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  1. AU="Daniela Bacherini"
  2. AU="Igarashi, Ikuo"
  3. AU="Naoki Nakashima"
  4. AU="Schrum, Adam G"
  5. AU="Hamann, Johann Georg"
  6. AU="Hochstrasser, Seraina"
  7. AU="Bronk, Marieke"
  8. AU=Lee Jeonghyun
  9. AU="Teshima, M"
  10. AU="Murray, Anne M"
  11. AU="Suaña Calsín, Milciades Conrado"
  12. AU="Bai, Yao" AU="Bai, Yao"
  13. AU="Strandberg, Erik"
  14. AU="Dar Dowlatshahi"
  15. AU="Capote, Ailem Rabasa"
  16. AU="Richier, Q"
  17. AU="Jamla, Monica"
  18. AU="Shimomura, Taizou"
  19. AU="Tampakakis, Emmanouil"
  20. AU="Tabares, Jeffrey V"

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  1. Artikel ; Online: Three-Dimensional Visualization System for Vitreoretinal Surgery

    Fabrizio Giansanti / Cristina Nicolosi / Daniela Bacherini / Federica Soloperto / Federica Sarati / Dario Giattini / Giulio Vicini

    Life, Vol 13, Iss 1289, p

    Results from a Monocentric Experience and Comparison with Conventional Surgery

    2023  Band 1289

    Abstract: Purpose: To describe the experience of our centre (Careggi University Hospital, Florence, Italy) in using a heads-up three-dimensional (3D) surgical viewing system in vitreoretinal surgery, making a comparison with the conventional microscope surgery. ... ...

    Abstract Purpose: To describe the experience of our centre (Careggi University Hospital, Florence, Italy) in using a heads-up three-dimensional (3D) surgical viewing system in vitreoretinal surgery, making a comparison with the conventional microscope surgery. Methods: We retrospectively analyzed data taken from 240 patients (240 eyes) with surgical macular diseases (macular hole and epiretinal membrane), retinal detachment or vitreous hemorrhage who underwent vitreoretinal surgeries, by means of the NGENUITY 3D Visualization System (Alcon Laboratories Inc., Fort Worth, TX, USA), in comparison with 210 patients (210 eyes) who underwent vitreoretinal surgeries performed using a conventional microscope. All surgeries were performed with standardized procedures by the same surgeons. We analyzed data over a follow-up period of 6 months, comparing the surgical outcomes (best-corrected visual acuity, anatomical success rate and postoperative complication rate) between the two groups. Results: the 3D group included 74 patients with retinal detachment, 78 with epiretinal membrane, 64 with macular hole and 24 with vitreous hemorrhage. There were no significant differences in the demographic and clinical characteristics between the 3D group and the conventional group. We found no significant differences in outcome measures at three and six months follow-up between the two groups ( p -value ≥ 0.05 for all comparisons). Surgery durations were similar between the two groups. Conclusions: In our experience, a heads-up 3D surgical viewing system provided comparable functional and anatomical outcomes in comparison with conventional microscope surgery, proving to be a valuable tool for vitreoretinal surgery in the treatment of different retinal diseases.
    Schlagwörter 3D surgical viewing system ; vitreoretinal surgery ; vitreoretinal diseases ; retinal detachment ; macular hole ; epiretinal membrane ; Science ; Q
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Swept-source OCT reduces the risk of axial length measurement errors in eyes with cataract and epiretinal membranes.

    Francesco Faraldi / Carlo Alessandro Lavia / Marco Nassisi / Raphael A Kilian / Daniela Bacherini / Stanislao Rizzo

    PLoS ONE, Vol 16, Iss 9, p e

    2021  Band 0257654

    Abstract: Aims To compare the biometric data from partial coherence interferometry (PCI) and swept-source OCT (SS-OCT) in patients with age-related cataract and epiretinal membrane (ERM): ERM, ERM with foveoschisis and macular pseudohole. Methods 49 eyes of 49 ... ...

    Abstract Aims To compare the biometric data from partial coherence interferometry (PCI) and swept-source OCT (SS-OCT) in patients with age-related cataract and epiretinal membrane (ERM): ERM, ERM with foveoschisis and macular pseudohole. Methods 49 eyes of 49 subjects including 36 ERM, 9 ERM foveoschisis and 4 macular pseudohole were analysed to evaluate the axial length (AL) measurements and the presence of AL measurement errors, defined basing on the shape of the biometric output graphs and on the concordance of AL values between instruments. Eyes with ERM were divided in four stages according to OCT features (i.e. presence/absence of the foveal pit, presence of ectopic inner foveal layers, disrupted retinal layers). Results The devices provided similar mean AL measurements in all subgroups, with differences <0.1 mm in 41/49 cases (83.6%). AL measurement errors were observed in ERM stages 3 and 4, characterized by ectopic inner foveal layers, and were significantly more frequent with the PCI (8/17, 47%) as compared with the SS-OCT device (2/17, 12%), p = 0.02. The refractive prediction error in cases with AL measurement errors was significantly greater using the PCI compared to the SS-OCT device (p<0.05). Conclusion Both devices provide reliable biometric data in the majority of patients and can be used in the preoperative assessment of patients with age-related cataract and ERM. In eyes with ectopic inner foveal layers, attention should be paid as AL measurement and refractive prediction errors may occur, more frequently with the PCI device.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 620
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Scanning Laser Ophthalmoscopy Retromode Imaging Compared to Fundus Autofluorescence in Detecting Outer Retinal Features in Central Serous Chorioretinopathy

    Fabrizio Giansanti / Stefano Mercuri / Federica Serino / Tomaso Caporossi / Alfonso Savastano / Clara Rizzo / Francesco Faraldi / Stanislao Rizzo / Daniela Bacherini

    Diagnostics, Vol 12, Iss 2638, p

    2022  Band 2638

    Abstract: Central serous chorioretinopathy (CSCR) is a retinal disease characterized by a heterogeneous clinical phenotype, depending on the influence of different factors in its pathogenesis, including the presence of subretinal fluid (SRF), trophism of the ... ...

    Abstract Central serous chorioretinopathy (CSCR) is a retinal disease characterized by a heterogeneous clinical phenotype, depending on the influence of different factors in its pathogenesis, including the presence of subretinal fluid (SRF), trophism of the retinal pigmented epithelium (RPE) and choroidal hyper-permeability. Our study has the purpose of assessing the ability of scanning laser ophthalmoscopy (SLO) retromode imaging, compared to fundus autofluorescence (FAF), to identify outer retinal features in a cohort of patients with a diagnosis of CSCR. A total of 27 eyes of 21 patients were enrolled in our study. All patients underwent full ophthalmological examination, including fundus retinography, fundus fluorescein angiography, optical coherence tomography (OCT), FAF and SLO retromode imaging. For each patient, the following features were evaluated: SRF, the presence of pigmented epithelium detachment (PED), RPE dystrophy, and RPE atrophy. RPE dystrophy was further characterized according to the appearance in FAF of iso-, hyper- and hypo-autofluorescent dystrophy. The ability to identify each feature was evaluated for FAF and SLO retromode alone, compared to a multimodal imaging approach. FAF identified SRF in 11/14 eyes (78%), PED in 14/19 (74%), RPE dystrophy with iso-autofluorescence in 0/13 (0%), hyper-autofluorescence in 18/19 (95%), hypo-autofluorescence in 20/20 (100%), and RPE atrophy in 7/7 (100%). SLO retromode imaging identified SRF in 13/14 eyes (93%), PED in 15/19 (79%), RPE dystrophy with iso-autofluorescence in 13/13 (100%), hyper-autofluorescence in 13/19 (68%), hypo-autofluorescent in 18/20 (90%), and RPE atrophy in 4/7 (57%). SLO retromode imaging is able to detect retinal and RPE changes in CSCR patients with a higher sensitivity than FAF, while it is not able to identify the depth of lesions or supply qualitative information about RPE cells’ health status, meaning that it is less specific. SLO retromode imaging may have a promising role in the assessment of patients with CSCR, but always ...
    Schlagwörter central serous chorioretinopathy ; retinal pigmented epithelium ; scanning laser ophthalmoscopy retromode imaging ; fundus autofluorescence ; multimodal imaging ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Correction

    Stanislao Rizzo / Alfonso Savastano / Jacopo Lenkowicz / Maria Cristina Savastano / Luca Boldrini / Daniela Bacherini / Benedetto Falsini / Vincenzo Valentini

    Diagnostics, Vol 12, Iss 1593, p

    Rizzo et al. Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine. Diagnostics 2021, 11 , 2319

    2022  Band 1593

    Abstract: In the original publication [.] ...

    Abstract In the original publication [.]
    Schlagwörter n/a ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
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  5. Artikel ; Online: Optical Coherence Tomography Angiography for the Evaluation of Retinal and Choroidal Vasculature in Retinitis Pigmentosa

    Fabrizio Giansanti / Giulio Vicini / Andrea Sodi / Cristina Nicolosi / Lavinia Bellari / Gianni Virgili / Stanislao Rizzo / Daniela Bacherini

    Diagnostics, Vol 12, Iss 1020, p

    A Monocentric Experience

    2022  Band 1020

    Abstract: Purpose: We investigated the chorioretinal microvascular changes in patients with retinitis pigmentosa (RP) by optical coherence tomography angiography (OCTA). Methods: Twenty-six patients (52 eyes) affected by RP were compared with 19 healthy controls ( ... ...

    Abstract Purpose: We investigated the chorioretinal microvascular changes in patients with retinitis pigmentosa (RP) by optical coherence tomography angiography (OCTA). Methods: Twenty-six patients (52 eyes) affected by RP were compared with 19 healthy controls (38 eyes). OCTA 3 mm × 3 mm macular scans were performed in all subjects. We evaluated the vessel density (VD) of the superficial capillary plexus (VD SCP), deep capillary plexus (VD DCP), choriocapillaris (VD CC), and choroid (VD choroid). We also evaluated the foveal avascular zone (FAZ) area, and the correlation between clinical and OCTA parameters. We also measured central retinal thickness (CRT) and subfoveal choroidal thickness (CT). Results: RP patients compared to healthy controls showed significantly lower VD SCP values (27.56% ± 15.37 vs. 49.39% ± 1.55; p -value < 0.0001), lower VD DCP values (38.43% ± 15.23 vs. 3.34% ± 0.26; p -value < 0.0001), lower VD CC values (46.02% ± 1.293 vs. 50.63% ± 0.4274; p -value = 0.0040), and lower VD choroid values (38.48% ± 15.23 vs. 3.34% ± 0.26; p -value < 0.0001). Even the FAZ area was significantly lower in RP patients (0.45 mm 2 ± 0.35 vs. 0.26 mm 2 ± 0.13; p -value < 0.0001). The FAZ area was larger with increasing age, both in control (r = 0.42; p = 0.012) and RP group (r = 0.46; p -value = 0.009). In RP patients, there was a statistically significant correlation between best-corrected visual acuity and VD SCP (r = 0.24, p -value = 0.04) and VD DCP (r = 0.52; p -value = 0.0004) and between subfoveal choroidal thickness and VD SCP (r = 0.43, p -value < 0.001) and VD DCP (r = 0.35, p -value < 0.001). Conclusions: In our study, OCTA reported relevant vascular alterations in RP patients in comparison with the healthy controls, in agreement with the published literature. These abnormalities were associated with choroidal atrophy and related to visual acuity loss. OCTA provided clinically significant information and may represent a reliable tool for the management of RP patients.
    Schlagwörter retinitis pigmentosa ; OCTA ; optical coherence tomography angiography ; vascular density ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Retromode Imaging Modality of Epiretinal Membranes

    Alfonso Savastano / Matteo Ripa / Maria Cristina Savastano / Tomaso Caporossi / Daniela Bacherini / Raphael Kilian / Clara Rizzo / Stanislao Rizzo

    Journal of Clinical Medicine, Vol 11, Iss 14, p

    2022  Band 3936

    Abstract: 1) Purpose: To determine the characteristics of macular epiretinal membranes (ERM) using non-invasive retromode imaging (RMI) and to compare retromode images with those acquired via fundus autofluorescence (FAF) and fundus photography. (2) Methods: ... ...

    Abstract (1) Purpose: To determine the characteristics of macular epiretinal membranes (ERM) using non-invasive retromode imaging (RMI) and to compare retromode images with those acquired via fundus autofluorescence (FAF) and fundus photography. (2) Methods: Prospective observational case-series study including patients with macular ERM with no other ocular disease affecting their morphology and/or imaging quality. We compared RMI, FAF and fundus photography features by cropping and overlapping images to obtain topographic correspondence. (3) Results: In total, 21 eyes (21 patients) affected by ERM were included in this study. The mean area of retinal folds detected by RMI was significantly higher than that detected by FAF (11.85 ± 3.92 mm 2 and 5.67 ± 2.15 mm 2 , respectively, p < 0.05) and similar to that revealed by fundus photography (11.85 ± 3.92 mm 2 and 10.58 ± 3.45 mm 2 , respectively, p = 0.277). (4) Conclusions: RMI appears to be a useful tool in the evaluation of ERMs. It allows for an accurate visualization of the real extension of the retinal folds and provides a precise structural assessment of the macula before surgery. Clinicians should be aware of RMI’s advantages and should be able to use them to warrant a wide range of information and, thus, a more personalized therapeutic approach.
    Schlagwörter epiretinal membranes ; retromode retinal imaging ; confocal scanning laser ophthalmoscope ; fundus autofluorescence ; personalized medicine ; Medicine ; R
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Human amniotic membrane plug to promote failed macular hole closure

    Tomaso Caporossi / Bianca Pacini / Daniela Bacherini / Francesco Barca / Francesco Faraldi / Stanislao Rizzo

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 8

    Abstract: Abstract The failed macular hole is a full-thickness defect involving the fovea that fails to close despite 1 or more surgeries. While many surgical options have been proposed to manage it, none of these guarantee complete anatomical success and ... ...

    Abstract Abstract The failed macular hole is a full-thickness defect involving the fovea that fails to close despite 1 or more surgeries. While many surgical options have been proposed to manage it, none of these guarantee complete anatomical success and satisfactory visual recovery. We report postoperative outcomes on 36 patients affected by failed macular hole, treated with a human amniotic membrane plug transplant. Follow-ups were performed with a standard ophthalmological examination and with advanced multimodal diagnostic imaging. Anatomical closure was achieved at 3 months in all patients. Mean best-corrected visual acuity improved statistically significantly at 6 months (p < 0.05). Through microperimetric tests, we assessed a partial recovery of the macular sensitivity on the edges of the plug. Analyzing SD-OCT images, we reported a tissutal ingrowth above the plug, and its segmentation into layers, mimicking normal retinal architecture. OCT-Angiography images non invasively analysed the retinal parafoveal capillary microvasculature; the elaboration of Adaptive Optics images showed the presence of photoreceptors at the edges of the plug. This work demonstrates not only the complete anatomical success of our technique, but also remarkable functional results, and opens the door to a greater understanding of modifications induced by the presence of a human amniotic membrane plug.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine

    Stanislao Rizzo / Alfonso Savastano / Jacopo Lenkowicz / Maria Cristina Savastano / Luca Boldrini / Daniela Bacherini / Benedetto Falsini / Vincenzo Valentini

    Diagnostics, Vol 11, Iss 2319, p

    2021  Band 2319

    Abstract: Purpose: To evaluate the 1-year visual acuity predictive performance of an artificial intelligence (AI) based model applied to optical coherence tomography angiography (OCT-A) vascular layers scans from eyes with a full-thickness macular hole (FTMH). ... ...

    Abstract Purpose: To evaluate the 1-year visual acuity predictive performance of an artificial intelligence (AI) based model applied to optical coherence tomography angiography (OCT-A) vascular layers scans from eyes with a full-thickness macular hole (FTMH). Methods: In this observational cross-sectional, single-center study, 35 eyes of 35 patients with FTMH were analyzed by OCT-A before and 1-year after surgery. Superficial vascular plexus (SVP) and deep vascular plexus (DVP) images were collected for the analysis. AI approach based on convolutional neural networks (CNN) was used to generate a continuous predictive variable based on both SVP and DPV. Different pre-trained CNN networks were used for feature extraction and compared for predictive accuracy. Results: Among the different tested models, the inception V3 network, applied on the combination of deep and superficial OCT-A images, showed the most significant differences between the two obtained image clusters defined in C1 and C2 (best-corrected visual acuity [BCVA] C1 = 49.10 [±18.60 SD] and BCVA C2 = 66.67 [±16.00 SD, p = 0.005]). Conclusions: The AI-based analysis of preoperative OCT-A images of eyes affected by FTMH may be a useful support system in setting up visual acuity recovery prediction. The combination of preoperative SVP and DVP images showed a significant morphological predictive performance for visual acuity recovery.
    Schlagwörter artificial intelligence ; deep learning ; full thickness macular hole ; innovative biotechnologies ; optical coherence tomography angiography ; personalized medicine ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Applications of the Amniotic Membrane in Vitreoretinal Surgery

    Tomaso Caporossi / Ruggero Tartaro / Daniela Bacherini / Bianca Pacini / Lorenzo De Angelis / Lorenzo Governatori / Laura Di Leo / Leandro Oliverio / Stanislao Rizzo

    Journal of Clinical Medicine, Vol 9, Iss 2675, p

    2020  Band 2675

    Abstract: Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers ...

    Abstract Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers involving the external limiting membrane (ELM) and the ellipsoid zone (EZ). After that, the application of the hAM for retinal pathologies was extended to large macular tears, high myopic retinal detachment associated with MH, paravascular tears, serous macular detachment associated with optic pit, complicated retinal detachment and advanced age-related macular degeneration (AMD). The hAM has shown a potential in repairing retinal tissue through a regeneration process. This review aims to highlight the use of the hAM in various vitreo-retinal surgical fields, and to confront it with other cutting-edge surgical techniques used to treat challenging vitreo-retinal pathologies.
    Schlagwörter vitreoretinal surgery ; amniotic membrane ; vitrectomy ; macular hole ; retinal detachment ; age related macular degeneration ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: OCT-Angiography Findings in Patients with Amblyopia

    Annabella Salerni / Gloria Gambini / Chiara Fedeli / Ludovica Paris / Emanuele Crincoli / Gustavo Savino / Maria Cristina Savastano / Daniela Bacherini / Umberto De Vico / Clara Rizzo / Raphael Killian / Stanislao Rizzo

    Diagnostics, Vol 11, Iss 1751, p

    Comparison between Healthy Controls, Treatment-Responsive, and Treatment-Unresponsive Amblyopic Patients

    2021  Band 1751

    Abstract: There is no consensus on whether amblyopia affects the retinal vascular plexus and morphology. Previous studies focused on the differences between amblyopic patients and normal controls without evaluating amblyopic eyes after patching. To evaluate ... ...

    Abstract There is no consensus on whether amblyopia affects the retinal vascular plexus and morphology. Previous studies focused on the differences between amblyopic patients and normal controls without evaluating amblyopic eyes after patching. To evaluate differences in the superficial vascular density of amblyopic eyes, normal eyes, and amblyopic eyes reaching normal BCVA after patch therapy, OCTA was used. All patients underwent a comprehensive ophthalmological examination, including visual acuity, refraction, ocular motility tests, and anterior and posterior segment examination. OCTA was performed by an expert physician using the Zeiss Cirrus 5000-HD-OCT Angioplex (Carl Zeiss, Meditec, Inc., Dublin, OH, USA). OCTA scans were performed using a 3 × 3 mm 2 and 6 × 6 mm 2 fovea-centered image setting. The mean outer macular vessel density in the previously amblyopic group was 19.15 ± 0.51%. This was statistically significantly higher than in both the amblyopic group (18.70 ± 1.14%) and the normal controls (18.18 ± 1.40%) ( p = 0.014). The previously amblyopic group also significantly differed from both normal controls and amblyopic eyes with regards to the inner ( p = 0.011), outer ( p = 0.006), and full ( p = 0.003) macular perfusion. Finally, linear regression analysis revealed that BCVA was linearly correlated to outer perfusion in amblyopic ( p = 0.003) and ex amblyopic eyes ( p < 0.001). Considering the cross-sectional nature of our study, from our results, we can only hypothesize a possible correlation between light stimulation and retinal vasculature development. However, further longitudinal studies are needed to support this hypothesis.
    Schlagwörter amblyopia ; optical coherence tomography angiography ; pediatric ophthalmology ; retina ; innovative biotechnology ; personalized medicine ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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