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Article ; Online: Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee

Li, Zhi / Wang, Yuedi / Qin, Qiqian / Chen, Lanchun / Dang, Xiaoqun / Ma, Zhengang / Zhou, Zeyang

2024 Volume 12

Abstract: Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinator, ...

Abstract	Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinator,
MeSH term(s)	Bees ; Animals ; Larva ; Molting ; Pilot Projects ; Energy Metabolism ; Nutrients ; Neonicotinoids ; Nitro Compounds
Chemical Substances	imidacloprid (3BN7M937V8) ; Neonicotinoids ; Nitro Compounds
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.88772
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Article ; Online: Melatonin enhances the antioxidant capacity to rescue the honey bee Apis mellifera from the ecotoxicological effects caused by environmental imidacloprid.

Li, Zhi / Duan, Jiaxin / Chen, Lanchun / Wang, Yuedi / Qin, Qiqian / Dang, Xiaoqun / Zhou, Zeyang

Ecotoxicology and environmental safety

2022 Volume 239, Page(s) 113622

Abstract: Imidacloprid severely poisons the nontarget insect honey bee Apis mellifera. Few treatments are available to mitigate the adverse effects of imidacloprid. The primary concern is that the molecular understanding of imidacloprid toxicity is not ... ...

Abstract	Imidacloprid severely poisons the nontarget insect honey bee Apis mellifera. Few treatments are available to mitigate the adverse effects of imidacloprid. The primary concern is that the molecular understanding of imidacloprid toxicity is not comprehensive enough. Oxidative stress is the primary pathophysiological mechanism by which pesticides cause high mortality. Our pilot study found for the first time that imidacloprid stimulates bee brains to secrete melatonin, a free radical scavenger. However, the molecular basis for imidacloprid toxicity and the role of melatonin in coping with imidacloprid have not been systematically investigated in bees. This study administered an environmental dose of imidacloprid (36 ng/bee) orally to A. mellifera. The detoxification gene cytochrome P450 CYP4G11 was significantly induced. However, potent cytotoxicity of imidacloprid suppressed the expression of the antioxidants catalase (CAT) and thioredoxin reductase (TrxR), and the activity of guaiacol peroxidase (GPX), superoxide dismutase (SOD), and reduced glutathione (GSH) was not induced. The levels of reactive oxygen species (ROS) and the lipid peroxidation marker malondialdehyde (MDA) were increased. The expression of the apoptotic genes cysteinyl aspartate specific proteinase (Caspase-3) and apoptosis inducing factor (AIF) increased, and the apoptotic features of midgut cells were prominently apparent. These results suggest that imidacloprid disrupts the bee antioxidant system, causing severe oxidative stress and tissue damage and ultimately leading to apoptosis. Significantly, however, imidacloprid exposure also stimulated bee brains to continuously secrete melatonin. Further preadministration of exogenous melatonin (200 ng/bee) orally to bees significantly reversed and enhanced the activity of the imidacloprid-suppressed antioxidants CAT, SOD, and GSH, which allowed imidacloprid-induced ROS accumulation to be effectively alleviated. The MDA content, apoptotic genes Caspase-3 and AIF, and detoxification gene CYPG411 expression were restored to normalization; midgut cell damage, apoptosis, and mortality were significantly reduced. These findings strongly suggest that melatonin enhanced bee antioxidant capacity, thus attenuating oxidative stress and apoptosis to confer imidacloprid tolerance to honey bees. Melatonin secretion may be a defense mechanism to mitigate imidacloprid toxicity.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Bees ; Caspase 3 ; Insecticides/toxicity ; Melatonin/pharmacology ; Neonicotinoids/toxicity ; Nitro Compounds/toxicity ; Pilot Projects ; Reactive Oxygen Species ; Superoxide Dismutase
Chemical Substances	Antioxidants ; Insecticides ; Neonicotinoids ; Nitro Compounds ; Reactive Oxygen Species ; imidacloprid (3BN7M937V8) ; Superoxide Dismutase (EC 1.15.1.1) ; Caspase 3 (EC 3.4.22.-) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2022-05-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113622
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Article ; Online: A Domain of Herpes Simplex Virus pU

Yang, Kui / Dang, Xiaoqun / Baines, Joel D

Journal of virology

2017 Volume 91, Issue 20

Abstract: Monomeric herpesvirus DNA is cleaved from concatemers and inserted into preformed capsids through the actions of the viral terminase. The terminase of herpes simplex virus (HSV) is composed of three subunits encoded by ... ...

Abstract	Monomeric herpesvirus DNA is cleaved from concatemers and inserted into preformed capsids through the actions of the viral terminase. The terminase of herpes simplex virus (HSV) is composed of three subunits encoded by U
MeSH term(s)	Animals ; Cell Line ; Chlorocebus aethiops ; Chromosomes, Artificial, Bacterial ; DNA Packaging ; DNA, Concatenated/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Electrophoresis, Gel, Pulsed-Field ; Genome, Viral ; Herpesvirus 1, Human/enzymology ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/physiology ; Humans ; Vero Cells ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Assembly ; Virus Replication
Chemical Substances	DNA, Concatenated ; DNA, Viral ; UL33 protein, Human herpesvirus 1 ; Viral Proteins
Language	English
Publishing date	2017-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00854-17
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Article ; Online: Imidacloprid activates ROS and causes mortality in honey bees (Apis mellifera) by inducing iron overload.

He, Biao / Liu, Zhihao / Wang, Yuedi / Cheng, Lanchun / Qing, Qiqian / Duan, Jiaxin / Xu, Jinshan / Dang, Xiaoqun / Zhou, Zeyang / Li, Zhi

Ecotoxicology and environmental safety

2021 , Page(s) 112709

Abstract: Imidacloprid, a neonicotinoid pesticide widely used for insect pest control, has become a potential pollutant to pollinators. Previous reports have demonstrated the toxicity of this drug in activating oxidative stress resulting in high mortality in the ... ...

Abstract	Imidacloprid, a neonicotinoid pesticide widely used for insect pest control, has become a potential pollutant to pollinators. Previous reports have demonstrated the toxicity of this drug in activating oxidative stress resulting in high mortality in the honey bee Apis mellifera. However, the mechanisms underlying the toxicity of imidacloprid have not been fully elucidated. In this study, sublethal (36 ng/bee) and median lethal (132 ng/bee) doses of imidacloprid were administered to bees. The results showed dose-dependent increases in reactive oxygen species (ROS), Fe
Language	English
Publishing date	2021-09-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112709
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Article: Lipidomic Profiling Reveals Distinct Differences in Sphingolipids Metabolic Pathway between Healthy Apis cerana cerana larvae and Chinese Sacbrood Disease

Dang, Xiaoqun / Li, Yan / Li, Xiaoqing / Wang, Chengcheng / Ma, Zhengang / Wang, Linling / Fan, Xiaodong / Li, Zhi / Huang, Dunyuan / Xu, Jinshan / Zhou, Zeyang

Insects. 2021 Aug. 05, v. 12, no. 8

2021

Abstract: Chinese sacbrood disease (CSD), which is caused by Chinese sacbrood virus (CSBV), is a major viral disease in Apis cerana cerana larvae. Analysis of lipid composition is critical to the study of CSBV replication. The host lipidome profiling during CSBV ... ...

Abstract	Chinese sacbrood disease (CSD), which is caused by Chinese sacbrood virus (CSBV), is a major viral disease in Apis cerana cerana larvae. Analysis of lipid composition is critical to the study of CSBV replication. The host lipidome profiling during CSBV infection has not been conducted. This paper identified the lipidome of the CSBV–larvae interaction through high-resolution mass spectrometry. A total of 2164 lipids were detected and divided into 20 categories. Comparison of lipidome between healthy and CSBV infected-larvae showed that 266 lipid species were altered by CSBV infection. Furthermore, qRT-PCR showed that various sphingolipid enzymes and the contents of sphingolipids in the larvae were increased, indicating that sphingolipids may be important for CSBV infection. Importantly, Cer (d14:1 + hO/21:0 + O), DG (41:0e), PE (18:0e/18:3), SM (d20:0/19:1), SM (d37:1), TG (16:0/18:1/18:3), TG (18:1/20:4/21:0) and TG (43:7) were significantly altered in both CSBV_24 h vs. CK_24 h and CSBV_48 h vs. CK_48 h. Moreover, TG (39:6), which was increased by more than 10-fold, could be used as a biomarker for the early detection of CSD. This study provides evidence that global lipidome homeostasis in A. c. cerana larvae is remodeled after CSBV infection. Detailed studies in the future may improve the understanding of the relationship between the sphingolipid pathway and CSBV replication.
Keywords	Apis cerana ; Sacbrood virus ; biochemical pathways ; biomarkers ; homeostasis ; lipid composition ; lipidomics ; mass spectrometry ; sphingolipids
Language	English
Dates of publication	2021-0805
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects12080703
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Article: Imidacloprid activates ROS and causes mortality in honey bees (Apis mellifera) by inducing iron overload

He, Biao / Liu, Zhihao / Wang, Yuedi / Cheng, Lanchun / Qing, Qiqian / Duan, Jiaxin / Xu, Jinshan / Dang, Xiaoqun / Zhou, Zeyang / Li, Zhi

Ecotoxicology and environmental safety. 2021 Dec. 25, v. 228

2021

Abstract	Imidacloprid, a neonicotinoid pesticide widely used for insect pest control, has become a potential pollutant to pollinators. Previous reports have demonstrated the toxicity of this drug in activating oxidative stress resulting in high mortality in the honey bee Apis mellifera. However, the mechanisms underlying the toxicity of imidacloprid have not been fully elucidated. In this study, sublethal (36 ng/bee) and median lethal (132 ng/bee) doses of imidacloprid were administered to bees. The results showed dose-dependent increases in reactive oxygen species (ROS), Fe²⁺, and mortality in bees. Notably, imidacloprid also induced upregulation of the gene encoding ferritin (AmFth), which plays a pivotal role in reducing Fe²⁺ overload. Upregulation of AmFth has been suggested to be closely related to ROS accumulation and high mortality in bees. To confirm the role played by AmFth in imidacloprid-activated ROS, dsAmFth double-strand was orally administered to bees after exposure to imidacloprid. The results revealed aggravated Fe²⁺ overload, higher ROS activation, and elevated mortality in the bees, indicating that imidacloprid activated ROS and caused mortality in the bees, probably by inducing iron overload. This study helps to elucidate the molecular mechanisms underlying the toxicity of imidacloprid from the perspective of iron metabolism.
Keywords	Apis mellifera ; dose response ; drugs ; ecotoxicology ; ferritin ; genes ; honey ; honey bees ; imidacloprid ; insect pests ; iron absorption ; iron overload ; mortality ; oxidative stress ; pollutants ; reactive oxygen species ; toxicity
Language	English
Dates of publication	2021-1225
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112709
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Maturation of subtilisin-like protease NbSLP1 from microsporidia

Wang, Rong / Li, Qingyan / Liu, Fangyan / Dang, Xiaoqun / Sun, Quan / Sheng, Xiaotian / Hu, Mingyu / Bao, Jialing / Chen, Jie / Pan, Guoqing / Zhou, Zeyang

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 897509

Abstract: Microsporidia are obligate intracellular parasites and possess a unique way of invading hosts, namely germination. Microsporidia are able to infect almost all animal cells by germination. During the process, the polar tube extrudes from the spores within, ...

Abstract	Microsporidia are obligate intracellular parasites and possess a unique way of invading hosts, namely germination. Microsporidia are able to infect almost all animal cells by germination. During the process, the polar tube extrudes from the spores within, thus injecting infectious sporoplasm into the host cells. Previous studies indicated that subtilisin-like protease 1 (NbSLP1) of microsporidia
MeSH term(s)	Animals ; Fungal Proteins/genetics ; Nosema/genetics ; Spores, Fungal ; Subtilisin/genetics
Chemical Substances	Fungal Proteins ; Subtilisin (EC 3.4.21.62)
Language	English
Publishing date	2022-08-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.897509
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Article: Nbseptin2 Expression Pattern and Its Interaction with NbPTP1 during Microsporidia Nosema bombycis Polar Tube Extrusion

Liu, Fangyan / Chen, Jie / Dang, Xiaoqun / Meng, Xianzhi / Wang, Rong / Bao, Jialing / Long, Mengxian / Li, Tian / Ma, Qiang / Huang, Jun / Pan, Guoqing / Zhou, Zeyang

journal of eukaryotic microbiology. 2020 Jan., v. 67, no. 1

2020

Abstract: Nosema bombycis (Nb) is a deadly species of microsporidia capable of causing pébrine, leading to heavy losses in sericulture. Germination is an important biological event in the invasion process of microsporidia. Septins, a family of membrane‐associated ... ...

Abstract	Nosema bombycis (Nb) is a deadly species of microsporidia capable of causing pébrine, leading to heavy losses in sericulture. Germination is an important biological event in the invasion process of microsporidia. Septins, a family of membrane‐associated proteins, play a critical role in tissue invasion and have been recognized as a virulence factor in numerous pathogens. Previous work in our laboratory has shown that Nosema bombycis septin2 (Nbseptin2) interacts with subtilisin‐like protease 2 (NbSLP2). Herein, we found that Nbseptin2 was mainly associated with the plasma membrane in spores. Following spore germination, Nbseptin2 was found to co‐localize with polar tube protein 1 (NbPTP1) at the polar cap and proximal zone of the polar tube. Co‐immunoprecipitation and yeast two‐hybrid analysis further confirmed that Nbseptin2 interacted with NbPTP1. The translocation and interaction of Nbseptin2 in the spores suggest that Nbseptin2 may play a significant role in microsporidia polar tube extrusion process. Our findings improve understanding of the mechanisms underlying microsporidia germination.
Keywords	Nosema bombycis ; extrusion ; membrane proteins ; pathogens ; plasma membrane ; precipitin tests ; proteinases ; sericulture ; spore germination ; spores ; two hybrid system techniques ; virulence
Language	English
Dates of publication	2020-01
Size	p. 45-53.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1147218-2
ISSN	1550-7408 ; 1066-5234
ISSN (online)	1550-7408
ISSN	1066-5234
DOI	10.1111/jeu.12752
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Article ; Online: Clone and Classification of Endoglucanase Gene of Mulberry Bacterial Wilt Pathogen G12-9

MIAO Xue, / TANG Cuiming / DANG Xiaoqun / ZHOU Zeyang / WANG Linling

Journal of Chongqing Normal University, Vol 31, Iss 05, Pp 116-

2014 Volume 119

Abstract: Mulberry bacterial wilt pathogen is a soilborne bacterial disease，a pathogen G12-9 was isolated from the root of mulberry which was infected bacterial wilt plant disease from mulberry field in Guangdong province. This pathogen on TZC solid medium was ... ...

Abstract	Mulberry bacterial wilt pathogen is a soilborne bacterial disease，a pathogen G12-9 was isolated from the root of mulberry which was infected bacterial wilt plant disease from mulberry field in Guangdong province. This pathogen on TZC solid medium was rounded or irregular round, the colony center color showed pink. It was a negative Gram strain. By endoglucanase gene within G12-9 isolate cloning, sequencing and cluster analysis, mulberry Ralstonia solanacearum G12-9 endoglucanase belonging to glycosyl hydrolase family 12.The most important pathogenicity secretion system in R.solanacearum are Ⅱ, Ⅲ, Ⅳ, endoglucanase belongs to T2S.It plays an important role on colonization and host infection, so it is very significant for the disease prevention and treatment by clearing mulberry R.solanacearum endoglucanase position in the classification of glycosyl hydrolase family.
Keywords	mulberry bacterial wilt ; Ralstonia solanacearum ; endoglucanase ; classification ; Science (General) ; Q1-390 ; Science ; Q
Language	Chinese
Publishing date	2014-09-01T00:00:00Z
Document type	Article ; Online
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Article ; Online: Comparative Analysis of the Proteins with Tandem Repeats from 8 Microsporidia and Characterization of a Novel Endospore Wall Protein Colocalizing with Polar Tube from Nosema bombycis.

Wang, Ying / Geng, Huixia / Dang, Xiaoqun / Xiang, Heng / Li, Tian / Pan, Guoqing / Zhou, Zeyang

The Journal of eukaryotic microbiology

2017 Volume 64, Issue 5, Page(s) 707–715

Abstract: As a common feature of eukaryotic proteins, tandem amino acid repeat has been studied extensively in both animal and plant proteins. Here, a comparative analysis focusing on the proteins having tandem repeats was conducted in eight microsporidia, ... ...

Abstract	As a common feature of eukaryotic proteins, tandem amino acid repeat has been studied extensively in both animal and plant proteins. Here, a comparative analysis focusing on the proteins having tandem repeats was conducted in eight microsporidia, including four mammal-infecting microsporidia (Encephalitozoon cuniculi, Encephalitozoon intestinalis, Encephalitozoon hellem and Encephalitozoon bieneusi) and four insect-infecting microsporidia (Nosema apis, Nosema ceranae, Vavraia culicis and Nosema bombycis). We found that the proteins with tandem repeats were abundant in these species. The quantity of these proteins in insect-infecting microsporidia was larger than that of mammal-infecting microsporidia. Additionally, the hydrophilic residues were overrepresented in the tandem repeats of these eight microsporidian proteins and the amino acids residues in these tandem repeat sequences tend to be encoded by GC-rich codons. The tandem repeat position within proteins of insect-infecting microsporidia was randomly distributed, whereas the tandem repeats within proteins of mammal-infecting microsporidia rarely tend to be present in the N terminal regions, when compared with those present in the C terminal and middle regions. Finally, a hypothetical protein EOB14572 possessing four tandem repeats was successfully characterized as a novel endospore wall protein, which colocalized with polar tube of N. bombycis. Our study provided useful insight for the study of the proteins with tandem repeats in N. bombycis, but also further enriched the spore wall components of this obligate unicellular eukaryotic parasite.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Wall/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Insecta/microbiology ; Mammals/microbiology ; Microsporidia/genetics ; Microsporidia/metabolism ; Tandem Repeat Sequences
Chemical Substances	Fungal Proteins
Language	English
Publishing date	2017-05-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147218-2
ISSN	1550-7408 ; 1066-5234
ISSN (online)	1550-7408
ISSN	1066-5234
DOI	10.1111/jeu.12412
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