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  1. Book ; Online: Autophagy in Endocrine-metabolic Diseases Associated with Aging

    Ines Vaccaro, Maria / De Tata, Vincenzo / Daniel Gonzalez, Claudio

    2020  

    Keywords Medicine ; Endocrinology ; autophagy ; autophagy (macroautophagy) ; chaperon mediated autophagy (CMA) ; secretory autophagy ; aging ; diabetes mellitus ; cancer ; skeletal muscle atrophy
    Size 1 electronic resource (142 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231540
    ISBN 9782889660797 ; 2889660796
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Costos de las diversas modalidades posoperatorias de la colecistectomía laparoscópica. Cooperativa Médica de Florida (COMEF), 2016-2021

    Daniel González González

    Revista Médica del Uruguay, Vol 38, Iss

    2022  Volume 3

    Abstract: Introducción: la colecistectomía laparoscópica constituye el patrón oro en el tratamiento de la litiasis biliar. Bajo una estricta selección de pacientes, la modalidad ambulatoria ha demostrado ser factible y segura. En COMEF se realiza desde el año 2016. ...

    Abstract Introducción: la colecistectomía laparoscópica constituye el patrón oro en el tratamiento de la litiasis biliar. Bajo una estricta selección de pacientes, la modalidad ambulatoria ha demostrado ser factible y segura. En COMEF se realiza desde el año 2016. El posoperatorio transcurrió por diferentes etapas, internación en cuidados moderados, internación en sala de cirugía del día más internación domiciliaria, internación únicamente en sala de cirugía del día y finalmente alta domiciliaria desde block quirúrgico. El objetivo del trabajo es calcular los costos de cada una de las modalidades posoperatorias de la colecistectomía laparoscópica en el período 2016-2021. Materiales y método: se realizó un estudio de costos de cada una de las modalidades posoperatorias mediante la determinación del costo del día cama ocupada en cuidados moderados e internación domiciliaria, así como la retribución de un auxiliar de enfermería encargado de la sala de cirugía del día. Los datos fueron obtenidos de la Estructura de Costos de Atención a la Salud y la producción de cada servicio. Resultados: el costo del día cama ocupada en cuidados moderados es de $15.056, el de internación en sala de cirugía del día y luego internación domiciliaria $4.953,69, únicamente en sala de cirugía del día $807,69 y finalmente el alta domiciliaria desde block quirúrgico $33. Conclusiones: los costos del posoperatorio de la colecistectomía laparoscópica en modalidad ambulatoria son menores que los que requieren internación en cuidados moderados, y dichos costos se reducen progresivamente cuando se pasa de la internación domiciliaria al alta sin internación domiciliaria y sin recuperación en sala de cirugía del día.
    Keywords COLECISTECTOMÍA LAPAROSCÓPICA ; CIRUGÍA MAYOR AMBULATORIA ; COSTOS ; Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2022-10-01T00:00:00Z
    Publisher Sindicato Médico del Uruguay
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Retraso en la obtención del título de especialista en cirugía general

    Daniel González González

    Revista Médica del Uruguay, Vol 36, Iss

    2020  Volume 1

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2020-02-01T00:00:00Z
    Publisher Sindicato Médico del Uruguay
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Efficacy of CAD/CAM technology in dental procedures performed by students

    Carlos M. Ardila / Daniel González-Arroyave

    Heliyon, Vol 9, Iss 4, Pp e15322- (2023)

    A systematic scoping review of randomized clinical trials

    2023  

    Abstract: Objectives: To assess the efficacy of computer-aided design/computer-aided manufacturing (CAD/CAM) in dental procedures performed by dental students. Methods: A systematic scoping review was performed. MeSH terms and keywords were specified to assess ... ...

    Abstract Objectives: To assess the efficacy of computer-aided design/computer-aided manufacturing (CAD/CAM) in dental procedures performed by dental students. Methods: A systematic scoping review was performed. MeSH terms and keywords were specified to assess randomized clinical trials (RCTs) in all idioms. Results: Nine RCTs that include 520 students were selected. Two RCTs studied implant placement, and the rest of the trials explored implant impressions, intraoral scans, canal obturation, head positioning errors in panoramic images, deep caries and pulp exposure, diagnosis of temporomandibular disorders, and a tooth for restorations. Considering efficacy, variable results were found. The RCTs that explored implant impressions, deep caries and pulp exposure, and diagnosis of temporomandibular disorders showed better results when CAD/CAM technology was performed by students. Two RCTs that investigated implant placement presented contradictory outcomes; one showed better results when CAD/CAM systems were used while the other described similar results to conventional methods. The remaining RCTs did not find differences with conventional procedures. Considering the time spent during the procedures, two studies showed no differences between groups, while another indicated that the time spent was less for digital impressions (p < 0.001). A continuous decrease in scanning time was also perceived for all groups as skills in intraoral scanning augmented (p = 0.0005). Students indicated an interest in utilizing the CAD/CAM systems and recognized that their abilities were enhanced. Conclusions: Considering the limitations of this review and the limited number of RCTs evaluated, students recognized that their skills improved using CAD/CAM systems; however, only in some specific procedures greater efficacy and less time spent were observed when this technology was used. Dental students also showed great interest in using these techniques.
    Keywords Dental students ; CAD/CAM ; Interventions ; Clinical trials ; efficacy ; Scoping review ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Esplenectomía laparoscópica en esplenomegalia masiva por linfoma no Hodgkin de zona marginal

    Martina Tristant / Daniel González González

    Revista Médica del Uruguay, Vol 37, Iss

    2021  Volume 3

    Abstract: Introducción: si bien la esplenectomía laparoscópica en esplenomegalias masivas y supramasivas constituye un desafío técnico, su realización es factible y segura en centros con equipos con experiencia en cirugía laparoscópica. Objetivo: presentar el ... ...

    Abstract Introducción: si bien la esplenectomía laparoscópica en esplenomegalias masivas y supramasivas constituye un desafío técnico, su realización es factible y segura en centros con equipos con experiencia en cirugía laparoscópica. Objetivo: presentar el primer caso de esplenectomía laparoscópica en esplenomegalia masiva realizada en Uruguay. Caso clínico: se trata de una paciente de 70 años portadora de una pancitopenia periférica, esplenomegalia masiva y diagnóstico realizado por punción de médula ósea de neoplasia linfoproliferativa tipo B de bajo grado, a quien se le indicó la esplenectomía con fines diagnósticos y terapéuticos. La paciente se operó en decúbito lateral derecho a 15 grados, los trócares se colocaron bajo visión directa adaptados al tamaño del bazo que se extendía desde el diafragma hasta el estrecho superior de la pelvis. Se realizó la esplenectomía en un tiempo de 220 minutos, extrayéndose la pieza íntegra y sin haberla colocado en bolsa a través de un hemi Pfannenstiel, protegiendo la pared con un retractor de heridas quirúrgicas. No presentó complicaciones, fue dada de alta a las 48 horas. El hemograma realizado a las 24 horas demostró un aumento de las cifras de todas las series celulares y el informe anatomopatológico diagnosticó un linfoma no Hodgkin de zona marginal. Discusión: la esplenectomía laparoscópica en esplenomegalias masivas requiere de un mayor tiempo quirúrgico, aunque las pérdidas sanguíneas y la estadía hospitalaria son menores en comparación a los procedimientos convencionales, presentando una morbilidad similar. En la experiencia inicial de los equipos quirúrgicos se reporta un porcentaje de conversiones y reingresos cercanos al 30%.
    Keywords ESPLENOMEGALIA MASIVA ; ESPLENECTOMÍA ; LAPAROSCOPÍA ; LINFOMA NO HODGKIN ; Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2021-09-01T00:00:00Z
    Publisher Sindicato Médico del Uruguay
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Metabolomics of Type 1 and Type 2 Diabetes: Insights into Risk Prediction and Mechanisms.

    Izundegui, Daniel Gonzalez / Nayor, Matthew

    Current diabetes reports

    2022  Volume 22, Issue 2, Page(s) 65–76

    Abstract: Purpose of review: Metabolomics enables rapid interrogation of widespread metabolic processes making it well suited for studying diabetes. Here, we review the current status of metabolomic investigation in diabetes, highlighting its applications for ... ...

    Abstract Purpose of review: Metabolomics enables rapid interrogation of widespread metabolic processes making it well suited for studying diabetes. Here, we review the current status of metabolomic investigation in diabetes, highlighting its applications for improving risk prediction and mechanistic understanding.
    Recent findings: Findings of metabolite associations with type 2 diabetes risk have confirmed experimental observations (e.g., branched-chain amino acids) and also pinpointed novel pathways of diabetes risk (e.g., dimethylguanidino valeric acid). In type 1 diabetes, abnormal metabolite patterns are observed prior to the development of autoantibodies and hyperglycemia. Diabetes complications display specific metabolite signatures that are distinct from the metabolic derangements of diabetes and differ across vascular beds. Lastly, metabolites respond acutely to pharmacologic treatment, providing opportunities to understand inter-individual treatment responses. Metabolomic studies have elucidated biological mechanisms underlying diabetes development, complications, and therapeutic response. While not yet ready for clinical translation, metabolomics is a powerful and promising precision medicine tool.
    MeSH term(s) Amino Acids, Branched-Chain ; Biomarkers/metabolism ; Diabetes Complications ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Metabolic Diseases ; Metabolomics
    Chemical Substances Amino Acids, Branched-Chain ; Biomarkers
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-022-01449-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Thermal Tolerance of Honeybees (Apis mellifera L.) Changes Across an Elevation Gradient in the Mexican Transition Zone

    José Benito Barreiro / Brenda Ratoni / Fernanda Baena-Díaz / Daniel González-Tokman / Wesley Dáttilo

    Sociobiology, Vol 71, Iss

    2024  Volume 1

    Abstract: The objective of this study was to determine the critical thermal minimum [CTmin], critical thermal maximum [CTmax], and thermal tolerance range of A. mellifera at three different elevations located in the Mexican Transition Zone: 11; 1,324, and 3,304 m ... ...

    Abstract The objective of this study was to determine the critical thermal minimum [CTmin], critical thermal maximum [CTmax], and thermal tolerance range of A. mellifera at three different elevations located in the Mexican Transition Zone: 11; 1,324, and 3,304 m.a.s.l. In general, we found that the CTmin of A. mellifera was lower at the site with the highest elevation (i.e., they tolerate colder temperatures). At the same time, the CTmax remained constant across the three studied elevations, revealing higher plasticity for cold tolerance rather than heat. Moreover, we did not find evidence that the body mass of the individuals was associated with their thermal tolerance at any of the three sampled elevations. Our findings suggest processes of local adaptation of A. mellifera populations in environmentally contrasting sites, allowing them to expand their range of distribution, which could be useful in predicting responses to future environmental change.
    Keywords thermal tolerance range ; environmental gradients ; body size ; thermal variability ; intrapopulation variation ; Zoology ; QL1-991 ; Ecology ; QH540-549.5 ; Natural history (General) ; QH1-278.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Universidade Estadual de Feira de Santana
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Efficacy of three-dimensional models for medical education

    Carlos M. Ardila / Daniel González-Arroyave / Mateo Zuluaga-Gómez

    Heliyon, Vol 9, Iss 2, Pp e13395- (2023)

    A systematic scoping review of randomized clinical trials

    2023  

    Abstract: Objectives: To estimate the efficacy of three-dimensional (3D) models for medical education. Methods: A systematic scoping review was performed containing diverse databases such as SCOPUS, PubMed/MEDLINE, SCIELO, and LILACS. MeSH terms and keywords were ... ...

    Abstract Objectives: To estimate the efficacy of three-dimensional (3D) models for medical education. Methods: A systematic scoping review was performed containing diverse databases such as SCOPUS, PubMed/MEDLINE, SCIELO, and LILACS. MeSH terms and keywords were stipulated to explore randomized clinical trials (RCTs) in all languages. Solely RCTs that accomplished the eligibility criteria were admitted. Results: Fifteen RCTs including 1659 medical students were chosen. Five RCTs studied heart models, 3 RCTs explored facial, spinal and bone fractures and the rest of the trials investigated eye, arterial, pelvic, hepatic, chest, skull, and cleft lip and palate models. Regarding the efficacy of 3D models, in terms of learning skills and knowledge gained by medical students, most RCTs reported higher scores. Considering the test-taking times, the results were variable. Two RCTs showed less time for the 3D group, another RCT indicated variable results in the response times of the test depending on the anatomical zone evaluated, while another described that the students in the 3D group were slightly quicker to answer all questions when compared with the traditional group, but without statistical significance. The other 11 experiments did not present results about test-taking times. Most students in all RCTs indicated satisfaction, enjoyment, and interest in utilizing the 3D systems, and recognized that their abilities were enhanced. Conclusions: Higher efficacy in terms of learning skills and knowledge gained was observed when the 3D systems were used by medical students. Undergraduates also expressed great satisfaction with the use of these technologies. Regarding the test-taking times, the results favored the 3D group.
    Keywords Medical students ; Three-dimensional printing ; Interventions ; Clinical trials ; Efficacy ; Scoping review ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 796
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Identificación de dilemas bioéticos en la práctica clínica

    Daniel González González / Luis Ruso

    Revista Médica del Uruguay, Vol 36, Iss

    2020  Volume 1

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2020-02-01T00:00:00Z
    Publisher Sindicato Médico del Uruguay
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Carcinoma de células de Merkel de región glútea

    Jimena Garmendia / Daniel González González

    Revista Médica del Uruguay, Vol 36, Iss

    2020  Volume 2

    Abstract: Introducción: el carcinoma de células de Merkel es un tumor primario maligno de piel que afecta fundamentalmente regiones expuestas a las radiaciones solares. Pocos casos han sido comunicados en una región no expuesta al factor de riesgo mencionado, como ...

    Abstract Introducción: el carcinoma de células de Merkel es un tumor primario maligno de piel que afecta fundamentalmente regiones expuestas a las radiaciones solares. Pocos casos han sido comunicados en una región no expuesta al factor de riesgo mencionado, como es la glútea. El objetivo de este trabajo es comunicar un caso clínico de carcinoma de células de Merkel de región glútea. Caso clínico: paciente de 63 años, sexo masculino, que consultó por tumoración de 2 cm de diámetro en región glútea derecha, de rápido crecimiento, que se operó de coordinación con anestesia, realizándose su resección completa. El resultado del estudio anatomopatológico informó carcinoma de células de Merkel. No se evidenció diseminación a distancia, por lo que de acuerdo con la clasificación TNM se determinó como estadio I. Se completó el tratamiento con radioterapia local. Actualmente el paciente sigue en seguimiento y asintomático. Discusión: los carcinomas de células de Merkel son tumores altamente agresivos. Además de la radiación solar como factor de riesgo, se mencionan la inmunodeficiencia y un nuevo poliomavirus, el poliomavirus de células de Merkel. Se presentan como tumoraciones de color violáceo y rápido crecimiento, y es frecuente el compromiso ganglionar sincrónico o metacrónico. La resección quirúrgica con márgenes suficientes y vaciamiento ganglionar, en caso de haber compromiso o estudio de ganglio centinela en caso de no haberlo, es lo indicado. El pronóstico depende del estadio y se ha reportado hasta 30% de recidiva a dos años.
    Keywords CARCINOMA DE CÉLULAS DE MERKEL ; NALGAS ; Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2020-04-01T00:00:00Z
    Publisher Sindicato Médico del Uruguay
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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