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  1. AU="Danilova, Olga V"
  2. AU="Jian, Shang"
  3. AU="Jae-Gyu Jeon"
  4. AU="Andrade, Letícia G."
  5. AU="Hosseinzadeh, Sara Ali"
  6. AU="Lee, Kristen"
  7. AU="Gentile, Giulia"
  8. AU="Shoben, Abigail B."
  9. AU="Rowe, Elizabeth"
  10. AU="Pandemic Response COVID-19 Research Collaboration Platform for HCQ/CQ Pooled Analyses"
  11. AU="Rahali, Anwar"
  12. AU="Zhang, Zhuang-Wei"
  13. AU="Townsend, Elizabeth C"
  14. AU="Lange, Mona V"
  15. AU="Bruner, Brenda G"
  16. AU="Michael Craigen"
  17. AU="Lambard, G."
  18. AU="Dempsey, Connor P"
  19. AU=Li Youxian
  20. AU="Bhosale, Chanakya R"

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  1. Artikel ; Online: Current status of phosphoinotiside-3 kinase inhibitors in blood cancers.

    Shouse, Geoffrey / Danilova, Olga V / Danilov, Alexey V

    Current opinion in oncology

    2022  Band 34, Heft 5, Seite(n) 540–545

    Abstract: Purpose of review: Treatment of non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) underwent paradigm shifts, with targeted agents rapidly displacing chemotherapy. Phosphoinotiside-3 kinase (PI3K) is essential for survival and ... ...

    Abstract Purpose of review: Treatment of non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) underwent paradigm shifts, with targeted agents rapidly displacing chemotherapy. Phosphoinotiside-3 kinase (PI3K) is essential for survival and proliferation of neoplastic B cells and has proven a tractable target in NHL, with four agents receiving FDA approval in the last decade. This review summarizes key data and challenges associated with use of PI3K inhibitors in routine practice.
    Recent findings: Idelalisib and duvelisib are active in CLL and indolent NHL, including in patients with high-risk features. Despite differential targeting of PI3K isoforms, they exhibit comparable efficacy and adverse event profile including autoimmune events (transaminitis, colitis, pneumonitis), mediated by Treg/Th17 imbalance. Although copanlisib, a pan-PI3K inhibitor, is associated with a distinct safety profile (hyperglycemia, hypertension), preclinical studies indicate that umbralisib, a dual inhibitor of PI3Kδ and casein kinase 1ε, may have less effect on Tregs. However, both drugs may still cause immune-mediated toxicities.
    Summary: With close monitoring and management of adverse events, PI3K inhibitors continue to have a role in therapy of R/R CLL and NHL. Strategies to mitigate adverse events and increase efficacy of PI3K inhibitors include time-limited combination approaches, intermittent dosing schedules.
    Mesh-Begriff(e) Antineoplastic Agents/adverse effects ; Hematologic Neoplasms/drug therapy ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Lymphoma, Non-Hodgkin/drug therapy ; Phosphatidylinositol 3-Kinases ; Phosphoinositide-3 Kinase Inhibitors
    Chemische Substanzen Antineoplastic Agents ; Phosphoinositide-3 Kinase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-07-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000871
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: One Step Closer to Enigmatic USCα Methanotrophs: Isolation of a

    Danilova, Olga V / Oshkin, Igor Y / Belova, Svetlana E / Miroshnikov, Kirill K / Ivanova, Anastasia A / Dedysh, Svetlana N

    Microorganisms

    2023  Band 11, Heft 11

    Abstract: The scavenging of atmospheric trace gases has been recognized as one of the lifestyle-defining capabilities of microorganisms in terrestrial polar ecosystems. Several metagenome-assembled genomes of as-yet-uncultivated methanotrophic bacteria, which ... ...

    Abstract The scavenging of atmospheric trace gases has been recognized as one of the lifestyle-defining capabilities of microorganisms in terrestrial polar ecosystems. Several metagenome-assembled genomes of as-yet-uncultivated methanotrophic bacteria, which consume atmospheric CH
    Sprache Englisch
    Erscheinungsdatum 2023-11-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11112800
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Rokubacteria in Northern Peatlands: Habitat Preferences and Diversity Patterns

    Ivanova, Anastasia A. / Oshkin, Igor Y. / Danilova, Olga V. / Philippov, Dmitriy A. / Ravin, Nikolai V. / Dedysh, Svetlana N.

    Microorganisms. 2021 Dec. 22, v. 10, no. 1

    2021  

    Abstract: Rokubacteria is a phylogenetic clade of as-yet-uncultivated prokaryotes, which are detected in diverse terrestrial habitats and are commonly addressed as members of the rare biosphere. This clade was originally described as a candidate phylum; however, ... ...

    Abstract Rokubacteria is a phylogenetic clade of as-yet-uncultivated prokaryotes, which are detected in diverse terrestrial habitats and are commonly addressed as members of the rare biosphere. This clade was originally described as a candidate phylum; however, based on the results of comparative genome analysis, was later defined as the order-level lineage, Rokubacteriales, within the phylum Methylomirabilota. The physiology and lifestyles of these bacteria are poorly understood. A dataset of 16S rRNA gene reads retrieved from four boreal raised bogs and six eutrophic fens was examined for the presence of the Rokubacteriales; the latter were detected exclusively in fens. Their relative abundance varied between 0.2 and 4% of all bacteria and was positively correlated with pH, total nitrogen content, and availability of Ca and Mg. To test an earlier published hypothesis regarding the presence of methanotrophic capabilities in Rokubacteria, peat samples were incubated with 10% methane for four weeks. No response to methane availability was detected for the Rokubacteriales, while clear a increase in relative abundance was observed for the conventional Methylococcales methanotrophs. The search for methane monooxygenase encoding genes in 60 currently available Rokubacteriales metagenomes yielded negative results, although copper-containing monooxygenases were encoded by some members of this order. This study suggests that peat-inhabiting Rokubacteriales are neutrophilic non-methanotrophic bacteria that colonize nitrogen-rich wetlands.
    Schlagwörter Methylococcales ; biosphere ; data collection ; eutrophication ; fens ; genes ; habitats ; metagenomics ; methane ; methane monooxygenases ; methanotrophs ; pH ; peat ; peatlands ; phylogeny ; physiology ; prokaryotic cells ; sequence analysis ; total nitrogen
    Sprache Englisch
    Erscheinungsverlauf 2021-1222
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10010011
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Pericardial involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma.

    Danilova, Olga V / Danilov, Alexey V

    Blood

    2015  Band 126, Heft 3, Seite(n) 424

    Mesh-Begriff(e) Aged ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell/surgery ; Male ; Pericardial Effusion ; Prognosis
    Sprache Englisch
    Erscheinungsdatum 2015-09-14
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-04-641571
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Methylomonas rapida sp. nov., a novel species of fast-growing, carotenoid-producing obligate methanotrophs with high biotechnological potential

    Tikhonova, Ekaterina N. / Suleimanov, Ruslan Z. / Miroshnikov, Kirill K. / Oshkin, Igor Y. / Belova, Svetlana E. / Danilova, Olga V. / Ashikhmin, Aleksandr A. / Konopkin, Aleksey A. / But, Sergey Y. / Khmelenina, Valentina N. / Pimenov, Nikolai V. / Dedysh, Svetlana N.

    Systematic and Applied Microbiology. 2023 Apr., v. 46, no. 2 p.126398-

    2023  

    Abstract: The genus Methylomonas accommodates strictly aerobic, obligate methanotrophs, with their sole carbon and energy sources restricted to methane and methanol. These bacteria inhabit oxic-anoxic interfaces of various freshwater habitats and have attracted ... ...

    Abstract The genus Methylomonas accommodates strictly aerobic, obligate methanotrophs, with their sole carbon and energy sources restricted to methane and methanol. These bacteria inhabit oxic-anoxic interfaces of various freshwater habitats and have attracted considerable attention as potential producers of a single-cell protein. Here, we characterize two fast-growing representatives of this genus, strains 12 and MP1ᵀ, which are phylogenetically distinct from the currently described Methylomonas species (94.0–97.3 % 16S rRNA gene sequence similarity). Strains 12 and MP1ᵀ were isolated from freshwater sediments collected in Moscow and Krasnodar regions, respectively. Cells of these strains are Gram-negative, red-pigmented, highly motile thick rods that contain a type I intracytoplasmic membrane system and possess a particulate methane monooxygenase (pMMO) enzyme. These bacteria grow between 8 and 45 °C (optimum 35 °C) in a relatively narrow pH range of 5.5–7.3 (optimum pH 6.6–7.2). Major carotenoids synthesized by these methanotrophs are 4,4′-diaplycopene-4,4′-dioic acid, 1,1′-dihydroxy-3,4-didehydrolycopene and 4,4′-diaplycopenoic acid. High biomass yield, of up to 3.26 g CDW/l, is obtained during continuous cultivation of MP1ᵀ on natural gas in a bioreactor at a dilution rate of 0.22 h⁻¹. The complete genome sequence of strain MP1ᵀ is 4.59 Mb in size; the DNA G + C content is 52.8 mol%. The genome encodes four rRNA operons, one pMMO operon and 4,216 proteins. The genome sequence displays 82–85 % average nucleotide identity to those of earlier described Methylomonas species. We propose to classify these bacteria as representing a novel species of the genus Methylomonas, M. rapida sp. nov., with the type strain MP1ᵀ (=KCTC 92586ᵀ = VKM B-3663ᵀ).
    Schlagwörter DNA ; Methylomonas ; biomass production ; bioreactors ; carbon ; carotenoids ; energy ; freshwater ; methane ; methane monooxygenase (particulate) ; methanol ; methanotrophs ; natural gas ; nucleotide sequences ; operon ; pH ; phylogeny ; sequence homology ; single cell protein ; Methanotrophic bacteria ; Cultivation studies ; Fast growth on methane ; Cultivation in bioreactor ; Production of carotenoids ; Comparative genomics
    Sprache Englisch
    Erscheinungsverlauf 2023-04
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel ; Online
    ZDB-ID 283612-9
    ISSN 1618-0984 ; 0723-2020
    ISSN (online) 1618-0984
    ISSN 0723-2020
    DOI 10.1016/j.syapm.2023.126398
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: Methane-Oxidizing Communities in Lichen-Dominated Forested Tundra Are Composed Exclusively of High-Affinity USCα Methanotrophs.

    Belova, Svetlana E / Danilova, Olga V / Ivanova, Anastasia A / Merkel, Alexander Y / Dedysh, Svetlana N

    Microorganisms

    2020  Band 8, Heft 12

    Abstract: Upland soils of tundra function as a constant sink for atmospheric ... ...

    Abstract Upland soils of tundra function as a constant sink for atmospheric CH
    Sprache Englisch
    Erscheinungsdatum 2020-12-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8122047
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  7. Artikel ; Online: Methylomonas rapida sp. nov., a novel species of fast-growing, carotenoid-producing obligate methanotrophs with high biotechnological potential.

    Tikhonova, Ekaterina N / Suleimanov, Ruslan Z / Miroshnikov, Kirill K / Oshkin, Igor Y / Belova, Svetlana E / Danilova, Olga V / Ashikhmin, Aleksandr A / Konopkin, Aleksey A / But, Sergey Y / Khmelenina, Valentina N / Pimenov, Nikolai V / Dedysh, Svetlana N

    Systematic and applied microbiology

    2023  Band 46, Heft 2, Seite(n) 126398

    Abstract: The genus Methylomonas accommodates strictly aerobic, obligate methanotrophs, with their sole carbon and energy sources restricted to methane and methanol. These bacteria inhabit oxic-anoxic interfaces of various freshwater habitats and have attracted ... ...

    Abstract The genus Methylomonas accommodates strictly aerobic, obligate methanotrophs, with their sole carbon and energy sources restricted to methane and methanol. These bacteria inhabit oxic-anoxic interfaces of various freshwater habitats and have attracted considerable attention as potential producers of a single-cell protein. Here, we characterize two fast-growing representatives of this genus, strains 12 and MP1
    Mesh-Begriff(e) Methylomonas/genetics ; RNA, Ribosomal, 16S/genetics ; Fatty Acids/chemistry ; DNA, Bacterial/genetics ; Phylogeny ; Sequence Analysis, DNA ; Bacterial Typing Techniques
    Chemische Substanzen RNA, Ribosomal, 16S ; Fatty Acids ; DNA, Bacterial
    Sprache Englisch
    Erscheinungsdatum 2023-01-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 283612-9
    ISSN 1618-0984 ; 0723-2020
    ISSN (online) 1618-0984
    ISSN 0723-2020
    DOI 10.1016/j.syapm.2023.126398
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  8. Artikel: Methane-Oxidizing Communities in Lichen-Dominated Forested Tundra Are Composed Exclusively of High-Affinity USCα Methanotrophs

    Belova, Svetlana E / Danilova, Olga V / Ivanova, Anastasia A / Merkel, Alexander Y / Dedysh, Svetlana N

    Microorganisms. 2020 Dec. 21, v. 8, no. 12

    2020  

    Abstract: Upland soils of tundra function as a constant sink for atmospheric CH₄ but the identity of methane oxidizers in these soils remains poorly understood. Methane uptake rates of -0.4 to -0.6 mg CH₄-C m⁻² day⁻¹ were determined by the static chamber method in ...

    Abstract Upland soils of tundra function as a constant sink for atmospheric CH₄ but the identity of methane oxidizers in these soils remains poorly understood. Methane uptake rates of -0.4 to -0.6 mg CH₄-C m⁻² day⁻¹ were determined by the static chamber method in a mildly acidic upland soil of the lichen-dominated forested tundra, North Siberia, Russia. The maximal CH₄ oxidation activity was localized in an organic surface soil layer underlying the lichen cover. Molecular identification of methanotrophic bacteria based on retrieval of the pmoA gene revealed Upland Soil Cluster Alpha (USCα) as the only detectable methanotroph group. Quantification of these pmoA gene fragments by means of specific qPCR assay detected ~10⁷pmoA gene copies g⁻¹ dry soil. The pmoA diversity was represented by seven closely related phylotypes; the most abundant phylotype displayed 97.5% identity to pmoA of Candidatus Methyloaffinis lahnbergensis. Further analysis of prokaryote diversity in this soil did not reveal 16S rRNA gene fragments from well-studied methanotrophs of the order Methylococcales and the family Methylocystaceae. The largest group of reads (~4% of all bacterial 16S rRNA gene fragments) that could potentially belong to methanotrophs was classified as uncultivated Beijerinckiaceae bacteria. These reads displayed 96–100 and 95–98% sequence similarity to 16S rRNA gene of Candidatus Methyloaffinis lahnbergensis and “Methylocapsa gorgona” MG08, respectively, and were represented by eight species-level operational taxonomic units (OTUs), two of which were highly abundant. These identification results characterize subarctic upland soils, which are exposed to atmospheric methane concentrations only, as a unique habitat colonized mostly by USCα methanotrophs.
    Schlagwörter Beijerinckiaceae ; Methylococcales ; Methylocystaceae ; Otus ; Siberia ; assays ; bacteria ; genes ; habitats ; lichens ; methane ; methanotrophs ; oxidants ; oxidation ; phylotype ; prokaryotic cells ; sequence homology ; tundra ; upland soils
    Sprache Englisch
    Erscheinungsverlauf 2020-1221
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8122047
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  9. Artikel: Rokubacteria in Northern Peatlands: Habitat Preferences and Diversity Patterns.

    Ivanova, Anastasia A / Oshkin, Igor Y / Danilova, Olga V / Philippov, Dmitriy A / Ravin, Nikolai V / Dedysh, Svetlana N

    Microorganisms

    2021  Band 10, Heft 1

    Abstract: Rokubacteria is a phylogenetic clade of as-yet-uncultivated prokaryotes, which are detected in diverse terrestrial habitats and are commonly addressed as members of the rare biosphere. This clade was originally described as a candidate phylum; however, ... ...

    Abstract Rokubacteria is a phylogenetic clade of as-yet-uncultivated prokaryotes, which are detected in diverse terrestrial habitats and are commonly addressed as members of the rare biosphere. This clade was originally described as a candidate phylum; however, based on the results of comparative genome analysis, was later defined as the order-level lineage,
    Sprache Englisch
    Erscheinungsdatum 2021-12-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10010011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells.

    Kittai, Adam S / Danilova, Olga V / Lam, Vi / Liu, Tingting / Bruss, Nur / Best, Scott / Fan, Guang / Danilov, Alexey V

    Oncotarget

    2021  Band 12, Heft 20, Seite(n) 2068–2074

    Abstract: Peripheral T-cell lymphoma (PTCL) is characterized by poor outcomes. We and others have shown that targeting the NEDD8-activating enzyme (NAE) with an investigational inhibitor pevonedistat deregulates cell cycle and mitosis in lymphoma and leukemia. ... ...

    Abstract Peripheral T-cell lymphoma (PTCL) is characterized by poor outcomes. We and others have shown that targeting the NEDD8-activating enzyme (NAE) with an investigational inhibitor pevonedistat deregulates cell cycle and mitosis in lymphoma and leukemia. Here, we report that PTCL is characterized by increased rate of chromosomal instability. NAE inhibition promotes cell cycle arrest and induces multipolar anaphases in T-cell lymphoma cell lines, resulting in apoptosis, also observed in primary malignant PTCL cells treated with pevonedistat. We identified p27
    Sprache Englisch
    Erscheinungsdatum 2021-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28063
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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