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  1. Article ; Online: Accelerated Intermittent Theta Burst Stimulation: Expediting and Enhancing Treatment Outcomes in Treatment-Resistant Depression.

    Weissman, Cory R / Daskalakis, Zafiris J

    The American journal of psychiatry

    2022  Volume 179, Issue 2, Page(s) 85–87

    MeSH term(s) Depression/therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Double-Blind Method ; Humans ; Transcranial Magnetic Stimulation ; Treatment Outcome
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2021.21121221
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  2. Article ; Online: Identifying novel biomarkers with TMS-EEG - Methodological possibilities and challenges.

    Kallioniemi, Elisa / Daskalakis, Zafiris J

    Journal of neuroscience methods

    2022  Volume 377, Page(s) 109631

    Abstract: Biomarkers are essential for understanding the underlying pathologies in brain disorders and for developing effective treatments. Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an emerging neurophysiological tool that ... ...

    Abstract Biomarkers are essential for understanding the underlying pathologies in brain disorders and for developing effective treatments. Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an emerging neurophysiological tool that can be used for biomarker development. This method can identify biomarkers associated with the function and dynamics of the inhibitory and excitatory neurotransmitter systems and effective connectivity between brain areas. In this review, we outline the current state of the TMS-EEG biomarker field by summarizing the existing protocols and the possibilities and challenges associated with this methodology.
    MeSH term(s) Biomarkers ; Electroencephalography/methods ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-24
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2022.109631
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  3. Article ; Online: Getting things right - Proper training in non-invasive brain stimulation.

    Daskalakis, Zafiris J / Poorganji, Mohsen

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 132, Issue 3, Page(s) 810–811

    MeSH term(s) Brain/physiology ; Clinical Competence/standards ; Deep Brain Stimulation/methods ; Deep Brain Stimulation/standards ; Humans ; Stereotaxic Techniques/education ; Stereotaxic Techniques/standards ; Transcranial Direct Current Stimulation/methods ; Transcranial Direct Current Stimulation/standards ; Transcranial Magnetic Stimulation/methods ; Transcranial Magnetic Stimulation/standards
    Language English
    Publishing date 2021-01-12
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.01.002
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  4. Article ; Online: The importance of individual beliefs in assessing treatment efficacy.

    Fassi, Luisa / Hochman, Shachar / Daskalakis, Zafiris J / Blumberger, Daniel M / Cohen Kadosh, Roi

    eLife

    2024  Volume 12

    Abstract: In recent years, there has been debate about the effectiveness of treatments from different fields, such as neurostimulation, neurofeedback, brain training, and pharmacotherapy. This debate has been fuelled by contradictory and nuanced experimental ... ...

    Abstract In recent years, there has been debate about the effectiveness of treatments from different fields, such as neurostimulation, neurofeedback, brain training, and pharmacotherapy. This debate has been fuelled by contradictory and nuanced experimental findings. Notably, the effectiveness of a given treatment is commonly evaluated by comparing the effect of the active treatment versus the placebo on human health and/or behaviour. However, this approach neglects the individual's subjective experience of the type of treatment she or he received in establishing treatment efficacy. Here, we show that individual differences in
    MeSH term(s) Adult ; Female ; Humans ; Neurofeedback/methods ; Transcranial Direct Current Stimulation ; Transcranial Magnetic Stimulation ; Treatment Outcome ; Male
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88889
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  5. Article ; Online: Boxing as an Intervention in Mental Health: A Scoping Review.

    Bozdarov, Johny / Jones, Brett D M / Daskalakis, Zafiris J / Husain, M Ishrat

    American journal of lifestyle medicine

    2022  Volume 17, Issue 4, Page(s) 589–600

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2265653-4
    ISSN 1559-8284 ; 1559-8276
    ISSN (online) 1559-8284
    ISSN 1559-8276
    DOI 10.1177/15598276221124095
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  6. Article ; Online: Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample.

    Dunlop, Katharine / Grosenick, Logan / Downar, Jonathan / Vila-Rodriguez, Fidel / Gunning, Faith M / Daskalakis, Zafiris J / Blumberger, Daniel M / Liston, Conor

    Biological psychiatry

    2024  

    Abstract: Background: Recent studies have reported significant advances in modeling the biological basis of heterogeneity in major depressive disorder, but investigators have also identified important technical challenges, including scanner-related artifacts, a ... ...

    Abstract Background: Recent studies have reported significant advances in modeling the biological basis of heterogeneity in major depressive disorder, but investigators have also identified important technical challenges, including scanner-related artifacts, a propensity for multivariate models to overfit, and a need for larger samples with more extensive clinical phenotyping. The goals of the current study were to evaluate dimensional and categorical solutions to parsing heterogeneity in depression that are stable and generalizable in a large, single-site sample.
    Methods: We used regularized canonical correlation analysis to identify data-driven brain-behavior dimensions that explain individual differences in depression symptom domains in a large, single-site dataset comprising clinical assessments and resting-state functional magnetic resonance imaging data for 328 patients with major depressive disorder and 461 healthy control participants. We examined the stability of clinical loadings and model performance in held-out data. Finally, hierarchical clustering on these dimensions was used to identify categorical depression subtypes.
    Results: The optimal regularized canonical correlation analysis model yielded 3 robust and generalizable brain-behavior dimensions that explained individual differences in depressed mood and anxiety, anhedonia, and insomnia. Hierarchical clustering identified 4 depression subtypes, each with distinct clinical symptom profiles, abnormal resting-state functional connectivity patterns, and antidepressant responsiveness to repetitive transcranial magnetic stimulation.
    Conclusions: Our results define dimensional and categorical solutions to parsing neurobiological heterogeneity in major depressive disorder that are stable, generalizable, and capable of predicting treatment outcomes, each with distinct advantages in different contexts. They also provide additional evidence that regularized canonical correlation analysis and hierarchical clustering are effective tools for investigating associations between functional connectivity and clinical symptoms.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2024.01.012
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  7. Article ; Online: Treating resistant depression with 2 forms of convulsive therapy: a clinical case study

    Daskalakis, Anastasios A. / Daskalakis, Zafiris J.

    Journal of psychiatry & neuroscience : JPN

    2019  Volume 44, Issue 2, Page(s) 143–144

    MeSH term(s) Adult ; Amnesia/etiology ; Convulsive Therapy/adverse effects ; Convulsive Therapy/methods ; Depressive Disorder, Treatment-Resistant/therapy ; Electroconvulsive Therapy/adverse effects ; Electroconvulsive Therapy/methods ; Female ; Frontal Lobe ; Humans ; Magnetic Field Therapy/adverse effects ; Magnetic Field Therapy/methods
    Language English
    Publishing date 2019-02-26
    Publishing country Canada
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.180141
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  8. Article ; Online: A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation.

    Daskalakis, Zafiris J / Tyndale, Rachel F

    Clinical pharmacology and therapeutics

    2019  Volume 106, Issue 4, Page(s) 691–695

    MeSH term(s) Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Deep Brain Stimulation/methods ; Deep Brain Stimulation/trends ; Depressive Disorder, Treatment-Resistant/physiopathology ; Depressive Disorder, Treatment-Resistant/therapy ; Humans ; Transcranial Direct Current Stimulation/methods ; Transcranial Direct Current Stimulation/trends
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1576
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  9. Article ; Online: Pre-clinical indications of brain stimulation treatments for non-affective psychiatric disorders, a status update.

    Benster, Lindsay L / Weissman, Cory R / Stolz, Louise A / Daskalakis, Zafiris J / Appelbaum, Lawrence G

    Translational psychiatry

    2023  Volume 13, Issue 1, Page(s) 390

    Abstract: Over the past two decades noninvasive brain stimulation (NIBS) techniques have emerged as powerful therapeutic options for a range of psychiatric and neurological disorders. NIBS are hypothesized to rebalance pathological brain networks thus reducing ... ...

    Abstract Over the past two decades noninvasive brain stimulation (NIBS) techniques have emerged as powerful therapeutic options for a range of psychiatric and neurological disorders. NIBS are hypothesized to rebalance pathological brain networks thus reducing symptoms and improving functioning. This development has been fueled by controlled studies with increasing size and rigor aiming to characterize how treatments induce clinically effective change. Clinical trials of NIBS for specific indications have resulted in federal approval for unipolar depression, bipolar depression, smoking cessation, and obsessive-compulsive disorder in the United States, and several other indications worldwide. As a rapidly emerging field, there are numerous pre-clinical indications currently in development using a variety of electrical and magnetic, non-convulsive, and convulsive approaches. This review discusses the state-of-the-science surrounding promising avenues of NIBS currently in pre-approval stages for non-affective psychiatric disorders. We consider emerging therapies for psychosis, anxiety disorders, obsessive-compulsive disorder, and borderline personality disorder, utilizing transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and magnetic seizure therapy (MST), with an additional brief section for early-stage techniques including transcranial focused ultrasound stimulation (tFUS) and transcranial alternating current stimulation (tACS). As revealed in this review, there is considerable promise across all four psychiatric indications with different NIBS approaches. Positive findings are notable for the treatment of psychosis using tDCS, MST, and rTMS. While rTMS is already FDA approved for the treatment of obsessive-compulsive disorder, methodologies such as tDCS also demonstrate potential in this condition. Emerging techniques show promise for treating non-affective disorders likely leading to future regulatory approvals.
    MeSH term(s) Humans ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation/methods ; Brain/physiology ; Depressive Disorder/therapy ; Obsessive-Compulsive Disorder/therapy
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02673-2
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  10. Article ; Online: Within-subject reliability of concurrent TMS-fMRI during a single session.

    Hawco, Colin / Steeves, Jennifer K E / Voineskos, Aristotle N / Blumberger, Daniel M / Daskalakis, Zafiris J

    Psychophysiology

    2023  Volume 60, Issue 7, Page(s) e14252

    Abstract: Concurrent transcranial magnetic stimulation with functional MRI (concurrent TMS-fMRI) allows real-time causative probing of brain connectivity. However, technical challenges, safety, and tolerability may limit the number of trials employed during a ... ...

    Abstract Concurrent transcranial magnetic stimulation with functional MRI (concurrent TMS-fMRI) allows real-time causative probing of brain connectivity. However, technical challenges, safety, and tolerability may limit the number of trials employed during a concurrent TMS-fMRI experiment. We leveraged an existing data set with 100 trials of active TMS compared to a sub-threshold control condition to assess the reliability of the evoked BOLD response during concurrent TMS-fMRI. This data will permit an analysis of the minimum number of trials that should be employed in a concurrent TMS-fMRI protocol in order to achieve reliable spatial changes in activity. Single-subject maps of brain activity were created by splitting the trials within the same experimental session into groups of 50, 40, 30, 25, 20, 15, or 10 trials, correlations (R) between t-maps derived from paired subsets of trials within the same individual were calculated as reliability. R was moderate-high for 50 trials (mean R = .695) and decreased as the number of trials decreased. Consistent with previous findings of high individual variability in the spatial patterns of evoked neuronal changes following a TMS pulse, the spatial pattern of Rs differed across participants, but regional R was correlated with the magnitude of TMS-evoked activity. These results demonstrate concurrent TMS-fMRI produces a reliable pattern of activity at the individual level at higher trial numbers, particularly within localized regions. The spatial pattern of reliability is individually idiosyncratic and related to the individual pattern of evoked changes.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods ; Reproducibility of Results ; Brain/diagnostic imaging ; Brain/physiology ; Transcranial Magnetic Stimulation/methods ; Evoked Potentials, Motor/physiology
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14252
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