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Book ; Online: Occupant's Behavior and Emotion Based Indoor Environment's Illumination Regulation

Das, Shreya

2023

Abstract: This paper presents an efficient approach for building occupancy modeling to reduce energy consumption. In this work, a novel approach to occupancy modeling based on the posture and comfort level of the occupant is developed, and subsequently, we report ... ...

Abstract	This paper presents an efficient approach for building occupancy modeling to reduce energy consumption. In this work, a novel approach to occupancy modeling based on the posture and comfort level of the occupant is developed, and subsequently, we report a new and efficient framework for detecting posture and emotion from skeleton joints and face points data respectively obtained from the Kinect sensor. The proposed approach is tested in terms of accuracy, region of convergence, and confusion matrix using several machine learning techniques. Out of all the techniques, random forest classifier gave the maximum blind test accuracy for multi-class classification of posture detection. Deep learning is used for emotion detection using several optimizers out of which Adadelta gave the maximum blind test accuracy for multi-class classification. Along with the Kinect sensor, several other sensors such as the magnetic door sensor, pyroelectric sensors, and illumination sensors are connected through a wireless network using Raspberry Pi Zero W. Thus creating an unmanned technique for illumination regulation.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	006
Publishing date	2023-02-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.

Das, Shreya / Preethi, B / Kushwaha, Sapana / Shrivastava, Richa

Histology and histopathology

2024 , Page(s) 18730

Abstract: Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatment. Alterations in gut microbial composition have emerged as a significant contributor to the pathophysiology of ... ...

Abstract	Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatment. Alterations in gut microbial composition have emerged as a significant contributor to the pathophysiology of multiple diseases. Recently, its association with muscle health has pointed to its potential role in mediating sarcopenia. The current review focuses on the association of gut microbiota and mediators of muscle health, connecting the dots between the influence of gut microbiota and their metabolites on biomarkers of sarcopenia. It further delineates the mechanism by which the gut microbiota affects muscle health with progressing age, aiding the formulation of a multi-modal treatment plan involving nutritional supplements and pharmacological interventions along with lifestyle changes compiled in the review. Nutritional supplements containing proteins, vitamin D, omega-3 fatty acids, creatine, curcumin, kefir, and ursolic acid positively impact the gut microbiome. Dietary fibres foster a conducive environment for the growth of beneficial microbes such as
Language	English
Publishing date	2024-03-06
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-730
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Article ; Online: Limestone and yellow gypsum can reduce cadmium accumulation in groundnut (Arachis hypogaea): A study from a three-decade old landfill site.

Das, Shreya / Sengupta, Sudip / Patra, Prasanta Kumar / Dey, Pradip

Chemosphere

2024 Volume 353, Page(s) 141645

Abstract: Cadmium (Cd) toxicity has cropped up as an important menace in the soil-plant system. The use of industrial by-products to immobilise Cd in situ in polluted soils is an interesting remediation strategy. In the current investigation, two immobilizing ... ...

Abstract	Cadmium (Cd) toxicity has cropped up as an important menace in the soil-plant system. The use of industrial by-products to immobilise Cd in situ in polluted soils is an interesting remediation strategy. In the current investigation, two immobilizing amendments of Cd viz., Limestone (traditionally used) and Yellow gypsum (industrial by-product) have been used through a green-house pot culture experiment. Soil samples were collected from four locations based on four graded levels of DTPA extractable Cd as Site 1 (0.43 mg kg
MeSH term(s)	Arachis ; Cadmium/analysis ; Cadmium/toxicity ; Calcium Carbonate ; Calcium Sulfate ; Pentetic Acid ; Soil ; Soil Pollutants/analysis ; Soil Pollutants/toxicity ; Waste Disposal Facilities
Chemical Substances	Cadmium (00BH33GNGH) ; Calcium Carbonate (H0G9379FGK) ; Calcium Sulfate (WAT0DDB505) ; Pentetic Acid (7A314HQM0I) ; Soil ; Soil Pollutants
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141645
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Article ; Online: Degradable Polymer-Based Nanoassemblies for Precise Targeting and Drug Delivery to Breast Cancer Cells without Affecting Normal Healthy Cells.

Santra, Subrata / Das, Shreya / Dey, Sananda / Sengupta, Arunima / Giri, Biplab / Molla, Mijanur Rahaman

Biomacromolecules

2024 Volume 25, Issue 3, Page(s) 1724–1737

Abstract: Stimuli-responsive amphiphilic polymers are known to be precursors to forming promising nanoarchitectonics with tunable properties for application in biomedical sciences. Currently, self-immolative polymers are widely recognized as an emerging class of ... ...

Abstract	Stimuli-responsive amphiphilic polymers are known to be precursors to forming promising nanoarchitectonics with tunable properties for application in biomedical sciences. Currently, self-immolative polymers are widely recognized as an emerging class of responsive materials with excellent degradability, which is one of the crucial criteria for designing a robust drug delivery vehicle. Here, we design an amphiphilic polyurethane endowed with a redox-responsive self-immolative linker and a pH-responsive tertiary amine on the backbone, which forms entropy-driven nanoscale supramolecular assemblies (average hydrodynamic diameter ∼110 nm) and is programmed to disassemble in a redox environment (GSH) due to the degradation of the polymer in a self-immolative fashion. The nanoassembly shows efficient drug sequestration and release in a controlled manner in response to glutathione (10 mM). The tertiary amine residing on the surface of the nanoassembly becomes protonated in the tumor microenvironment (pH ∼ 6.4-6.8) and generates positively charged nanoassembly (ζ-potential = +36 mV), which enhances the cancer cell-selective cellular uptake. The biological evaluation of the drug-loaded nanoassembly revealed triple-negative breast cancer (MDAMB-231) selective internalization and cell death while shielding normal cells (RBCs or PBMCs) from off-targeting toxicity. We envision that polyurethane with a redox-responsive self-immolative linker might open up new opportunities for a completely degradable polyurethane-based nanocarrier for drug delivery and diagnosis applications.
MeSH term(s)	Humans ; Female ; Polymers/chemistry ; Polyurethanes/chemistry ; Breast Neoplasms/drug therapy ; Drug Delivery Systems ; Glutathione ; Amines ; Drug Carriers/chemistry ; Drug Liberation ; Tumor Microenvironment
Chemical Substances	Polymers ; Polyurethanes ; Glutathione (GAN16C9B8O) ; Amines ; Drug Carriers
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c01232
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Article ; Online: Tumor acidity-induced surface charge modulation in covalent nanonetworks for activated cellular uptake: targeted delivery of anticancer drugs and selective cancer cell death.

Santra, Subrata / Das, Shreya / Sengupta, Arunima / Molla, Mijanur Rahaman

Biomaterials science

2023 Volume 11, Issue 16, Page(s) 5549–5559

Abstract: A β-thioester and tertiary amine based covalently cross-linked nanoassembly coined as a nanonetwork (NN) endowed with dual pH responsive features (tumor acidity induced surface charge modulation and endosomal pH triggered controlled degradation) has been ...

Abstract	A β-thioester and tertiary amine based covalently cross-linked nanoassembly coined as a nanonetwork (NN) endowed with dual pH responsive features (tumor acidity induced surface charge modulation and endosomal pH triggered controlled degradation) has been designed and synthesized for stable sequestration and sustained release of drug molecules in response to endosomal pH. An amphiphile integrated with tertiary amine and acrylate (ATA) functionalities was synthesized to fabricate the nanonetwork. This amphiphile showed entropically driven self-assembly and micellar nanostructures (nanoassemblies), which can sequester hydrophobic drug molecules at neutral pH. To further stabilize the nanoassemblies and the sequestered drug molecules even below its critical aggregation concentration (CAC), the micellar core was cross-linked
MeSH term(s)	Humans ; Delayed-Action Preparations ; Reproducibility of Results ; Nanoparticles/chemistry ; Antineoplastic Agents/pharmacology ; Doxorubicin/chemistry ; Micelles ; Cell Death ; Acrylates ; Hydrogen-Ion Concentration ; Drug Carriers ; Drug Delivery Systems ; Neoplasms/drug therapy
Chemical Substances	Delayed-Action Preparations ; Antineoplastic Agents ; Doxorubicin (80168379AG) ; Micelles ; Acrylates ; Drug Carriers
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00491k
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Article ; Online: Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cell.

Jena, Shipra Kanti / Das, Shreya / Chakraborty, Shreeta / Ain, Rupasri

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10978

Abstract: Trophectoderm cells of the blastocyst are the precursor of the placenta that is comprised of trophoblast, endothelial and smooth muscle cells. Since trophoectoderm cells are epithelial in nature, epithelial mesenchymal transition (EMT) of trophoblast ... ...

Abstract	Trophectoderm cells of the blastocyst are the precursor of the placenta that is comprised of trophoblast, endothelial and smooth muscle cells. Since trophoectoderm cells are epithelial in nature, epithelial mesenchymal transition (EMT) of trophoblast stem (TS) cells might play pivotal role in placental morphogenesis. However, the molecular regulation of EMT during placental development and trophoblast differentiation still remained elusive. In this report, we sought to identify the molecular signature that regulates EMT during placental development and TS cell differentiation in mice. On E7.5 onwards the TS cells, located in the ectoplacental cone (EPC), rapidly divide and differentiate leading to formation of placenta proper. Using a real time PCR based array of functional EMT transcriptome with RNA from mouse implantation sites (IS) on E7.5 and E9.5, it was observed that there was an overall reduction of EMT gene expression in the IS as gestation progressed from E7.5 to E9.5 albeit the levels of EMT gene expression were substantial on both days. Further validation of array results using real time PCR and western blot analysis showed significant decrease in EMT-associated genes that included (a) transcription factors (Snai2, Zeb1, Stat3 and Foxc2), (b) extracellular matrix and cell adhesion related genes (Bmp1, Itga5, Vcan and Col3A1), (c) migration and motility- associated genes (Vim, Msn and FN1) and (d) differentiation and development related genes (Wnt5b, Jag1 and Cleaved Notch-1) on E9.5. To understand whether EMT is an ongoing process during placentation, the EMT-associated signatures genes, prevalent on E 7.5 and 9.5, were analysed on E12.5, E14.5 and E17.5 of mouse placenta. Interestingly, expression of these EMT-signature proteins were significantly higher at E12.5 though substantial expressions was observed in placenta with progression of gestation from mid- to late. To evaluate whether TS cells have the potential to undergo EMT ex vivo, TS cells were subjected to EMT induction, which was confirmed using morphological analysis and marker gene expression. Induction of EMT in TS cells showed similar gene expression profile of placental EMT. These results have broad biological implications, as inadequate mesenchymal transition leading to improper trophoblast-vasculogenic mimicry leads to placental pathophysiology and pregnancy failure.
MeSH term(s)	Pregnancy ; Female ; Animals ; Mice ; Trophoblasts/metabolism ; Placenta/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Placentation/genetics ; Cell Differentiation/genetics ; Stem Cells
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37977-2
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Article ; Online: Whole exome sequencing, clinical exome or targeted gene panels: what to choose for suspected lethal skeletal dysplasia (short rib thoracic dysplasia type IV).

Das, Shreya / Sharma, Charu / Gothwal, Meenakshi / Tada, Nayan

BMJ case reports

2022 Volume 15, Issue 9

Abstract: Lethal skeletal dysplasias (SDs) are a heterogeneous group of rare but important genetic disorders characterised by abnormal growth and development of bone and cartilage. The phenotypic variation of SD highlights the complex aetiology for this group of ... ...

Abstract	Lethal skeletal dysplasias (SDs) are a heterogeneous group of rare but important genetic disorders characterised by abnormal growth and development of bone and cartilage. The phenotypic variation of SD highlights the complex aetiology for this group of disorders. Short rib polydactyly syndrome (SRPS) types I-IV are a group of rare congenital autosomal recessive types of SD.We report a case of a non-consanguineous couple whose two successive pregnancies were diagnosed with multiple congenital anomalies in fetuses suggestive of lethal SD (likely SRPS type IV) at 24 and 19 weeks period of gestation, respectively. Pregnancy was terminated, and the whole exome sequencing of the abortus for genetic analysis in the second pregnancy confirmed an autosomal recessive type of short rib thoracic dysplasia-4 (SRTD-4) also called SRPS in homozygous condition. Our case is unique as it was also associated with cystic hygroma which is a rare association with SRPS/SRTD-4.
MeSH term(s)	Exome/genetics ; Female ; Humans ; Pregnancy ; Ribs/diagnostic imaging ; Short Rib-Polydactyly Syndrome ; Ultrasonography, Prenatal ; Whole Exome Sequencing
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-251118
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Book ; Online: Resolving Left-Right Ambiguity During Bearing Only Tracking of an Underwater Target Using Towed Array

Das, Shreya / Tiwari, Ranjeet Kumar / Bhaumik, Shovan

2023

Abstract: In bearing only tracking using a towed array, the array can sense the bearing angle of the target but is unable to differentiate whether the target is on the left or the right side of the array. Thus, the traditional tracking algorithm generates tracks ... ...

Abstract	In bearing only tracking using a towed array, the array can sense the bearing angle of the target but is unable to differentiate whether the target is on the left or the right side of the array. Thus, the traditional tracking algorithm generates tracks in both the sides of the array which create difficulties when interception is required. In this paper, we propose a method based on likelihood of measurement which along with the estimators can resolve left-right ambiguity and track the target. A case study has been presented where the target moves (a) in a straight line with a near constant velocity, (b) maneuvers with a turn, and observer takes a `U'-like maneuver. The method along with the various estimators has been applied which successfully resolves the ambiguity and tracks the target. Further, the tracking results are compared in terms of the root mean square error in position and velocity, bias norm, \% of track loss and the relative execution time. Comment: 6 pages, 10 figures, correspondence paper
Keywords	Electrical Engineering and Systems Science - Signal Processing
Publishing date	2023-02-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Tracking an Underwater Target with Unknown Measurement Noise Statistics Using Variational Bayesian Filters

Das, Shreya / Kumar, Kundan / Bhaumik, Shovan

2023

Abstract: This paper considers a bearings-only tracking problem using noisy measurements of unknown noise statistics from a passive sensor. It is assumed that the process and measurement noise follows the Gaussian distribution where the measurement noise has an ... ...

Abstract	This paper considers a bearings-only tracking problem using noisy measurements of unknown noise statistics from a passive sensor. It is assumed that the process and measurement noise follows the Gaussian distribution where the measurement noise has an unknown non-zero mean and unknown covariance. Here an adaptive nonlinear filtering technique is proposed where the joint distribution of the measurement noise mean and its covariance are considered to be following normal inverse Wishart distribution (NIW). Using the variational Bayesian (VB) method the estimation technique is derived with optimized tuning parameters i.e, the confidence parameter and the initial degree of freedom of the measurement noise mean and the covariance, respectively. The proposed filtering technique is compared with the adaptive filtering techniques based on maximum likelihood and maximum aposteriori in terms of root mean square error in position and velocity, bias norm, average normalized estimation error squared, percentage of track loss, and relative execution time. Both adaptive filtering techniques are implemented using the traditional Gaussian approximate filters and are applied to a bearings-only tracking problem illustrated with moderately nonlinear and highly nonlinear scenarios to track a target following a nearly straight line path. Two cases are considered for each scenario, one when the measurement noise covariance is static and another when the measurement noise covariance is varying linearly with the distance between the target and the ownship. In this work, the proposed adaptive filters using the VB approach are found to be superior to their corresponding adaptive filters based on the maximum aposteriori and the maximum likelihood at the expense of higher computation cost. Comment: 24 pages, 26 figures
Keywords	Electrical Engineering and Systems Science - Signal Processing ; Electrical Engineering and Systems Science - Systems and Control
Subject code	310
Publishing date	2023-05-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Appraisal of environmental, ecological and carcinogenic risk due to heavy metals in a sewage and solid waste contaminated area

Das, Shreya / Sengupta, Sudip / Patra, Prasanta Kumar / Acharjee, Pravat Utpal / Pal, Susanta Kumar

Soil and Sediment Contamination: An International Journal. 2023 July 04, v. 32, no. 5 p.591-614

2023

Abstract: Unsystematic use of city waste, sludge and sewage water in agricultural fields elevated the heavy metal load in soil warranting critical introspection. The present study aims to delineate heavy metals in polluted soils of peri-urban Kolkata, determine ... ...

Abstract	Unsystematic use of city waste, sludge and sewage water in agricultural fields elevated the heavy metal load in soil warranting critical introspection. The present study aims to delineate heavy metals in polluted soils of peri-urban Kolkata, determine pollution and ecological risk, assess the heavy metal uptake and human dietary risk in commonly cultivated crops. Total 36 sampling points were selected and paired sampling of soil and crops were done. Significant available heavy metal (mg kg-1) in surface soil like Cd (0.72-3.76), Pb (28.59-87.29), Ni (3.11-8.73), and Cr (2.23-8.43) and in crops as Cd (0.55-2.73), Pb (2.82-29.85), Ni (2.45-8.27) and Cr (0.80-6.85) was observed. Use of machine learning revealed soil pH and organic carbon as the influencing factors of heavy metal contamination. Moderate to considerable environmental and ecological risk was observed. Substantial carcinogenic risk was observed as Cd (1.13x10-3 to 3.77x10-4), Pb (2.75x10-4 to 3.47x10-5), Ni (1.15x10-3 to 1.73x10-4), and Cr (2.78x10-4 to 1.18x10-4), for almost all crops, with a general trend of spinach > cabbage > radish > red amaranthus > bottle gourd > maize. The results can serve as the baseline information to enforce policy decisions for solving this conundrum of managing waste and saving human lives.
Keywords	Amaranthus ; Lagenaria siceraria ; cabbage ; carcinogenicity ; corn ; heavy metals ; humans ; issues and policy ; municipal wastewater ; organic carbon ; radishes ; risk ; sediment contamination ; sewage ; sludge ; soil pH ; solid wastes ; spinach ; Toxic heavy metals ; paired soil-crop sampling ; machine learning ; spatial mapping ; target cancer risk ; pollution indices
Language	English
Dates of publication	2023-0704
Size	p. 591-614.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2017739-2
ISSN	1549-7887 ; 1532-0383
ISSN (online)	1549-7887
ISSN	1532-0383
DOI	10.1080/15320383.2022.2112651
Database	NAL-Catalogue (AGRICOLA)

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