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  1. Article ; Online: Safety of Ultrasound Contrast Agents in Pediatric Patients With Sickle Cell Disease and Trait.

    Ntoulia, Aikaterini / Darge, Kassa / Thompson, Alexis A / Back, Susan J

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2023  Volume 43, Issue 1, Page(s) 189–200

    Abstract: Ultrasound contrast agent (UCA) use is increasing. Recent isolated reports observed a rise in pain-related adverse events with the intravenous administration of the UCA Definity in adults with sickle cell disease. To date, no studies have investigated ... ...

    Abstract Ultrasound contrast agent (UCA) use is increasing. Recent isolated reports observed a rise in pain-related adverse events with the intravenous administration of the UCA Definity in adults with sickle cell disease. To date, no studies have investigated the incidence of similar adverse events with UCA Lumason or Optison. We describe our experience regarding the safety of Lumason and Optison in children with sickle cell disease and trait who underwent contrast-enhanced ultrasound exams in our department with intravenous, intravesical, and other intracavitary routes. No pain-related or other adverse events were observed in this pediatric population with any route of UCA administration.
    MeSH term(s) Adult ; Humans ; Child ; Contrast Media/adverse effects ; Ultrasonography ; Infusions, Intravenous ; Anemia, Sickle Cell/complications ; Incidence
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.16341
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  2. Article ; Online: Increasing CEUS utilization in the USA: a call to action for the adult and pediatric body imaging community.

    Wilson, Stephanie R / Merrill, Christina D / Darge, Kassa / Barr, Richard G

    Abdominal radiology (New York)

    2022  Volume 48, Issue 1, Page(s) 418–423

    Abstract: Despite its well-established benefits and a powerful body of scientific literature supporting the efficacy of contrast-enhanced ultrasound (CEUS), it has faced challenges in being fully adopted as a diagnostic and problem-solving tool within the USA. ... ...

    Abstract Despite its well-established benefits and a powerful body of scientific literature supporting the efficacy of contrast-enhanced ultrasound (CEUS), it has faced challenges in being fully adopted as a diagnostic and problem-solving tool within the USA. This effort, written by experts in performance of and interpretation of CEUS, acts as a roadmap, for those interested in expanding CEUS within their facility. CEUS benefits from a Champion who is knowledgeable and passionate about its performance and who is capable of transferring evidence-based enthusiasm to others. They must be willing to do the legwork required for the successful implementation of a CEUS program, including increasing referrals, expanding applications, and encouraging the inclusion of CEUS into current and established guidelines. The ability of CEUS to resolve a wide range of indeterminate results which come from CT and MR scan represents one of the most compelling arguments for the use of CEUS, decreasing down-stream testing, and reducing time to diagnosis. As utilization grows, the benefits of CEUS will become apparent to other healthcare teams. However, the ultimate beneficiary of improved CEUS utilization will be the patients themselves, who will have greater access to a safe, speedy, cost effective, reliable, and radiation-free diagnostic imaging tool.
    MeSH term(s) Humans ; Child ; Adult ; Contrast Media ; Ultrasonography/methods ; Diffusion Magnetic Resonance Imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-022-03686-z
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  3. Article ; Online: Accurate dilated renal pelvis measurement: reply to Mihmanli.

    Nguyen, Hiep T / Phelps, Andrew / Coley, Brian / Darge, Kassa / Rhee, Audrey / Chow, Jeanne S

    Pediatric radiology

    2023  Volume 53, Issue 6, Page(s) 1217

    MeSH term(s) Humans ; Kidney Diseases ; Kidney Pelvis/diagnostic imaging
    Language English
    Publishing date 2023-02-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-023-05609-6
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  4. Article ; Online: Contrast-enhanced ultrasound in children: a first-of-its-kind comprehensive compendium!

    Ntoulia, Aikaterini / Back, Susan J / Darge, Kassa

    Pediatric radiology

    2021  Volume 51, Issue 12, Page(s) 2115–2116

    MeSH term(s) Child ; Contrast Media ; Humans ; Ultrasonography
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-07-23
    Publishing country Germany
    Document type Editorial
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05120-w
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  5. Article ; Online: Retrograde urethrography in children: a decade of experience at a children's hospital.

    Elsingergy, Mohamed M / Bellah, Richard D / Back, Susan J / Weiss, Dana A / Darge, Kassa

    Pediatric radiology

    2023  Volume 53, Issue 5, Page(s) 862–874

    Abstract: Background: Retrograde urethrography (RUG) is a radiologic procedure that optimizes imaging evaluation of the urethra, particularly in settings of difficulty with micturition or urethral injury.: Objective: To review our experience with RUG at a ... ...

    Abstract Background: Retrograde urethrography (RUG) is a radiologic procedure that optimizes imaging evaluation of the urethra, particularly in settings of difficulty with micturition or urethral injury.
    Objective: To review our experience with RUG at a large pediatric radiology practice.
    Materials and methods: We conducted a retrospective review of medical records and fluoroscopic images of RUGs performed from January 2010 to December 2020.
    Results: We identified 180 RUG exams (median frequency 17 exams per year), all in male children (median age 13 years). The most common indications were stricture (42%; n=76), postsurgical evaluation (34%; n=62) and trauma (16%; n=29). The most commonly used catheter was Foley (40%; n=72), with a median catheter size of 5 French (Fr) for infants younger than 1 year, 7 Fr for children ages 1-5 years and 8 Fr for children older than 5 years. About a third of the children (57; 32%) had combined voiding cystourethrography (VCUG)-RUG exams. Water-soluble contrast agent, either 17% or 43% Cysto-Conray, was used. Most RUG exams were normal (46%; n=83). The most common urethral pathology was stricture (30%; n=54), commonly involving a bulbar urethra (n=26). Urethral trauma was seen in 11 children (6%), 10 bulbar and 1 membranous. Most children with stricture were surgically treated (n=40; 74%), whereas most children with trauma were conservatively treated (n=8; 73%). The remaining diagnoses included diverticula, polyps, valves, fistulas and duplications, constituting <17% of our sample; most of these were surgically treated. Four exams (2%) were non-diagnostic. RUG showed 89% sensitivity and 97% specificity compared to cystourethroscopy/VCUG findings. Technical difficulties occurred in 14 (8%) children (e.g., pain or inappropriate catheter seal).
    Conclusion: Our experience indicates that when catheterization techniques are properly tailored, RUG provides a useful and successful radiologic method of evaluating the pediatric male urethra.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Male ; Constriction, Pathologic ; Hospitals, Pediatric ; Radiography ; Urethra/diagnostic imaging ; Urethra/surgery ; Urethral Stricture/diagnostic imaging ; Urethral Stricture/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-023-05589-7
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  6. Article ; Online: Establishing pediatric radiology in a low-income country: the Ethiopian partnership experience.

    Derbew, Hermon Miliard / Otero, Hansel J / Zewdneh, Daniel / Hailu, Samuel Sisay / Darge, Kassa

    Pediatric radiology

    2023  Volume 54, Issue 3, Page(s) 392–399

    Abstract: In 2008, a partnership between the academic pediatric radiology department at the Children's Hospital of Philadelphia in the USA and the radiology department at Tikur Anbessa Specialized Hospital in Ethiopia, was established. The partnership aims to ... ...

    Abstract In 2008, a partnership between the academic pediatric radiology department at the Children's Hospital of Philadelphia in the USA and the radiology department at Tikur Anbessa Specialized Hospital in Ethiopia, was established. The partnership aims to support pediatric radiology education during radiology residency and to establish pediatric radiology subspeciality training in Ethiopia. In this paper, we review the needs that elicit this type of partnership, its structure, achievements, challenges and future state as a successful roadmap to the establishment of a high-impact subspeciality program in a bilateral partnership.
    MeSH term(s) Humans ; Child ; Hospitals ; Internship and Residency ; Radiology ; Ethiopia
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-023-05713-7
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  7. Article ; Online: Contrast-enhanced US (CEUS) in children: ready for prime time in the United States.

    Darge, Kassa

    Pediatric radiology

    2011  Volume 41, Issue 11, Page(s) 1486–1488

    MeSH term(s) Contrast Media/standards ; Europe ; Humans ; Ultrasonography/standards ; Ultrasonography/trends ; United States
    Chemical Substances Contrast Media
    Language English
    Publishing date 2011-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-011-2240-y
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  8. Article ; Online: The impact of per diem senior pediatric radiologists in an academic setting.

    Markowitz, Richard I / Taylor, George A / Darge, Kassa

    Pediatric radiology

    2020  Volume 51, Issue 5, Page(s) 686–690

    MeSH term(s) Humans ; Pediatrics ; Radiologists
    Keywords covid19
    Language English
    Publishing date 2020-11-17
    Publishing country Germany
    Document type Editorial
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-020-04886-9
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  9. Article ; Online: Voiding urosonography: an additional important indication for use of US contrast agents.

    Darge, Kassa

    Radiology

    2011  Volume 259, Issue 2, Page(s) 614–5; author reply 615

    MeSH term(s) Albumins ; Carcinoma, Hepatocellular/diagnostic imaging ; Cholangiocarcinoma/diagnostic imaging ; Contrast Media ; Diagnosis, Differential ; Fluorocarbons ; Humans ; Image Enhancement ; Liver Neoplasms/diagnostic imaging ; Microbubbles ; Phospholipids ; Polysaccharides ; Sulfur Hexafluoride ; Ultrasonography, Interventional ; Vesico-Ureteral Reflux/diagnostic imaging
    Chemical Substances Albumins ; Contrast Media ; Definity ; FS 069 ; Fluorocarbons ; Phospholipids ; Polysaccharides ; contrast agent BR1 ; SHU 508 (127279-08-7) ; Sulfur Hexafluoride (WS7LR3I1D6)
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.11102479
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  10. Article ; Online: Cerebrospinal Fluid Flow Detection in Post-hemorrhagic Hydrocephalus With Novel Microvascular Imaging Modality.

    Hwang, Misun / Tierradentro-García, Luis Octavio / Kozak, Brandi L / Darge, Kassa

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2021  Volume 41, Issue 4, Page(s) 1013–1017

    Abstract: Cerebrospinal fluid flow dynamics serve as an important biomarker to guide medical and/or surgical intervention of hydrocephalus in infants. Imaging of cerebrospinal fluid flow can be assessed with magnetic resonance imaging, but routine evaluation is ... ...

    Abstract Cerebrospinal fluid flow dynamics serve as an important biomarker to guide medical and/or surgical intervention of hydrocephalus in infants. Imaging of cerebrospinal fluid flow can be assessed with magnetic resonance imaging, but routine evaluation is limited by practical challenges. We show for the first time that cerebrospinal fluid flow can be depicted using brain ultrasound by implementing highly sensitive ultrasound-based microvascular imaging technology (B-flow). This novel application could potentially expand the use of this technology beyond its current application in depiction of vascular flow pathologies in newborns.
    MeSH term(s) Brain ; Cerebrospinal Fluid ; Head ; Hemodynamics ; Humans ; Hydrocephalus/diagnostic imaging ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Case Reports
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.15781
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