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  1. Book ; Online: Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

    Danti, Serena / Negrini, Nicola Contessi / Franchi, Alessandro

    2023  

    Keywords Research & information: general ; Biology, life sciences ; Technology, engineering, agriculture ; biomaterials ; tissue engineering ; 3D cell culture ; cancer cells ; bioprinting ; breast cancer ; metastasis ; bone ; 3D modeling ; tumor microenvironment ; extracellular matrix ; 3D printing ; 3D bioprinting ; bone cancer ; calcium phosphates ; bone model ; orthopedics ; EGFR ; trafficking ; degradation ; self-assembling peptides ; 3D culture ; pancreatic ductal adenocarcinoma ; PDAC ; drug resistance ; 3D tumor model ; 3D microfiber ; amoeboid cell migration ; brain cancer ; PTEN ; RHO ; ROCK ; durotaxis ; topotaxis ; pancreatic cancer ; tumour microenvironment (TME) ; treatment resistance ; radiotherapy ; radiation ; radioprotection ; hypoxia ; polyurethane scaffolds ; extracellular matrix (ECM) ; HIF-1a ; PANC-1 ; organoids ; tumour heterogeneity ; colorectal neoplasms ; clonal evolution ; longitudinal imaging ; neoplasm recurrence ; cell lineage ; self-renewal ; cell culture techniques ; 3D cancer models ; immunotherapies ; tumor escape mechanisms ; epithelial ovarian cancer ; 3D in vitro model ; chemotherapy ; Cisplatin ; spheroids ; hydrogels ; polymeric scaffolds ; A2780 ; SK-OV-3 ; fused deposition modeling ; cancer tissue engineering ; in vitro model ; mechanical properties ; mesenchymal stromal cell ; bone matrix ; personalized therapy ; scaffold ; primary cancer cells ; experimental models ; screening ; 3Rs ; tumour modelling ; polyhydroxyalkanoates (PHAs) ; colon cancer ; epithelial-mesenchymal transition (EMT) ; scaffolds ; 3D ; three-dimensional ; model ; ovarian ; cancer ; patient-derived ; personalised ; n/a
    Language English
    Size 1 electronic resource (312 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722294
    ISBN 9783036568430 ; 3036568433
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: High Performance Functional Bio-based Polymers for Skin-contact Products

    Coltelli, Maria Beatrice / Danti, Serena

    2021  

    Keywords Research & information: general ; pullulan ; biopolymers ; exopolysaccharides ; biodegradation ; biocompatibility ; poly(lactic acid) ; poly(butylene succinate) ; chitin nanofibrils ; starch ; skin compatibility ; anti-microbial ; poly(hydroxyalkanoate) ; biopolyesters ; beauty masks ; releasing ; skin compatible ; polyhydroxyalkanotes ; sugarcane molasses ; antibacterial materials ; essential oils ; coating ; poly(lactide) ; chitin-lignin nanocomplex ; grafting from ; lactide oligomers ; platelet-rich fibrin ; wound healing ; skin wounds ; wound dressing ; hyperspectral imaging ; principal component analysis ; spectroscopy ; chitosan ; partial least squares regression ; nir ; actives substances ; cn-nl/ga ; skin ; antifouling ; antimicrobial ; antiviral ; electrospinning ; breast implant ; ear prosthesis ; biomedical device ; chronic wound ; biopolymer ; bio-based ; surface modification ; nanolignin ; electrospray ; anti-inflammatory ; blends ; PLA ; PHBV ; nanocomposite ; tissue engineering ; biodegradable ; nanofiber ; n/a
    Size 1 electronic resource (224 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044618
    ISBN 9783039438624 ; 303943862X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches.

    Contessi Negrini, Nicola / Franchi, Alessandro / Danti, Serena

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Cancers are a leading cause of death around the world, accounting for nearly 10 million deaths yearly [ ... ]. ...

    Abstract Cancers are a leading cause of death around the world, accounting for nearly 10 million deaths yearly [...].
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effect of Nanocellulose Types on Microporous Acrylic Acid/Sodium Alginate Super Absorbent Polymers.

    Ismaeilimoghadam, Saeed / Jonoobi, Mehdi / Hamzeh, Yahya / Danti, Serena

    Journal of functional biomaterials

    2022  Volume 13, Issue 4

    Abstract: The aim of this study was to investigate the effect of different types of nanocellulose, i.e., cellulose nanocrystal (CNC), cellulose nanofiber (CNF) and bacterial nanocellulose (BNC), and also different drying methods (oven-drying and freeze-drying) on ... ...

    Abstract The aim of this study was to investigate the effect of different types of nanocellulose, i.e., cellulose nanocrystal (CNC), cellulose nanofiber (CNF) and bacterial nanocellulose (BNC), and also different drying methods (oven-drying and freeze-drying) on the properties of acrylic acid (AA)/sodium alginate (SA) super absorbent polymers (SAPs). In addition, the presence of ammonium per sulfate as an initiator and
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb13040273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Biobased Materials for Skin-Contact Products Promoted by POLYBIOSKIN Project.

    Coltelli, Maria-Beatrice / Danti, Serena

    Journal of functional biomaterials

    2020  Volume 11, Issue 4

    Abstract: The skin is the body outermost tissue and acts as a barrier and defense line to protect our organs [ ... ]. ...

    Abstract The skin is the body outermost tissue and acts as a barrier and defense line to protect our organs [...].
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb11040077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emerging Multiscale Biofabrication Approaches for Bacteriotherapy.

    Rovelli, Roberta / Cecchini, Beatrice / Zavagna, Lorenzo / Azimi, Bahareh / Ricci, Claudio / Esin, Semih / Milazzo, Mario / Batoni, Giovanna / Danti, Serena

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: Bacteriotherapy is emerging as a strategic and effective approach to treat infections by providing putatively harmless bacteria (i.e., probiotics) as antagonists to pathogens. Proper delivery of probiotics or their metabolites (i.e., post-biotics) can ... ...

    Abstract Bacteriotherapy is emerging as a strategic and effective approach to treat infections by providing putatively harmless bacteria (i.e., probiotics) as antagonists to pathogens. Proper delivery of probiotics or their metabolites (i.e., post-biotics) can facilitate their availing of biomaterial encapsulation via innovative manufacturing technologies. This review paper aims to provide the most recent biomaterial-assisted strategies proposed to treat infections or dysbiosis using bacteriotherapy. We revised the encapsulation processes across multiscale biomaterial approaches, which could be ideal for targeting different tissues and suit diverse therapeutic opportunities. Hydrogels, and specifically polysaccharides, are the focus of this review, as they have been reported to better sustain the vitality of the live cells incorporated. Specifically, the approaches used for fabricating hydrogel-based devices with increasing dimensionality (D)-namely, 0D (i.e., particles), 1D (i.e., fibers), 2D (i.e., fiber meshes), and 3D (i.e., scaffolds)-endowed with probiotics, were detailed by describing their advantages and challenges, along with a future overlook in the field. Electrospinning, electrospray, and 3D bioprinting were investigated as new biofabrication methods for probiotic encapsulation within multidimensional matrices. Finally, examples of biomaterial-based systems for cell and possibly post-biotic release were reported.
    MeSH term(s) Tissue Engineering/methods ; Bioprinting/methods ; Biocompatible Materials ; Printing, Three-Dimensional ; Technology ; Hydrogels/therapeutic use ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials ; Hydrogels
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Cellulose-Based Fibrous Materials From Bacteria to Repair Tympanic Membrane Perforations.

    Azimi, Bahareh / Milazzo, Mario / Danti, Serena

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 669863

    Abstract: Perforation is the most common illness of the tympanic membrane (TM), which is commonly treated with surgical procedures. The success rate of the treatment could be improved by novel bioengineering approaches. In fact, a successful restoration of a ... ...

    Abstract Perforation is the most common illness of the tympanic membrane (TM), which is commonly treated with surgical procedures. The success rate of the treatment could be improved by novel bioengineering approaches. In fact, a successful restoration of a damaged TM needs a supporting biomaterial or scaffold able to meet mechano-acoustic properties similar to those of the native TM, along with optimal biocompatibility. Traditionally, a large number of biological-based materials, including paper, silk, Gelfoam
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.669863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Local Piezoelectric Response of Polymer/Ceramic Nanocomposite Fibers.

    Magnani, Aurora / Capaccioli, Simone / Azimi, Bahareh / Danti, Serena / Labardi, Massimiliano

    Polymers

    2022  Volume 14, Issue 24

    Abstract: Effective converse piezoelectric coefficient ( ...

    Abstract Effective converse piezoelectric coefficient (
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14245379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tunable ciprofloxacin delivery through personalized electrospun patches for tympanic membrane perforations.

    Anand, Shivesh / Fusco, Alessandra / Günday, Cemre / Günday-Türeli, Nazende / Donnarumma, Giovanna / Danti, Serena / Moroni, Lorenzo / Mota, Carlos

    Bioactive materials

    2024  Volume 38, Page(s) 109–123

    Abstract: Approximately 740 million symptomatic patients are affected by otitis media every year. Being an inflammatory disease affecting the middle ear, it is one of the primary causes of tympanic membrane (TM) perforations, often resulting in impaired hearing ... ...

    Abstract Approximately 740 million symptomatic patients are affected by otitis media every year. Being an inflammatory disease affecting the middle ear, it is one of the primary causes of tympanic membrane (TM) perforations, often resulting in impaired hearing abilities. Antibiotic therapy using broad-spectrum fluoroquinolones, such as ciprofloxacin (CIP), is frequently employed and considered the optimal route to treat otitis media. However, patients often get exposed to high dosages to compensate for the low drug concentration reaching the affected site. Therefore, this study aims to integrate tissue engineering with drug delivery strategies to create biomimetic scaffolds promoting TM regeneration while facilitating a localized release of CIP. Distinct electrospinning (ES) modalities were designed in this regard either by blending CIP into the polymer ES solution or by incorporating nanoparticles-based co-ES/electrospraying. The combination of these modalities was investigated as well. A broad range of release kinetic profiles was achieved from the fabricated scaffolds, thereby offering a wide spectrum of antibiotic concentrations that could serve patients with diverse therapeutic needs. Furthermore, the incorporation of CIP into the TM patches demonstrated a favorable influence on their resultant mechanical properties. Biological studies performed with human mesenchymal stromal cells confirmed the absence of any cytotoxic or anti-proliferative effects from the released antibiotic. Finally, antibacterial assays validated the efficacy of CIP-loaded scaffolds in suppressing bacterial infections, highlighting their promising relevance for TM applications.
    Language English
    Publishing date 2024-04-24
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2024.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interpenetrating and semi-interpenetrating network superabsorbent hydrogels based on sodium alginate and cellulose nanocrystals: A biodegradable and high-performance solution for adult incontinence pads.

    Ismaeilimoghadam, Saeed / Jonoobi, Mehdi / Ashori, Alireza / Shahraki, Afsaneh / Azimi, Bahareh / Danti, Serena

    International journal of biological macromolecules

    2023  Volume 253, Issue Pt 8, Page(s) 127118

    Abstract: Superabsorbent hydrogels (SAHs) are essential in various applications, including hygienic products like adult incontinence pads. However, synthetic-based super absorbent polymers (SAPs) dominate the market despite being non-biodegradable. Alternatively, ... ...

    Abstract Superabsorbent hydrogels (SAHs) are essential in various applications, including hygienic products like adult incontinence pads. However, synthetic-based super absorbent polymers (SAPs) dominate the market despite being non-biodegradable. Alternatively, bio-based hydrogels, such as sodium alginate (SA)-based hydrogels, offer biodegradable alternatives. In this study, we aimed to enhance the practical applied properties of SA-based hydrogels by grafting SA with acrylic acid (AA) and incorporating cellulose nanocrystals (CNCs). Specifically, we investigated the potential of interpenetrating network (IPN) and semi-interpenetrating network (S-IPN) hydrogels as absorbent materials in adult incontinence pads. The fabricated SAHs were characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). They were also evaluated for absorption and rheological properties. The results showed that in IPN/SAHs, the addition of CNCs decreased pore sizes, while in S-IPN/SAHs, CNC incorporation increased pore sizes. The S-IPN/SAHs exhibited a significantly higher free swelling capacity (FSC) with CNCs loading, reaching 142.29 g/g in 0.9 % NaCl solution and 817.4 g/g in distilled water. On the other hand, IPN/SAHs showed a higher storage modulus and lower loss modulus compared to S-IPN/SAHs. Notably, the superior samples from this study showed a 33 % reduction in SAP consumption compared to commercial SAPs, making them more cost-effective for adult incontinence pad manufacturers. Overall, our research demonstrates the potential of interpenetrating and semi-interpenetrating network superabsorbent hydrogels as high-performance absorbent materials. The results offer improved absorbency and cost savings for producers of adult incontinence pads, and bio-based hydrogels like SA-based hydrogels are promising biodegradable alternatives to synthetic-based SAPs.
    MeSH term(s) Cellulose/chemistry ; Alginates/chemistry ; Incontinence Pads ; Hydrogels/chemistry ; Spectroscopy, Fourier Transform Infrared ; Polymers/chemistry ; Nanoparticles
    Chemical Substances Cellulose (9004-34-6) ; Alginates ; Hydrogels ; Polymers
    Language English
    Publishing date 2023-10-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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