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  1. Article: Serum Irisin in Polycystic Ovary Syndrome and its Alteration with Metformin Intervention.

    Telagareddy, Radhakrishna / Kumar, Padala Ravi / Pattanaik, Sudhi Ranjan / Dash, Deepak Kumar / Patro, Debasish / Sahoo, Bijay K / Sahu, Mahija

    Indian journal of endocrinology and metabolism

    2024  Volume 28, Issue 1, Page(s) 91–97

    Abstract: Introduction: Studies investigating the alterations of serum irisin and its change with metformin therapy in patients with polycystic ovary syndrome (PCOS) are conflicting. Our aim is to study serum irisin in PCOS patients and the change of irisin ... ...

    Abstract Introduction: Studies investigating the alterations of serum irisin and its change with metformin therapy in patients with polycystic ovary syndrome (PCOS) are conflicting. Our aim is to study serum irisin in PCOS patients and the change of irisin levels with metformin therapy over 6 months.
    Methods: This is a randomized control study conducted in 187 PCOS cases and 94 age-matched controls aged 18-40 years. Detailed evaluation of anthropometric, biochemical, and hormonal parameters was performed. A subset of 99 overweight/obese patients with body mass index (BMI) ≥23 kg/m
    Results: Serum irisin was higher in PCOS patients than in controls [12.47 (8.1-17.7) vs 8.3 (7.0-9.6) ng/ml,
    Conclusion: Serum irisin is increased in PCOS patients independent of BMI. Metformin therapy reduced serum irisin levels in overweight/obese PCOS patients by improving insulin resistance.
    Language English
    Publishing date 2024-02-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2600211-5
    ISSN 2230-9500 ; 2230-8210
    ISSN (online) 2230-9500
    ISSN 2230-8210
    DOI 10.4103/ijem.ijem_379_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients with type 2 diabetes mellitus.

    Dash, Deepak Kumar / Choudhury, Arun Kumar / Singh, Mamta / Mangaraj, Swayamsidha / Mohanty, Binoy Kumar / Baliarsinha, Anoj Kumar

    Diabetes & metabolic syndrome

    2017  Volume 12, Issue 3, Page(s) 285–289

    Abstract: Aim and objective: To study the effect of parental history of diabetes on markers of inflammation, insulin resistance, adiposity indices and carotid intima media thickness (cIMT) in first degree relatives of patients with type 2 diabetes mellitus (T2DM). ...

    Abstract Aim and objective: To study the effect of parental history of diabetes on markers of inflammation, insulin resistance, adiposity indices and carotid intima media thickness (cIMT) in first degree relatives of patients with type 2 diabetes mellitus (T2DM).
    Materials and methods: Normal glucose tolerant (NGT) first degree relatives of T2DM patients of age group 20-40 years designated as FH
    Results: No difference existed with regards to BMI, hsCRP, degree of insulin resistance, adiposity markers and cIMT between FH
    Conclusions: hsCRP and cIMT are significantly higher in the first degree relatives of type2 diabetes mellitus patients than controls. Individuals with history of T2DM in both parents have significantly worse glycemic status, increased cIMT and adverse cardiovascular risk profile than those with T2DM history in only single parent.
    MeSH term(s) Adult ; Atherosclerosis/epidemiology ; Atherosclerosis/metabolism ; Biomarkers/analysis ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/physiopathology ; Disease Susceptibility ; Family ; Female ; Follow-Up Studies ; Humans ; Inflammation/epidemiology ; Inflammation/metabolism ; Insulin Resistance ; Male ; Parents ; Prevalence ; Prognosis ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-12-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2017.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antidiabetic, antioxidant and antihyperlipidemic status of Heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats.

    Murugesh, Kandasamy / Yeligar, Veerendra / Dash, Deepak Kumar / Sengupta, Pinaki / Maiti, Bhim Chandra / Maity, Tapan Kumar

    Biological & pharmaceutical bulletin

    2006  Volume 29, Issue 11, Page(s) 2202–2205

    Abstract: The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration ... ...

    Abstract The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.
    MeSH term(s) Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Antioxidants/therapeutic use ; Blood Glucose/analysis ; Body Weight/drug effects ; Catalase/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/prevention & control ; Drinking/drug effects ; Eating/drug effects ; Glutathione/metabolism ; Heliotropium/chemistry ; Hypercholesterolemia/chemically induced ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/prevention & control ; Hypertriglyceridemia/chemically induced ; Hypertriglyceridemia/metabolism ; Hypertriglyceridemia/prevention & control ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/therapeutic use ; Hypolipidemic Agents/administration & dosage ; Hypolipidemic Agents/isolation & purification ; Hypolipidemic Agents/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Male ; Phytotherapy/methods ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar ; Streptozocin ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism ; Tolbutamide/pharmacology
    Chemical Substances Antioxidants ; Blood Glucose ; Hypoglycemic Agents ; Hypolipidemic Agents ; Plant Extracts ; Thiobarbituric Acid Reactive Substances ; Streptozocin (5W494URQ81) ; Tolbutamide (982XCM1FOI) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2006-06-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.29.2202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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