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Article ; Online: Chitosan-Decorated PLGA-NPs Loaded with Tannic Acid/Vitamin E Mitigate Colon Cancer via the NF-κB/β-Cat/EMT Pathway.

Nag, Sayoni / Das Saha, Krishna

ACS omega

2021 Volume 6, Issue 43, Page(s) 28752–28769

Abstract: Colon cancer is the second highest contributor of cancer-related deaths throughout the world. Treatment strategies with tannic acid and vitamin E are envisaged as desirable and safe owing to their robust antioxidative and anti-inflammatory potential. In ... ...

Abstract	Colon cancer is the second highest contributor of cancer-related deaths throughout the world. Treatment strategies with tannic acid and vitamin E are envisaged as desirable and safe owing to their robust antioxidative and anti-inflammatory potential. In the present report, these bioactives have been nanoencapsulated in poly(d,l-lactide-
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c03477
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Article: Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model.

Saha, Moumita / Manna, Krishnendu / Das Saha, Krishna

Journal of inflammation research

2022 Volume 15, Page(s) 3235–3258

Abstract: Background: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet- ... ...

Abstract	Background: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet-induced NASH in the murine model by modulating NLRP3 mediated inflammation. P2X7R-mediated inflammasome activation is reported in several inflammatory models including NASH. Objective: The role of MLT in P2X7R-mediated inflammation in the NASH model has not yet been explored. The present study investigated the role of MLT in amending high-fat diet-induced nonalcoholic steatohepatitis in the murine liver. Methods: To evaluate the hepatological changes, mice were divided into four groups to investigate the improvement potential of this MLT (10 and 20 mg/kg) and to assess the experimental findings. Histology, biochemical assays, ELISA, FACS analysis, Western blotting, and IF were performed to assess the physical and molecular changes upon melatonin treatment. Results: The result demonstrated that MLT administration reduced HFD (high-fat diet)-induced non-alcoholic steatohepatitic indices, which successively restored the hepatic morphological architecture and other pathophysiological features too. Moreover, the application of MLT suppressed HFD-induced activation of the inflammasome and through TLR4/NF-κB signaling. Herein, we report that MLT significantly suppresses P2X7R expression and calcium influx along with inflammasome in both in vitro and in vivo. The docking study revealed a strong binding affinity of MLT with P2X7R. Moreover, the results also showed that the Nrf2 level was boosted which may normalize the expression of antioxidant proteins that safeguard against oxidative damage triggered by inflammation. Furthermore, some matrix metalloproteinases like MMP 2 and MMP 9 were repressed and TIMP-1 level was increased, which also signifies that MLT could improve liver fibrosis in this model. Conclusion: Based on our findings, this study may conclude that MLT could be used as a therapeutic agent in the high-fat diet-induced NASH model as it has persuasive anti-inflammatory potential.
Language	English
Publishing date	2022-05-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S343236
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Article ; Online: Quercetin and 5-Fu Loaded Chitosan Nanoparticles Trigger Cell-Cycle Arrest and Induce Apoptosis in HCT116 Cells via Modulation of the p53/p21 Axis.

Das, Sanjib / Saha, Moumita / Mahata, Lokesh Chandra / China, Arya / Chatterjee, Niloy / Das Saha, Krishna

ACS omega

2023 Volume 8, Issue 40, Page(s) 36893–36905

Abstract: Nanoparticles (NPs) are encapsulating agents that exist in the nanometer range. They can be classified into different classes based on their properties, shapes, or sizes. Metal NPs, fullerenes, polymeric NPs, ceramic NPs, and luminescent nanoporous ... ...

Abstract	Nanoparticles (NPs) are encapsulating agents that exist in the nanometer range. They can be classified into different classes based on their properties, shapes, or sizes. Metal NPs, fullerenes, polymeric NPs, ceramic NPs, and luminescent nanoporous hybrid materials are only a few examples. This study explored the anticancer potential of quercetin and 5-fluorouracil-encapsulated chitosan nanoparticles (CS-5-FU-QCT NPs). The nanoparticles were prepared by ionic gelation, and their efficacy and mechanism of action were examined. CS-5-FU-QCT NPs were characterized using dynamic light scattering (DLS), atomic force microscopy (AFM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR); cytotoxicity was analyzed using an MTT assay. Cells were treated with CS-5-FU-QCT NPs and incubated for 12, 24, and 36 h, and apoptosis analysis (using Annexin V/FITC), cell-cycle analysis, Western blotting, and confocal microscopic analysis were performed. Biophysical analysis revealed that the CS-5-FU-QCT NPs fall in the range of 300-400 nm with a near-spherical shape. The i
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03933
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Article: Leishmania donovani infection induce Extracellular signal-regulated kinase ½ (ERK½) mediated lipid droplet generation in macrophages

Banerjee, Somenath / Bose, Dipayan / Das, Subhadip / Chatterjee, Nabanita / Mishra, Snehasish / Das Saha, Krishna

Molecular immunology. 2022 Jan., v. 141

2022

Abstract: Recently unfolded mechanisms showed lipid droplet helps in pathogen survival and paralyzes host immune response. In the present study, we showed the extent of lipid droplet(LD) generation in Leishmania donovani infection, the signaling involved, and ... ...

Abstract	Recently unfolded mechanisms showed lipid droplet helps in pathogen survival and paralyzes host immune response. In the present study, we showed the extent of lipid droplet(LD) generation in Leishmania donovani infection, the signaling involved, and their function concerning pathogenicity. RAW 264.7 and J774A.1 cells were used to infect with L. donovani and then flow cytometry and confocal microscopy were used to detect lipid droplet generation and subsequent assays. In this study, we showed that L. donovani AG83 (AG83/MHOM/1983) triggers lipid droplet formation in macrophages in a time-dependent manner. We provide novel insight into the signaling molecules which is responsible for LD accumulation. Interestingly, LPG deficient attenuated Leishmania strain UR6 (UR6/MHOM/1978) failed to fuel LD generation. But inhibition of phagosome maturation drastically stimulates LD accumulation in UR6 infected MΦs. Aspirin treatment in AG83 infected MΦs does not only lower LD load but also favors phagolysosome biogenesis and corrects cytokine balance. Employing strategies to circumvent halt in phagosome maturation using drugs that manipulate lipid droplet generation could be used as a therapeutic tool to resist parasite growth in the early hour of infection.
Keywords	Leishmania donovani ; aspirin ; biogenesis ; confocal microscopy ; cytokines ; droplets ; flow cytometry ; immune response ; lipids ; macrophages ; mitogen-activated protein kinase ; parasites ; pathogen survival ; pathogenicity ; phagosomes ; therapeutics
Language	English
Dates of publication	2022-01
Size	p. 328-337.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2021.12.008
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Article: Host P2X7R-p38MAPK axis mediated intra-macrophage leishmanicidal activity of Spergulin-A

Mukherjee, Niladri / Banerjee, Saswati / Amin, Sk. Abdul / Jha, Tarun / Datta, Sriparna / Das Saha, Krishna

Experimental parasitology. 2022 Oct., v. 241

2022

Abstract: Current drugs are inefficient for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani. Regrettably, there is no plant-origin antileishmanial drug present. P2X₇R is constitutively present on macrophage ... ...

Abstract	Current drugs are inefficient for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani. Regrettably, there is no plant-origin antileishmanial drug present. P2X₇R is constitutively present on macrophage surfaces and can be a putative therapeutic target in intra-macrophage pathogens with function attributes towards inflammation, host cell apoptosis, altered redox, and phagolysosomal maturation by activating p₃₈MAPK. Here we demonstrated that the initial interaction of Spergulin-A (Sp A), a triterpenoid saponin with RAW 264.7 macrophages was mediated through P2X₇R involving the signaling cascade intermediates Ca⁺⁺, p₃₈MAPK, and NF-κβ. Phospho (P)-p38MAPK involvement is shown to have specific and firm importance in leishmanial killing with increased NF-κβp65. Phago-lysosomal maturation by Sp A also campaigns for another contribution of P2X₇R. In vivo evaluation of the anti-leishmanial activity of Sp A was monitored through expression analyses of P2X₇R, P-p38MAPK, and NF-κβp65 in murine spleen and bone-marrow macrophages and supported Sp A being a natural compound of leishmanicidal functions which acted through the P2X₇R-p38MAPK axis.
Keywords	Leishmania donovani ; antileishmanial properties ; apoptosis ; bone marrow ; drugs ; immunosuppression ; inflammation ; macrophages ; mice ; parasitology ; spleen ; therapeutics ; triterpenoid saponins ; visceral leishmaniasis
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2022.108365
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Article ; Online: Host P2X

Mukherjee, Niladri / Banerjee, Saswati / Amin, Sk Abdul / Jha, Tarun / Datta, Sriparna / Das Saha, Krishna

Experimental parasitology

2022 Volume 241, Page(s) 108365

Abstract	Current drugs are inefficient for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani. Regrettably, there is no plant-origin antileishmanial drug present. P2X
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Leishmania donovani/metabolism ; Leishmaniasis, Visceral/drug therapy ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; Receptors, Purinergic P2X7/metabolism ; Signal Transduction ; Spleen/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Carrier Proteins ; Receptors, Purinergic P2X7 ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2022.108365
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Article: Manjari Medika Grape Seed Extract Protects Methotrexate-Induced Hepatic Inflammation: Involvement of NF-κB/NLRP3 and Nrf2/HO-1 Signaling System.

Manna, Krishnendu / Khan, Zareen S / Saha, Moumita / Mishra, Snehasis / Gaikwad, Nilesh / Bhakta, Jatindra Nath / Banerjee, Kaushik / Das Saha, Krishna

Journal of inflammation research

2023 Volume 16, Page(s) 467–492

Abstract: Objective: Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum ... ...

Abstract	Objective: Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum pharmacological activities. Therefore, studying the hepatoprotective effects and elucidation of mechanisms of action of the Indian Variety, Manjari Medika grape seed extract (GSE), may give an insight into therapeutic benefits. Methotrexate (MTX) is the first-line pharmacological therapy for different rheumatic diseases. The major adverse events such as hepatotoxicity are evident even in the low doses used for the treatment. The present study investigated the role of MTX on hepatic damage in murine liver and the plausible protective effects of the Indian grape variety, Manjari Medika grape seed extract, in ameliorating it. Methods and results: To assess the hepatological modulation, mice were divided into eight groups to investigate the ameliorative potential of this GSE (75 and 125 mg/kg) and correlate the experimental findings. The active components of the extract were assessed through UPLC-(ESI)-QToF-MS analysis. On the other hand, various biochemical and immunological indices were carried out to correlate the experimental data. The result demonstrated that the prophylactic administration of GSE reduced MTX-induced hepatic toxicity indices, which subsequently restored the hepatic morphological architecture. Moreover, the application of GSE in a dual dosage (75 and 125 mg/kg) suppressed MTX-induced reactive oxygen species generation, followed by lipid peroxidation and cellular nitrite formation. MTX-induced inflammasome activation through the redox-assisted cascade of TLR4/NF-κB signaling was further reduced by applying the GSE. The results showed that the activation of cytoprotective transcription factor Nrf2 enhanced the level of endogenous antioxidants. Furthermore, through the regulation of TLR4/NF-κB and Nrf2/HO-1 axis, this extract could reduce the MTX-mediated hepatic damage. Conclusion: Our findings suggest that Manjari Medika seed extract could be used as a therapeutic agent to relieve the side effects of MTX and other hepatic disorders.
Language	English
Publishing date	2023-02-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S338888
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Article ; Online: Leishmania donovani infection induce Extracellular signal-regulated kinase ½ (ERK½) mediated lipid droplet generation in macrophages.

Banerjee, Somenath / Bose, Dipayan / Das, Subhadip / Chatterjee, Nabanita / Mishra, Snehasish / Das Saha, Krishna

Molecular immunology

2021 Volume 141, Page(s) 328–337

Abstract	Recently unfolded mechanisms showed lipid droplet helps in pathogen survival and paralyzes host immune response. In the present study, we showed the extent of lipid droplet(LD) generation in Leishmania donovani infection, the signaling involved, and their function concerning pathogenicity. RAW 264.7 and J774A.1 cells were used to infect with L. donovani and then flow cytometry and confocal microscopy were used to detect lipid droplet generation and subsequent assays. In this study, we showed that L. donovani AG83 (AG83/MHOM/1983) triggers lipid droplet formation in macrophages in a time-dependent manner. We provide novel insight into the signaling molecules which is responsible for LD accumulation. Interestingly, LPG deficient attenuated Leishmania strain UR6 (UR6/MHOM/1978) failed to fuel LD generation. But inhibition of phagosome maturation drastically stimulates LD accumulation in UR6 infected MΦs. Aspirin treatment in AG83 infected MΦs does not only lower LD load but also favors phagolysosome biogenesis and corrects cytokine balance. Employing strategies to circumvent halt in phagosome maturation using drugs that manipulate lipid droplet generation could be used as a therapeutic tool to resist parasite growth in the early hour of infection.
MeSH term(s)	Animals ; Cell Line ; Cytokines/metabolism ; Leishmania donovani/pathogenicity ; Leishmaniasis, Visceral/metabolism ; Lipid Droplets/metabolism ; MAP Kinase Signaling System/physiology ; Macrophages/metabolism ; Mice ; Phagocytosis/physiology ; RAW 264.7 Cells
Chemical Substances	Cytokines
Language	English
Publishing date	2021-12-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2021.12.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway.

Nag, Sayoni / Manna, Krishnendu / Saha, Moumita / Das Saha, Krishna

Nanomedicine (London, England)

2019 Volume 15, Issue 3, Page(s) 235–257

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Animals ; Apoptosis/drug effects ; Disease Models, Animal ; Drug Delivery Systems ; Drug Liberation/drug effects ; ErbB Receptors/genetics ; Gene Expression Regulation/drug effects ; Humans ; Liver/drug effects ; Liver/pathology ; Liver Diseases, Alcoholic/drug therapy ; Liver Diseases, Alcoholic/pathology ; Mice ; Nanoparticles/chemistry ; Oncogene Protein v-akt/genetics ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacology ; STAT3 Transcription Factor/genetics ; Tannins/chemistry ; Tannins/pharmacology ; Vitamin E/chemistry ; Vitamin E/pharmacology
Chemical Substances	STAT3 Transcription Factor ; STAT3 protein, human ; Tannins ; Vitamin E (1406-18-4) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Oncogene Protein v-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2019-0340
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Article ; Online: Designing of novel zinc(ii) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities.

Dasgupta, Sanchari / Karim, Suhana / Banerjee, Saswati / Saha, Moumita / Das Saha, Krishna / Das, Debasis

Dalton transactions (Cambridge, England : 2003)

2020 Volume 49, Issue 4, Page(s) 1232–1240

Abstract: Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio- ... ...

Abstract	Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Cell Line, Tumor ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; DNA Fragmentation/drug effects ; Humans ; Hydrazones/chemistry ; Kinetics ; Phosphoric Monoester Hydrolases/metabolism ; Schiff Bases/chemistry ; Zinc/chemistry
Chemical Substances	Antineoplastic Agents ; Coordination Complexes ; Hydrazones ; Schiff Bases ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2020-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c9dt04636d
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