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Article: Autosomal Recessive Myotonia Congenita in an Adolescent Boy With Novel Mutation: A Case Report With Discussion on Management.

Das, Palash / Panigrahi, Debasis

2024 Volume 16, Issue 2, Page(s) e53981

Abstract: Congenital myotonia represents a rare group of genetically inherited conditions. It can be either autosomal dominant (Thomsen) or autosomal recessive (Becker). It is characterized by muscular hypertrophy, proximal weakness, and myotonia, or impaired ... ...

Abstract	Congenital myotonia represents a rare group of genetically inherited conditions. It can be either autosomal dominant (Thomsen) or autosomal recessive (Becker). It is characterized by muscular hypertrophy, proximal weakness, and myotonia, or impaired relaxation after contraction. These are due to mutations in the CLC1 gene. A 14-year-old male child presented with complaints of gradually progressive weakness for five years. Weakness was more pronounced in the proximal muscle groups. The weakness worsened after rest and improved with activity. This led to absenteeism and affected his school performance. Clinical examination showed generalized muscular hypertrophy with pronounced hypertrophy of the calf muscles. A neurological examination showed significant myotonia and impaired relaxation after making a fist. The diagnosis of myotonia was confirmed by electromyography, which produced a dive-bomber sound on insertion. Next-generation sequencing revealed a homozygous eight-base pair insertion in exon 19 of the CLCN1 gene. This mutation has not been reported in the existing literature for myotonia congenita. The child was started on mexiletine and improved significantly. Presently, the patient is on regular medications and doing well on follow-up. Though rare, congenital myotonia is an important cause of neuromuscular weakness. It can be easily diagnosed with a thorough clinical examination and routine testing for myotonia in all children with weakness. The treatment is relatively simple and can give the patient significant relief. Myotonia can be easily diagnosed clinically, and pharmacotherapy and proper monitoring can remarkably improve patients' quality of life.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53981
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Article: Analysis of thermomechanical stresses in dual compound thick cylinders under asymmetric loads: An analytical and numerical method.

Das, Palash / Islam, Md Ashraful / Mondal, Dipayan

Heliyon

2024 Volume 10, Issue 3, Page(s) e24938

Abstract: This study presents a 2D comprehensive analytical and numerical analysis of the thermomechanical stresses in an unsymmetric dual compound thick cylinder under steady-state conditions. By employing mathematical analysis, this research aims to investigate ... ...

Abstract	This study presents a 2D comprehensive analytical and numerical analysis of the thermomechanical stresses in an unsymmetric dual compound thick cylinder under steady-state conditions. By employing mathematical analysis, this research aims to investigate the effectiveness of a 2D compound cylinder in reducing elastic and thermoelastic stresses. The temperature and displacement fields are thought to be dependent on the radial and circumferential directions, subject to asymmetric thermal and mechanical boundary conditions on the inner and outer surfaces. In this scenario, the Poisson ratio is considered to be a constant. The techniques of variable separation and complex Fourier series are employed analytically in the solution of heat conduction and Navier equations. The results obtained from the developed analytical method are compared and validated against those obtained from a finite difference method (FDM). The findings of this study suggest that the clamping of the outer layer has a significant influence on stress distribution in the structure, and the impact of tangential stress on the behavior of a compound cylinder is highly dominant. Furthermore, changes in temperature significantly influence hoop stress compared to variations in internal pressure levels. Moreover, the influence of internal pressure is relatively attenuated when a pressure vessel is fabricated utilizing different metals. In addition, the findings indicated that the configuration of layers and the location of the highest temperature had a significant impact on the performance of the vessel. Nevertheless, the technology provided has sufficient robustness to effectively address the complexities associated with the design of multilayered graded materials (GM) in additive manufacturing applications.
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24938
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Article ; Online: Effect of megaloblastic anemia on hemoglobin A

Sahoo, Sulagna / Sahu, Nageswar / Das, Palash / Senapati, Urmila

Indian journal of pathology & microbiology

2023 Volume 66, Issue 2, Page(s) 327–331

Abstract: Context: β-thalassemia trait is usually diagnosed by raised hemoglobin A: Materials and methods: Cases of megaloblastic anemia with raised HbA: Results: There was a significant decrease in HbA: Conclusions: Megaloblastic anemia can lead to ... ...

Abstract	Context: β-thalassemia trait is usually diagnosed by raised hemoglobin A Materials and methods: Cases of megaloblastic anemia with raised HbA Results: There was a significant decrease in HbA Conclusions: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA
MeSH term(s)	Humans ; beta-Thalassemia/diagnosis ; Hemoglobin A2/analysis ; Anemia, Megaloblastic/diagnosis ; Vitamin B 12 ; Folic Acid
Chemical Substances	hemoglobin AS (52012-19-8) ; Hemoglobin A2 (9034-53-1) ; Vitamin B 12 (P6YC3EG204) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2023-04-18
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_233_21
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Article ; Online: Catastrophic costs for tuberculosis patients in India: Impact of methodological choices.

Chatterjee, Susmita / Das, Palash / Stallworthy, Guy / Bhambure, Gayatri / Munje, Radha / Vassall, Anna

PLOS global public health

2024 Volume 4, Issue 4, Page(s) e0003078

Abstract: As financial risk protection is one of the goals towards universal health coverage, detailed information on costs, catastrophic costs and other economic consequences related to any disease are required for designing social protection measures. End ... ...

Abstract	As financial risk protection is one of the goals towards universal health coverage, detailed information on costs, catastrophic costs and other economic consequences related to any disease are required for designing social protection measures. End Tuberculosis (TB) Strategy set a milestone of achieving zero catastrophic cost by 2020. However, a recent literature review noted that 7%-32% TB affected households in India faced catastrophic cost. Studies included in the review were small scale cross-sectional. We followed a cohort of 1482 notified drug-susceptible TB patients from four states in India: Assam, Maharashtra, Tamil Nadu, and West Bengal to provide a comprehensive picture of economic burden associated with TB treatment. Treatment cost was calculated using World Health Organization guidelines on TB patient cost survey and both human capital and output approaches of indirect cost (time, productivity, and income loss related to an episode) calculation were used to provide the range of households currently facing catastrophic cost. Depending on choice of indirect cost calculation method, 30%-61% study participants faced catastrophic cost. For over half of them, costs became catastrophic even before starting TB treatment as there was average 7-9 weeks delay from symptom onset to treatment initiation which was double the generally accepted delay of 4 weeks. During that period, they made average 8-11 visits to different providers and spent money on consultations, drugs, tests, and travel. Following the largest cohort of drug-susceptible TB patients till date, the study concluded that a significant proportion of study participants faced catastrophic cost and the proportion was much higher when income loss was considered as indirect cost calculation method. Therefore, ensuring uninterrupted livelihood during TB treatment is an absolute necessity. Another reason of high cost was the delay in diagnosis and costs incurred during pre-diagnosis period. This delay and consequently, economic burden, can be reduced by both supply side (intense private sector engagement, rapid diagnosis) and demand side (community engagement) initiatives. Reimbursement of expenses incurred before treatment initiation could be used as short-term measure for mitigating financial hardship.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0003078
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Article: Analytical and numerical (FEA) solution for steady-state heat transfer in generic FGM cylinder coated with two layers of isotropic material under convective-radiative boundary conditions.

Das, Palash / Islam, Md Ashraful / Mondal, Dipayan / Nazim, Md Sharier

Heliyon

2023 Volume 9, Issue 11, Page(s) e21725

Abstract: An investigation was carried out in order to develop an accurate analytical solution and a numerical (FEA) solution for steady-state heat transfer in a circular sandwich structure incorporated with convective-radiative boundary conditions. The ... ...

Abstract	An investigation was carried out in order to develop an accurate analytical solution and a numerical (FEA) solution for steady-state heat transfer in a circular sandwich structure incorporated with convective-radiative boundary conditions. The dimensional governing equations and boundary conditions were developed in the form of a 4th order algebraic equation, and then the solution was obtained using Ferrari's method. By solving for the roots of the quartic equation, we were able to determine the dimensionless temperature fields of the FG sandwich composite. The findings obtained utilizing the exact analytical solution for the FG sandwich composite under thermal loads were satisfactorily validated against those data obtained using the Galerkin finite element approximation. The impact of geometric and thermo-physical characteristics, such as Biot number
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21725
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Article ; Online: Journey of the tuberculosis patients in India from onset of symptom till one-year post-treatment.

Chatterjee, Susmita / Das, Palash / Shikhule, Aaron / Munje, Radha / Vassall, Anna

PLOS global public health

2023 Volume 3, Issue 2, Page(s) e0001564

Abstract: Historically, economic studies on tuberculosis estimated out-of-pocket expenses related to tuberculosis treatment and catastrophic cost, however, no study has yet been conducted to understand the post-treatment economic conditions of the tuberculosis ... ...

Abstract	Historically, economic studies on tuberculosis estimated out-of-pocket expenses related to tuberculosis treatment and catastrophic cost, however, no study has yet been conducted to understand the post-treatment economic conditions of the tuberculosis patients in India. In this paper, we add to this body of knowledge by examining the experiences of the tuberculosis patients from the onset of symptoms till one-year post-treatment. 829 adult drug-susceptible tuberculosis patients from general population and from two high risk groups: urban slum dwellers and tea garden families were interviewed during February 2019 to February 2021 at their intensive and continuation phases of treatment and about one-year post-treatment using adapted World Health Organization tuberculosis patient cost survey instrument. Interviews covered socio-economic conditions, employment status, income, out-of-pocket expenses and time spent for outpatient visits, hospitalization, drug-pick up, medical follow-ups, additional food, coping strategies, treatment outcome, identification of post-treatment symptoms and treatment for post-treatment sequalae/recurrent cases. All costs were calculated in 2020 Indian rupee (INR) and converted into US dollar (US$) (1 US$ = INR 74.132). Total cost of tuberculosis treatment since the onset of symptom till one-year post-treatment ranged from US$359 (Standard Deviation (SD) 744) to US$413 (SD 500) of which 32%-44% of costs incurred in pre-treatment phase and 7% in post-treatment phase. 29%-43% study participants reported having outstanding loan with average amount ranged from US $103 to US$261 during the post-treatment period. 20%-28% participants borrowed during post-treatment period and 7%-16% sold/mortgaged personal belongings. Therefore, economic impact of tuberculosis persists way beyond treatment completion. Major reasons of continued hardship were costs associated with initial tuberculosis treatment, unemployment, and reduced income. Therefore, policy priorities to reduce treatment cost and to protect patients from the economic consequences of the disease by ensuring job security, additional food support, better management of direct benefit transfer and improving coverage through medical insurances need consideration.
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0001564
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Article ; Online: Impact of COVID-19 restrictive measures on income and health service utilization of tuberculosis patients in India.

Chatterjee, Susmita / Das, Palash / Vassall, Anna

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 711

Abstract: Background: The nationwide lockdown (March 25 to June 8, 2020) to curb the spread of coronavirus infection had significant health and economic impacts on the Indian economy. There is limited empirical evidence on how COVID-19 restrictive measures may ... ...

Abstract	Background: The nationwide lockdown (March 25 to June 8, 2020) to curb the spread of coronavirus infection had significant health and economic impacts on the Indian economy. There is limited empirical evidence on how COVID-19 restrictive measures may impact the economic welfare of specific groups of patients, e.g., tuberculosis patients. We provide the first such evidence for India. Methods: A total of 291 tuberculosis patients from the general population and from a high-risk group, patients from tea garden areas, were interviewed at different time points to understand household income loss during the complete lockdown, three and eight months after the complete lockdown was lifted. Income loss was estimated by comparing net monthly household income during and after lockdown with prelockdown income. Tuberculosis service utilization patterns before and during the lockdown period also were examined. Household income loss, travel and other expenses related to tuberculosis drug pickup were presented in 2020 US dollars (1 US$ = INR 74.132). Results: 26% of households with tuberculosis patients in tea garden areas and 51% of households in the general population had zero monthly income during the complete lockdown months (April-May 2020). Overall income loss slowly recovered during July-August compared to April-May 2020. Approximately 7% of patients in the general population and 4% in tea garden areas discontinued their tuberculosis medicines because of the complete lockdown. Conclusion: Discontinuation of medicine will have an additional burden on the tuberculosis elimination program in terms of additional cases, including multidrug resistant tuberculosis cases. Income loss for households and poor restoration of income after the lockdown will likely have an impact on the nutrition of tuberculosis patients and families. Tuberculosis patients working in the informal sector were the worst affected group during the nationwide lockdown. This emphasizes that a policy priority must continue to protect those working in informal sectors from the economic consequences of such restrictive measures, including paid sick leave, additional food support, and direct benefit transfers. Alongside ensuring widespread access to COVID-19 vaccines, these policy actions remain pivotal in ensuring the well-being of those who are unfortunate enough to be living with tuberculosis.
MeSH term(s)	COVID-19/epidemiology ; COVID-19 Vaccines ; Communicable Disease Control ; Health Services ; Humans ; Income ; India/epidemiology ; Tea ; Tuberculosis/epidemiology
Chemical Substances	COVID-19 Vaccines ; Tea
Language	English
Publishing date	2022-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07681-z
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Article: Assessing the impacts of land use-land cover changes on direct surface runoff: a remote sensing approach in Khulna City.

Das, Palash Chandra / Esraz-Ul-Zannat, Md

Water science and technology : a journal of the International Association on Water Pollution Research

2022 Volume 85, Issue 10, Page(s) 3122–3144

Abstract: The increased risks of storm flood occurrences in large cities are the result of land use changes due to rapid urbanization. This study examines the influence of land use changes in Khulna City Corporation (KCC) area on surface runoff over a period of 15 ...

Abstract	The increased risks of storm flood occurrences in large cities are the result of land use changes due to rapid urbanization. This study examines the influence of land use changes in Khulna City Corporation (KCC) area on surface runoff over a period of 15 years, from 2005 to 2020. Land use-land cover (LULC) maps for 2005, 2010, 2015, and 2020 were created employing support vector machine (SVM)-based supervised image classification using time-series satellite data, and the surface runoff was determined using Soil Conservation Service-Curve Number model. The major land use change drivers of surface runoff were determined through a correlation analysis. Surface runoff was observed to follow a similar trend as that of impervious urban areas, which went up by 5.44% from 2005 to 2020 (17.00 mm increment in average runoff) and the opposite trend was found in vegetation land cover, which declined by 13.34% in areal extent throughout the study period. In comparison with other types of land use, surface runoff changes were most significantly associated with the changes in urban impervious areas and vegetation land use-land cover (LULC) class. In fast-growing cities across the world, and especially in developing nations, the results of this study may serve as a guide for urban storm flood management and urban planning efforts.
MeSH term(s)	Cities ; Environmental Monitoring/methods ; Remote Sensing Technology ; Soil ; Urbanization
Chemical Substances	Soil
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	764273-8
ISSN	1996-9732 ; 0273-1223
ISSN (online)	1996-9732
ISSN	0273-1223
DOI	10.2166/wst.2022.097
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Article ; Online: Minor Cross-Matching in the Diagnosis of Pneumococcal Hemolytic Uremic Syndrome in an 18-Month-Old Boy.

Routray, Suman Sudha / Tripathy, Sukanta / Das, Palash / Ray, Gopal Krushna

Laboratory medicine

2022 Volume 54, Issue 2, Page(s) 215–219

Abstract: In developing nations, limitations in diagnostic facilities act as a barrier for differentiation of hemolytic uremic syndrome (HUS) based on the etiology. A sick-looking 18-month-old boy presented to our hospital in Bhubaneswar, India, with clinical ... ...

Abstract	In developing nations, limitations in diagnostic facilities act as a barrier for differentiation of hemolytic uremic syndrome (HUS) based on the etiology. A sick-looking 18-month-old boy presented to our hospital in Bhubaneswar, India, with clinical signs and symptoms of left lobar pneumonia, abnormal hematological and renal parameters, no growth in blood culture, a negative direct antiglobulin test (DAT) result, and low complement levels. A rapid deterioration in his clinical condition necessitated intensive care support, blood transfusion, and renal replacement therapy (peritoneal dialysis and hemodialysis). Because his health care team suspected atypical HUS, therapeutic plasma exchange (TPE) was initiated as soon as possible. In the absence of a lectin panel, minor cross-matching confirmed T-antigen exposure. With a diagnosis of HUS induced by Streptococcus pneumoniae (sp-HUS), TPE was stopped immediately, and washed blood components were administered. Despite the aforementioned measures, the boy died of HUS on day 20 after presentation. This case emphasized the role of minor cross-matching in the detecting of polyagglutination in resolving the diagnostic dilemma of sp-HUS.
MeSH term(s)	Male ; Humans ; Infant ; Streptococcus pneumoniae ; Hemolytic-Uremic Syndrome/diagnosis ; Hemolytic-Uremic Syndrome/therapy ; Blood Grouping and Crossmatching ; Kidney ; Plasma Exchange
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	391758-7
ISSN	1943-7730 ; 0007-5027
ISSN (online)	1943-7730
ISSN	0007-5027
DOI	10.1093/labmed/lmac092
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Article ; Online: Hook Worm Infestation in a Neonate.

Praharaj, Dibya L / Mallick, Bipadabhanjan / Nath, Preetam / Das, Palash

Journal of pediatric gastroenterology and nutrition

2022 Volume 74, Issue 2, Page(s) e39

MeSH term(s)	Hookworm Infections ; Humans
Language	English
Publishing date	2022-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003284
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