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  1. Book ; Thesis: Metabolische Tumorbildgebung mittels Sauerstoff-17 Magnetresonanztomographie bei Gliompatienten

    Schultheiss, Miriam / Paech, Daniel

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Miriam Naomi Schultheiß ; Doktorvater: Herr Priv.-Doz. Dr. med. Dipl.-Phys. Daniel Paech
    Language German
    Size 78 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030622073
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2024 E 6 order for loan Magazin

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  2. Book ; Thesis: Chemical exchange saturation transfer Bildgebung bei Glioblastom-Patienten an 7 Tesla Magnetresonanz-Tomographen

    Paech, Daniel

    2015  

    Author's details vorgelegt von Daniel Christian Paech
    Language German
    Size 108 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2016
    HBZ-ID HT019175638
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  3. Book ; Thesis: Quantitative Bewertung der diagnostischen Treffsicherheit bei der Erkennung kindlicher Herzerkrankungen durch verschiedene Untersucher - ist die Echokardiografie immer erforderlich?

    Vilser, Daniel

    2018  

    Author's details von Daniel Vilser
    Language German
    Size V, 113, 4 Seiten, Illustrationen, 31 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2018
    Accompanying material 1 CD-ROM
    HBZ-ID HT019892344
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  4. Book ; Thesis: Tolperison

    Hinck, Daniel Christian

    ein Kaliumstrom-modulierendes Lokalanästhetikum?

    2001  

    Author's details vorgelegt von Daniel Christian Hinck
    Language German
    Size 53 S., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2001
    HBZ-ID HT013341419
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Analysis of attitudes and practices influencing adherence to seasonal malaria chemoprevention in children under 5 years of age in the Dosso Region of Niger

    Daniel Christian Koko / Aminata Maazou / Hadiza Jackou / Charlotte Eddis

    Malaria Journal, Vol 21, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Abstract Background Seasonal malaria chemoprevention (SMC) consists of the intermittent administration of a 3 day course of anti-malarial medications during the months of highest malaria risk in the Sahel region, where malaria transmission is highly ... ...

    Abstract Abstract Background Seasonal malaria chemoprevention (SMC) consists of the intermittent administration of a 3 day course of anti-malarial medications during the months of highest malaria risk in the Sahel region, where malaria transmission is highly seasonal. SMC is an effective intervention to reduce episodes of uncomplicated and severe malaria in children. However, morbidity cannot be lowered without adherence to medications. The objective of this study was to examine SMC medication adherence and to identify the attitudes and practices of caregivers during the 2020 SMC campaign in the Dosso region. Methods This study was conducted based on data from independent monitoring using random cluster sampling. Adherence levels and the attitudes and practices of caregivers were evaluated using data from caregivers’ self-reports and analysed according to Bernard Vrijens’ taxonomy. Results At the initiation of treatment phase, 99% of children (N = 2296) received their first administration of medication, with 90% of caregivers (N = 1436) knowing that the medications help prevent malaria. However, only 56% of caregivers (N = 1856) reported that treatment initiation took place under direct observation by the distributor. At the implementation of treatment phase, 90% of children (N = 2132) took their medication on the second day and 84% (N = 1068) took it the third day. “Forgetting,” “not having time,” and “the mother’s absence” were the main reasons caregivers gave to explain discontinuation of the 3 day course of medication. Conclusion This simple, low-cost survey demonstrated that coverage of SMC and adherence by caregivers to completing the full 3 day medication course was high. The survey also showed that knowledge, attitudes, and practices of some caregivers regarding adherence to medications during the SMC campaign could be improved. Expanding distributors’ training, developing and providing them with tools for interpersonal communication, and strengthening supervision could lead to even higher adherence.
    Keywords Seasonal malaria chemoprevention ; Adherence ; Attitudes ; Practices ; Distributor ; Caregivers ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Subject code 360
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Thesis: Plasmaspiegel-Wirkungs-Beziehung von Clozapin

    Glaenz, Daniel Christian

    1998  

    Author's details vorgelegt von Daniel Christian Glaenz
    Language German
    Size II, 71 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 1998
    HBZ-ID HT009068423
    Database Catalogue ZB MED Medicine, Health

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  7. Book ; Thesis: Überprüfung von Effekten und Nebeneffekten einer Wurzeloberflächenbearbeitung mit dem ER:YAG-Laser

    Aniol, Daniel Christian

    eine histologische und rasterelektronenmikroskopische In-vitro-Studie

    2002  

    Author's details vorgelegt von Daniel Christian Aniol
    Language German
    Size 117 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2002
    HBZ-ID HT013508403
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 70 order for loan Magazin

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  8. Book ; Thesis: Die Regulation des kardialen I-K1-Stroms durch die Proteinkinase C-Beta und Beta-3-Adrenozeptoren

    Scherer, Daniel

    2010  

    Author's details vorgelegt von Daniel Christian Scherer
    Language German
    Size 130 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2011
    HBZ-ID HT016968993
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 3311 order for loan Magazin

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  9. Article ; Online: Analysis of attitudes and practices influencing adherence to seasonal malaria chemoprevention in children under 5 years of age in the Dosso Region of Niger.

    Koko, Daniel Christian / Maazou, Aminata / Jackou, Hadiza / Eddis, Charlotte

    Malaria journal

    2022  Volume 21, Issue 1, Page(s) 375

    Abstract: Background: Seasonal malaria chemoprevention (SMC) consists of the intermittent administration of a 3 day course of anti-malarial medications during the months of highest malaria risk in the Sahel region, where malaria transmission is highly seasonal. ... ...

    Abstract Background: Seasonal malaria chemoprevention (SMC) consists of the intermittent administration of a 3 day course of anti-malarial medications during the months of highest malaria risk in the Sahel region, where malaria transmission is highly seasonal. SMC is an effective intervention to reduce episodes of uncomplicated and severe malaria in children. However, morbidity cannot be lowered without adherence to medications. The objective of this study was to examine SMC medication adherence and to identify the attitudes and practices of caregivers during the 2020 SMC campaign in the Dosso region.
    Methods: This study was conducted based on data from independent monitoring using random cluster sampling. Adherence levels and the attitudes and practices of caregivers were evaluated using data from caregivers' self-reports and analysed according to Bernard Vrijens' taxonomy.
    Results: At the initiation of treatment phase, 99% of children (N = 2296) received their first administration of medication, with 90% of caregivers (N = 1436) knowing that the medications help prevent malaria. However, only 56% of caregivers (N = 1856) reported that treatment initiation took place under direct observation by the distributor. At the implementation of treatment phase, 90% of children (N = 2132) took their medication on the second day and 84% (N = 1068) took it the third day. "Forgetting," "not having time," and "the mother's absence" were the main reasons caregivers gave to explain discontinuation of the 3 day course of medication.
    Conclusion: This simple, low-cost survey demonstrated that coverage of SMC and adherence by caregivers to completing the full 3 day medication course was high. The survey also showed that knowledge, attitudes, and practices of some caregivers regarding adherence to medications during the SMC campaign could be improved. Expanding distributors' training, developing and providing them with tools for interpersonal communication, and strengthening supervision could lead to even higher adherence.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Niger
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04407-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of Geriatric Assessment on the Tolerability of Combination Chemotherapy in Older Patients with Advanced Cancer: A Matched-Pair Analysis.

    Stahl, Michael Konrad / Ertl, Sebastian Willy / Engelmeyer, Pouneh / Heuer, Hans-Christoph / Christoph, Daniel Christian

    Oncology research and treatment

    2023  Volume 46, Issue 3, Page(s) 100–105

    Abstract: Because of their individual vulnerabilities, treatment decisions for older patients can be difficult. Geriatric assessment (GA) may help to select patients for systemic treatment, but its value is still unproven. Older cancer patients (≥65 years of age) ... ...

    Abstract Because of their individual vulnerabilities, treatment decisions for older patients can be difficult. Geriatric assessment (GA) may help to select patients for systemic treatment, but its value is still unproven. Older cancer patients (≥65 years of age) with and without complex GA followed by discussion in the geriatric-oncologic conference, who had been treated in palliative intention with standard combination chemotherapy at the Evang. Kliniken Essen-Mitte, were retrospectively evaluated. All patients had been orally informed about the treatment options and had chosen chemotherapy beside supportive care. To reduce selection bias, the method of propensity-score matching was performed. Patient groups treated in the years 2011-2013 (without GA, group 1) and in the years 2014-2015 (with GA, group 2) were compared regarding different toxicity endpoints. The primary endpoint of the study was defined as numbers of patients with unplanned admission to the hospital or death during first-line chemotherapy and GA should reduce these events by 15%. Overall, 114 patients were evaluated in both groups. The median age was 74 years. Patients suffered from gastrointestinal carcinomas (47%), lung cancer (28%), breast cancer (12%), and other cancer types (3%). Consequently, most patients were treated with platinum-based (41%), fluoropyrimidine-based (35%), or anthracycline-based (13%) combination chemotherapy. In group 2, the events were numerically lower for all toxicity endpoints. The need for a premature stop of treatment was 54.4% in group 1 compared to 29.8% in group 2 (p < 0.01) and also the treatment-related mortality was significantly lower in group 2 (17.5% vs. 5.3%; p = 0.04). The primary endpoint, the rate of unplanned hospital admission, and death was 49.1% versus 35.1% (difference 14.0%), which did not reach the predefined border of 15%. There was a nonsignificant overall survival benefit in the group with GA (22.6 vs. 18.4 months). GA appears useful to better select older patients with advanced cancer for combination chemotherapy. The significant reduction of mortality during chemotherapy justifies the efforts and costs which need to be expended. To evaluate the effect of GA on overall survival, prospective trials are required.
    MeSH term(s) Humans ; Aged ; Geriatric Assessment/methods ; Matched-Pair Analysis ; Prospective Studies ; Retrospective Studies ; Lung Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000529097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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