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  1. AU="Daniel H Miller"
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  1. Artikel ; Online: Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1

    Gat Rauner / Dexter X. Jin / Daniel H. Miller / Todd M. Gierahn / Carman M. Li / Ethan S. Sokol / Yu-Xiong Feng / Robert A. Mathis / J. Christopher Love / Piyush B. Gupta / Charlotte Kuperwasser

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 14

    Abstract: Mammary morphogenesis is a complex process. Here the authors describe how stem cells build a three-dimensional self-organizing multi-lineage tissue by showing that positional signals from the extracellular matrix through the collagen receptor DDR1 lead ... ...

    Abstract Mammary morphogenesis is a complex process. Here the authors describe how stem cells build a three-dimensional self-organizing multi-lineage tissue by showing that positional signals from the extracellular matrix through the collagen receptor DDR1 lead stem cells to differentiate into multi-lineage committed multi-layered progeny.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

    Yu-Xiong Feng / Dexter X. Jin / Ethan S. Sokol / Ferenc Reinhardt / Daniel H. Miller / Piyush B. Gupta

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Band 10

    Abstract: PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition ... ...

    Abstract PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

    Yu-Xiong Feng / Dexter X. Jin / Ethan S. Sokol / Ferenc Reinhardt / Daniel H. Miller / Piyush B. Gupta

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Band 10

    Abstract: PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition ... ...

    Abstract PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-10-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors.

    Winyoo Chowanadisai / Shanta M Messerli / Daniel H Miller / Jamie E Medina / Joshua W Hamilton / Mark A Messerli / Alexander S Brodsky

    PLoS ONE, Vol 11, Iss 3, p e

    2016  Band 0151089

    Abstract: The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated ... ...

    Abstract The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian carcinoma cells were exposed to sub-lethal concentrations of cisplatin to create a matched cisplatin-resistant cell line, OVCAR-8R. Genome-wide gene expression profiling of sensitive and resistant ovarian cancer spheroids identified 3,331 significantly differentially expressed probesets coding for 3,139 distinct protein-coding genes (Fc >2, FDR < 0.05) (S2 Table). Despite significant expression changes in some transporters including MDR1, cisplatin resistance was not associated with differences in intracellular cisplatin concentration. Cisplatin resistant cells were significantly enriched for a mesenchymal gene expression signature. OVCAR-8R resistance derived gene sets were significantly more biased to patients with shorter survival. From the most differentially expressed genes, we derived a 17-gene expression signature that identifies ovarian cancer patients with shorter overall survival in three independent datasets. We propose that the use of cisplatin resistant cell lines in 3D spheroid models is a viable approach to gain insight into resistance mechanisms relevant to ovarian tumors in patients. Our data support the emerging concept that ovarian cancers can acquire drug resistance through an epithelial-to-mesenchymal transition.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Dedifferentiated liposarcoma of the esophagus

    Christopher L. Brett / Daniel H. Miller / Liuyan Jiang / Herbert C. Wolfsen / Steven Attia / Lauren Hintenlang / Niveditha Jagadesh / Robert C. Miller

    Rare Tumors, Vol 8, Iss

    a case report and selected review of the literature

    2016  Band 4

    Abstract: Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-yearold gentleman presenting with dysphagia ... ...

    Abstract Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-yearold gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Pathology demonstrated an undifferentiated pleomorphic sarcoma later determined to represent dedifferentiated liposarcoma after fluorescence in situ hybridization analysis. The patient received no additional adjuvant therapy and remains disease free 20 months from the procedure. While treatment experience is limited, our case demonstrates that in selected patients, sustained local control can be obtained without radical resection.
    Schlagwörter dedifferentiated liposarcoma ; undifferentiated pleomorphic sarcoma ; surgical resection ; esophageal mass ; Medicine ; R ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Sprache Englisch
    Erscheinungsdatum 2016-12-01T00:00:00Z
    Verlag PAGEPress Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: A Very Inconvenient Truth

    Charles H. Greene / D. James Baker / Daniel H. Miller

    Oceanography, Vol 23, Iss 1, Pp 214-

    2010  Band 218

    Abstract: Studies conducted after those that contributed to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (FAR) suggest that human society may be facing a very inconvenient truth—that emission reduction efforts alone are unlikely to ...

    Abstract Studies conducted after those that contributed to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (FAR) suggest that human society may be facing a very inconvenient truth—that emission reduction efforts alone are unlikely to stabilize greenhouse gas concentrations at levels low enough to prevent dangerous anthropogenic interference with the climate system. Here, we discuss reasons why the IPCC process is prone to underestimating the threats of global climate change. We then review some of the critical policy-relevant scientific findings that have emerged since the release of the IPCC FAR. Finally, we discuss how these new findings fundamentally transform the debate on efforts needed to prevent dangerous changes to our climate system. It now appears that to avoid such changes, society will likely need to adopt a mixed strategy of reducing greenhouse gas emissions and employing geoengineering approaches that extract carbon dioxide from the atmosphere and/or reduce the level of incoming solar radiation reaching Earth’s surface.
    Schlagwörter climate change ; geoengineering ; anthropogenic interference ; carbon dioxide ; global warming ; greenhouse gases ; Oceanography ; GC1-1581 ; Geography. Anthropology. Recreation ; G ; DOAJ:Oceanography ; DOAJ:Earth and Environmental Sciences
    Thema/Rubrik (Code) 910 ; 333
    Sprache Englisch
    Erscheinungsdatum 2010-03-01T00:00:00Z
    Verlag The Oceanography Society (TOS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation

    Daniel H. Miller / Dexter X. Jin / Ethan S. Sokol / Janel R. Cabrera / Daphne A. Superville / Rebecca A. Gorelov / Charlotte Kuperwasser / Piyush B. Gupta

    Stem Cell Reports, Vol 10, Iss 3, Pp 1131-

    2018  Band 1145

    Abstract: Summary: The epithelial compartment of the mammary gland contains basal and luminal cell lineages, as well as stem and progenitor cells that reside upstream in the differentiation hierarchy. Stem and progenitor cell differentiation is regulated to ... ...

    Abstract Summary: The epithelial compartment of the mammary gland contains basal and luminal cell lineages, as well as stem and progenitor cells that reside upstream in the differentiation hierarchy. Stem and progenitor cell differentiation is regulated to maintain adult tissue and mediate expansion during pregnancy and lactation. The genetic factors that regulate the transition of cells between differentiation states remain incompletely understood. Here, we present a genome-scale method to discover genes driving cell-state specification. Applying this method, we identify a transcription factor, BCL11B, which drives stem cell self-renewal in vitro, by inhibiting differentiation into the basal lineage. To validate BCL11B's functional role, we use two-dimensional colony-forming and three-dimensional tissue differentiation assays to assess the lineage differentiation potential and functional abilities of primary human mammary cells. These findings show that BCL11B regulates mammary cell differentiation and demonstrate the utility of our proposed genome-scale strategy for identifying lineage regulators in mammalian tissues. : Miller et al. describe a strategy to identify candidate master regulators of cell lineage specification. This approach identified BCL11B as a key regulator of human mammary stem cell self-renewal in in vitro progenitor and differentiation assays. Using a combination of 2D and 3D primary cell culture techniques, they show that BCL11B drives stem cell self-renewal by inhibiting basal lineage commitment. Keywords: human mammary gland biology, mammary epithelial stem cells, BCL11B, epigenetics, single-cell genomics, epithelial differentiation, three-dimensional cell culture
    Schlagwörter Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Perturbation-expression analysis identifies RUNX1 as a regulator of human mammary stem cell differentiation.

    Ethan S Sokol / Sandhya Sanduja / Dexter X Jin / Daniel H Miller / Robert A Mathis / Piyush B Gupta

    PLoS Computational Biology, Vol 11, Iss 4, p e

    2015  Band 1004161

    Abstract: The search for genes that regulate stem cell self-renewal and differentiation has been hindered by a paucity of markers that uniquely label stem cells and early progenitors. To circumvent this difficulty we have developed a method that identifies cell- ... ...

    Abstract The search for genes that regulate stem cell self-renewal and differentiation has been hindered by a paucity of markers that uniquely label stem cells and early progenitors. To circumvent this difficulty we have developed a method that identifies cell-state regulators without requiring any markers of differentiation, termed Perturbation-Expression Analysis of Cell States (PEACS). We have applied this marker-free approach to screen for transcription factors that regulate mammary stem cell differentiation in a 3D model of tissue morphogenesis and identified RUNX1 as a stem cell regulator. Inhibition of RUNX1 expanded bipotent stem cells and blocked their differentiation into ductal and lobular tissue rudiments. Reactivation of RUNX1 allowed exit from the bipotent state and subsequent differentiation and mammary morphogenesis. Collectively, our findings show that RUNX1 is required for mammary stem cells to exit a bipotent state, and provide a new method for discovering cell-state regulators when markers are not available.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2015-04-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Primary histiocytic sarcoma of the central nervous system

    Jackson M. May / Mark R. Waddle / Daniel H. Miller / William C. Stross / Tasneem A. Kaleem / Byron C. May / Robert C. Miller / Liuyan Jiang / Gerald W. Strong / Daniel M. Trifiletti / Kaisorn L. Chaichana / Ronald Reimer / Han W. Tun / Jennifer L. Peterson

    Radiation Oncology, Vol 13, Iss 1, Pp 1-

    a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review

    2018  Band 8

    Abstract: Abstract Background Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the central nervous system with ... ...

    Abstract Abstract Background Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the central nervous system with treatment including surgery, radiotherapy, and chemotherapy. Case presentation Our patient was a 47 year old female presenting with progressive ataxia, headaches, imbalance, nausea, vomiting, and diplopia. MRI showed a heterogeneously enhancing lesion approximately 2.9 × 3.0 × 2.3 cm centered upon the cerebellar vermis with mild surrounding vasogenic edema and abnormal enhancement of multiple cranial nerves. The patient underwent surgical debulking, which revealed histiocytic sarcoma with grossly purulent drainage. Staging revealed diffuse leptomeningeal involvement, primarily involving the brain and lower thoracic and lumbar spine. She underwent adjuvant radiotherapy to the brain and lower spine and was started on high dose methotrexate. However, she experienced progressive disease in the cervical and thoracic spine as well as pulmonary involvement. Genomic sequencing of her tumor showed a mutation in the platelet-derived growth factor receptor A (p.V0681) which could be targeted with Dasatinib. However, she did not tolerate Dasatinib and she succumbed to progressive disseminated disease eight months from original diagnosis. Our pathologic evaluation also revealed expression of PD-L1 and PD-L2 by tumor cells raising the potential therapeutic role for immune checkpoint inhibition. Conclusions This case provides an example of effective CNS control with resection and moderate doses of radiation therapy. A review of the literature confirms aggressive multidisciplinary treatment is the most effective treatment against this disease. In addition, genomic sequencing may play an important role in determining new therapeutic options. However, CNS histiocytic sarcoma remains an aggressive disease with a propensity for early widespread dissemination and few long term ...
    Schlagwörter Histiocytic sarcoma ; CNS ; Radiation ; Review ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-09-01T00:00:00Z
    Verlag BMC
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  10. Artikel ; Online: Small cell carcinoma of the prostate in an elderly patient

    Dale Alan Whitaker Jr. / Daniel H. Miller / Niveditha Jagadesh / Gerald W. Strong / Lauren Hintenlang / William B. Schenk / Gregory A. Broderick / Katherine S. Tzou / Steven J. Buskirk

    Rare Tumors, Vol 8, Iss

    a case report and review of the literature

    2016  Band 4

    Abstract: Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited ... ...

    Abstract Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation therapy, androgen deprivation therapy, or prostatectomy. Here we present the case of an elderly 89- year-old Caucasian male who was diagnosed with SCC of the prostate. Despite proceeding with a course of definitive radiotherapy, the patient experienced rapid progression of disease and ultimately elected to discontinue radiation therapy and receive hospice care.
    Schlagwörter Small cell carcinoma ; Prostate cancer ; Radiotherapy ; Medicine ; R ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-12-01T00:00:00Z
    Verlag PAGEPress Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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