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  1. AU="Daneman, Richard"
  2. AU="Jenkins, Robert B"

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  1. Article ; Online: Dural mural cells paint an anti-inflammatory picture.

    Lummis, Nicole C / Gastfriend, Benjamin D / Daneman, Richard

    The Journal of experimental medicine

    2024  Volume 221, Issue 2

    Abstract: Mural cells directly contact macrophages in the dural layer of the meninges to suppress pro-inflammatory phenotypes, including antigen presentation and lymphocyte differentiation. These mechanisms represent new targets for modulating CNS immune ... ...

    Abstract Mural cells directly contact macrophages in the dural layer of the meninges to suppress pro-inflammatory phenotypes, including antigen presentation and lymphocyte differentiation. These mechanisms represent new targets for modulating CNS immune surveillance and pathological inflammation (Min et al. 2024. J. Exp. Med.https://doi.org/10.1084/jem.20230326).
    MeSH term(s) Humans ; Anti-Inflammatory Agents ; Paint ; Inflammation ; Antigen Presentation ; Immunologic Surveillance
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20232263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Finding NMO.

    Daneman, Richard

    Neurology(R) neuroimmunology & neuroinflammation

    2017  Volume 4, Issue 1, Page(s) e313

    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2767740-0
    ISSN 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000000313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Brain arteriovenous malformations: cerebrovasculature behaving badly.

    Shoemaker, Lorelei D / Daneman, Richard / Stoodley, Marcus A

    Frontiers in human neuroscience

    2023  Volume 17, Page(s) 1212184

    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2023.1212184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown.

    Lawrence, Jennifer H / Patel, Asha / King, Melvin W / Nadarajah, Collin J / Daneman, Richard / Musiek, Erik S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. Permeability of the BBB to lipophilic molecules shows circadian variation due to rhythmic transporter expression, while basal ... ...

    Abstract The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. Permeability of the BBB to lipophilic molecules shows circadian variation due to rhythmic transporter expression, while basal permeability to polar molecules is non-rhythmic. Whether daily timing influences BBB permeability in response to inflammation is unknown. Here, we induced systemic inflammation through repeated lipopolysaccharide (LPS) injections either in the morning (ZT1) or evening (ZT13) under standard lighting conditions, then examined BBB permeability to a polar molecule, sodium fluorescein. We observed clear diurnal variation in inflammatory BBB permeability, with a striking increase in paracellular leak across the BBB specifically following evening LPS injection. Evening LPS led to persisting glia activation and inflammation in the brain that was not observed in the periphery. The exaggerated evening neuroinflammation and BBB disruption were suppressed by microglial depletion or through keeping mice in constant darkness. Our data show that diurnal rhythms in microglial inflammatory responses to LPS drive daily variability in BBB breakdown and reveals time-of-day as a key regulator of inflammatory BBB disruption.
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.10.588924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unexpected amount of blood-borne protein enters the young brain.

    Munji, Roeben N / Daneman, Richard

    Nature

    2020  Volume 583, Issue 7816, Page(s) 362–363

    MeSH term(s) Blood Proteins ; Blood-Brain Barrier ; Brain ; Transcytosis
    Chemical Substances Blood Proteins
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01791-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest.

    Gastfriend, Benjamin D / Snyder, Margaret E / Holt, Hope E / Daneman, Richard / Palecek, Sean P / Shusta, Eric V

    Science advances

    2024  Volume 10, Issue 5, Page(s) eadi1737

    Abstract: Brain mural cells regulate development and function of the blood-brain barrier and control blood flow. Existing in vitro models of human brain mural cells have low expression of key mural cell genes, ... ...

    Abstract Brain mural cells regulate development and function of the blood-brain barrier and control blood flow. Existing in vitro models of human brain mural cells have low expression of key mural cell genes, including
    MeSH term(s) Humans ; Endothelial Cells/metabolism ; Neural Crest/metabolism ; Cell Differentiation/genetics ; Pluripotent Stem Cells/metabolism ; Brain/metabolism ; Forkhead Transcription Factors/metabolism
    Chemical Substances FOXS1 protein, human ; Forkhead Transcription Factors
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi1737
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  7. Article ; Online: The blood-brain barrier in health and disease.

    Daneman, Richard

    Annals of neurology

    2012  Volume 72, Issue 5, Page(s) 648–672

    Abstract: The blood-brain barrier (BBB) is a term used to describe a series of properties possessed by the vasculature of the central nervous system (CNS) that tightly regulate the movement of ions, molecules, and cells between the blood and the CNS. This barrier ... ...

    Abstract The blood-brain barrier (BBB) is a term used to describe a series of properties possessed by the vasculature of the central nervous system (CNS) that tightly regulate the movement of ions, molecules, and cells between the blood and the CNS. This barrier is crucial to provide the appropriate environment to allow for proper neural function, as well as protect the CNS from injury and disease. In this review, I discuss the cellular and molecular composition of the BBB and how the development and function of the BBB is regulated by interactions with the CNS microenvironment. I further discuss what is known about BBB dysfunction during CNS injury and disease, as well as methodology used to deliver drugs across the BBB to the CNS.
    MeSH term(s) Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/physiopathology ; Gene Expression Regulation/physiology ; Humans ; Nervous System Diseases/pathology
    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.23648
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    Zs.MO 478: Show issues

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  8. Article ; Online: The amazing brain drain.

    Blanchette, Marie / Daneman, Richard

    The Journal of experimental medicine

    2017  Volume 214, Issue 12, Page(s) 3469–3470

    Abstract: In this issue of JEM, Antila et al. (https://doi.org/10.1084/jem.20170391) demonstrate that central nervous system lymphatics develop in the mouse meninges during early postnatal periods and display remarkable plasticity in adult periods through ... ...

    Abstract In this issue of JEM, Antila et al. (https://doi.org/10.1084/jem.20170391) demonstrate that central nervous system lymphatics develop in the mouse meninges during early postnatal periods and display remarkable plasticity in adult periods through manipulation of VEGF-C-VEGFR3 signaling.
    MeSH term(s) Animals ; Central Nervous System ; Glymphatic System ; Lymphatic Vessels ; Mice ; Signal Transduction ; Vascular Endothelial Growth Factor C
    Chemical Substances Vascular Endothelial Growth Factor C
    Language English
    Publishing date 2017-11-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20172031
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  9. Article ; Online: Brain barriers in health and disease.

    Daneman, Richard / Engelhardt, Britta

    Neurobiology of disease

    2017  Volume 107, Page(s) 1–3

    MeSH term(s) Arachnoid/physiology ; Blood-Brain Barrier/physiology ; Brain Diseases/cerebrospinal fluid ; Brain Diseases/physiopathology ; Choroid Plexus/physiology ; Humans
    Language English
    Publishing date 2017-05-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2017.05.008
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  10. Article ; Online: The blood-brain barrier in health and disease: Important unanswered questions.

    Profaci, Caterina P / Munji, Roeben N / Pulido, Robert S / Daneman, Richard

    The Journal of experimental medicine

    2020  Volume 217, Issue 4

    Abstract: The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during ... ...

    Abstract The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood-brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer's disease. This review will discuss current knowledge and key unanswered questions regarding the blood-brain barrier in health and disease.
    MeSH term(s) Animals ; Biological Transport/physiology ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/physiology ; Central Nervous System/pathology ; Central Nervous System/physiology ; Humans
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20190062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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