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Conference proceedings ; Online: An unsupervised machine learning-based methodology to study the seasonal dispersal pathways of short-lived pollutants from Major Population Centers

Poulidis, A. / Daskalakis, N. / Kanakidou, M. / Vrekoussis, M.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The rapid increase in human population since 1900 has occurred along with a rapid increase in urbanization - the process of migration from rural into urban areas. The fossil fuel combustion-based emissions affecting areas with high population densities ... ...

Abstract	The rapid increase in human population since 1900 has occurred along with a rapid increase in urbanization - the process of migration from rural into urban areas. The fossil fuel combustion-based emissions affecting areas with high population densities induce a significant health risk for local populations. Protection of human health requires better knowledge of local and regional impacts of urban pollution dispersal. This study addresses the issue of short-lived pollutant transport (e.g. NOx) by constructing a methodology to study the seasonality of common dispersal pathways from Major Population Centers (MPCs); initially applied to 5 MPCs in south America during 2018. For each city, ERA5 reanalysis data were used to drive the FLEXPART emission transport model to simulate the dispersal of near-surface emissions. Simulations are performed for a total of 8 hours from release in the early morning and in the evening, to capture the effects of commuting. A total of 100,000 trajectories per release time per city were analyzed to create representative average trajectories. The k-means clustering algorithm was then applied to categorize the emissions per MPC. Clustering for each MPC led to a robust grouping of trajectories that were seen to reflect climatological and topographic phenomena during the simulation period and exhibit strong seasonality. This finding supports potential applicability of the proposed methodology for a global analysis of MPC emissions.
Subject code	910
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of shipping emissions on air pollution and pollutant deposition over the Barents Sea.

Raut, Jean-Christophe / Law, Kathy S / Onishi, Tatsuo / Daskalakis, Nikos / Marelle, Louis

Environmental pollution (Barking, Essex : 1987)

2022 Volume 298, Page(s) 118832

Abstract: Arctic warming leading to reduced summertime sea-ice is likely to lead to increased local shipping especially along the Northeast Passage near the northern coasts of Norway and Russia, which are shorter than the traditional southerly routes. Here, the ... ...

Abstract	Arctic warming leading to reduced summertime sea-ice is likely to lead to increased local shipping especially along the Northeast Passage near the northern coasts of Norway and Russia, which are shorter than the traditional southerly routes. Here, the regional chemistry-transport model WRF-Chem is used to examine the effects of shipping emissions on levels of air pollutants and deposition fluxes over the Barents Sea both for present-day and future conditions, based on a high growth scenario. Present-day shipping emissions are found to have already substantial effects on ozone concentrations, but limited effects on sulphate and nitrate aerosols. Predicted future changes in ozone are also important, particularly in regions with low nitrogen oxide concentrations, and results are sensitive to the way in which diversion shipping is distributed due to non-linear effects on photochemical ozone production. Whilst modest future increases in sulphate and nitrate aerosols are predicted, large enhancements in dry deposition of sulphur dioxide and wet deposition of nitrogen compounds to the Barents Sea are predicted. Such levels of future nitrogen deposition would represent a significant atmospheric source of oceanic nitrogen affecting sensitive marine ecosystems.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution ; Ecosystem ; Environmental Pollutants ; Ships
Chemical Substances	Air Pollutants ; Environmental Pollutants
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.118832
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Endovascular Recanalization of an Infrarenal Aortoiliac Occlusion Using a Combined Bilateral Subintimal Approach.

Galanakis, Nikolaos / Kontopodis, Nikolaos / Kehagias, Elias / Daskalakis, Nikolaos / Ioannou, Christos V / Tsetis, Dimitrios

Vascular specialist international

2021 Volume 37, Page(s) 32

Language	English
Publishing date	2021-09-28
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2288-7970
ISSN	2288-7970
DOI	10.5758/vsi.210053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Local Metastatic Neck Cancer Involving the Distal Internal Carotid Artery Treated with En Bloc Resection and Arterial Reconstruction after Mandibular Osteotomy.

Kontopodis, Nikolaos / Igoumenakis, Dimosthenis / Mastorakis, George / Logothetis, Ioannis / Daskalakis, Nikolaos / Ioannou, Christos V

Vascular specialist international

2020 Volume 36, Issue 4, Page(s) 252–257

Abstract: Head and neck cancers represent an aggressive form of neoplastic diseases that warrant surgical resection, in order to achieve optimal outcomes. Moreover, the involvement of the carotid artery is associated with a dismal prognosis and radical tumor ... ...

Abstract	Head and neck cancers represent an aggressive form of neoplastic diseases that warrant surgical resection, in order to achieve optimal outcomes. Moreover, the involvement of the carotid artery is associated with a dismal prognosis and radical tumor resection becomes challenging. The current case report presents a patient with locally metastatic neck carcinoma attached to the right carotid bifurcation, involving both the external and internal carotid arteries up to the distal segment of the internal carotid artery (ICA) at the level of the C1 vertebra. The patient underwent en bloc tumor and vessel resection. The carotid artery was reconstructed using an interposition graft from the common carotid artery to the ICA by means of an autologous saphenous vein graft. A vertical mandibular osteotomy was performed, in order to expose the distal ICA. The postoperative recovery was uneventful. The patient was under follow-up for six months, without any signs of recurrence.
Language	English
Publishing date	2020-11-11
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2288-7970
ISSN	2288-7970
DOI	10.5758/vsi.200046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The behaviour of SMEs' capital structure determinants in different macroeconomic states

Daskalakis, Nikolaos / Balios, Dimitrios / Dalla, Violetta

The journal of corporate finance : contracting, governance and organization Vol. 46 , p. 248-260

2017 Volume 46, Page(s) 248–260

Author's details	Nikolaos Daskalakis, Dimitrios Balios, Violetta Dalla
Keywords	SMEs ; Corporate finance ; Financial leverage ; Capital structure ; Macroeconomic states
Language	English
Publisher	Elsevier
Publishing place	Amsterdam
Document type	Article
ZDB-ID	1189269-9
ISSN	0929-1199
Database	ECONomics Information System

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Article: Direct Iliac Vein Stenting in Phlegmasia Cerulea Dolens Caused by May-Thurner Syndrome.

Galanakis, Nikolaos / Kontopodis, Nikolaos / Kehagias, Elias / Daskalakis, Nikolaos / Tsetis, Konstantinos / Ioannou, Christos V / Tsetis, Dimitrios

Vascular specialist international

2021 Volume 37, Page(s) 37

Abstract: Phlegmasia cerulea dolens (PCD) is an uncommon but potentially limb-threatening complication of acute deep vein thrombosis. A 56-year-old male presented with PCD. Color Doppler ultrasonography revealed extensive thrombosis of the left superficial and ... ...

Abstract	Phlegmasia cerulea dolens (PCD) is an uncommon but potentially limb-threatening complication of acute deep vein thrombosis. A 56-year-old male presented with PCD. Color Doppler ultrasonography revealed extensive thrombosis of the left superficial and common femoral and external and common iliac veins. After an unsuccessful iliofemoral thrombectomy, contrast-enhanced computed tomography revealed iliofemoral deep vein thrombosis due to May-Thurner syndrome (MTS). After the deployment of an inferior vena cava filter, the thrombotic occlusion was traversed with a guidewire and direct stenting was performed to achieve immediate recanalization. The patient was discharged two days after the procedure, demonstrating significant clinical improvement. MTS is a rare cause of PCD. Direct iliac vein stenting may be a safe and effective alternative treatment for rapid recanalization if percutaneous mechanical thrombectomy devices are unavailable.
Language	English
Publishing date	2021-12-27
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2288-7970
ISSN	2288-7970
DOI	10.5758/vsi.210031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Heavy metal speciation and acid treatment of activated sludge developed in a membrane bioreactor.

Daskalakis, N / Katsou, E / Malamis, S / Haralambous, K J

Environmental technology

2013 Volume 34, Issue 17-20, Page(s) 2599–2606

Abstract: The aim of this study was to identify the heavy metals forms (exchangeable and bound to carbonate, Fe/Mn oxides, bound to organic matter and sulphide, and residual) associated with different fractions of excess sludge produced by a membrane bioreactor ( ... ...

Abstract	The aim of this study was to identify the heavy metals forms (exchangeable and bound to carbonate, Fe/Mn oxides, bound to organic matter and sulphide, and residual) associated with different fractions of excess sludge produced by a membrane bioreactor (MBR). Furthermore, the release of metals from the sludge to the liquid was investigated by applying acid treatment using 10% (v/v) H2SO4 (T = 25 degrees C, solid-liquid ratio 1:5 w/v) for contact time ranging from 15 min to 4 h. Metal partitioning in sludge, as determined by the sequential chemical extraction showed that the dominant form of both Ni and Zn was bound to the exchangeable and carbonate fraction; the latter were very unstable and sensitive to environmental conditions. The dominant Cu fraction was bound to organic matter and sulphide, while Pb was found to be mainly in the residual fraction which is very stable. Metal speciation after acidification with H2SO4 indicates changes of metal content in sludge and an increase of the exchangeable and bound to carbonate fraction for all metals except Cu. Acidification resulted in removal of 82% for Ni, 78% for Zn, 47% for Cu and 45% for Pb.
MeSH term(s)	Bioreactors ; Carbonates/chemistry ; Metals, Heavy/isolation & purification ; Oxides/chemistry ; Sewage/microbiology ; Sulfides/chemistry ; Sulfuric Acids/chemistry ; Water Pollutants, Chemical/isolation & purification
Chemical Substances	Carbonates ; Metals, Heavy ; Oxides ; Sewage ; Sulfides ; Sulfuric Acids ; Water Pollutants, Chemical ; sulfuric acid (O40UQP6WCF)
Language	English
Publishing date	2013-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0959-3330
ISSN	0959-3330
DOI	10.1080/09593330.2013.781227
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Focal and segmental glomerulosclerosis.

Daskalakis, N / Winn, M P

Cellular and molecular life sciences : CMLS

2006 Volume 63, Issue 21, Page(s) 2506–2511

Abstract: An increasing cause of end-stage renal disease is the pathological lesion focal and segmental glomerulosclerosis (FSGS). FSGS is characterized by proteinuria and frequently nephrotic syndrome with ensuing renal failure. The etiology remains unknown in ... ...

Abstract	An increasing cause of end-stage renal disease is the pathological lesion focal and segmental glomerulosclerosis (FSGS). FSGS is characterized by proteinuria and frequently nephrotic syndrome with ensuing renal failure. The etiology remains unknown in the majority of individuals. The idiopathic form of FSGS is most common; however, secondary forms of FSGS do exist. There is a form of FSGS that is fulminant that frequently recurs after renal transplantation with an estimated frequency of approximately 30%, suggesting that the pathogenesis is not solely a result of intrinsic kidney disease. Recently, hereditary forms of the disease were recognized as well as those associated with other congenital syndromes. Known genetic causes of the hereditary form of this disease have been suggested to account for upwards of 18% of cases. This review will address recent discoveries of the genetic mechanisms of hereditary FSGS and the current interpretations of their interactions at the slit diaphragm.
MeSH term(s)	Genome, Human/genetics ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Membrane Proteins/genetics ; Mutation/genetics ; TRPV Cation Channels/genetics
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; NPHS2 protein ; TRPV Cation Channels ; TRPV6 channel ; nephrin
Language	English
Publishing date	2006-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-006-6171-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SMEs capital structure determinants during severe economic crisis

Balios, D / Daskalakis, N / Eriotis, Nicos / Vasiliou, D

Cogent economics & finance Vol. 4, No. 1 , p. 1-11

the case of Greece D. Balios, N. Daskalakis, N. Eriotis and D. Vasiliou

2016 Volume 4, Issue 1, Page(s) 1–11

Abstract: The objective of this paper was to explore whether and how the main capital structure determinants of SMEs affected capital structure determination in different ways during the years of economic crisis. We used panel data of 8,052 SMEs operating in ... ...

Abstract	The objective of this paper was to explore whether and how the main capital structure determinants of SMEs affected capital structure determination in different ways during the years of economic crisis. We used panel data of 8,052 SMEs operating in Greece during 2009-2012. We found that the effect of capital structure determinants on leverage does not change in an environment of economic crisis; larger SMEs continued to show higher debt ratios, the relationship between profitability and tangibility of assets with leverage continued to be negative, and growth was positively related to leverage.
Keywords	corporate finance ; financial leverage ; capital structure ; Greek firms
Language	Undetermined
Size	Online-Ressource
Publisher	Taylor & Francis
Publishing place	Abingdon
Document type	Article ; Online
ZDB-ID	2773198-4
ISSN	2332-2039
ISSN	2332-2039
DOI	10.1080/23322039.2016.1145535
Database	ECONomics Information System

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Article ; Online: First-in-human study of JNJ-67571244, a CD33 × CD3 bispecific antibody, in relapsed/refractory acute myeloid leukemia and myelodysplastic syndrome.

Clinical and translational science

2024 Volume 17, Issue 3, Page(s) e13742

Abstract: Relapsed/refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) outcomes remain poor. A targeted cluster of differentiation (CD)33 × CD3 bispecific antibody, JNJ-67571244, was assessed to identify the maximum tolerated dose (MTD) ...

Abstract	Relapsed/refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) outcomes remain poor. A targeted cluster of differentiation (CD)33 × CD3 bispecific antibody, JNJ-67571244, was assessed to identify the maximum tolerated dose (MTD), recommended phase II dose (RP2D), safety and tolerability, and preliminary clinical activity in patients with r/rAML or r/rMDS. This first-in-human, open-label, phase I, dose-escalation/dose-expansion study included patients with r/rAML or r/rMDS who were ineligible for or had exhausted standard therapeutic options. JNJ-67571244 was administered intravenously or subcutaneously using step-up dosing until ≥1 discontinuation condition was met. Outcomes included safety/tolerability, preliminary clinical activity, and systemic pharmacokinetics and pharmacodynamics. The study was terminated after evaluating 10 dose-escalation cohorts (n = 68) and before starting dose-expansion. Overall, 11 (16.2%) patients experienced ≥1 dose-limiting toxicity; all experienced ≥1 treatment-emergent adverse event (TEAE; treatment related: 60 [88.2%]); and 64 (94.1%) experienced ≥1 TEAE of Grade ≥3 toxicity (treatment related: 28 [41.2%]). Although some patients had temporary disease burden reductions, no responses were seen. JNJ-67571244 administration increased multiple cytokines, which coincided with incidence of cytokine release syndrome, infusion-related reactions, and elevated liver function tests. A prolonged step-up strategy was tested to improve tolerability, though this approach did not prevent hepatotoxicity. T-cell activation following treatment suggested target engagement but did not correlate with clinical activity. Safely reaching the projected exposure level for JNJ-67571244 efficacy was not achieved, thus MTD and RP2D were not determined.
MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Myelodysplastic Syndromes/drug therapy ; Sialic Acid Binding Ig-like Lectin 3/immunology
Chemical Substances	Antineoplastic Agents ; CD33 protein, human ; Sialic Acid Binding Ig-like Lectin 3
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13742
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