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  1. Article ; Online: Editorial Comment.

    Darras, Frank S

    Urology practice

    2024  Volume 11, Issue 2, Page(s) 354–355

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000516.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial Commentary.

    Darras, Frank S

    Urology practice

    2023  Volume 10, Issue 1, Page(s) 81–82

    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Editorial
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000353.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence.

    Du, Chris / Waltzer, Wayne C / Wilusz, Jeremy E / Spaliviero, Massimiliano / Darras, Frank / Romanov, Victor

    Cancers

    2024  Volume 16, Issue 5

    Abstract: The current study aimed to elucidate the regulatory mechanisms of the circRNA hsa_circ_0139697 (circSTAG2(16-25)) in BCa and to consider the opportunity of using circSTAG2(16-25) isolated from BCa patient urine as a marker for disease development ... ...

    Abstract The current study aimed to elucidate the regulatory mechanisms of the circRNA hsa_circ_0139697 (circSTAG2(16-25)) in BCa and to consider the opportunity of using circSTAG2(16-25) isolated from BCa patient urine as a marker for disease development prediction. The selection of this circRNA was determined by the special role of its parental gene STAG2 in BCa biology. The circRNA hsa_circ_0139697 was chosen from 25 STAG2 circRNAs due to its differential expression in the urine of BCa patients and healthy volunteers. Higher levels of circSTAG2(16-25) were detected in urine samples obtained from patients with recurrent tumors. A higher expression of circSTAG2(16-25) was also detected in more tumorigenic BCa cell lines. The overexpression of circSTAG2(16-25) in BCa cells induced the elevation of proliferation, motility, and invasion. To study the mechanisms of circSTAG2(16-25) activity, we confirmed that circSTAG2(16-25) can bind miR-145-5p in vitro as was predicted by bioinformatic search. miR-145-5p was shown to suppress some genes that promoted BCa progression. One of these genes, TAGLN2, encodes the protein Transgelin 2, which plays a role in BCa cell motility and invasion. Therefore, the possible mechanism of action of circSTAG2(16-25) could be sponging the tumor suppressor miR-145-5p, which results in activation of TAGLN2. In addition, circSTAG2(16-25) might be considered as a potential biomarker for recurrence prediction.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Organoid model of urothelial cancer: establishment and applications for bladder cancer research.

    Whyard, Terry / Liu, Jingxuan / Darras, Frank S / Waltzer, Wayne C / Romanov, Victor

    BioTechniques

    2020  Volume 69, Issue 3, Page(s) 193–199

    Abstract: 3D cancer cell models are suitable for drug evaluation because they more precisely mimic tissue architecture than 2D cultures. To study cytotoxicity of anticancer agents, the most sensitive CellTiter-Glo 3D assay is used. However, this is an end point ... ...

    Abstract 3D cancer cell models are suitable for drug evaluation because they more precisely mimic tissue architecture than 2D cultures. To study cytotoxicity of anticancer agents, the most sensitive CellTiter-Glo 3D assay is used. However, this is an end point assay, so it is not possible to consider the variance of the starting material amount in the final reading. It is difficult to maintain an even plating density of 3D organoids for cytotoxicity analysis. We present a simple, 3D bladder cancer culture that can be maintained, cryopreserved and used for molecular and drug response studies. We applied a simple modification of the drug response assay for 3D cultures by measuring the background signal with the CellTiter Blue assay before drug application.
    MeSH term(s) Humans ; Organoids/pathology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Urothelium/pathology
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 48453-2
    ISSN 1940-9818 ; 0736-6205
    ISSN (online) 1940-9818
    ISSN 0736-6205
    DOI 10.2144/btn-2020-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Urologic considerations and complications in kidney transplant recipients.

    Di Carlo, Heather N / Darras, Frank S

    Advances in chronic kidney disease

    2015  Volume 22, Issue 4, Page(s) 306–311

    Abstract: Urologic considerations during the kidney transplantation process, starting with initial recipient evaluation and continuing through the post-transplant, long-term follow-up, are critical for minimizing urologic complications and improving graft survival. ...

    Abstract Urologic considerations during the kidney transplantation process, starting with initial recipient evaluation and continuing through the post-transplant, long-term follow-up, are critical for minimizing urologic complications and improving graft survival. Appropriate, targeted, preoperative urologic evaluation of the recipient allows for an optimized urinary tract to accept the graft, whereas post-transplant urologic follow-up and monitoring decrease the risk of graft lost secondary to a urologic cause, particularly in patients with a urologic reason for their kidney failure and in those patients with concomitant urologic diagnoses. Urologic complications comprise the second most common adverse post-transplant event, occurring in 2.5% to 14% of patients and are associated with high morbidity, graft loss, and mortality. Early and late urologic complications, including hematuria, hematoma, lymphocele, urine leak, ureteral stricture, nephrolithiasis, and vesicoureteral reflux, and their causes and treatment options are explored. A multidisciplinary team approach to kidney transplantation, including transplant surgery, urology, and nephrology, optimizes outcomes and graft survival. Although the current role of the urologist in kidney transplantation varies greatly by institution, appropriate consultation, participation, and monitoring in select patients is essential.
    MeSH term(s) Graft Survival ; Hematoma ; Hematuria ; Humans ; Kidney Transplantation ; Lymphocele ; Nephrolithiasis ; Postoperative Complications ; Preoperative Care ; Referral and Consultation ; Ureteral Obstruction ; Urologic Diseases ; Vesico-Ureteral Reflux
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2015.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes.

    Jones, Eyone / Mazirka, Pavel / McNurlan, Margaret A / Darras, Frank / Gelato, Marie C / Caso, Giuseppe

    World journal of virology

    2017  Volume 6, Issue 3, Page(s) 53–58

    Abstract: Aim: To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome.: Methods: Preadipocytes from healthy donors were assessed for proliferation and differentiation ... ...

    Abstract Aim: To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome.
    Methods: Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs) individually and in combination. Effects on proliferation were assessed with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and effects on differentiation were assessed from glycerol-3-phosphate dehydrogenase (GP DH) activity and quantitation of Oil Red O staining for intracellular lipid. Data were analyzed with a randomized block ANOVA with post-hoc Fisher's Least Significant Difference test.
    Results: Preadipocyte proliferation was inhibited by a combination of NNRTI + NRTI (14% at 48 h,
    Conclusion: Although combination antiretroviral therapy is clinically more efficacious than single drug regimens, it also has a much greater inhibitory effect on preadipocyte proliferation and differentiation.
    Language English
    Publishing date 2017-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2829019-7
    ISSN 2220-3249
    ISSN 2220-3249
    DOI 10.5501/wjv.v6.i3.53
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Renal Artery Pseudoaneurysm in Kawasaki Disease.

    Chen, Andrew / DeBartolo, Merrit / Darras, Frank / Ferretti, John / Wasnick, Robert

    Urology

    2016  Volume 98, Page(s) 165–166

    Abstract: Whereas coronary aneurysms are commonly associated with Kawasaki disease, involvement of the renal vasculature is exceedingly rare. Genitourinary involvement in patients with Kawasaki disease is typically limited to sterile pyuria and proteinuria. In ... ...

    Abstract Whereas coronary aneurysms are commonly associated with Kawasaki disease, involvement of the renal vasculature is exceedingly rare. Genitourinary involvement in patients with Kawasaki disease is typically limited to sterile pyuria and proteinuria. In this case, a 13-year-old girl who presented with right flank pain and microhematuria was found to have an intraparenchymal hemorrhagic mass on computerized tomography scan. Renal arteriography confirmed the diagnosis of pseudoaneurysm in a lower pole segmental artery branch and complete occlusion was achieved with endovascular embolization.
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2016.05.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 275: Show issues

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  8. Article: 5 Years Experience With Drug Eluting and Bare Metal Stents as Primary Intervention in Transplant Renal Artery Stenosis.

    Estrada, Chelsea C / Musani, Muzammil / Darras, Frank / Suh, Heesuck / Abate, Mersema T / Mani, Anil / Nord, Edward P

    Transplantation direct

    2017  Volume 3, Issue 2, Page(s) e128

    Abstract: Background: Transplant renal artery stenosis (TRAS) is a common vascular complication after kidney transplantation and is associated with refractory hypertension, volume overload, and graft injury or loss. This article describes 5-year outcomes of ... ...

    Abstract Background: Transplant renal artery stenosis (TRAS) is a common vascular complication after kidney transplantation and is associated with refractory hypertension, volume overload, and graft injury or loss. This article describes 5-year outcomes of endovascular intervention for TRAS with bare metal and drug eluting stents (DES).
    Methods: We investigated, as a prospective cohort study, patient and graft outcomes after the targeted use of DES for vessel diameter less than 5 mm and bare metal stents (BMS) for vessel diameter greater than 5 mm as the primary management for TRAS.
    Results: From March 2008 to November 2014, 57 patients were stented for hemodynamically significant TRAS; 29 received DES, 26 received BMS, and 2 patients received both stent types. They were followed up for a mean of 35.1 ± 22.8 months; a subset of these patients who all received DES were followed up for 61.7 ± 17.5 months. Mean serum creatinine declined from 2.87 ± 1.5 mg/dL at the time of intervention to 1.98 ± 0.76 mg/dL (
    Conclusions: Primary stenting with DES and BMS is both successful in the initial treatment of TRAS and also produced an immediate and long-term reduction in serum creatinine and systolic blood pressure.
    Language English
    Publishing date 2017-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000000643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Different Management Options for Transplant Ureteral Obstructions within an Inguinal Hernia.

    Cheung, Felix / Debartolo, Merrit Marion / Copertino, Leonard Michael / Szafran, April Adams / Estrada, Chelsea Caron / Lynch, Patrick Gerard / Darras, Frank Sam

    Case reports in transplantation

    2016  Volume 2016, Page(s) 4730494

    Abstract: Ureteral obstruction secondary to an inguinal hernia with transplant ureteral component is an extremely rare entity with only several case reports found in literature. In all previously reported cases, management of the obstruction involved temporary ... ...

    Abstract Ureteral obstruction secondary to an inguinal hernia with transplant ureteral component is an extremely rare entity with only several case reports found in literature. In all previously reported cases, management of the obstruction involved temporary drainage with ureteral stenting or nephrostomy tube placements followed by delayed definitive repair. We present two case reports, here one being the first one managed by immediate definitive repair via ureteral reimplant and herniorrhaphy and a second case by delayed definitive repair after percutaneous nephrostomy tube placement. Both patients continued to do well postoperatively with normalization of renal function on follow-up.
    Language English
    Publishing date 2016-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627657-4
    ISSN 2090-6951 ; 2090-6943
    ISSN (online) 2090-6951
    ISSN 2090-6943
    DOI 10.1155/2016/4730494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Partial nephrectomy for a large renal lymphatic malformation in a child presenting with hypertension.

    Lee, Wai / Vemulapalli, Praneeth / Miller, Frederick / Melquist, Jonathan / Lee, Thomas K / Darras, Frank S

    Journal of pediatric surgery

    2012  Volume 47, Issue 1, Page(s) e23–6

    Abstract: A 9-year-old girl had hypertension (systolic blood pressure of 125 mm Hg) noted at an annual well child visit. An ultrasound study demonstrated a large right renal cystic mass. A partial nephrectomy was performed. The surgical specimen was 9.7 × 9.4 × 6 ... ...

    Abstract A 9-year-old girl had hypertension (systolic blood pressure of 125 mm Hg) noted at an annual well child visit. An ultrasound study demonstrated a large right renal cystic mass. A partial nephrectomy was performed. The surgical specimen was 9.7 × 9.4 × 6.4 cm and weighed 413.2 g. The tumor stained diffusely positive for smooth muscle actin and focally positive for factor VIII. Final histologic diagnosis was primary intrarenal lymphatic malformation. The case is unusual because of the presentation, size of the mass, as well as the therapeutic approach of partial nephrectomy.
    MeSH term(s) Child ; Female ; Humans ; Hypertension/etiology ; Kidney ; Lymphatic Abnormalities/complications ; Lymphatic Abnormalities/diagnosis ; Lymphatic Abnormalities/surgery ; Nephrectomy/methods
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2011.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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