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  1. AU="Daniel A. Haber"
  2. AU=Bu Fangfang
  3. AU="Fox, Kevin J"
  4. AU="Nawazish Naqvi"
  5. AU="Marquardt, Viktoria"
  6. AU="Watts, Robyn"
  7. AU="Caballero, Susana J"
  8. AU="van Dijk, J Hessel M"
  9. AU=Della Guardia Lucio
  10. AU="Zhilich V.N."
  11. AU="George, Darren"
  12. AU=Lin Xiukun
  13. AU="Kanwal Gujral"
  14. AU="Christian Young"
  15. AU=Takeuchi Kaoru
  16. AU="Wiślicki, W."
  17. AU="Veiga, Susana"
  18. AU="Reynolds, Matthew W."
  19. AU="Oates, Stephen B"
  20. AU=Okubo K
  21. AU="Behnood, Sanaz"

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  1. Artikel ; Online: A landscape of response to drug combinations in non-small cell lung cancer

    Nishanth Ulhas Nair / Patricia Greninger / Xiaohu Zhang / Adam A. Friedman / Arnaud Amzallag / Eliane Cortez / Avinash Das Sahu / Joo Sang Lee / Anahita Dastur / Regina K. Egan / Ellen Murchie / Michele Ceribelli / Giovanna S. Crowther / Erin Beck / Joseph McClanaghan / Carleen Klump-Thomas / Jessica L. Boisvert / Leah J. Damon / Kelli M. Wilson /
    Jeffrey Ho / Angela Tam / Crystal McKnight / Sam Michael / Zina Itkin / Mathew J. Garnett / Jeffrey A. Engelman / Daniel A. Haber / Craig J. Thomas / Eytan Ruppin / Cyril H. Benes

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 19

    Abstract: Abstract Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 5000 ... ...

    Abstract Abstract Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 5000 targeted agent combinations across 81 non-small cell lung cancer cell lines. Our analysis reveals a profound heterogeneity of response across the tumor models. Notably, combinations very rarely result in a strong gain in efficacy over the range of response observable with single agents. Importantly, gain of activity over single agents is more often seen when co-targeting functionally proximal genes, offering a strategy for designing more efficient combinations. Because combinatorial effect is strongly context specific, tumor specificity should be achievable. The resource provided, together with an additional validation screen sheds light on major challenges and opportunities in building efficacious combinations against cancer and provides an opportunity for training computational models for synergy prediction.
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 004
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Modeling background radiation using geochemical data: A case study in and around Cameron, Arizona

    Marsac, Kara E / Pamela C. Burnley / Christopher T. Adcock / Daniel A. Haber / Russell L. Malchow / Elisabeth M. Hausrath

    Journal of environmental radioactivity. 2016,

    2016  

    Abstract: This study compares high resolution forward models of natural gamma-ray background with that measured by high resolution aerial gamma-ray surveys. The ability to predict variations in natural background radiation levels should prove useful for those ... ...

    Abstract This study compares high resolution forward models of natural gamma-ray background with that measured by high resolution aerial gamma-ray surveys. The ability to predict variations in natural background radiation levels should prove useful for those engaged in measuring anthropogenic contributions to background radiation for the purpose of emergency response and homeland security operations. The forward models are based on geologic maps and remote sensing multi-spectral imagery combined with two different sources of data: 1) bedrock geochemical data (uranium, potassium and thorium concentrations) collected from national databases, the scientific literature and private companies, and 2) the low spatial resolution NURE (National Uranium Resource Evaluation) aerial gamma-ray survey. The study area near Cameron, Arizona, is located in an arid region with minimal vegetation and, due to the presence of abandoned uranium mines, was the subject of a previous high resolution gamma-ray survey. We found that, in general, geologic map units form a good basis for predicting the geographic distribution of the gamma-ray background. Predictions of background gamma-radiation levels based on bedrock geochemical analyses were not as successful as those based on the NURE aerial survey data sorted by geologic unit. The less successful result of the bedrock geochemical model is most likely due to a number of factors including the need to take into account the evolution of soil geochemistry during chemical weathering and the influence of aeolian addition. Refinements to the forward models were made using ASTER visualizations to create subunits of similar exposure rate within the Chinle Formation, which contains multiple lithologies and by grouping alluvial units by drainage basin rather than age.
    Schlagwörter Advanced Spaceborne Thermal Emission and Reflection Radiometer ; arid zones ; bedrock ; case studies ; databases ; gamma radiation ; geochemistry ; geographical distribution ; models ; multispectral imagery ; potassium ; prediction ; private enterprises ; remote sensing ; soil formation ; surveys ; thorium ; uranium ; vegetation ; watersheds ; weathering ; Arizona
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 1483112-0
    ISSN 1879-1700 ; 0265-931X
    ISSN (online) 1879-1700
    ISSN 0265-931X
    DOI 10.1016/j.jenvrad.2016.07.012
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Ultra-fast vitrification of patient-derived circulating tumor cell lines.

    Rebecca D Sandlin / Keith H K Wong / Shannon N Tessier / Anisa Swei / Lauren D Bookstaver / Bennett E Ahearn / Shyamala Maheswaran / Daniel A Haber / Shannon L Stott / Mehmet Toner

    PLoS ONE, Vol 13, Iss 2, p e

    2018  Band 0192734

    Abstract: Emerging technologies have enabled the isolation and characterization of rare circulating tumor cells (CTCs) from the blood of metastatic cancer patients. CTCs represent a non-invasive opportunity to gain information regarding the primary tumor and ... ...

    Abstract Emerging technologies have enabled the isolation and characterization of rare circulating tumor cells (CTCs) from the blood of metastatic cancer patients. CTCs represent a non-invasive opportunity to gain information regarding the primary tumor and recent reports suggest CTCs have value as an indicator of disease status. CTCs are fragile and difficult to expand in vitro, so typically molecular characterization must be performed immediately following isolation. To ease experimental timelines and enable biobanking, cryopreservation methods are needed. However, extensive cellular heterogeneity and the rarity of CTCs complicates the optimization of cryopreservation methods based upon cell type, necessitating a standardized protocol. Here, we optimized a previously reported vitrification protocol to preserve patient-derived CTC cell lines using highly conductive silica microcapillaries to achieve ultra-fast cooling rates with low cryoprotectant concentrations. Using this vitrification protocol, five CTC cell lines were cooled to cryogenic temperatures. Thawed CTCs exhibited high cell viability and expanded under in vitro cell culture conditions. EpCAM biomarker expression was maintained for each CTC cell line. One CTC cell line was selected for molecular characterization, revealing that RNA integrity was maintained after storage. A qPCR panel showed no significant difference in thawed CTCs compared to fresh controls. The data presented here suggests vitrification may enable the standardization of cryopreservation methods for CTCs.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: SETD1A protects from senescence through regulation of the mitotic gene expression program

    Ken Tajima / Satoru Matsuda / Toshifumi Yae / Benjamin J. Drapkin / Robert Morris / Myriam Boukhali / Kira Niederhoffer / Valentine Comaills / Taronish Dubash / Linda Nieman / Hongshan Guo / Neelima K. C. Magnus / Nick Dyson / Toshihiro Shioda / Wilhelm Haas / Daniel A. Haber / Shyamala Maheswaran

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 13

    Abstract: SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence. ...

    Abstract SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: SETD1A protects from senescence through regulation of the mitotic gene expression program

    Ken Tajima / Satoru Matsuda / Toshifumi Yae / Benjamin J. Drapkin / Robert Morris / Myriam Boukhali / Kira Niederhoffer / Valentine Comaills / Taronish Dubash / Linda Nieman / Hongshan Guo / Neelima K. C. Magnus / Nick Dyson / Toshihiro Shioda / Wilhelm Haas / Daniel A. Haber / Shyamala Maheswaran

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 13

    Abstract: SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence. ...

    Abstract SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

    Joseph W. Franses / Julia Philipp / Pavlos Missios / Irun Bhan / Ann Liu / Chittampalli Yashaswini / Eric Tai / Huili Zhu / Matteo Ligorio / Benjamin Nicholson / Elizabeth M. Tassoni / Niyati Desai / Anupriya S. Kulkarni / Annamaria Szabolcs / Theodore S. Hong / Andrew S. Liss / Carlos Fernandez-del Castillo / David P. Ryan / Shyamala Maheswaran /
    Daniel A. Haber / George Q. Daley / David T. Ting

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 12

    Abstract: Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic ... ...

    Abstract Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to halt cancer metastasis.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: HIF1A signaling selectively supports proliferation of breast cancer in the brain

    Richard Y. Ebright / Marcus A. Zachariah / Douglas S. Micalizzi / Ben S. Wittner / Kira L. Niederhoffer / Linda T. Nieman / Brian Chirn / Devon F. Wiley / Benjamin Wesley / Brian Shaw / Edwin Nieblas-Bedolla / Lian Atlas / Annamaria Szabolcs / Anthony J. Iafrate / Mehmet Toner / David T. Ting / Priscilla K. Brastianos / Daniel A. Haber / Shyamala Maheswaran

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 13

    Abstract: The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and ... ...

    Abstract The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the brain.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

    Joseph W. Franses / Julia Philipp / Pavlos Missios / Irun Bhan / Ann Liu / Chittampalli Yashaswini / Eric Tai / Huili Zhu / Matteo Ligorio / Benjamin Nicholson / Elizabeth M. Tassoni / Niyati Desai / Anupriya S. Kulkarni / Annamaria Szabolcs / Theodore S. Hong / Andrew S. Liss / Carlos Fernandez-del Castillo / David P. Ryan / Shyamala Maheswaran /
    Daniel A. Haber / George Q. Daley / David T. Ting

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 12

    Abstract: Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic ... ...

    Abstract Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to halt cancer metastasis.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

    Sam H. Au / Jon Edd / Amy E. Stoddard / Keith H. K. Wong / Fabio Fachin / Shyamala Maheswaran / Daniel A. Haber / Shannon L. Stott / Ravi Kapur / Mehmet Toner

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Band 10

    Abstract: Abstract Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from ...

    Abstract Abstract Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from blood, these devices are ineffective at capturing CTC clusters, incapable of separating clusters from single cells and/or cause cluster damage or dissociation during processing. The only device currently able to specifically isolate CTC clusters from single CTCs and blood cells relies on the batch immobilization of clusters onto micropillars which necessitates long residence times and causes damage to clusters during release. Here, we present a two-stage continuous microfluidic chip that isolates and recovers viable CTC clusters from blood. This approach uses deterministic lateral displacement to sort clusters by capitalizing on two geometric properties: size and asymmetry. Cultured breast cancer CTC clusters containing between 2–100 + cells were recovered from whole blood using this integrated two-stage device with minimal cluster dissociation, 99% recovery of large clusters, cell viabilities over 87% and greater than five-log depletion of red blood cells. This continuous-flow cluster chip will enable further studies examining CTC clusters in research and clinical applications.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions

    Rebecca D. Sandlin / Keith H. K. Wong / Leo Boneschansker / Thomas R. Carey / Kathleen L. Miller / Gregory Rose / Daniel A. Haber / Shyamala Maheswaran / Daniel Irimia / Shannon L. Stott / Mehmet Toner

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Band 11

    Abstract: Abstract The deterioration of whole blood ex vivo represents a logistical hurdle in clinical and research settings. Here, a cocktail preservative is described that stabilizes leukocyte viability and erythrocyte morphology in whole blood under ambient ... ...

    Abstract Abstract The deterioration of whole blood ex vivo represents a logistical hurdle in clinical and research settings. Here, a cocktail preservative is described that stabilizes leukocyte viability and erythrocyte morphology in whole blood under ambient storage. Neutrophil biostabilization was explored using a sophisticated microfluidic assay to examine the effectiveness of caspase inhibition to stabilize purified neutrophils. Following 72 h ambient storage, neutrophils remained fully functional to migrate towards chemical cues and maintained their ability to undergo NETosis after stimulation. Furthermore, stored neutrophils exhibited improved CD45 biomarker retention and reduced apoptosis and mortality compared to untreated controls. To stabilize erythrocyte morphology, a preservative solution was formulated using Taguchi methods of experimental design, and combined with the caspase inhibitor to form a whole blood cocktail solution, CSWB. CSWB was evaluated in blood from healthy donors and from women with metastatic breast cancer stored under ambient conditions for 72 h. CSWB-treated samples showed a significant improvement in erythrocyte morphology compared to untreated controls. Leukocytes in CSWB-treated blood exhibited significantly higher viability and CD45 biomarker retention compared to untreated controls. This 72 h shelf life under ambient conditions represents an opportunity to transport isolates or simply ease experimental timelines where blood degradation is problematic.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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