Language	English
Dates of publication	2013-0801
Size	p. 2037-2048.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2013.03.029
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Primary lung tumour visualised by transthoracic echocardiography.

Dencker, Magnus / Cronberg, Carin / Damm, Sabine / Valind, Sven / Wadbo, Monica

Cardiovascular ultrasound

2008 Volume 6, Page(s) 60

Abstract: We present images of a rare case where a primary lung tumour was visualised by transthoracic echocardiography. The patient was a 78-year-old male where Chest X-ray had revealed a tumour-suspected structure in the left lung. Both transthoracic ... ...

Abstract	We present images of a rare case where a primary lung tumour was visualised by transthoracic echocardiography. The patient was a 78-year-old male where Chest X-ray had revealed a tumour-suspected structure in the left lung. Both transthoracic echocardiography and combined PET/CT images showed a large tumour located close to the heart. Fine-needle biopsy showed non-small cell lung cancer.
MeSH term(s)	Aged ; Echocardiography/methods ; Humans ; Incidental Findings ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Male
Language	English
Publishing date	2008-12-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1476-7120
ISSN (online)	1476-7120
DOI	10.1186/1476-7120-6-60
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Diffusion umweltbewusster Verhaltensweisen bei privaten Haushalten

Dietrich-Damm, Sabine / Damm, Sabine Dietrich-

dargestellt am Beispiel Energieeinsparung in der Stadt Bonn

1994

Author's details	vorgelegt von Sabine Dietrich-Damm
Keywords	Hauswirtschaft ; Energieeinsparung ; Bonn
Language	German
Size	VI, 250 S, graph. Darst, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Bonn, 1994
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.

Bernhart, Eva / Damm, Sabine / Wintersperger, Andrea / DeVaney, Trevor / Zimmer, Andreas / Raynham, Tony / Ireson, Christopher / Sattler, Wolfgang

Experimental cell research

2013 Volume 319, Issue 13, Page(s) 2037–2048

Abstract	Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which, despite combined modality treatment, reoccurs and is invariably fatal for affected patients. Recently, a member of the serine/threonine protein kinase D (PRKD) family, PRKD2, was shown to be a potent mediator of glioblastoma growth. Here we studied the role of PRKD2 in U87MG glioblastoma cell migration and invasion in response to sphingosine-1-phosphate (S1P), an activator of PRKD2 and a GBM mitogen. Time-lapse microscopy demonstrated that random cell migration was significantly diminished in response to PRKD2 silencing. The pharmacological PRKD family inhibitor CRT0066101 decreased chemotactic migration and invasion across uncoated or matrigel-coated Transwell inserts. Silencing of PRKD2 attenuated migration and invasion of U87MG cells even more effectively. In terms of downstream signaling, CRT0066101 prevented PRKD2 autophosphorylation and inhibited p44/42 MAPK and to a smaller extent p54/46 JNK and p38 MAPK activation. PRKD2 silencing impaired activation of p44/42 MAPK and p54/46 JNK, downregulated nuclear c-Jun protein levels and decreased c-Jun(S73) phosphorylation without affecting the NFκB pathway. Finally, qPCR array analyses revealed that silencing of PRKD2 downregulates mRNA levels of integrin alpha-2 and -4 (ITGA2 and -4), plasminogen activator urokinase (PLAU), plasminogen activator urokinase receptor (PLAUR), and matrix metallopeptidase 1 (MMP1). Findings of the present study identify PRKD2 as a potential target to interfere with glioblastoma cell migration and invasion, two major determinants contributing to recurrence of glioblastoma after multimodality treatment.
MeSH term(s)	Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Drug Evaluation, Preclinical ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Lysophospholipids/pharmacology ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Neoplasm Invasiveness ; Protein Kinase Inhibitors/pharmacology ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Protein Kinases/physiology ; Pyrimidines/pharmacology ; RNA Interference/physiology ; RNA, Small Interfering/pharmacology ; Sphingosine/analogs & derivatives ; Sphingosine/pharmacology
Chemical Substances	CRT 0066101 ; Lysophospholipids ; Protein Kinase Inhibitors ; Pyrimidines ; RNA, Small Interfering ; sphingosine 1-phosphate (26993-30-6) ; Protein Kinases (EC 2.7.-) ; protein kinase D2 (EC 2.7.1.-) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2013-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2013.03.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 563: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Endocytosis and intracellular processing of BODIPY-sphingomyelin by murine CATH.a neurons.

Nusshold, Christoph / Uellen, Andreas / Bernhart, Eva / Hammer, Astrid / Damm, Sabine / Wintersperger, Andrea / Reicher, Helga / Hermetter, Albin / Malle, Ernst / Sattler, Wolfgang

Biochimica et biophysica acta

2013 Volume 1831, Issue 12, Page(s) 1665–1678

Abstract: Neuronal sphingolipids (SL) play important roles during axonal extension, neurotrophic receptor signaling and neurotransmitter release. Many of these signaling pathways depend on the presence of specialized membrane microdomains termed lipid rafts. ... ...

Abstract	Neuronal sphingolipids (SL) play important roles during axonal extension, neurotrophic receptor signaling and neurotransmitter release. Many of these signaling pathways depend on the presence of specialized membrane microdomains termed lipid rafts. Sphingomyelin (SM), one of the main raft constituents, can be formed de novo or supplied from exogenous sources. The present study aimed to characterize fluorescently-labeled SL turnover in a murine neuronal cell line (CATH.a). Our results demonstrate that at 4°C exogenously added BODIPY-SM accumulates exclusively at the plasma membrane. Treatment of cells with bacterial sphingomyelinase (SMase) and back-exchange experiments revealed that 55-67% of BODIPY-SM resides in the outer leaflet of the plasma membrane. Endocytosis of BODIPY-SM occurs via caveolae with part of internalized BODIPY-fluorescence ending up in the Golgi and the ER. Following endocytosis BODIPY-SM undergoes hydrolysis, a reaction substantially faster than BODIPY-SM synthesis from BODIPY-ceramide. RNAi demonstrated that both, acid (a)SMase and neutral (n)SMases contribute to BODIPY-SM hydrolysis. Finally, high-density lipoprotein (HDL)-associated BODIPY-SM was efficiently taken up by CATH.a cells. Our findings indicate that endocytosis of exogenous SM occurs almost exclusively via caveolin-dependent pathways, that both, a- and nSMases equally contribute to neuronal SM turnover and that HDL-like particles might represent physiological SM carriers/donors in the brain.
MeSH term(s)	Animals ; Boron Compounds ; Caveolins/genetics ; Caveolins/metabolism ; Cell Line ; Endocytosis ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Fluorescent Dyes ; Gene Expression Regulation ; Golgi Apparatus/drug effects ; Golgi Apparatus/metabolism ; Hydrolysis ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Lipoproteins, HDL/metabolism ; Membrane Microdomains/drug effects ; Membrane Microdomains/metabolism ; Mice ; Neurons/cytology ; Neurons/drug effects ; Neurons/enzymology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/antagonists & inhibitors ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; Sphingomyelins/metabolism ; Sphingomyelins/pharmacology ; Temperature
Chemical Substances	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Boron Compounds ; Caveolins ; Fluorescent Dyes ; Isoenzymes ; Lipoproteins, HDL ; RNA, Small Interfering ; Sphingomyelins ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	2013-08-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2013.08.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells.

Bernhart, Eva / Damm, Sabine / Wintersperger, Andrea / Nusshold, Christoph / Brunner, Anna Martina / Plastira, Ioanna / Rechberger, Gerald / Reicher, Helga / Wadsack, Christian / Zimmer, Andreas / Malle, Ernst / Sattler, Wolfgang

Biochemical pharmacology

2015 Volume 96, Issue 2, Page(s) 119–130

Abstract: Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In ... ...

Abstract	Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particular sphingosine-1-phosphate (S1P) and the corresponding G protein-coupled S1P receptors transmit proliferative signals to glioma cells. To investigate the contribution to glioma cell proliferation we inhibited the first step of de novo SL synthesis in p53(wt) and p53(mut) glioma cells, and interfered with S1P signaling specifically in p53(wt) U87MG cells. Subunit silencing (RNAi) or pharmacological antagonism (using myriocin) of serine palmitoyltransferase (SPT; catalyzing the first committed step of SL biosynthesis) reduced proliferation of p53(wt) but not p53(mut) GBM cells. In U87MG cells these observations were accompanied by decreased ceramide, sphingomyelin, and S1P content. Inhibition of SPT upregulated p53 and p21 expression and induced an increase in early and late apoptotic U87MG cells. Exogenously added S1P (complexed to physiological carriers) increased U87MG proliferation. In line, silencing of individual members of the S1P receptor family decreased U87MG proliferation. Silencing and pharmacological inhibition of the ATP-dependent cassette transporter A1 (ABCA1) that facilitates S1P efflux in astrocytes attenuated U87MG growth. Glyburide-mediated inhibition of ABCA1 resulted in intracellular accumulation of S1P raising the possibility that ABCA1 promotes S1P efflux in U87MG glioma cells thereby contributing to inside-out signaling. Our findings indicate that de novo SL synthesis, S1P receptor-mediated signaling, and ABCA1-mediated S1P efflux could provide pharmacological targets to interfere with glioma cell proliferation.
MeSH term(s)	ATP Binding Cassette Transporter 1/metabolism ; Apoptosis ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Gene Silencing ; Glioma/metabolism ; Glioma/pathology ; Humans ; Receptors, Lysosphingolipid/genetics ; Receptors, Lysosphingolipid/metabolism ; Serine C-Palmitoyltransferase/antagonists & inhibitors ; Signal Transduction ; Sphingolipids/biosynthesis
Chemical Substances	ATP Binding Cassette Transporter 1 ; Receptors, Lysosphingolipid ; Sphingolipids ; Serine C-Palmitoyltransferase (EC 2.3.1.50)
Language	English
Publishing date	2015-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2015.05.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Diffusion umweltbewußter Verhaltensweisen bei privaten Haushalten

Dietrich-Damm, Sabine

dargestellt am Beispiel Energieeinsparung in der Stadt Bonn

1994

Author's details	von Sabine Dietrich-Damm
Keywords	Hauswirtschaft ; Energieeinsparung ; Bonn
Language	German
Size	VI, 250 S., graph. Darst., Kt.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Bonn, 1994
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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