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Article ; Online: Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes.

Das, Soma / Behera, Padmanava / Shewale, Dipeshwari J / Bodele, Janhavi / Das, Saumitra / Karande, Anjali A

2024 Volume 169, Issue 5, Page(s) 112

Abstract: Previously, we reported a neutralizing monoclonal antibody, A8A11, raised against a novel conserved epitope within the hepatitis C virus (HCV) E2 protein, that could significantly reduce HCV replication. Here, we report the nucleotide sequence of A8A11 ... ...

Abstract	Previously, we reported a neutralizing monoclonal antibody, A8A11, raised against a novel conserved epitope within the hepatitis C virus (HCV) E2 protein, that could significantly reduce HCV replication. Here, we report the nucleotide sequence of A8A11 and demonstrate the efficacy of a single-chain variable fragment (scFv) protein that mimics the antibody, inhibits the binding of an HCV virus-like particle to hepatocytes, and reduces viral RNA replication in a cell culture system. More importantly, scFv A8A11 was found to effectively restrict the increase of viral RNA levels in the serum of HCV-infected chimeric mice harbouring human hepatocytes. These results suggest a promising approach to neutralizing-antibody-based therapeutic interventions against HCV infection.
MeSH term(s)	Hepacivirus/immunology ; Hepacivirus/genetics ; Hepacivirus/physiology ; Single-Chain Antibodies/immunology ; Single-Chain Antibodies/genetics ; Hepatocytes/virology ; Hepatocytes/immunology ; Animals ; Humans ; Epitopes/immunology ; Mice ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Virus Internalization ; Hepatitis C/virology ; Hepatitis C/immunology ; Antibodies, Neutralizing/immunology ; Virus Replication ; Antibodies, Monoclonal/immunology
Chemical Substances	Single-Chain Antibodies ; Epitopes ; Viral Envelope Proteins ; glycoprotein E2, Hepatitis C virus (157184-61-7) ; Antibodies, Neutralizing ; Antibodies, Monoclonal
Language	English
Publishing date	2024-04-29
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-024-06024-4
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Article: Real-world evidence of glycemic control among patients with type 2 diabetes mellitus in India: the TIGHT study.

Borgharkar, Surendra S / Das, Soma S

BMJ open diabetes research & care

2019 Volume 7, Issue 1, Page(s) e000654

Abstract: Objective: To determine glycemic control in adult patients with type 2 diabetes receiving antidiabetic therapy as part of routine healthcare in India.: Research design and methods: This was a retrospective analysis of cross-sectional data of patients ...

Abstract	Objective: To determine glycemic control in adult patients with type 2 diabetes receiving antidiabetic therapy as part of routine healthcare in India. Research design and methods: This was a retrospective analysis of cross-sectional data of patients with type 2 diabetes receiving oral hypoglycemic agents (OHAs) with or without insulin between 2015 and 2017. We assessed proportion of patients with uncontrolled glycemia and performed logistic regression to evaluate its association with various risk factors and microvascular complications. Results: A total of 55 639 eligible records were identified; mean age of patients was 54.31 (±11.11) years. One-third of the study population had microvascular complications, predominantly neuropathy. Nearly 76.6% of patients had uncontrolled glycated hemoglobin (HbA1c) ≥7% (53 mmol/mol); 62% of these patients had HbA1c between 7% and 8% (53-64 mmol/mol). Glycemic control from combination of OHAs with or without insulin varied between 14.2% and 24.8%. In multivariate analysis, factors statistically associated with uncontrolled glycemia were obesity (OR: 1.15), hypertension (stage I OR: 1.65 and stage II OR: 2.73) and diabetes duration >5 years (OR: 1.19) (p<0.001). Similarly, the odds of having any microvascular complication increased with duration of diabetes (past 1-2 years, OR: 1.67; 2-5 years, OR: 2.53; >5 years, OR: 4.01; p<0.0001), hypertension (stage I, OR: 1.18 and stage II, OR: 1.34; p<0.05) and uncontrolled HbA1c (OR: 1.28; p<0.0001). Conclusions: Indian population with type 2 diabetes has a high burden (76.6%) of poor glycemic control. This study highlights the need for early implementation of optimum diabetes pharmacotherapy to maintain recommended glycemic control, thereby reducing burden of microvascular complications.
MeSH term(s)	Aged ; Biomarkers/analysis ; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/chemically induced ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/epidemiology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/analysis ; Humans ; Hyperglycemia/chemically induced ; Hyperglycemia/diagnosis ; Hyperglycemia/epidemiology ; Hypoglycemia/chemically induced ; Hypoglycemia/diagnosis ; Hypoglycemia/epidemiology ; Hypoglycemic Agents/adverse effects ; Incidence ; India/epidemiology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
Language	English
Publishing date	2019-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732918-5
ISSN	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2019-000654
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrafast carrier dynamics in 2D-2D hybrid structures of functionalized GO and CdSe nanoplatelets.

Das, Soma / Dutta, Avisek / Bera, Rajesh / Patra, Amitava

Physical chemistry chemical physics : PCCP

2019 Volume 21, Issue 28, Page(s) 15568–15575

Abstract: Considerable attention has been paid to designing graphene based 2D hybrid nanostructures for their potential applications in various areas from healthcare to energy harvesting. Herein, we have prepared 2D-2D hybrid structures of 2D CdSe nanoplatelets ( ... ...

Abstract	Considerable attention has been paid to designing graphene based 2D hybrid nanostructures for their potential applications in various areas from healthcare to energy harvesting. Herein, we have prepared 2D-2D hybrid structures of 2D CdSe nanoplatelets (NPLs) with thiol (-SH) functionalized reduced graphene oxide (G-Ph-SH). Microscopic and spectroscopic studies reveal that the G-Ph-SH surface is successfully decorated by CdSe NPLs through a thiophenol (-SH) linker. The significant photoluminescence quenching (65%) and the shortening of decay time from 1 ns to 0.4 ns of CdSe NPLs are observed after adding 100 μg of G-Ph-SH. Furthermore, the femto-second transient absorption spectroscopic (fs-TAS) study reveals that the growth time of CdSe NPLs in the composite is reduced to 0.4 ps from 0.8 ps due to faster hot electron cooling. A faster component of 1.4 ps in the kinetic parameters of the composite system further suggests that the ultrafast electron transfer occurs from the conduction band of CdSe NPLs to surface functionalized reduced graphene oxide. This type of 2D-2D hybrid structure may open up new possibilities in light harvesting applications.
Language	English
Publishing date	2019-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c9cp02823d
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Article ; Online: RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System.

Raheja, Harsha / Das, Soma / Banerjee, Anindita / P, Dikshaya / C, Deepika / Mukhopadhyay, Debanjan / Ramachandra, Subbaraya G / Das, Saumitra

Microbiology spectrum

2022 Volume 10, Issue 4, Page(s) e0078122

Abstract: The emergence and evolution of SARS-CoV-2 is characterized by the occurrence of diverse sets of mutations that affect virus characteristics, including transmissibility and antigenicity. Recent studies have focused mostly on spike protein mutations; ... ...

Abstract	The emergence and evolution of SARS-CoV-2 is characterized by the occurrence of diverse sets of mutations that affect virus characteristics, including transmissibility and antigenicity. Recent studies have focused mostly on spike protein mutations; however, SARS-CoV-2 variants of interest (VoI) or concern (VoC) contain significant mutations in the nucleocapsid protein as well. To study the relevance of mutations at the virion level, recombinant baculovirus expression system-based virus-like particles (VLPs) were generated for the prototype Wuhan sequence along with spike protein mutants like D614G and G1124V and the significant RG203KR mutation in nucleocapsid. All four structural proteins were assembled in a particle for which the morphology and size, confirmed by transmission electron microscopy, closely resembled that of the native virion. The VLP harboring RG203KR mutations in nucleocapsid exhibited augmentation of humoral immune responses and enhanced neutralization by immunized mouse sera. Results demonstrate a noninfectious platform to quickly assess the implication of mutations in structural proteins of the emerging variant.
MeSH term(s)	Animals ; COVID-19/virology ; Coronavirus Nucleocapsid Proteins/genetics ; Mice ; Mutation ; Phosphoproteins/genetics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus ; Virion/genetics
Chemical Substances	Coronavirus Nucleocapsid Proteins ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00781-22
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Article ; Online: Exome sequencing identifies PD-L2 as a potential predisposition gene for lymphoma.

Shao, Jianming / Gao, Lei / Leung, Marco L / Gallinger, Bailey / Inglese, Cara / Meyn, M Stephen / Del Gaudio, Daniela / Das, Soma / Li, Zejuan

Hematological oncology

2022 Volume 40, Issue 3, Page(s) 475–478

Abstract: To investigate germline predisposition in lymphoma, we performed whole-exome sequencing and discovered a novel variant (c.817-1G>T) in programmed cell death 1 ligand 2 (PD-L2) in a family with early-onset lymphomas and other cancers. The variant was ... ...

Abstract	To investigate germline predisposition in lymphoma, we performed whole-exome sequencing and discovered a novel variant (c.817-1G>T) in programmed cell death 1 ligand 2 (PD-L2) in a family with early-onset lymphomas and other cancers. The variant was present in the proband with follicular lymphoma and his son with Hodgkin's lymphoma. It was in the terminal splice acceptor site of PD-L2 and embedded in a putative enhancer of Janus kinase 2 (JAK2) and programmed cell death 1 ligand (PD-L1). We also found that gene expression of PD-L2, PD-L1, and JAK2 was significantly increased. Using 3' rapid amplification of cDNA ends (3' RACE), we detected an abnormal PD-L2 transcript in the son. Thus, the c.817-1G>T variant may result in the elevated PD-L2 expression due to the abnormal PD-L2 transcript and the elevated PD-L1 and JAK2 expression due to increased enhancer activity of PD-L1 and JAK2. The PD-L2 novel variant likely underlies the genetic etiology of the lymphomas in the family. As PD-L2 plays critical roles in tumor immunity, identification of PD-L2 as a germline predisposition gene may inform personalized immunotherapy in lymphoma patients.
MeSH term(s)	B7-H1 Antigen/genetics ; Exome ; Genetic Predisposition to Disease ; Humans ; Ligands ; Lymphoma/genetics ; Programmed Cell Death 1 Ligand 2 Protein/genetics ; Whole Exome Sequencing
Chemical Substances	B7-H1 Antigen ; Ligands ; PDCD1LG2 protein, human ; Programmed Cell Death 1 Ligand 2 Protein
Language	English
Publishing date	2022-05-29
Publishing country	England
Document type	Letter
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.3033
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Article ; Online: Expedited evaluation of hereditary hematopoietic malignancies in the setting of stem cell transplantation.

Roloff, Gregory W / Kosuri, Satyajit / Nawas, Mariam T / DuVall, Adam S / Patel, Anand A / Riedell, Peter A / Odenike, Olatoyosi / Stock, Wendy / Larson, Richard A / Bishop, Michael R / Nunley, Emma / Godley, Lucy A / Hathaway, Feighanne / Del Gaudio, Daniela / Das, Soma / Canham, Lorraine E / Drazer, Michael W

Haematologica

2024

Abstract: Not available. ...

Abstract	Not available.
Language	English
Publishing date	2024-04-11
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284584
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Article: Quality-by-design approach for development of sustained-release multiple-unit beads of lamotrigine based on ion-cross-linked composite of pectin and okra mucilage: An in vitro appraisal

Das, Soma / Ghosh, Ananya / Changder, Abhijit / Nandi, Gouranga / Ghosh, Lakshmi Kanta

International journal of biological macromolecules. 2020 Nov. 15, v. 163

2020

Abstract: The main objective of the present study was to develop a sustained release multiple-unit beads of lamotrigine based on ionotropically cross-linked natural polysaccharides such as pectin (PTN) and okra mucilage (OM) and optimize the polymer-concentration, ...

Abstract	The main objective of the present study was to develop a sustained release multiple-unit beads of lamotrigine based on ionotropically cross-linked natural polysaccharides such as pectin (PTN) and okra mucilage (OM) and optimize the polymer-concentration, polymer ratio and cross-linker concentration by 2³ full factorial design. Two different levels of three independent variables (total polymer concentration, polymer ratio and [CaCl₂]) were considered for the experimental design. Drug-polymers compatibility was examined by FTIR, DSC, TGA and powder-XRD. The surface morphology of the bead before and after dissolution test was examined by SEM. Effects of the independent variables on bead-size, drug-encapsulation-efficiency (DEE), drug-release along with release similarity and difference factors were examined. The independent variables were then numerically optimized using Design-Expert software (Version 12) with the targets to meet USP-reference release profile after the analysis of variance of all the response parameters such as DEE, percent drug release at 2 h, 5 h, 12 h, Korsmeyer-Peppas rate constant, release similarity and difference factors. The optimized formulation showed excellent DEE of 89.2 ± 4.4% and a sustained release profile with release similarity factor of 94.9. Kinetic modeling of drug release data demonstrated a release mechanism combined of hydration, diffusion and erosion.
Keywords	analysis of variance ; computer software ; crosslinking ; drugs ; experimental design ; mucilages ; okra ; pectins ; polymers
Language	English
Dates of publication	2020-1115
Size	p. 842-853.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.07.033
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Article: Potato starch-derived almond-shaped carbon nanoparticles for non enzymatic detection of sucrose

Das, Soma / Saha, Mitali

Carbon. 2015 Nov., v. 93

2015

Abstract: We report the formation of almond-shaped carbon nanoparticles (ASCNs) from peeled potatoes and the fabrication of a highly sensitive and a selective non enzymatic sucrose sensor based on this carbon nanoparticle electrode. The potato was pyrolyzed ... ...

Abstract	We report the formation of almond-shaped carbon nanoparticles (ASCNs) from peeled potatoes and the fabrication of a highly sensitive and a selective non enzymatic sucrose sensor based on this carbon nanoparticle electrode. The potato was pyrolyzed initially at 400–500°C in vacuum, followed by slow heating at around 800°C, which produces the ASCNs. The ASCNs were examined by SEM, XRD, EDX and AFM and were further characterized by fluorescence microscopy, which clearly suggested their fluorescent nature. Electrochemical detection of sucrose was examined by cyclic voltammetry, differential pulse voltammetry and linear sweep voltammetry in an acidic solution. The new sensor shows a good response towards the sucrose oxidation, with a wide linear range (R2 = 0.99679), a high sensitivity of ∼41.73725±0.01μAM-1cm-2 and a low detection limit of 1μmol/L. Moreover, it is also stable and has a short response time (9s).[New Carbon Materials 2015, 30(3): 244–251]
Keywords	atomic force microscopy ; carbon nanoparticles ; electrochemistry ; electrodes ; energy-dispersive X-ray analysis ; fluorescence ; fluorescence microscopy ; heat ; oxidation ; potatoes ; scanning electron microscopy ; sucrose ; X-ray diffraction
Language	English
Dates of publication	2015-11
Size	p. 1086.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0008-6223
DOI	10.1016/j.carbon.2015.06.049
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Article: Synthesis of carbon nanosheet from barley and its use as non-enzymatic glucose biosensor.

Das, Soma / Saha, Mitali

Journal of pharmaceutical analysis

2014 Volume 4, Issue 6, Page(s) 351–359

Abstract: In this work, carbon nanosheet (CNS) based electrode was designed for electrochemical biosensing of glucose. CNS has been obtained by the pyrolysis of barley at 600-750 °C in a muffle furnace; it was then purified and functionalized. The CNS has been ... ...

Abstract	In this work, carbon nanosheet (CNS) based electrode was designed for electrochemical biosensing of glucose. CNS has been obtained by the pyrolysis of barley at 600-750 °C in a muffle furnace; it was then purified and functionalized. The CNS has been characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Raman spectroscopic techniques. The electrochemical activity of CNS-based electrode was investigated by linear sweep voltammetry (LSV) and square wave voltammetry (SWV), for the oxidation of glucose in 0.001 M H
Language	English
Publishing date	2014-04-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2630174-X
ISSN	2095-1779
ISSN	2095-1779
DOI	10.1016/j.jpha.2014.03.004
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Article ; Online: Clinical exome sequencing: the new standard in genetic diagnosis.

Gomez, Christopher M / Das, Soma

JAMA neurology

2014 Volume 71, Issue 10, Page(s) 1215–1216

MeSH term(s)	Cerebellar Ataxia/genetics ; Exome/genetics ; Female ; Humans ; Male ; Sequence Analysis, DNA
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2014.2015
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