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  1. Book ; Audio / Video ; Thesis: New immunopharmacologic strategies for the treatment of inflammatory bowel disease

    Daniel, Carolin

    in vivo investigations with the TNBS- and Oxazolone-model in mice

    2008  

    Author's details vorgelegt von Carolin Daniel
    Language English
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2008
    HBZ-ID HT015628761
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 MO 48 order for loan Magazin

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  2. Article ; Online: Niche-specific control of tissue function by regulatory T cells-Current challenges and perspectives for targeting metabolic disease.

    Becker, Maike / Dirschl, Sandra M / Scherm, Martin G / Serr, Isabelle / Daniel, Carolin

    Cell metabolism

    2024  Volume 36, Issue 2, Page(s) 229–239

    Abstract: Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and ... ...

    Abstract Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Homeostasis ; Metabolic Diseases/metabolism
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes.

    Scherm, Martin G / Daniel, Carolin

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 606322

    Abstract: The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized. Consequently, aberrant miRNA expression contributes to the defective regulation of T ... ...

    Abstract The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized. Consequently, aberrant miRNA expression contributes to the defective regulation of T cell development, differentiation, and function. This can result in immune activation and impaired tolerance mechanisms, which exert a cardinal function for the onset of islet autoimmunity and the progression to T1D. The specific impact of miRNAs for immune regulation and how miRNAs and their downstream targets are involved in the pathogenesis of islet autoimmunity and T1D has been investigated recently. These studies revealed that increased expression of individual miRNAs is involved in several layers of tolerance impairments, such as inefficient Treg induction and Treg instability. The targeted modulation of miRNAs using specific inhibitors, resulting in improved immune homeostasis, as well as improved methods for the targeting of miRNAs, suggest that miRNAs, especially in T cells, are a promising target for the reestablishment of immune tolerance.
    MeSH term(s) Animals ; Autoimmunity/genetics ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Gene Expression Regulation ; Humans ; Immune Tolerance ; Islets of Langerhans/immunology ; MicroRNAs/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-11-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.606322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes.

    Scherm, Martin G / Daniel, Carolin

    Current diabetes reports

    2020  Volume 20, Issue 9, Page(s) 41

    Abstract: Purpose of review: Regulatory T cells (Tregs) are critical contributors to immune homeostasis and their dysregulation can lead to the loss of immune tolerance and autoimmune diseases like type 1 diabetes (T1D). Recent studies have highlighted microRNAs ( ...

    Abstract Purpose of review: Regulatory T cells (Tregs) are critical contributors to immune homeostasis and their dysregulation can lead to the loss of immune tolerance and autoimmune diseases like type 1 diabetes (T1D). Recent studies have highlighted microRNAs (miRNAs) as important regulators of the immune system, by fine-tuning relevant genes in various immune cell types. In this review article, we discuss recent insights into miRNA regulation of immune tolerance and activation. Specifically, we discuss how the dysregulation of miRNAs in T cells contributes to their aberrant function and the onset of islet autoimmunity, as well as their potential as targets of novel intervention strategies to interfere with autoimmune activation.
    Recent findings: Several studies have shown that the dysregulation of individual miRNAs in T cells can contribute to impaired immune tolerance, contributing to onset and progression of islet autoimmunity. Importantly, the targeting of these miRNAs, including miR-92a, miR-142-3p and miR-181a, resulted in relevant effects on downstream pathways, improved Treg function and reduced islet autoimmunity in murine models. miRNAs are critical regulators of immune homeostasis and the dysregulation of individual miRNAs in T cells contributes to aberrant T cell function and autoimmunity. The specific targeting of individual miRNAs could improve Treg homeostasis and therefore limit overshooting T cell activation and islet autoimmunity.
    MeSH term(s) Animals ; Autoimmune Diseases ; Autoimmunity ; Diabetes Mellitus, Type 1/genetics ; Humans ; Mice ; MicroRNAs/genetics ; T-Lymphocytes, Regulatory
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-020-01325-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5628: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Mechanismen der Immuntoleranz bei Typ-1-Diabetes im Kindesalter – Ferdinand-Bertram-Preis 2021 – eine Kurzübersicht der Preisträgerin Carolin Daniel

    Daniel, Carolin / Scherm, Martin

    Diabetologie und Stoffwechsel

    2021  Volume 16, Issue 06, Page(s) 459–461

    Language German
    Publishing date 2021-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/a-1664-5026
    Database Thieme publisher's database

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    Zs.A 6479: Show issues Location:
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    Zs.A 6479/X: Show issues Location:
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  6. Article: Autoimmunerkrankung Typ-1-Diabetes

    Scherm, Martin G. / Daniel, Carolin

    Diabetes aktuell

    2021  Volume 19, Issue 02, Page(s) 76–80

    Abstract: Die umfassende Erforschung der Immunologie des Typ-1-Diabetes kann entscheidend zu unserem Verständnis der Krankheit beitragen. Hierbei ist insbesondere auch die Identifizierung der zugrundeliegenden Signalwege, die zur fehlerhaften Immuntoleranz sowie ... ...

    Abstract Die umfassende Erforschung der Immunologie des Typ-1-Diabetes kann entscheidend zu unserem Verständnis der Krankheit beitragen. Hierbei ist insbesondere auch die Identifizierung der zugrundeliegenden Signalwege, die zur fehlerhaften Immuntoleranz sowie der Aktivierung und dem Fortschreiten der Inselautoimmunität beitragen, von entscheidender Bedeutung für die Entwicklung zukünftiger Interventionsstrategien, um die Entstehung von Typ-1-Diabetes zu verlangsamen oder sogar ganz zu verhindern 1. So bieten kürzlich identifizierte miRNAs, die zur Entstehung von Inselautoimmunität beitragen, einen vielversprechenden Ansatz, um Treg-vermittelte Toleranzdefekte mittels gezielter miRNA-Modulation zu reduzieren.
    Language German
    Publishing date 2021-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2225026-8
    ISSN 1864-1733 ; 1861-6089 ; 1617-0482
    ISSN (online) 1864-1733
    ISSN 1861-6089 ; 1617-0482
    DOI 10.1055/a-1452-1412
    Database Thieme publisher's database

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    Zs.A 6239: Show issues Location:
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  7. Article ; Online: Antigen-Specific Treg Therapy in Type 1 Diabetes - Challenges and Opportunities.

    Serr, Isabelle / Drost, Felix / Schubert, Benjamin / Daniel, Carolin

    Frontiers in immunology

    2021  Volume 12, Page(s) 712870

    Abstract: Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment ... ...

    Abstract Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment of autoimmune diseases given reduced side effects compared to general immunosuppressive therapies. However, the translation of antigen-specific Treg inducing therapies for the treatment or prevention of autoimmune diseases into the clinic remains challenging. In this mini review, we will discuss promising results for antigen-specific Treg therapies in allergy and specific challenges for such therapies in autoimmune diseases, with a focus on type 1 diabetes (T1D). We will furthermore discuss opportunities for antigen-specific Treg therapies in T1D, including combinatorial strategies and tissue-specific Treg targeting. Specifically, we will highlight recent advances in miRNA-targeting as a means to foster Tregs in autoimmunity. Additionally, we will discuss advances and perspectives of computational strategies for the detailed analysis of tissue-specific Tregs on the single-cell level.
    MeSH term(s) Animals ; Autoimmune Diseases ; Autoimmunity ; Biomarkers ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/therapy ; Disease Management ; Disease Susceptibility ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunotherapy, Adoptive/methods ; Organ Specificity/immunology ; T-Cell Antigen Receptor Specificity/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Biomarkers ; Epitopes, T-Lymphocyte
    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.712870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Regulation of T Follicular Helper Cells in Islet Autoimmunity.

    Serr, Isabelle / Daniel, Carolin

    Frontiers in immunology

    2018  Volume 9, Page(s) 1729

    Abstract: T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune ... ...

    Abstract T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune diseases including type 1 diabetes (T1D). Symptomatic T1D is preceded by a preclinical phase (indicated by the presence of islet autoantibodies) with a highly variable progression time to the symptomatic disease. This heterogeneity points toward differences in immune activation in children with a fast versus slow progressor phenotype. In the context of T1D, previous studies on TFH cells have mainly focused on the clinically active state of the disease. In this review article, we aim to specifically discuss recent insights on TFH cells in human islet autoimmunity before the onset of symptomatic T1D. Furthermore, we will highlight advances in the field of TFH differentiation and function during human islet autoimmunity. Specifically, we will focus on the regulation of TFH cells by microRNAs (miRNAs), as well as on the potential use of miRNAs as biomarkers to predict disease progression time and as future drug targets to interfere with autoimmune activation.
    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies.

    Serr, Isabelle / Kral, Maria / Scherm, Martin G / Daniel, Carolin

    Frontiers in immunology

    2021  Volume 12, Page(s) 643544

    Abstract: Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies. One prerequisite for advancing personalized ... ...

    Abstract Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies. One prerequisite for advancing personalized medicine is modeling the immune system of individuals or disease groups in a preclinical setting. HIS mice engrafted with peripheral blood mononuclear cells have provided fundamental insights in underlying mechanisms guiding immune activation vs. regulation in several diseases including cancer. However, the development of Graft-vs.-host disease restrains relevant long-term studies in HIS mice. Alternatively, engraftment with hematopoietic stem cells (HSCs) enables mimicking different disease stages, however, low frequencies of HSCs in peripheral blood of adults impede engraftment efficacy. One possibility to overcome those limitations is the use of patient-derived induced pluripotent stem cells (iPSCs) reprogrammed into HSCs, a challenging process which has recently seen major advances. Personalized HIS mice bridge research in mice and human diseases thereby facilitating the translation of immunomodulatory therapies. Regulatory T cells (Tregs) are important mediators of immune suppression and thereby contribute to tumor immune evasion, which has made them a central target for cancer immunotherapies. Importantly, studying Tregs in the human immune system
    MeSH term(s) Animals ; Humans ; Immune Tolerance ; Immunotherapy ; Mice ; Models, Immunological ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes, Regulatory/immunology ; Tumor Escape
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.643544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention.

    Ziegler, Anette-Gabriele / Danne, Thomas / Daniel, Carolin / Bonifacio, Ezio

    Med (New York, N.Y.)

    2021  Volume 2, Issue 10, Page(s) 1120–1137

    Abstract: In this review, we bring our personal experiences to showcase insulin from its breakthrough discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and potential cause of type 1 diabetes and eventually as an opportunity to ... ...

    Abstract In this review, we bring our personal experiences to showcase insulin from its breakthrough discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and potential cause of type 1 diabetes and eventually as an opportunity to prevent autoimmune diabetes. The work covers the birth of insulin to treat patients, which is now 100 years ago, the development of human insulin, insulin analogues, devices, and the way into automated insulin delivery, the realization that insulin is the primary autoimmune target of type 1 diabetes in children, novel approaches of immunotherapy using insulin for immune tolerance induction, the possible limitations of insulin immunotherapy, and an outlook how modern vaccines could remove the need for another 100 years of insulin therapy.
    MeSH term(s) Autoantigens ; Autoimmunity ; Child ; Diabetes Mellitus, Type 1/drug therapy ; Humans ; Immune Tolerance ; Insulin/therapeutic use ; Insulin, Regular, Human/therapeutic use
    Chemical Substances Autoantigens ; Insulin ; Insulin, Regular, Human
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2021.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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