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Article: Roles of gut microbiota and metabolites in overweight and obesity of children.

Zhang, Shengan / Dang, Yanqi

2022 Volume 13, Page(s) 994930

Abstract: The prevalence of overweight and obesity in children and adolescents is an increasing public health problem. Pediatric overweight and obesity result from multiple factors, including genetic background, diet, and lifestyle. In addition, the gut microbiota ...

Abstract	The prevalence of overweight and obesity in children and adolescents is an increasing public health problem. Pediatric overweight and obesity result from multiple factors, including genetic background, diet, and lifestyle. In addition, the gut microbiota and their metabolites play crucial roles in the progression of overweight and obesity of children. Therefore, we reviewed the roles of gut microbiota in overweight/obese children. The relationship between pediatric overweight/obesity and gut metabolites, such as short-chain fatty acids, medium-chain fatty acids, amino acids, amines, and bile acids, are also summarized. Targeting gut microbiota and metabolites might be a promising strategy for interventions aimed at reducing pediatric overweight/obesity.
MeSH term(s)	Adolescent ; Amines ; Amino Acids ; Bile Acids and Salts ; Child ; Fatty Acids, Volatile ; Gastrointestinal Microbiome ; Humans ; Overweight ; Pediatric Obesity/epidemiology
Chemical Substances	Amines ; Amino Acids ; Bile Acids and Salts ; Fatty Acids, Volatile
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.994930
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Article ; Online: The role of N6-methyladenosine in macrophage polarization: A novel treatment strategy for non-alcoholic steatohepatitis.

Wu, Jiaxuan / Pan, Jiashu / Zhou, Wenjun / Ji, Guang / Dang, Yanqi

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 171, Page(s) 116145

Abstract: RNA methylation modifications, as a widespread type of modification in eukaryotic cells, especially N6-methyladenosine ( ... ...

Abstract	RNA methylation modifications, as a widespread type of modification in eukaryotic cells, especially N6-methyladenosine (m
MeSH term(s)	Humans ; Animals ; Mice ; Non-alcoholic Fatty Liver Disease ; Liver ; Macrophages ; Mice, Inbred C57BL
Language	English
Publishing date	2024-01-09
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116145
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Article ; Online: Recent advances in lean NAFLD.

Xu, Ruohui / Pan, Jiashu / Zhou, Wenjun / Ji, Guang / Dang, Yanqi

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 153, Page(s) 113331

Abstract: As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the most pivotal role in NAFLD, approximately 10-20% of individuals with NAFLD who ...

Abstract	As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the most pivotal role in NAFLD, approximately 10-20% of individuals with NAFLD who are not overweight or obese (BMI < 25 kg/m2, or BMI < 23 kg/m2 in Asians) have "lean NAFLD." Lean individuals with NAFLD have a lower prevalence of diabetes, hypertension, hypertriglyceridemia, central obesity, and metabolic syndrome than nonlean individuals with NAFLD, but higher fibrosis scores and rates of cardiovascular morbidity and all-cause mortality in advanced stages. The pathophysiological mechanisms of lean NAFLD remain poorly understood. Studies have shown that lean NAFLD is more correlated with factors such as environmental, genetic susceptibility, and epigenetic regulation. This review will examine the way in which the research progress and characteristic of lean NAFLD, and explore the function of epigenetic modification to provide the basis for the clinical treatment and diagnosis of lean NAFLD.
MeSH term(s)	Body Mass Index ; Epigenesis, Genetic ; Humans ; Metabolic Syndrome ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/genetics ; Obesity/epidemiology
Language	English
Publishing date	2022-06-29
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113331
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Article ; Online: Impact of smoking cessation on non-alcoholic fatty liver disease prevalence: a systematic review and meta-analysis.

Zhang, Shengan / Liu, Zhidong / Yang, Qinghua / Hu, Zichun / Zhou, Wenjun / Ji, Guang / Dang, Yanqi

BMJ open

2023 Volume 13, Issue 12, Page(s) e074216

Abstract: Objectives: The negative effects of smoking on numerous cardiovascular and metabolic diseases have been widely acknowledged. However, the potential effect of smoking cessation is relatively unelucidated. The objective of this study is to explore whether ...

Abstract	Objectives: The negative effects of smoking on numerous cardiovascular and metabolic diseases have been widely acknowledged. However, the potential effect of smoking cessation is relatively unelucidated. The objective of this study is to explore whether the prevalence of non-alcoholic fatty liver disease (NAFLD) in former smokers differs from the prevalence in current smokers. Design: Systematic review and meta-analysis. Data sources: Four databases, that is, PubMed, Web of Science, Journal@Ovid and Scopus were searched from inception to 31 January 2023. Eligibility criteria: Population-based cross-sectional studies, including the baseline data of cohort studies with identified NAFLD diagnostic methods, and smoking status (current smoker or former smoker) of participants were included. Data extraction and synthesis: Two reviewers independently extracted the data including cigarette smoking status, country/region of studies, NAFLD diagnostic methods, sex, the average age and body mass index (BMI) of NAFLD participants and assessed the risk of bias with Agency for Healthcare Research and Quality (AHRQ) methodology checklist. Risk ratio (RR) of NAFLD prevalence in former smokers was pooled using the random-effects model. Results: 28 studies involving 4 465 862 participants were included. Compared with current smokers, the RR of overall NAFLD prevalence in former smokers was 1.13 (95% CI: 1.08 to 1.19, prediction interval: 0.92-1.39). This result persisted after adjustment for diagnostic methods, country/region, sex, age and BMI. Sensitivity analysis and risk of bias assessment indicated a stable conclusion. Conclusions: NAFLD prevalence in former smokers was at least not lower than that in current smokers and was partially related to increased BMI after smoking cessation, indicating that smoking cessation was possibly not a protective factor against NAFLD. Although the meta-analysis based on cross-sectional studies cannot conclude the causal relationships between smoking cessation and NAFLD onset, the potential onset of NAFLD associated with smoking cessation should be highlighted. Prospero registration number: CRD42023394944.
MeSH term(s)	Humans ; Smoking Cessation/methods ; Non-alcoholic Fatty Liver Disease/epidemiology ; Smoking/adverse effects ; Smoking/epidemiology ; Cross-Sectional Studies ; Cohort Studies
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-074216
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Article ; Online: Targeted metabolomics revealed the mechanisms underlying the role of Liansu capsule in ameliorating functional dyspepsia.

Pan, Jiashu / Wu, Jiaxuan / Zhang, Shengan / Wang, Kai / Ji, Guang / Zhou, Wenjun / Dang, Yanqi

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117568

Abstract: Ethnopharmacological relevance: Liansu capsule could alleviate dyspeptic symptoms; however, the mechanisms underlying its role in treating functional dyspepsia (FD) remain unclear.: Aim of the study: To elucidate the mechanism underlying the efficacy ...

Abstract	Ethnopharmacological relevance: Liansu capsule could alleviate dyspeptic symptoms; however, the mechanisms underlying its role in treating functional dyspepsia (FD) remain unclear. Aim of the study: To elucidate the mechanism underlying the efficacy of Liansu capsule in alleviating FD symptoms. Materials and methods: Thirty-six male mice were randomly divided into the following six groups: control, model, low-strength Liansu, moderate-strength Liansu, high-strength Liansu, and domperidone groups. Small intestine propulsion rate, gastric residual rate and histopathological analysis were performed to evaluate efficacy of Liansu capsule. Levels of interleukin-1β, interleukin-6, tumor necrosis factor α, phosphorylation of p65, ghrelin and gastrin were verified by real-time quantitative polymerase chain reaction and immunofluorescence assays. Targeted metabolomic analyses, western blotting and immunofluorescence assays were used to explore the mechanism of Liansu capsule in ameliorating FD. Results: The Liansu capsule significantly ameliorated the symptoms of FD, and markedly increased the levels of ghrelin and gastrin. Moreover, Liansu capsule significantly downregulated the levels of the proinflammatory cytokine interleukin-1β, interleukin-6, tumor necrosis factor α, and inhibited the phosphorylation of p65. Targeted metabolomic analyses showed that Liansu capsule significantly reduced the levels of deoxycholic acid and hyodeoxycholic acid, which were significantly elevated in the model group. Furthermore, these results showed that deoxycholic acid and hyodeoxycholic acid markedly promoted the levels of Takeda G-protein-coupled receptor 5 (TGR5), phosphorylated signal transducer and activator of transcription 3 (STAT3), and Kruppel-like factor 5 (KLF5) in vitro. whereas, Liansu capsule significantly reduced the levels of TGR5, phosphorylated STAT3, and KLF5. Conclusion: Our findings indicated that Liansu capsule improved FD by regulating the deoxycholic acid/hyodeoxycholic acid-TGR5-STAT3-KLF5 axis. The findings reveal a novel mechanism underlying the role of Liansu capsule, which may be a promising therapeutic strategy for FD.
MeSH term(s)	Male ; Mice ; Animals ; Dyspepsia/drug therapy ; Ghrelin/therapeutic use ; Tumor Necrosis Factor-alpha ; Gastrins ; Interleukin-6 ; Interleukin-1beta ; Deoxycholic Acid
Chemical Substances	Ghrelin ; Tumor Necrosis Factor-alpha ; Gastrins ; Interleukin-6 ; Interleukin-1beta ; Deoxycholic Acid (005990WHZZ)
Language	English
Publishing date	2023-12-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117568
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Article ; Online: tRNA-derived fragments are promising biomarkers for screening of early colorectal cancer.

Dang, Yanqi / Dai, Liang / Xu, Jingjuan / Zhou, Wenjun / Xu, Yangxian / Ji, Guang

MedComm

2023 Volume 4, Issue 3, Page(s) e227

Language	English
Publishing date	2023-05-03
Publishing country	China
Document type	Journal Article
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.227
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Article ; Online: Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease.

Pan, Jiashu / Zhou, Wenjun / Xu, Ruohui / Xing, Lianjun / Ji, Guang / Dang, Yanqi

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 151, Page(s) 113127

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD is relatively ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD is relatively complex, which has gradually changed from the previous 'two-hit' hypothesis to the current "multiple hits" hypothesis. However, there is currently no approved treatment for NAFLD in clinic, highlighting the urgent need for drug development. Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily, whose different subtypes have been proved to regulate different stages of NAFLD, thus becoming promising drug targets for NAFLD. As important sources of drug development, natural products have been proven to treat NAFLD through multiple pathways and multiple targets. In this paper, we outline the regulatory role of PPARs in NAFLD, and summarize some natural products that target PPARs to ameliorate NAFLD, in order to provide reference for drug development of NAFLD.
MeSH term(s)	Biological Products/metabolism ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Liver/metabolism ; Liver Cirrhosis/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Peroxisome Proliferator-Activated Receptors/agonists ; Peroxisome Proliferator-Activated Receptors/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism
Chemical Substances	Biological Products ; Hypoglycemic Agents ; Peroxisome Proliferator-Activated Receptors ; Receptors, Cytoplasmic and Nuclear
Language	English
Publishing date	2022-05-20
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113127
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Article ; Online: Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites.

Zhu, Mingzhe / Wang, Xue / Wang, Kai / Zhao, Zhiqiang / Dang, Yanqi / Ji, Guang / Li, Fenghua / Zhou, Wenjun

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1066053

Abstract: Background: Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis (NASH). However, the anti-NASH effects and ... ...

Abstract	Background: Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis (NASH). However, the anti-NASH effects and underlying mechanisms of Lingguizhugan decoction remain unclear. Methods: Male Sprague-Dawley rats were fed a methionine- and choline-deficient (MCD) diet to induce NASH, and then given Lingguizhugan decoction orally for four weeks. NASH indexes were evaluated by histopathological analysis and biochemical parameters including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver triglycerides (TG), Results: Four-week Lingguizhugan decoction treatment ameliorated MCD diet-induced NASH features, as evidenced by improved hepatic steatosis and inflammation, as well as decreased serum AST and ALT levels. Besides, Lingguizhugan decoction partially restored the changes in gut microbial community composition in NASH rats. Meanwhile, the relative abundance of 26 genera was significantly changed in NASH rats, and 11 genera (such as Conclusion: Lingguizhugan decoction may exert protective effects on NASH partially by modulating gut microbiota and correlated metabolites.
MeSH term(s)	Animals ; Male ; Mice ; Rats ; Choline/metabolism ; Choline/pharmacology ; Chromatography, Liquid ; Gastrointestinal Microbiome ; Liver/pathology ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Rats, Sprague-Dawley ; RNA, Ribosomal, 16S/genetics ; Tandem Mass Spectrometry ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Choline (N91BDP6H0X) ; RNA, Ribosomal, 16S ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1066053
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Article ; Online: Dynamic changes in DNA methylation and hydroxymethylation revealed the transformation of advanced adenoma into colorectal carcinoma.

Dang, Yanqi / Xu, Ruohui / Pan, Jiashu / Xiao, Xiaoli / Zhang, Shengan / Zhou, Wenjun / Xu, Yangxian / Ji, Guang

Clinical and translational medicine

2023 Volume 13, Issue 3, Page(s) e1202

MeSH term(s)	Humans ; DNA Methylation/genetics ; Colorectal Neoplasms/genetics
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1202
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Article ; Online: Role of epigenetics in transformation of inflammation into colorectal cancer.

Yang, Zhen-Hua / Dang, Yan-Qi / Ji, Guang

World journal of gastroenterology

2019 Volume 25, Issue 23, Page(s) 2863–2877

Abstract: Molecular mechanisms associated with inflammation-promoted tumorigenesis have become an important topic in cancer research. Various abnormal epigenetic changes, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA ... ...

Abstract	Molecular mechanisms associated with inflammation-promoted tumorigenesis have become an important topic in cancer research. Various abnormal epigenetic changes, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA regulation, occur during the transformation of chronic inflammation into colorectal cancer (CRC). These changes not only accelerate transformation but also lead to cancer progression and metastasis by activating carcinogenic signaling pathways. The NF-κB and STAT3 signaling pathways play a particularly important role in the transformation of inflammation into CRC, and both are critical to cellular signal transduction and constantly activated in cancer by various abnormal changes including epigenetics. The NF-κB and STAT3 signals contribute to the microenvironment for tumorigenesis through secretion of a large number of pro-inflammatory cytokines and their crosstalk in the nucleus makes it even more difficult to treat CRC. Compared with gene mutation that is irreversible, epigenetic inheritance is reversible or can be altered by the intervention. Therefore, understanding the role of epigenetic inheritance in the inflammation-cancer transformation may elucidate the pathogenesis of CRC and promote the development of innovative drugs targeting transformation to prevent and treat this malignancy. This review summarizes the literature on the roles of epigenetic mechanisms in the occurrence and development of inflammation-induced CRC. Exploring the role of epigenetics in the transformation of inflammation into CRC may help stimulate futures studies on the role of molecular therapy in CRC.
MeSH term(s)	Cell Transformation, Neoplastic/genetics ; Colon/immunology ; Colon/pathology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Disease Progression ; Epigenesis, Genetic/immunology ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Rectum/immunology ; Rectum/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Language	English
Publishing date	2019-06-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v25.i23.2863
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