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  1. Book ; Online: NTM - The New Uber-Bugs

    Dartois, Veronique / Sizemore, Christine / Dick, Thomas

    2019  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; NTM ; Non-TB mycobacteria ; Non-tuberculous mycobacteria ; Environmental mycobacteria ; lung disease ; antimicrobial resistance
    Size 1 electronic resource (240 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230073
    ISBN 9782889630127 ; 2889630129
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease.

    Dartois, Véronique / Dick, Thomas

    Nature reviews. Drug discovery

    2024  Volume 23, Issue 5, Page(s) 381–403

    Abstract: Tuberculosis (TB) drug discovery and development has undergone nothing short of a revolution over the past 20 years. Successful public-private partnerships and sustained funding have delivered a much-improved understanding of mycobacterial disease ... ...

    Abstract Tuberculosis (TB) drug discovery and development has undergone nothing short of a revolution over the past 20 years. Successful public-private partnerships and sustained funding have delivered a much-improved understanding of mycobacterial disease biology and pharmacology and a healthy pipeline that can tolerate inevitable attrition. Preclinical and clinical development has evolved from decade-old concepts to adaptive designs that permit rapid evaluation of regimens that might greatly shorten treatment duration over the next decade. But the past 20 years also saw the rise of a fatal and difficult-to-cure lung disease caused by nontuberculous mycobacteria (NTM), for which the drug development pipeline is nearly empty. Here, we discuss the similarities and differences between TB and NTM lung diseases, compare the preclinical and clinical advances, and identify major knowledge gaps and areas of cross-fertilization. We argue that applying paradigms and networks that have proved successful for TB, from basic research to clinical trials, will help to populate the pipeline and accelerate curative regimen development for NTM disease.
    MeSH term(s) Humans ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/pharmacology ; Animals ; Drug Development/methods ; Tuberculosis/drug therapy ; Tuberculosis/microbiology ; Nontuberculous Mycobacteria/drug effects ; Drug Discovery ; Lung Diseases/drug therapy ; Lung Diseases/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-024-00897-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Shortening Tuberculosis Treatment - A Strategic Retreat.

    Dartois, Véronique / Rubin, Eric J

    The New England journal of medicine

    2023  Volume 388, Issue 10, Page(s) 939–941

    MeSH term(s) Humans ; Tuberculosis/drug therapy ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/therapeutic use ; Time Factors
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2300413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: A color atlas of comparative pathology of pulmonary tuberculosis

    Leong, F. Joel W.-M. / Dartois, Véronique / Dick, Thomas

    2011  

    Author's details ed. by Franz Joel Leong ; Veronique Dartois ; Thomas Dick
    Keywords Tuberculosis, Pulmonary / pathology ; Lung / pathology ; Mycobacterium tuberculosis ; Pathology, Veterinary
    Language English
    Size XIX, 216 S. : zahlr. Ill.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016384643
    ISBN 978-1-4398-3527-2 ; 1-4398-3527-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 5144 order for loan Magazin

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  5. Article ; Online: Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue.

    Dartois, Véronique / Dick, Thomas

    The Journal of experimental medicine

    2022  Volume 219, Issue 6

    Abstract: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated with multiple repurposed drugs. Chemotherapy is long and often toxic, includes parenteral drugs, and suffers from poor cure rates. There is an urgent need for more efficacious, tolerated, ...

    Abstract Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated with multiple repurposed drugs. Chemotherapy is long and often toxic, includes parenteral drugs, and suffers from poor cure rates. There is an urgent need for more efficacious, tolerated, and oral antibiotics optimized towards the treatment of NTM-PD, adapted to the spectrum of disease. In contrast to the empty NTM pipeline, drug development for the related tuberculosis lung disease has experienced a renaissance. Here, we argue that applying lessons learned from tuberculosis will facilitate the discovery of curative oral regimens for NTM-PD.
    MeSH term(s) Drug Development ; Humans ; Lung ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Pneumonia ; Tuberculosis
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20220445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anti-tuberculosis treatment strategies and drug development: challenges and priorities.

    Dartois, Véronique A / Rubin, Eric J

    Nature reviews. Microbiology

    2022  Volume 20, Issue 11, Page(s) 685–701

    Abstract: Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit ... ...

    Abstract Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit organizations, the drug candidate pipeline is promising. This exceptional success comes with the inherent challenge of prioritizing multidrug regimens for clinical trials and revamping trial designs to accelerate regimen development and capitalize on drug discovery breakthroughs. Most wanted are markers of progression from latent infection to active pulmonary disease, markers of drug response and predictors of relapse, in vitro tools to uncover synergies that translate clinically and animal models to reliably assess the treatment shortening potential of new regimens. In this Review, we highlight the benefits and challenges of 'one-size-fits-all' regimens and treatment duration versus individualized therapy based on disease severity and host and pathogen characteristics, considering scientific and operational perspectives.
    MeSH term(s) Animals ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Drug Discovery ; Drug Industry ; Mycobacterium tuberculosis ; Tuberculosis/drug therapy
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-022-00731-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A pairwise approach to revitalize β-lactams for the treatment of TB.

    Negatu, Dereje A / Aragaw, Wassihun Wedajo / Dartois, Véronique / Dick, Thomas

    Antimicrobial agents and chemotherapy

    2024  , Page(s) e0003424

    Abstract: The dual β-lactam approach has been successfully applied to overcome target redundancy in nontuberculous mycobacteria. Surprisingly, this approach has not been leveraged ... ...

    Abstract The dual β-lactam approach has been successfully applied to overcome target redundancy in nontuberculous mycobacteria. Surprisingly, this approach has not been leveraged for
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00034-24
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  8. Article ; Online: Rifampicin has no role in treatment of

    van Ingen, Jakko / Hoefsloot, Wouter / Dartois, Véronique / Dick, Thomas

    The European respiratory journal

    2024  Volume 63, Issue 5

    MeSH term(s) Humans ; Mycobacterium avium-intracellulare Infection/drug therapy ; Rifampin/therapeutic use ; Mycobacterium avium Complex/drug effects ; Anti-Bacterial Agents/therapeutic use ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Treatment Outcome
    Chemical Substances Rifampin (VJT6J7R4TR) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Letter ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02210-2023
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  9. Article ; Online: A Ginger Root or Plum Model for the Tuberculosis "Granuloma"?

    Dartois, Véronique / Dick, Thomas

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 5, Page(s) 505–507

    MeSH term(s) Zingiber officinale ; Granuloma ; Humans ; Prunus domestica ; Tuberculosis/diagnosis
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202104-1052ED
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  10. Article ; Online: Drug Sensitivity Testing of Mycobacterium tuberculosis Growing in a Hollow Fiber Bioreactor.

    Mason, A Brett / Dartois, Véronique

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2314, Page(s) 715–731

    Abstract: Hollow fiber systems (HFSs) have been widely applied to study pharmacokinetic-pharmacodynamic (PK-PD) relationships in antibiotic research and development. The system comprises a bundle of high-density hollow capillary fibers that conduct a flow of ... ...

    Abstract Hollow fiber systems (HFSs) have been widely applied to study pharmacokinetic-pharmacodynamic (PK-PD) relationships in antibiotic research and development. The system comprises a bundle of high-density hollow capillary fibers that conduct a flow of medium with or without drug and an extra-capillary space (ECS) inoculated with the pathogen of interest. The semipermeable membrane of the hollow fibers allows for rapid exchange of small molecule drugs and solutes, while the pathogen is restricted to the ECS. The unique properties of the HFS are (1) the ability to simulate any PK profile within the fibers and ECS, including plasma or site-of-disease PK profiles, (2) the ability to simultaneously input several drugs with different half-lives, (3) the ability to manipulate growth conditions such as medium composition, carbon source, and pH, and (4) the ability to sample in both compartments in order to monitor drug concentrations and bacterial growth kinetics over time. The system is particularly suited for Mycobacterium tuberculosis research in a biosafety level 3 (BSL3) environment since pathogenic bacteria are sequestered in an isolated compartment. The HFS was qualified by the European Medicines Agency for antituberculosis drug development in 2015. Here, we describe the standard procedures used to study the growth kinetics of M. tuberculosis in the HFS and the killing effect of first-line antituberculous drugs applied under simulated human PK conditions. This animal-sparing and economical tool can be applied to optimize dosing schedules that minimize emergence of resistance and to prioritize drug regimens that accelerate sterilization.
    MeSH term(s) Animals ; Antitubercular Agents/pharmacology ; Bioreactors ; Diagnostic Tests, Routine ; Drug Discovery/methods ; Drug Tolerance ; Humans ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/growth & development ; Pharmaceutical Preparations/administration & dosage ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1460-0_31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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