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  1. AU="Daniel Cisterna"
  2. AU="Barré-Sinoussi, Françoise"
  3. AU="Siracusa, Massimiliano"
  4. AU="Mishra, Vipin Kumar"
  5. AU=Martinez Victor D.
  6. AU="Seol, Myung Do"
  7. AU="Sato, Keiyu"
  8. AU="Go, Ji Young"
  9. AU="Zhao, Bingjian"
  10. AU="Ringeisen, Bradley R"
  11. AU=Sciascia Savino
  12. AU="Capito, Carmen"
  13. AU=Osman Mahasin

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  1. Artikel ; Online: Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome

    Mariano Golubicki / Laia Bonjoch / José G. Acuña-Ochoa / Marcos Díaz-Gay / Jenifer Muñoz / Miriam Cuatrecasas / Teresa Ocaña / Soledad Iseas / Guillermo Mendez / Daniel Cisterna / Stephanie A. Schubert / Maartje Nielsen / Tom van Wezel / Yael Goldberg / Eli Pikarsky / Juan Robbio / Enrique Roca / Antoni Castells / Francesc Balaguer /
    Marina Antelo / Sergi Castellví-Bel

    JCI Insight, Vol 5, Iss

    2020  Band 18

    Abstract: Lynch syndrome is the most common cause of hereditary colorectal cancer (CRC), and it is characterized by DNA mismatch repair (MMR) deficiency. The term Lynch-like syndrome (LLS) is used for patients with MMR-deficient tumors and neither germline ... ...

    Abstract Lynch syndrome is the most common cause of hereditary colorectal cancer (CRC), and it is characterized by DNA mismatch repair (MMR) deficiency. The term Lynch-like syndrome (LLS) is used for patients with MMR-deficient tumors and neither germline mutation in MLH1, MSH2, MSH6, PMS2, or EPCAM nor MLH1 somatic methylation. Biallelic somatic inactivation or cryptic germline MMR variants undetected during genetic testing have been proposed to be involved. Sixteen patients with early-onset LLS CRC were selected for germline and tumor whole-exome sequencing. Two potentially pathogenic germline MCM8 variants were detected in a male patient with LLS with fertility problems. A knockout cellular model for MCM8 was generated by CRISPR/Cas9 and detected genetic variants were produced by mutagenesis. DNA damage, microsatellite instability, and mutational signatures were monitored. DNA damage was evident for MCM8KO cells and the analyzed genetic variants. Microsatellite instability and mutational signatures in MCM8KO cells were compatible with the involvement of MCM8 in MMR. Replication in an independent familial cancer cohort detected additional carriers. Unexplained MMR-deficient CRC cases, even showing somatic biallelic MMR inactivation, may be caused by underlying germline defects in genes different than MMR genes. We suggest MCM8 as a gene involved in CRC germline predisposition with a recessive pattern of inheritance.
    Schlagwörter Gastroenterology ; Genetics ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag American Society for Clinical investigation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza.

    Gustavo Palacios / Mady Hornig / Daniel Cisterna / Nazir Savji / Ana Valeria Bussetti / Vishal Kapoor / Jeffrey Hui / Rafal Tokarz / Thomas Briese / Elsa Baumeister / W Ian Lipkin

    PLoS ONE, Vol 4, Iss 12, p e

    2009  Band 8540

    Abstract: Initial reports in May 2009 of the novel influenza strain H1N1pdm estimated a case fatality rate (CFR) of 0.6%, similar to that of seasonal influenza. In July 2009, however, Argentina reported 3056 cases with 137 deaths, representing a CFR of 4.5%. ... ...

    Abstract Initial reports in May 2009 of the novel influenza strain H1N1pdm estimated a case fatality rate (CFR) of 0.6%, similar to that of seasonal influenza. In July 2009, however, Argentina reported 3056 cases with 137 deaths, representing a CFR of 4.5%. Potential explanations for increased CFR included virus reassortment or genetic drift, or infection of a more vulnerable population. Virus genomic sequencing of 26 Argentinian samples representing both severe and mild disease indicated no evidence of reassortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence. Furthermore, no evidence was found for increased frequency of risk factors for H1N1pdm disease.We examined nasopharyngeal swab samples (NPS) from 199 cases of H1N1pdm infection from Argentina with MassTag PCR, testing for 33 additional microbial agents. The study population consisted of 199 H1N1pdm-infected subjects sampled between 23 June and 4 July 2009. Thirty-nine had severe disease defined as death (n = 20) or hospitalization (n = 19); 160 had mild disease. At least one additional agent of potential pathogenic importance was identified in 152 samples (76%), including Streptococcus pneumoniae (n = 62); Haemophilus influenzae (n = 104); human respiratory syncytial virus A (n = 11) and B (n = 1); human rhinovirus A (n = 1) and B (n = 4); human coronaviruses 229E (n = 1) and OC43 (n = 2); Klebsiella pneumoniae (n = 2); Acinetobacter baumannii (n = 2); Serratia marcescens (n = 1); and Staphylococcus aureus (n = 35) and methicillin-resistant S. aureus (MRSA, n = 6). The presence of S. pneumoniae was strongly correlated with severe disease. S. pneumoniae was present in 56.4% of severe cases versus 25% of mild cases; more than one-third of H1N1pdm NPS with S. pneumoniae were from subjects with severe disease (22 of 62 S. pneumoniae-positive NPS, p = 0.0004). In subjects 6 to 55 years of age, the adjusted odds ratio (OR) of severe disease in the presence of S. pneumoniae was 125.5 (95% confidence ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2009-12-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina Caracterización molecular de cepas de influenza A (H1N1) 2009 de casos leves y graves de la Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide. Mientras que la tasa de letalidad (CFR) para (H1N1)pdm en todo el mundo era del 0.4%, en la Argentina la mortalidad observada fue de 4.5%. La secuenciación del genoma completo de 26 cepas de virus argentinos de influenza A (H1N1)pdm de casos leves y graves y de 8 cepas secuenciadas parcialmente no mostró evidencia de que la elevada tasa de letalidad se pueda atribuir directamente a cambios en el virus. No se encontraron hallazgos de recombinación, de mutaciones asociadas con la resistencia a los medicamentos antivirales ni de variaciones genéticas que puedan contribuir a la virulencia observada. Si bien la mutación D225G asociada con la gravedad, comunicada en informes procedentes de Ucrania y Noruega, no se ha encontrado en las cepas argentinas estudiadas, se ha observado un cambio aminoacídico en la región (S206T) en torno al dominio del sitio de unión al receptor en la HA, el mismo hallado en cepas distribuidas alrededor del mundo.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina

    Elsa Baumeister / Gustavo Palacios / Daniel Cisterna / Alexander Solovyov / Jeffrey Hui / Nazir Savji / Ana Valeria Bussetti / Ana Campos / Andrea Pontoriero / Omar J. Jabado / Craig Street / David L. Hirschberg / Raul Rabadan / Virginia Alonio / Viviana Molina / Stephen Hutchison / Michael Egholm / W. Ian Lipkin

    Medicina (Buenos Aires), Vol 70, Iss 6, Pp 518-

    2010  Band 523

    Abstract: While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on ... ...

    Abstract While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
    Schlagwörter H1N1 pdm ; Influenza ; Argentina ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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