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  1. Article ; Online: Evaluating the use of electroconvulsive therapy in low-middle income countries: A narrative review.

    Daskalakis, Anastasios A / Paric, Angela / Ravindran, Nisha / Ravindran, Arun

    Asian journal of psychiatry

    2023  Volume 91, Page(s) 103856

    Abstract: Background: Electroconvulsive therapy (ECT) is a well-accepted intervention for treatment-resistant, serious mental illnesses. Its acceptability, efficacy, and tolerability are well documented in high-income settings, but less so in lower- and middle- ... ...

    Abstract Background: Electroconvulsive therapy (ECT) is a well-accepted intervention for treatment-resistant, serious mental illnesses. Its acceptability, efficacy, and tolerability are well documented in high-income settings, but less so in lower- and middle-income countries (LMICs). This report is a narrative review of ECT practice in the latter setting.
    Methods: A literature search was conducted using Medline and PubMed. Initial results yielded 81 publications in English. Following the screening, 19 papers were included to evaluate the information on ECT practice and perceptions.
    Results: Reports from LMICs on efficacy, tolerability, and perceptions of ECT were relatively sparse. In general, they confirm its use mostly for treatment-resistant major mental illnesses (i.e., depression, schizophrenia, bipolar disorder). Both modified and unmodified forms of ECT are used and considered equally effective, although the former is better tolerated. Use of unmodified ECT remains significant in LMICs due to its low cost and limited resource requirements. In general, there is satisfaction with ECT and its outcomes. The education of patients and families, content process, and research have been noted as areas to improve.
    Conclusions: ECT is perceived as an effective intervention in LMICs, but use of unmodified ECT remains controversial. There is a need for the development and use of global guidelines to improve clinician training, knowledge sharing with patients and their families, and outcome research.
    MeSH term(s) Humans ; Electroconvulsive Therapy/methods ; Developing Countries ; Schizophrenia/therapy ; Bipolar Disorder/therapy ; Surveys and Questionnaires ; Treatment Outcome
    Language English
    Publishing date 2023-12-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2023.103856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treating resistant depression with 2 forms of convulsive therapy: a clinical case study

    Daskalakis, Anastasios A. / Daskalakis, Zafiris J.

    Journal of psychiatry & neuroscience : JPN

    2019  Volume 44, Issue 2, Page(s) 143–144

    MeSH term(s) Adult ; Amnesia/etiology ; Convulsive Therapy/adverse effects ; Convulsive Therapy/methods ; Depressive Disorder, Treatment-Resistant/therapy ; Electroconvulsive Therapy/adverse effects ; Electroconvulsive Therapy/methods ; Female ; Frontal Lobe ; Humans ; Magnetic Field Therapy/adverse effects ; Magnetic Field Therapy/methods
    Language English
    Publishing date 2019-02-26
    Publishing country Canada
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.180141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evidence for prefrontal cortex hypofunctioning in schizophrenia through somatosensory evoked potentials.

    Daskalakis, Anastasios A / Zomorrodi, Reza / Blumberger, Daniel M / Rajji, Tarek K

    Schizophrenia research

    2019  Volume 215, Page(s) 197–203

    Abstract: Patients with schizophrenia (SCZ) exhibit a variety of symptoms related to altered processing of somatosensory information. Little is known, however, about the neural substrates underlying somatosensory impairments in SCZ. This study endeavored to ... ...

    Abstract Patients with schizophrenia (SCZ) exhibit a variety of symptoms related to altered processing of somatosensory information. Little is known, however, about the neural substrates underlying somatosensory impairments in SCZ. This study endeavored to evaluate somatosensory processing in patients with SCZ compared to healthy individuals by generating somatosensory evoked potentials through stimulation of the right median nerve. The median nerve was stimulated by a peripheral nerve stimulator in 34 SCZ and 33 healthy control (HC) participants. The peripheral nerve stimulus (PNS) intensity was adjusted to 300 percent of sensory threshold and delivered at 0.1 Hz. The EEG data were acquired through 64-channels per 10-20 montage. We collected and averaged 100 trials and the recording electrodes of interest were the F3/F5 electrodes representing the dorsolateral prefrontal cortex (DLPFC) and C3/CP3 representing the somatosensory cortex (S1). In response to PNS, SCZ participants experienced over the DLPFC N30 amplitude that was significantly smaller than that of HC participants. By contrast, S1 N20 was of similar amplitude between the two groups. In addition, we found an association between N20 and N30 amplitudes in SCZ but not in HC participants. Our findings suggest that patients with SCZ demonstrate aberrant processing of somatosensory activation by the DLPFC locally and not due to a connectivity disruption between S1 and DLPFC. These results could help to develop a model through which to DLPFC hypofunctioning could be studied. Our findings may also help to identify a potential biological target to treat somatosensory information processing related deficits in SCZ.
    MeSH term(s) Adult ; Aged ; Electric Stimulation ; Electroencephalography ; Evoked Potentials, Somatosensory/physiology ; Female ; Humans ; Male ; Median Nerve/physiopathology ; Middle Aged ; Prefrontal Cortex/physiopathology ; Schizophrenia/physiopathology ; Somatosensory Cortex/physiopathology
    Language English
    Publishing date 2019-10-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2019.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differentiating transcranial magnetic stimulation cortical and auditory responses via single pulse and paired pulse protocols: A TMS-EEG study.

    Poorganji, Mohsen / Zomorrodi, Reza / Hawco, Colin / Hill, Aron T / Hadas, Itay / Rajji, Tarek K / Chen, Robert / Voineskos, Daphne / Daskalakis, Anastasios A / Blumberger, Daniel M / Daskalakis, Zafiris J

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 132, Issue 8, Page(s) 1850–1858

    Abstract: Objective: We measured the neurophysiological responses of both active and sham transcranial magnetic stimulation (TMS) for both single pulse (SP) and paired pulse (PP; long interval cortical inhibition (LICI)) paradigms using TMS-EEG ( ... ...

    Abstract Objective: We measured the neurophysiological responses of both active and sham transcranial magnetic stimulation (TMS) for both single pulse (SP) and paired pulse (PP; long interval cortical inhibition (LICI)) paradigms using TMS-EEG (electroencephalography).
    Methods: Nineteen healthy subjects received active and sham (coil 90° tilted and touching the scalp) SP and PP TMS over the left dorsolateral prefrontal cortex (DLPFC). We measured excitability through SP TMS and inhibition (i.e., cortical inhibition (CI)) through PP TMS.
    Results: Cortical excitability indexed by area under the curve (AUC
    Conclusion: The significant differences between active and sham stimulation in both excitatory and inhibitory neurophysiological responses showed that active stimulation elicits responses from the cortex that are different from the non-specific effects of sham stimulation.
    Significance: Our study reaffirms that TMS-EEG represents an effective tool to evaluate cortical neurophysiology with high fidelity.
    MeSH term(s) Adult ; Electroencephalography/methods ; Evoked Potentials, Auditory/physiology ; Evoked Potentials, Somatosensory/physiology ; Female ; Humans ; Male ; Middle Aged ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiology ; Transcranial Magnetic Stimulation/methods ; Young Adult
    Language English
    Publishing date 2021-05-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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