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Article ; Online: Regulation of oocyte maturation: Role of conserved ERK signaling.

Das, Debabrata / Arur, Swathi

2022 Volume 89, Issue 9, Page(s) 353–374

Abstract: During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for resuming meiosis, fertilization, and early embryonic development. Following this arrested period, oocytes resume meiosis in response to species-specific hormones, a ... ...

Abstract	During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for resuming meiosis, fertilization, and early embryonic development. Following this arrested period, oocytes resume meiosis in response to species-specific hormones, a process known as oocyte maturation, that precedes ovulation and fertilization. Involvement of endocrine and autocrine/paracrine factors and signaling events during maintenance of prophase I arrest, and resumption of meiosis is an area of active research. Studies in vertebrate and invertebrate model organisms have delineated the molecular determinants and signaling pathways that regulate oocyte maturation. Cell cycle regulators, such as cyclin-dependent kinase (CDK1), polo-like kinase (PLK1), Wee1/Myt1 kinase, and the phosphatase CDC25 play conserved roles during meiotic resumption. Extracellular signal-regulated kinase (ERK), on the other hand, while activated during oocyte maturation in all species, regulates both species-specific, as well as conserved events among different organisms. In this review, we synthesize the general signaling mechanisms and focus on conserved and distinct functions of ERK signaling pathway during oocyte maturation in mammals, non-mammalian vertebrates, and invertebrates such as Drosophila and Caenorhabditis elegans.
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Cyclin-Dependent Kinases/metabolism ; Drosophila ; Drosophila Proteins/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Hormones/metabolism ; Mammals ; Meiosis ; Oocytes/metabolism ; Oogenesis/physiology ; Phosphoric Monoester Hydrolases/metabolism ; Protein Kinases/metabolism ; Signal Transduction/physiology
Chemical Substances	Drosophila Proteins ; Hormones ; Protein Kinases (EC 2.7.-) ; Myt1 protein, Drosophila (EC 2.7.1.-) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
Language	English
Publishing date	2022-07-31
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.23637
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Article ; Online: Geochemical and health risk assessment of potentially toxic trace elements and nitrate via groundwater in agro-ecosystem of alluvial plain Punjab, India

, Karanveer / Bala, Ritu / Das, Debabrata

Human and Ecological Risk Assessment: An International Journal. 2022 Oct. 6, v. 28, no. 9 p.983-1011

2022

Abstract: Sporadic rainfall and limited surface water sources have increased dependency on groundwater in semi-arid region of Punjab. The present paper is comprehensive study carried out in an intensive agricultural region of southwest Punjab to examine the ... ...

Abstract	Sporadic rainfall and limited surface water sources have increased dependency on groundwater in semi-arid region of Punjab. The present paper is comprehensive study carried out in an intensive agricultural region of southwest Punjab to examine the quality and extent of contamination due to trace elements and nitrate in the aquifer system. Total 15 toxic elements are analyzed in groundwater samples (N = 129) covering both the shallow (<60 m) and deeper aquifers (>60 m). Elements such as As, B, Cd, Li, Mn, Pb, Sr, and Se exceed the prescribed limits. Overall, 68 and 13% of samples exceed the NO₃ ⁻ permissible limit (45 ppm) in shallow and deep aquifers, respectively. Contaminants concentration increases toward groundwater flow direction, that is, from northeast to southwest possibly due to arid climatic conditions. Relatively, shallow aquifer is more contaminated than deeper aquifer due to fertilizers input and irrigation return flow. Drinking water quality indices (DWQI) reveal that groundwater is unfit for drinking at most locations. Further, health risk indicate that comparatively, children are at higher risk in terms of non-carcinogenic risk posed by nitrate, and higher carcinogenic risk for As, Cr, and Cd is seen in all age groups. Multivariate analysis reveals the influence of anthropogenic activities on NO₃ ⁻, Mn, Ni, and Zn levels, while geogenic factors control the, As and Mo concentrations. Present findings suggest regular monitoring of wells to lower the public health risk.
Keywords	agroecosystems ; alluvial plains ; aquifers ; carcinogenicity ; drainage water ; environmental assessment ; groundwater ; groundwater flow ; health effects assessments ; humans ; irrigation ; multivariate analysis ; nitrates ; public health ; rain ; risk ; semiarid zones ; surface water ; water quality ; India ; Potentially toxic elements ; nitrate pollution ; agro-ecosystem ; geochemical and health risk assessment
Language	English
Dates of publication	2022-1006
Size	p. 983-1011.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1549-7860
DOI	10.1080/10807039.2022.2113734
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occurrence and behaviour of uranium in the groundwater and potential health risk associated in semi-arid region of Punjab, India

Bala, Ritu / Karanveer / Das, Debabrata

Groundwater for Sustainable Development. 2022 May, v. 17 p.100731-

2022

Abstract: Occurrence of uranium (U) in the groundwater of south-west Punjab is a matter of great concern due to the rise of contaminant levels at an alarming rate, its spatial and vertical variability and poor understanding of uranium mobility with depth. Present ... ...

Abstract	Occurrence of uranium (U) in the groundwater of south-west Punjab is a matter of great concern due to the rise of contaminant levels at an alarming rate, its spatial and vertical variability and poor understanding of uranium mobility with depth. Present study has been conducted to investigate the vertical extent of contamination and geochemical factors controlling U mobilization in the groundwater of semi-arid Punjab. Out of total 140 samples collected and analyzed, 76% samples have uranium levels greater than the chemical toxicity limit of World Health Organization (WHO, 30 μg.L⁻¹) and 34% samples have concentration higher than the radiological toxicity limit given by Atomic Energy Regulatory Board (AERB, 60 μg.L⁻¹). Water at shallow depth (<60 m) is found to be more contaminated than water at deeper depth (>60 m) and concentration lies in the range of 4.26–318.03 μg.L⁻¹. Spatial distribution graphs are used to identify the hotspots of contamination and concentration is higher in the flow direction of groundwater towards south-west. In both the aquifers, groundwater is alkaline and oxic in character with carbonate weathering as dominant hydrogeochemical process affecting chemical composition of water. Higher uranium concentration is seen in the oxidizing, alkaline and carbonate-rich water. Alkali earth metals (Na⁺ & K⁺) are also strongly correlated with the uranium in groundwater at both the levels. Use of environmental stable isotopes (δ¹⁸O & δ²H) shows the evaporation signature in both the aquifers. Health risk assessment is carried out and values higher than permissible limit give indication towards the health risk to the population exposed due to the consumption of uranium contaminated water from long time. This study provides a strong base for better understanding the source of uranium in the aquifer system of region and the results would be useful for further studies in quaternary alluvial aquifers of semi-arid regions.
Keywords	World Health Organization ; aquifers ; carbonates ; chemical composition ; evaporation ; groundwater ; health effects assessments ; hydrogeochemistry ; nuclear power ; risk ; semiarid zones ; sustainable development ; toxicity ; uranium ; India ; Stable isotope ; Human health risk ; Punjab ; AERB ; BDL ; Ca2+ ; Cl- ; cm ; EC ; HCO3- ; 2H ; K+ ; m ; mg.L-1 ; mg.kg-1 ; Mg2+ ; Na+ ; NO3- ; NW ; 18O ; ORP ; PO43- ; SO42- ; SW ; TDS ; U ; WHO ; μg.L−1
Language	English
Dates of publication	2022-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ISSN	2352-801X
DOI	10.1016/j.gsd.2022.100731
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Article ; Online: Biohydrogen production from starchy wastewater in upflow anaerobic sludge blanket (UASB) reactor: Possibilities toward circular bioeconomy

Mahata, Chandan / Dhar, Suman / Ray, Subhabrata / Das, Debabrata

Environmental Technology & Innovation. 20232023 May 02, Feb. 02, v. 30 p.103044-

2023

Abstract: The present study investigates the performance of upflow anaerobic sludge blanket (UASB) reactor for stable H2 production from starchy wastewater supplemented with groundnut de-oiled cake using mixed consortia. Insufficient reports are available on H2 ... ...

Abstract	The present study investigates the performance of upflow anaerobic sludge blanket (UASB) reactor for stable H2 production from starchy wastewater supplemented with groundnut de-oiled cake using mixed consortia. Insufficient reports are available on H2 production for UASB reactor. Operation of the UASB reactor was divided into two stages i.e., start-up period where desirable sludge height was developed and production period where different hydraulic retention time (HRT) was examined for H2 production. The maximum H2 production rate of 12.3 L L⁻¹ d⁻¹was observed at 3 h HRT. Details physicochemical characteristics of the granular sludge were studied using SEM-EDX image, FTIR spectra, particle size analyser, SVI value, EPS and metal content. Kinetic analysis of the process revealed that Grau, and modified Stover–Kincannon were the most suitable for H2 producing UASB reactor. This is the first report to implement these advanced bio-kinetic models of substrate consumption on hydrogen production in UASB reactor. Furthermore, a potential toward circular bioeconomy model has been discussed for the accomplishment of maximum resource recovery with a minimum waste generation.
Keywords	bioeconomics ; environmental technology ; hydrogen production ; kinetics ; models ; oilseed cakes ; particle size ; peanuts ; sludge ; upflow anaerobic sludge blanket reactor ; wastewater ; Upflow anaerobic sludge blanket (UASB) ; Dark fermentation ; Biohydrogen ; Sludge characterization ; Circular bioeconomy
Language	English
Dates of publication	2023-0202
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ISSN	2352-1864
DOI	10.1016/j.eti.2023.103044
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Raman Spectroscopic Characterization of Chemical Bonding and Phase Segregation in Tin (Sn)-Incorporated Ga

Das, Debabrata / Gutierrez, Guillermo / Ramana, C V

ACS omega

2023 Volume 8, Issue 13, Page(s) 11709–11716

Abstract: Using detailed Raman scattering analyses, the effect of tin (Sn) incorporation on the crystal structure, chemical bonding/inhomogeneity, and single-phase versus multiphase formation of gallium oxide ( ... ...

Abstract	Using detailed Raman scattering analyses, the effect of tin (Sn) incorporation on the crystal structure, chemical bonding/inhomogeneity, and single-phase versus multiphase formation of gallium oxide (Ga
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c05047
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Article: A Study on Clinico-Pathological Presentation and Management Prospective of Venolymphatic Malformation.

Das, Debabrata / Sardar, Subhadip / Nivetaa, R

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 1, Page(s) 687–694

Abstract: To evaluate the clinical perspective of Veno lymphatic malformation and definitive management in respect to outcome. (1) To discuss clinical presentation, symptomatology of Veno lymphatic malformation. (2) Demonstration of radiological features, ... ...

Abstract	To evaluate the clinical perspective of Veno lymphatic malformation and definitive management in respect to outcome. (1) To discuss clinical presentation, symptomatology of Veno lymphatic malformation. (2) Demonstration of radiological features, diagnosis and management of Veno lymphatic malformation with its complication. This prospective study was conducted on four patients attending ENT-OPD of R.G.Kar Medical College, Kolkata, India who had presented with suspected vascular malformation. The study was conducted from March 2021 to March 2023 for a period of 2 years. The patients were subjected to detailed history and examination. The diagnosis of the Veno lymphatic malformation was based on the results of Doppler ultrasonography, computed tomography and magnetic resonance imaging. In our study there was male predominance. Most of the patients belonged to the 2nd and 3rd decade of life. The main sites of involvement were lateral neck followed by parotid region. The lesion size ranged in between 3.5 × 3.5 cm and 7 × 5 cm. The patient with parotid lesion was found to have phlebolith. Since most of the lesions were small with well-defined margins, we were able to excise the lesions completely without leaving any residue. Out of four cases one patient developed temporary paresis of spinal accessory nerve which resolved eventually. Veno lymphatic malformations are rare and there is no definitive protocol for management and to be individualized. Our study will be helpful for furthering the existing knowledge regarding the management of Veno lymphatic lesion emphasizing the need of multimodality approach in surgical decision making.
Language	English
Publishing date	2023-10-14
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04253-8
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Article ; Online: One-Step Synthesis and Operando Electrochemical Impedance Spectroscopic Characterization of Heterostructured MoP-Mo

Attarzadeh, Navid / Lakshmi-Narayana, Ambadi / Das, Debabrata / Tan, Susheng / Shutthanandan, Vaithiyalingam / Ramana, C V

ACS applied materials & interfaces

2024 Volume 16, Issue 6, Page(s) 6958–6970

Abstract: This study presents a novel synthesis of self-standing MoP and ... ...

Abstract	This study presents a novel synthesis of self-standing MoP and Mo
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c14160
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Article ; Online: XoRehab: IoT Enabled Wheelchair based Lower Limb Rehabilitation System.

P, Jagan / Gvk, Sasirekha / Rao, Madhav / Bapat, Jyotsna / Das, Debabrata

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–5

Abstract: IoT in healthcare brought a technological revolution in rehabilitation, enabling the patients to get rehabilitation in the comfort of their home, while being supervised remotely by the professionals. IoT enabled rehabilitation ensures a best possible way ...

Abstract	IoT in healthcare brought a technological revolution in rehabilitation, enabling the patients to get rehabilitation in the comfort of their home, while being supervised remotely by the professionals. IoT enabled rehabilitation ensures a best possible way towards recovery, without inflicting further injuries. It also allows customization of rehabilitation plan based on the patient profile and progress, while helping in defining their personalised milestones. The main contribution of this paper is a novel wheelchair based IoT enabled 'XoRehab", exoskeleton for rehabilitation; a device for lower limb, with a backrest mechanism. This involves development of a well-trained robot based on electromechanical actuation with micro-controller and feedback system, which can replace the physical trainer or physiotherapist. This autonomous device will control speed of flexion and extension on patient's limbs to improve efficiency of the treatment. It also provides repetitive motion of flexion and extension. The edge system design to upload local rehabilitation data and logs to the cloud server is presented. We propose an opensource Elasticsearch Logstash Kibana (ELK) stack for providing the cloud services, which is a scalable solution. The design of the developed prototype has been discussed in detail along with the functional test results.Clinical Relevance- The introduction of well-trained exoskeleton in the rehabilitation process, gives a high level of performance in patient recovery, and it contributes to expeditious restoration of their joints and improvement in muscle and nerve system.
MeSH term(s)	Humans ; Robotics ; Exoskeleton Device ; Lower Extremity ; Wheelchairs
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340505
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Article: Complications of Thyroidectomy and Learning Curve for Thyroid Surgeons: An Institutional Experience.

Das, Debabrata / Gayen, Ganesh Chandra / Pradhan, Anurag / Maitra, Mainak

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 1, Page(s) 94–99

Abstract: To study the complications of thyroidectomy and the various methods to be followed in the intra and post-operative period to prevent complications. It is a prospective study of 5 years and 9 months duration from 1/1/2015 to 31/9/2020 done in a tertiary ... ...

Abstract	To study the complications of thyroidectomy and the various methods to be followed in the intra and post-operative period to prevent complications. It is a prospective study of 5 years and 9 months duration from 1/1/2015 to 31/9/2020 done in a tertiary care hospital. A total of 268 patients were included in this study. Adequate measures were taken intraoperatively to prevent any complications and the patients were observed post-operatively for development and management of any complications. The patients were followed up regularly. Out of the 268 thyroidectomies performed in our study following which 5 patients had hemorrhage, 19 patients had temporary recurrent laryngeal nerve dysfunction, 3 patients developed respiratory obstruction, 12 patients developed transient parathyroid insufficiency, 62 patients developed thyroid insufficiency,1 patient had permanent parathyroid insufficiency, permanent recurrent laryngeal nerve dysfunction was seen in 7 patients, 3 patients developed seroma formation, 7 patients developed post-operative hypertrophic scar and 3 developed keloid. Sound anatomical knowledge, meticulous surgical technique and effective protocol for the management of complication can reduce the postoperative morbidity of the patient.
Language	English
Publishing date	2023-01-29
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03480-3
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Book ; Conference proceedings: International Conference on Advances in Biohydrogen Production and Applications (ICABHPA - 2012),14 - 15 December 2012, Hyderabad, India

Das, Debabrata

(International journal of hydrogen energy : Special section ; 39.2014,14)

2014

Event/congress	ICABHPA (2012.12.14-15, Hyderabad) ; International Conference on Advances in Biohydrogen Production and Applications (2012.12.14-15, Hyderabad)
Author's details	guest ed.: Debabrata Das
Series title	International journal of hydrogen energy : Special section ; 39.2014,14
Language	English
Size	S 7467 - 7626
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Document type	Book ; Conference proceedings
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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