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Article: Median effective dose of intranasal dexmedetomidine for satisfactory mask induction in children undergoing examination under anaesthesia for retinoblastoma - A prospective up and down sequential allocation study.

Subramanian, Shalini / Shetty, Deepa / Dudeja, Gagan / Das, Priyanka

2024 Volume 68, Issue 2, Page(s) 165–169

Abstract: Background and aims: Inhalational technique is used to induce anaesthesia in children without intravenous access. We aimed to determine the median effective dose (ED50) of intranasal dexmedetomidine to ensure satisfactory mask acceptance during ... ...

Abstract	Background and aims: Inhalational technique is used to induce anaesthesia in children without intravenous access. We aimed to determine the median effective dose (ED50) of intranasal dexmedetomidine to ensure satisfactory mask acceptance during inhalation induction in children with retinoblastoma undergoing examination under anaesthesia. Methods: A prospective sequential allocation study was conducted in children aged 1-60 months divided into Group A (1-18 months) and Group B (18-60 months). Children were administered dexmedetomidine intranasally as premedication. Sedation was assessed using the modified Observer Assessment of Alertness and Sedation Scale until induction. Successful mask acceptance was defined as a cooperative or asleep child during inhalational induction. The starting dose of dexmedetomidine was 1 µg/kg. The next dose varied by 0.2 µg/kg depending on the outcome of this case. According to the Dixon up-and-down method, the mean of midpoints of the failure-success sequence was calculated to obtain the ED50 values. Results: The ED50 of intranasal dexmedetomidine for satisfactory mask acceptance was 0.7 µg/kg (95% confidence interval [CI]: 0.54-0.86) in Group A (n = 23) and 0.96 µg/kg (95% CI: 0.83-1.08) in Group B (n = 25) ( Conclusion: ED50 was lower in children younger than 18 months than in older children. There was no difference in the time to discharge from the post-anaesthesia care unit despite the procedure being longer in smaller children.
Language	English
Publishing date	2024-01-29
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0019-5049
ISSN	0019-5049
DOI	10.4103/ija.ija_496_23
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Article ; Online: Supramolecular Nanostructures for the Delivery of Peptides in Cancer Therapy.

Das, Priyanka / N, Manasa / Singh, Nidhi / Datta, Pallab

The Journal of pharmacology and experimental therapeutics

2024 Volume 388, Issue 1, Page(s) 67–80

Abstract: Supramolecular nanostructured based delivery systems are emerging as a meaningful approach in the treatment of cancer, offering controlled drug release and improved therapeutic efficacy. The self-assembled structures can be small molecules, polymers, ... ...

Abstract	Supramolecular nanostructured based delivery systems are emerging as a meaningful approach in the treatment of cancer, offering controlled drug release and improved therapeutic efficacy. The self-assembled structures can be small molecules, polymers, peptides, or proteins, which can be used and functionalized to achieve tailored release and target specific cells, tissues, or organs. These structures can improve the solubility and stability of drugs having low aqueous solubility by encapsulating and protecting them from degradation. Alongside, peptides as natural biomolecules have gained increasing attention as potential candidates in cancer treatment because of their biocompatibility, low cytotoxicity, and high specificity toward tumor cells. The amino acid sequences in peptide molecules are tunable, efficiently controlling the morphology of peptide-based self-assembled nanosystems and offering flexibility to form supramolecular nanostructures (SNs). It is evident from the current literature that the supramolecular nanostructures based delivery of peptide for cancer treatment hold great promise for future cancer therapy, offering potential strategies for personalized medicine with improved patient outcomes. SIGNIFICANCE STATEMENT: This review focuses on fundamentals and various drug delivery mechanisms based on SNs. Different SN approaches and recent literature reviews on peptide delivery are also presented to the readers.
MeSH term(s)	Humans ; Peptides/chemistry ; Proteins ; Nanostructures/chemistry ; Drug Delivery Systems ; Amino Acid Sequence ; Pharmaceutical Preparations ; Neoplasms/drug therapy
Chemical Substances	Peptides ; Proteins ; Pharmaceutical Preparations
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.123.001698
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Article ; Online: Bis(dinitropyrazolyl)methanes spruced up with hydroxyl groups: high performance energetic salts with reduced sensitivity.

Bhatia, Prachi / Pandey, Krishna / Das, Priyanka / Kumar, Dheeraj

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 95, Page(s) 14110–14113

Abstract: With an aim to improve the overall physical stability of high-performing 3,5-dinitro-functionalised bispyrazolymethanes, a hydroxyl functionality was introduced at the fourth position to obtain 1,1'-methylenebis(3,5-dinitro- ... ...

Abstract	With an aim to improve the overall physical stability of high-performing 3,5-dinitro-functionalised bispyrazolymethanes, a hydroxyl functionality was introduced at the fourth position to obtain 1,1'-methylenebis(3,5-dinitro-1
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc04445a
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Article ; Online: Aperture-patch sandwich metasurface for magnetic field enhancement in 1.5 T MRI.

Das, Priyanka / Gupta, Jegyasu / Sikdar, Debabrata / Bhattacharjee, Ratnajit

Magnetic resonance imaging

2023 Volume 100, Page(s) 1–9

Abstract: Magnetic resonance imaging (MRI) is an increasingly popular non-invasive technique for clinical diagnosis. Signal-to-noise ratio (SNR) is a crucial performance metric of MRI, improvement of which can be exchanged for increased image resolution or ... ...

Abstract	Magnetic resonance imaging (MRI) is an increasingly popular non-invasive technique for clinical diagnosis. Signal-to-noise ratio (SNR) is a crucial performance metric of MRI, improvement of which can be exchanged for increased image resolution or decreased scan time. Besides the progress in various hardware and software techniques for improving SNR in MRI scanners, use of metasurfaces as accessories has recently shown potential towards enhancing SNR by boosting local magnetic field in the scanned volume. Magnetic field enhancement over a larger depth from the skin is essential for imaging of deeper tissues, which can be facilitated by a specifically designed metasurface. Here we present such a metasurface with complementary-type resonant structures on the two sides of a high-permittivity dielectric, which substantially increases magnetic flux density on the skin (forty-five fold) that decays down to unity at a depth of 95 mm from the skin. This results in boosting of SNR up to forty-fold on the skin in 1.5 T MRI, while keeping tissue heating below the safety limit. An original analytical approach is formulated to readily estimate the SNR enhancement factor of this metasurface. Using the designed metasurface as an accessory for MRI scanners could help making MRI scans more efficient and affordable.
MeSH term(s)	Magnetic Resonance Imaging/methods ; Magnetic Fields ; Signal-To-Noise Ratio ; Phantoms, Imaging
Language	English
Publishing date	2023-03-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2023.03.005
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Zs.A 1817: Show issues

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Article: De novo

Das, Basanta Kumar / Kumar, Vikash / Das, Priyanka / Nayak, Kausalya K

Frontiers in microbiology

2023 Volume 14, Page(s) 1247652

Abstract: Aeromonas ... ...

Abstract	Aeromonas hydrophila
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1247652
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Article ; Online: Neoadjuvant chemotherapy for locally advanced head and neck squamous cell carcinoma - Is it still relevant? A practice pattern survey among oncologists of India.

Bandyopadhyay, Anis / Goswami, Uddiptya / Ghosh, Poulomi / Das, Priyanka / Mandal, Srikrishna

Journal of cancer research and therapeutics

2023 Volume 19, Issue 5, Page(s) 1316–1323

Abstract: Objectives: Concurrent chemotherapy is the recommended treatment for locally advanced head and neck (H&N) squamous cell carcinoma, and neoadjuvant chemotherapy (NACT) is debated with a few special indications. NACT for advanced head and neck cancer has ... ...

Abstract	Objectives: Concurrent chemotherapy is the recommended treatment for locally advanced head and neck (H&N) squamous cell carcinoma, and neoadjuvant chemotherapy (NACT) is debated with a few special indications. NACT for advanced head and neck cancer has been studied in clinical trials for more than 2 decades without clear demonstration of the benefit for loco regional tumor control or overall patient survival. Its benefit remains controversial in the absence of clear evidence to define its role. However, there is widespread use of NACT among oncologists. We conducted an online survey to find out the frequency, pattern, prevalence, and aims for use of NACT in locally advanced head and neck cancers among radiation, medical, and surgical oncologists. Materials and methods: Oncologists across India who expressed interest to participate in our survey were asked to complete a short online questionnaire designed to identify the current practice pattern of NACT in head and neck cancer. A mobile app-based questionnaire was sent to 200 oncologists across the country to assess the pattern of NACT use and to solicit their most frequent therapy approach for patients with locoregionally advanced head and neck cancer. Results: One hundred and fifty (150) oncologists completed and returned the survey (75%), and 130 were finalized (94 radiation oncologists, 19 medical oncologists, and 17 surgical oncologists). The single most common treatment approach reported for patients with locoregionally advanced H&N cancer was that of sequential chemoradiation (61%), specifically NACT with the TPF regimen (78.5%), followed by radiation therapy. The primary objectives cited by respondents for the use of NACT included the desire to buy time for definitive treatment (20%) and to achieve R0 resection (19.2%). Use of NACT in most patients was more preferred by medical oncologists (21.1%) and radiation oncologists (19.1%) than surgical oncologists (11.8%). Thus, there is not much difference in perception in practice of NACT in radiation, medical, and surgical oncologists. A minimum of two cycles of NACT was preferred by more than half of the doctors (55.4%) with 59.6% radiation oncologists using it before further assessment. Conclusion: Although level I evidence for inferior outcomes with NACT as compared to concurrent chemoradiation therapy is there, the use of NACT is quite common among various oncologists in the country because of reasons such as buying time for definitive treatment, achieving R0 resection, better outcome and survival, partial response, better tolerability, better distant control, LN size regression, down-staging of primary tumor, selection of chemosensitive patients, reducing the volume of the radiation field, and better tolerability of subsequent Chemoradiation (CTRT) intensity of subsequent chemoradiation therapy.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck ; Neoadjuvant Therapy ; Head and Neck Neoplasms/drug therapy ; Surveys and Questionnaires ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Radiation Oncologists
Language	English
Publishing date	2023-10-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_821_22
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Article ; Online: Bolboceras krikkeni (Coleoptera: Geotrupidae: Bolboceratinae), a new species from India.

Gupta, Devanshu / Ghosh, Joyjit / DAS, Priyanka / Chandra, Kailash

Zootaxa

2022 Volume 5168, Issue 1, Page(s) 92–96

MeSH term(s)	Animal Distribution ; Animals ; Coleoptera ; India
Language	English
Publishing date	2022-07-20
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5168.1.8
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Article ; Online: Trunk picking from a truncating menu: Dry season forage selection by Asian elephant in a multi-use landscape.

Das, Priyanka / Kshettry, Aritra / Kumara, H N

PloS one

2022 Volume 17, Issue 7, Page(s) e0271052

Abstract: Elephants show a strong selection towards areas with high foraging opportunities at the landscape level making top-down decisions by first selecting patch types within landscapes and finally species within them. Understanding forage selection in a multi- ... ...

Abstract	Elephants show a strong selection towards areas with high foraging opportunities at the landscape level making top-down decisions by first selecting patch types within landscapes and finally species within them. Understanding forage selection in a multi-use landscape is critical for prioritising patches for habitat management, ensuring availability of selected forage, helping in minimizing pressure on food crops and subsequent negative interactions with people. We assessed dry season forage selection in a multi-use landscape of West Bengal state, India. Relative forage use and relative plant species availability ratio were calculated to assess forage selection in a multi-use landscape comprising of the forest, tea estates, agricultural land, and human settlement. Forage use was assessed using the opportunistic feeding trail observation method (150.01 km). Stratified random sampling was used to assess plant species availability using the quadrat method (123 plots of 0.1 ha each). Among 286 plant species recorded, 132 plant species were consumed by elephants. A majority (80.21%) of plant species were consumed more than the proportional availability thereby showing selective foraging during the dry season in the study area. From forest to semi-open forest and open forest, canopy layer tree density and the total number of species decreased whereas invasive species density increased. This indicates the high impact on the forage species availability for elephants and the requirement of appropriate habitat management strategies. The presence of 32.14% of the selected forage species in human-use landscape alone demands the development of conservation interventions. This is the first study to assess forage selection by elephants in a multi-use landscape and used to prioritise conservation and management strategies at a landscape level.
MeSH term(s)	Animals ; Crops, Agricultural ; Ecosystem ; Elephants ; Forests ; Humans ; Seasons
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271052
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Article ; Online: Micromorphological studies of the leaf and stem of Camellia sinensis (L.) Kuntze with reference to their taxonomic significance.

Das, Priyanka / Chettri, Vivek / Ghosh, Sandipan / Ghosh, Chandra

Microscopy research and technique

2022 Volume 86, Issue 4, Page(s) 465–472

Abstract: The micro-morphological examinations of the leaf lamina, petiole and stem for Camellia sinensis (L.) Kuntze (Theaceae) was carried out using a variety of microscopic techniques widely implemented in the area of medicine. The objective of this study was ... ...

Abstract	The micro-morphological examinations of the leaf lamina, petiole and stem for Camellia sinensis (L.) Kuntze (Theaceae) was carried out using a variety of microscopic techniques widely implemented in the area of medicine. The objective of this study was the micromorphological characterization of stem, petiole, lamina, stomata, leaf trichomes and other internal characters. The anatomical studies included the cross section of stem and leaf of Camellia sinensis thereby exhibiting a typical pattern of arrangement of tissues similar to woody plants. Some idioblastic sclereids like astrosclereids, osteosclereids were found in the medullary parenchyma of tea stem and leaf. Large numbers of sclereids were found mainly in the parenchymatous tissue of leaf petiole. Other micro-morphological features like trichomes, stomata, and different tissue layer were also recorded. The leaf trichomes were unicellular, long and densely present in the lower surface of immature leaf but a decrease in amount of trichomes was seen in the mature leaf making it a prime taxonomic feature of the tea leaf. The microscopic morphological analysis of the stem, petiole, lamina, stomata, leaf trichomes of Camellia sinensis can be used for its identification. In addition, these techniques can be further implemented for the taxonomic characterization thereby establishing a genetic relationship and solving taxonomic disputes in the field of plant systematics.
MeSH term(s)	Camellia sinensis ; Plant Leaves/anatomy & histology ; Trichomes/ultrastructure ; Tea
Chemical Substances	Tea
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.24287
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Article ; Online: Public sector engagement of private healthcare providers during the COVID-19 pandemic in Uttar Pradesh, India.

Meghani, Ankita / Hariyani, Shreya / Das, Priyanka / Bennett, Sara

PLOS global public health

2022 Volume 2, Issue 7, Page(s) e0000750

Abstract: The COVID-19 pandemic has strained public health resources and overwhelmed health systems capacity of countries worldwide. In India, the private sector is a significant source of healthcare particularly in large states like Uttar Pradesh (UP). This study ...

Abstract	The COVID-19 pandemic has strained public health resources and overwhelmed health systems capacity of countries worldwide. In India, the private sector is a significant source of healthcare particularly in large states like Uttar Pradesh (UP). This study sought to examine: (i) the government's approach to engaging the private health sector in the COVID-19 response in UP; (ii) the effects of government's engagement on private providers' practices and (iii) the barriers and facilitators to effective private sector engagement during the period. While the literature acknowledges weaknesses in private sector engagement during emergencies, our study provides deep empirical insight into how this occurs, drawing on the UP experience. We reviewed 102 Government of UP (GOUP) policy documents and conducted 36 in-depth interviews with government officials, technical partners, and private providers at district- and state-levels. We developed timelines for policy change based on the policy review and analyzed interview transcripts thematically using a framework analysis. We found that GOUP's engagement of the private sector and private providers' experiences varied substantially. While the government rapidly engaged and mobilized private laboratories, and enlisted private hospitals to provide COVID-19 services, it undertook only limited engagement of solo private providers who largely acted as referral units for suspected cases and reported data to support contact tracing efforts. Informal private providers played no formal role in the COVID-19 response, but in one district supported community-level contact tracing. Allopathic, alternative medicine, and diagnostic private providers faced common barriers and facilitators affecting their engagement relating to provider fear, communication, testing capacity, case reporting, and regulations. The establishment of mixed diagnostic networks during COVID-19 demonstrates the potential for public-private collaboration, however, our study also reveals missed opportunities to engage smaller-scale private health providers and establish mechanisms to effectively communicate and mobilize them during the pandemic, and beyond.
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0000750
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