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  1. Article ; Online: Corrigendum

    Danying Liao / Huaibiao Li

    Frontiers in Cell and Developmental Biology, Vol

    Dissecting the Niche for Alveolar Type II Cells With Alveolar Organoids

    2021  Volume 9

    Keywords lung ; alveolar epithelium ; alveolar type II epithelial cell ; alveolar stem cell ; alveolar organoid ; Wnt pathway ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dissecting the Niche for Alveolar Type II Cells With Alveolar Organoids

    Danying Liao / Huaibiao Li

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Keywords lung ; alveolar epithelium ; alveolar type II epithelial cell ; alveolar stem cell ; alveolar organoid ; Wnt pathway ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Plasma proteomic and metabolomic signatures of B‐ALL patients during CAR‐T cell therapy

    Jianghua Wu / Lu Tang / Mengyi Du / Chenggong Li / Haiming Kou / Huiwen Jiang / Wenjing Luo / Yinqiang Zhang / Zhongpei Huang / Danying Liao / Wei Xiong / Heng Mei / Yu Hu

    Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)

    2023  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) nanoparticles as a carrier for the delivery of CCR2− shRNA to atherosclerotic macrophage in vitro

    Zhilin Wu / Chen Chen / Jiajia Luo / Jacques R. J. Davis / Bo Zhang / Liang Tang / Wei Shi / Danying Liao

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Abstract Reducing macrophage recruitment by silencing chemokine (C–C motif) receptor 2 (CCR2) expression is a promising therapeutic approach against atherosclerosis. However the transfection of macrophages with siRNA is often technically challenging. ... ...

    Abstract Abstract Reducing macrophage recruitment by silencing chemokine (C–C motif) receptor 2 (CCR2) expression is a promising therapeutic approach against atherosclerosis. However the transfection of macrophages with siRNA is often technically challenging. EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (ENPs) have a specific affinity to tissue factor (TF). In this study, the feasibility of ENPs as a carrier for target delivery of CCR2-shRNA to atherosclerotic cellular models of macrophages was investigated. Coumarin-6 loaded ENPs were synthesized using a double-emulsion method. Fluorescence microscopy and flow cytometry assay were taken to examine the uptake of Coumarin-6 loaded ENPs in the cellular model. Then a sequence of shRNA specific to CCR2 mRNA was constructed and encapsulated into ENPs. Target delivery of CCR2-shRNA to atherosclerotic cellular models of macrophages in vitro were evaluated. Results showed more uptake of ENPs by the cellular model than common PLGA nanoparticles. CCR2-shRNA loaded ENPs effectively silenced CCR2 gene in the atherosclerotic macrophages and exhibited a favorable cytotoxic profile to cultured cells. With their low cytotoxicity and efficient drug delivery, ENP could be a useful carrier for target delivery of CCR2-shRNA to inflammatory monocytes/macrophages for the therapy against atherosclerosis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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