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Article ; Online: Interprofessional staff perspectives on the adoption of or black box technology and simulations to improve patient safety

Krystle Campbell / Aimee Gardner / Daniel J. Scott / Jada Johnson / Jillian Harvey / Abby Kazley

Advances in Simulation, Vol 8, Iss 1, Pp 1-

a multi-methods survey

2023 Volume 13

Abstract: Abstract Introduction Medical errors still plague healthcare. Operating Room Black Box (ORBB) and ORBB-simulation (ORBBSIM) are innovative emerging technologies which continuously capture as well as categorize intraoperative data, team information, and ... ...

Abstract	Abstract Introduction Medical errors still plague healthcare. Operating Room Black Box (ORBB) and ORBB-simulation (ORBBSIM) are innovative emerging technologies which continuously capture as well as categorize intraoperative data, team information, and audio-visual files, in effort to improve objective quality measures. ORBB and ORBBSIM have an opportunity to improve patient safety, yet a paucity of implementation literature exists. Overcoming implementation barriers is critical. This study sought to obtain rich insights while identifying facilitators and barriers to adoption of ORBB and ORBBSIM in alignment with Donabedian’s model of health services and healthcare quality. Enrichment themes included translational performance improvement and real-world examples to develop sessions. Methods Interprofessional OR staff were invited to complete two surveys assessing staff’s perceptions using TeamSTEPPS’s validated Teamwork Perceptions Questionnaire (T-TPQ) and open-ended questions. Descriptive statistics were calculated for quantitative variables, and inductive phenomenological content analysis was used for qualitative. Results Survey 1 captured 71 responses from 334 invited (RR 21%) while survey 2 captured 47 responses from 157 (RR 29.9%). The T-TPQ score was 65.2, with Communication (70.4) the highest construct and Leadership (58.0) the lowest. Quality Improvement (QI), Patient Safety, and Objective Case Review were the most common perceived ORBB benefits. Trends suggested a reciprocal benefit of dual ORBB and ORBBSIM adoption. Trends also suggested that dual implementation can promote Psychological Safety, culture, trust, and technology comfort. The need for an implementation plan built on change management principles and a constructive culture were key findings. Conclusions Findings supported ORBB implementation themes from previous literature and deepened our understanding through the exploration of team culture. This blueprint provides a model to help organizations adopt ORBB and ORBBSIM. Outcomes can ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	650
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coronavirus disease 2019 (COVID-19) personal protective equipment training

Madhuri B. Nagaraj / Krystle K. Campbell / Minji Kang / Ian A. Nazareno / Doramarie Arocha / Julie B. Trivedi / Daniel J. Scott

Antimicrobial Stewardship & Healthcare Epidemiology, Vol

Using simulation-based training to prevent healthcare-associated infection

2022 Volume 2

Abstract: In this pre- and postintervention study, we demonstrate the feasibility and effectiveness of comprehensive simulation-based personal protective equipment (PPE) training amid the COVID-19 pandemic. With rapid-cycle, deliberate practice feedback, ... ...

Abstract	In this pre- and postintervention study, we demonstrate the feasibility and effectiveness of comprehensive simulation-based personal protective equipment (PPE) training amid the COVID-19 pandemic. With rapid-cycle, deliberate practice feedback, simulation-based training can improve the learners’ sense of confidence and security while standardizing PPE protocols.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of simulation-based training in healthcare-associated infection (HAI) prevention

Minji Kang / Madhuri B. Nagaraj / Krystle K. Campbell / Ian A. Nazareno / Daniel J. Scott / Doramarie Arocha / Julie B. Trivedi

Antimicrobial Stewardship & Healthcare Epidemiology, Vol

2022 Volume 2

Abstract: Abstract Objectives: To perform a review of the literature on the role of simulation-based training (SBT) in healthcare-associated infection (HAI) prevention and to highlight the importance of SBT as an educational tool in infection prevention. Methods: ... ...

Abstract	Abstract Objectives: To perform a review of the literature on the role of simulation-based training (SBT) in healthcare-associated infection (HAI) prevention and to highlight the importance of SBT as an educational tool in infection prevention. Methods: We reviewed English language publications from PubMed to select original articles that utilized SBT as the primary mode of education for infection prevention efforts in acute-care hospitals. Results: Overall, 27 publications utilized SBT as primary mode of education for HAI prevention in acute-care hospitals. Training included the following: hand hygiene in 3 studies (11%), standard precaution in 1 study (4%), disaster preparedness in 4 studies (15%), central-line–associated blood stream infection (CLABSI) prevention in 14 studies (52%), catheter-associated urinary tract infection (CAUTI) prevention in 2 studies (7%), surgical site infection prevention in 2 studies (7%), and ventilatory associated pneumonia prevention in 1 study (4%). SBT improved learner’s sense of competence and confidence, increased knowledge and compliance in infection prevention measures, decreased HAI rates, and reduced healthcare costs. Conclusion: SBT can function as a teaching tool in day-to-day infection prevention efforts as well as in disaster preparedness. SBT is underutilized in infection prevention but can serve as a crucial educational tool.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Adam L. Valkovic / Martina Kocan / Brad Hoare / Sarah Marshall / Daniel J. Scott / Ross A. D. Bathgate

International Journal of Molecular Sciences, Vol 23, Iss 1908, p

2022 Volume 1908

Abstract: Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The modulation of cGMP is important in many diseases, but reliably assaying cGMP in live cells in a plate-based format with ... ...

Abstract	Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The modulation of cGMP is important in many diseases, but reliably assaying cGMP in live cells in a plate-based format with temporal resolution is challenging. The Förster/fluorescence resonance energy transfer (FRET)-based biosensor cGES-DE5 has a high temporal resolution and high selectivity for cGMP over cAMP, so we converted it to use bioluminescence resonance energy transfer (BRET), which is more compatible with plate-based assays. This BRET variant, called CYGYEL (cyclic GMP sensor using YFP-PDE5-Rluc8), was cloned into a lentiviral vector for use across different mammalian cell types. CYGYEL was characterised in HEK293T cells using the nitric oxide donor diethylamine NONOate (DEA), where it was shown to be dynamic, reversible, and able to detect cGMP with or without the use of phosphodiesterase inhibitors. In human primary vascular endothelial and smooth muscle cells, CYGYEL successfully detected cGMP mediated through either soluble or particulate guanylate cyclase using DEA or C-type natriuretic peptide, respectively. Notably, CYGYEL detected differences in kinetics and strength of signal both between ligands and between cell types. CYGYEL remained selective for cGMP over cAMP, but this selectivity was reduced compared to cGES-DE5. CYGYEL streamlines the process of cGMP detection in plate-based assays and can be used to detect cGMP activity across a range of cell types.
Keywords	cGMP ; BRET ; biosensor ; cell signalling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

Fabian Bumbak / James B. Bower / Skylar C. Zemmer / Asuka Inoue / Miquel Pons / Juan Carlos Paniagua / Fei Yan / James Ford / Hongwei Wu / Scott A. Robson / Ross A. D. Bathgate / Daniel J. Scott / Paul R. Gooley / Joshua J. Ziarek

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has ... ...

Abstract	Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has been established by X-ray crystallography and cryo-EM and yet, the molecular determinants for why a receptor couples to G protein versus arrestin transducers remain poorly defined. We used 13CεH3-methionine NMR spectroscopy to show that binding of phosphatidylinositol-4,5-bisphosphate (PIP2) to the receptor’s intracellular surface allosterically tunes the timescale of motions at the orthosteric pocket and conserved activation motifs – without dramatically altering the structural ensemble. β-arrestin-1 further remodels the receptor ensemble by reducing conformational exchange kinetics for a subset of resonances, whereas G protein coupling has little to no effect on exchange rates. A β-arrestin biased allosteric modulator transforms the NTS1:G protein complex into a concatenation of substates, without triggering transducer dissociation, suggesting that it may function by stabilizing signaling incompetent G protein conformations such as the non-canonical state. Together, our work demonstrates the importance of kinetic information to a complete picture of the GPCR activation landscape.
Keywords	Science ; Q
Subject code	612
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

Kazem Asadollahi / Sunnia Rajput / Lazarus Andrew de Zhang / Ching-Seng Ang / Shuai Nie / Nicholas A. Williamson / Michael D. W. Griffin / Ross A. D. Bathgate / Daniel J. Scott / Thomas R. Weikl / Guy N. L. Jameson / Paul R. Gooley

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending ...

Abstract	Abstract The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the pharmacological efficacy of the ligand. How receptors recognize ligands and the kinetic mechanism underlying this population shift is poorly understood. Here, we investigate the kinetic mechanism of neurotensin recognition by neurotensin receptor 1 (NTS1) using 19F-NMR, hydrogen-deuterium exchange mass spectrometry and stopped-flow fluorescence spectroscopy. Our results indicate slow-exchanging conformational heterogeneity on the extracellular surface of ligand-bound NTS1. Numerical analysis of the kinetic data of neurotensin binding to NTS1 shows that ligand recognition follows an induced-fit mechanism, in which conformational changes occur after neurotensin binding. This approach is applicable to other GPCRs to provide insight into the kinetic regulation of ligand recognition by GPCRs.
Keywords	Science ; Q
Subject code	612
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

Alastair C. Keen / Maria Hauge Pedersen / Laura Lemel / Daniel J. Scott / Meritxell Canals / Dene R. Littler / Travis Beddoe / Yuki Ono / Lei Shi / Asuka Inoue / Jonathan A. Javitch / J. Robert Lane

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 10

Abstract: A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually. ...

Abstract	A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Differential temperature preferences and thresholds among summer campers in Ontario’s southern provincial parks: a Canadian case study in tourism climatology

Hewer, Micah J / Daniel J. Scott / William A. Gough

Theoretical and applied climatology. 2018 Aug., v. 133, no. 3-4

2018

Abstract: Weather and climate are important factors in relation to outdoor recreation and tourism. Camping and park visitation are weather sensitive activities very likely to be impacted by projected climate change. Temperature is the weather variable that has ... ...

Abstract	Weather and climate are important factors in relation to outdoor recreation and tourism. Camping and park visitation are weather sensitive activities very likely to be impacted by projected climate change. Temperature is the weather variable that has received the greatest attention within the tourism climatology literature and was the greatest predictor of park visitation within previous assessments. This study uses a stated climate preferences approach, relying on survey-based data, to explore differences for temperature preferences and thresholds among campers in Ontario parks. Statistically significant differences (at the 95% confidence level) in mean values for temperature preferences and thresholds were recorded based on various camper characteristics, such as the following: activity selection, age, gender, distance travelled, length of stay, life cycle stage, camping experience, and camping equipment. Swimmers preferred warmer day-time temperatures. Older campers preferred cooler temperatures and were more sensitive to heat stress, in the day and night time. Females preferred warmer temperatures and were less sensitive to heat stress during the night time. Campers who had travelled further distances to reach the park or planned to stay for longer periods were less sensitive to heat stress. Campers with children in their group preferred warmer temperatures and were less sensitive to heat stress, in the day and at night. Respondents with higher levels of camping experience preferred warmer temperatures at night. Tent campers were less sensitive to heat stress, in the day and at night. The results of this study have direct implications for previous and future climate change impact assessments on park visitation.
Keywords	camping ; case studies ; children ; climate ; climate change ; climatology ; equipment ; females ; heat stress ; parks ; summer ; temperature ; tourism ; weather ; Ontario
Language	English
Dates of publication	2018-08
Size	p. 1163-1173.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	1463177-5
ISSN	1434-4483 ; 0177-798X
ISSN (online)	1434-4483
ISSN	0177-798X
DOI	10.1007/s00704-017-2248-9
Database	NAL-Catalogue (AGRICOLA)

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Article: Differences in the importance of weather and weather-based decisions among campers in Ontario parks (Canada)

Hewer, Micah J / Daniel J. Scott / William A. Gough

International journal of biometeorology. 2017 Oct., v. 61, no. 10

2017

Abstract: Parks and protected areas represent an important resource for tourism in Canada, in which camping is a common recreational activity. The important relationship between weather and climate with recreation and tourism has been widely acknowledged within ... ...

Abstract	Parks and protected areas represent an important resource for tourism in Canada, in which camping is a common recreational activity. The important relationship between weather and climate with recreation and tourism has been widely acknowledged within the academic literature. Howbeit, the need for activity-specific assessments has been identified as an on-going need for future research in the field of tourism climatology. Furthermore, very little is known about the interrelationships between personal characteristics and socio-demographics with weather preferences and behavioural thresholds. This study uses a stated climate preferences approach (survey responses) to explore differences in the importance of weather and related weather-based decisions among summer campers in Ontario parks. Statistically significant differences were found among campers for each of the four dependent variables tested in this study. Physically active campers placed greater importance on weather but were still more tolerant of adverse weather conditions. Older campers placed greater importance on weather. Campers travelling shorter distances placed greater importance on weather and were more likely to leave the park early due to adverse weather. Campers staying for longer periods of time were less likely to leave early due to weather and were willing to endure longer durations of adverse weather conditions. Beginner campers placed greater importance on weather, were more likely to leave early due to weather and recorded lower temporal weather thresholds. The results of this study contribute to the study of tourism climatology by furthering understanding of how personal characteristics such as gender, age, activity selection, trip duration, distance travelled, travel experience and life cycles affect weather preferences and decisions, focusing this time on recreational camping in a park tourism context.
Keywords	bioclimatology ; camping ; climate ; conservation areas ; decision making ; gender ; parks ; sociodemographic characteristics ; summer ; surveys ; tourism ; travel ; weather ; Ontario
Language	English
Dates of publication	2017-10
Size	p. 1805-1818.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	127361-9
ISSN	0067-8902 ; 0020-7128
ISSN	0067-8902 ; 0020-7128
DOI	10.1007/s00484-017-1364-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition

Mattia Deluigi / Lena Morstein / Matthias Schuster / Christoph Klenk / Lisa Merklinger / Riley R. Cridge / Lazarus A. de Zhang / Alexander Klipp / Santiago Vacca / Tasneem M. Vaid / Peer R. E. Mittl / Pascal Egloff / Stefanie A. Eberle / Oliver Zerbe / David K. Chalmers / Daniel J. Scott / Andreas Plückthun

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 13

Abstract: This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects. ...

Abstract	This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects.
Keywords	Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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