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Book ; Online ; E-Book: Soils in the Hindu Kush Himalayas

Sharma, U. C. / Sharma, Vikas / Datta, M.

management for agricultural land use

(Geography of the Physical Environment,)

2023

Abstract: This book focuses on the nature and properties of soils of Hindu Kush-Himalayas and their management for agricultural land use. It discusses all aspects of climatic variations and potential of resources in the Himalayan region including examples from ... ...

Author's details	U. C. Sharma, M. Datta, and Vikas Sharma
Series title	Geography of the Physical Environment,
Abstract	This book focuses on the nature and properties of soils of Hindu Kush-Himalayas and their management for agricultural land use. It discusses all aspects of climatic variations and potential of resources in the Himalayan region including examples from Afghanistan, Bangladesh, Bhutan, China (Tibet), India, Myanmar, Nepal and Pakistan. Chapters cover the geology of the parent material of native soils, soils microbes, flora and fauna. Soil classification has been given in detail to better understand the nature of soils for judicious management strategies. The authors present land use practices and suggestions for changes in land use to benefit from the full potential of the soils in this region. Their ultimate aim is to find ways of feeding the ever-increasing population and raising the standard of life for the people living in the Himalayan mountain region. .
Keywords	Agriculture ; Land use. ; Hindu Kush-Himalayan Region
Subject code	810.935879405
Language	English
Size	1 online resource (502 pages)
Edition	1st ed. 2022.
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Note	Includes index.
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-031-11458-2 ; 9783031114571 ; 978-3-031-11458-8 ; 3031114574
DOI	10.1007/978-3-031-11458-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Pluronic F-68 Montmorillonite As A Drug Delivery Vehicle For Extended Release Of Venlafaxine Hydrochloride.

Jain, Shilpa / Datta, Monika

Drug research

2023 Volume 73, Issue 6, Page(s) 325–334

Abstract: Short half-life and low bioavailability of Venlafaxine hydrochloride (VF), an antidepressant drug, necessitates the frequent administration of VF tablets in a day in order to maintain adequate drug concentration in blood plasma. This generates the need ... ...

Abstract	Short half-life and low bioavailability of Venlafaxine hydrochloride (VF), an antidepressant drug, necessitates the frequent administration of VF tablets in a day in order to maintain adequate drug concentration in blood plasma. This generates the need for the development of formulations which could prolong the release of VF and reduce the multiple dosages. The present work explores the combination of Montmorillonite (Mt) with Pluronic F-68 (PF-68) (OrganoMT) for oral delivery of VF. The effect of various parameters including pH of aqueous drug solution, contact time and initial drug concentration on drug loading capacity of OrganoMT has been studied. The synthesized OrganoMT-VF complexes were characterized by various suitable techniques. XRD studies indicated that the VF molecules were intercalated within the OrganoMT layers. In vitro release behavior of VF from OrganoMT-VF complexes shows an extended-release pattern for a period of 30 h and reaches upto 70% and 60% compared to pure VF having complete release time of 5.5 h and 3.5 h in simulated gastric and intestinal fluid respectively. Various kinetic models were employed to elucidate the drug release mechanism where the best fitting was obtained with Korsmeyer Peppas model. The results suggest the possibility of designing an oral extended controlled release formulation for VF to minimize its administration frequency thereby increasing the effectiveness of drug. This improves patient compliance by reducing the dose from 4 times in 24 h to once in 24 h.
MeSH term(s)	Humans ; Venlafaxine Hydrochloride ; Poloxamer ; Bentonite ; Antidepressive Agents ; Drug Compounding ; Delayed-Action Preparations ; Excipients ; Tablets
Chemical Substances	Venlafaxine Hydrochloride (7D7RX5A8MO) ; Poloxamer (106392-12-5) ; Bentonite (1302-78-9) ; Antidepressive Agents ; Delayed-Action Preparations ; Excipients ; Tablets
Language	English
Publishing date	2023-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-2024-9964
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Article ; Online: Genetic analysis of translation initiation in bacteria: An initiator tRNA-centric view.

Lahry, Kuldeep / Datta, Madhurima / Varshney, Umesh

Molecular microbiology

2024

Abstract: Translation of messenger RNA (mRNA) in bacteria occurs in the steps of initiation, elongation, termination, and ribosome recycling. The initiation step comprises multiple stages and uses a special transfer RNA (tRNA) called initiator tRNA (i-tRNA), which ...

Abstract	Translation of messenger RNA (mRNA) in bacteria occurs in the steps of initiation, elongation, termination, and ribosome recycling. The initiation step comprises multiple stages and uses a special transfer RNA (tRNA) called initiator tRNA (i-tRNA), which is first aminoacylated and then formylated using methionine and N
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1111/mmi.15243
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Article ; Online: Investigation on trommeled legacy waste from full-scale mining of old dumpsites: Suitable for valorization or scientific disposal?

Parida, Debaprakash / Ramana, G V / Datta, Manoj

Journal of environmental management

2024 Volume 356, Page(s) 120580

Abstract: The burgeoning interest in resource recovery from old dumpsites has significantly propelled the adoption of Landfill Mining (LFM) in recent years. This study is centred around evaluating the quality of materials recovered from the full-scale LFM ... ...

Abstract	The burgeoning interest in resource recovery from old dumpsites has significantly propelled the adoption of Landfill Mining (LFM) in recent years. This study is centred around evaluating the quality of materials recovered from the full-scale LFM activities at two major dumpsites in India, focusing on the valorization potential of the segregated legacy waste. A detailed analysis was conducted on the segregated waste fractions based on particle size (-30 mm, 30 to 6 mm, and -6 mm, as sourced from the sites), employing both batch and column leaching methods across a range of liquid-to-solid (L/S) ratios (0.1-10.0 L/kg). The findings reveal a pronounced concentration of contaminants within the -6 mm fraction compared to the 30 to 6 mm and -30 mm fractions. Column leaching tests revealed a reduction in contaminant concentration, correlating with incremental changes in L/S ratio. Notably, this trend remained consistent across varying particle sizes and specific type of contaminants assessed. Notably, color intensity of leachate reduced significantly from 720 to 1640 Platinum Cobalt Units (PCU) at an L/S ratio of 0.1 L/kg to a minimal 94-225 PCU at an L/S of 10 L/kg. Dissolved salts emerged as a primary concern, marking them as significant contaminants in both leaching methods. The analysis confirmed that the segregated fractions comply with the USEPA Waste Acceptance Criteria (WAC), permitting their disposal in non-hazardous waste landfills. However, the elevated presence of dissolved salts, exceeding reuse limits by 5-35 times, limits their open or unrestricted reuse. Despite this, isolated reuse aligns with regulations from the Netherlands and Germany, suggesting viable pathways for compliant utilization. Geotechnical assessments indicate the potential for repurposing the -30 mm fraction as alternative earthfill and construction material. While heavy metal leaching does not pose significant concerns, the prevalent unscientific disposal practices near urban settlements highlight potential human health risks. This investigation enriches the understanding of the physicochemical properties, leaching behaviour, and reuse potential of segregated legacy waste, offering crucial insights for civic authorities in determining appropriate reuse and disposal strategies for such materials.
MeSH term(s)	Humans ; Refuse Disposal/methods ; Salts ; Waste Disposal Facilities ; Metals, Heavy/analysis ; Cobalt/analysis ; Solid Waste/analysis
Chemical Substances	Salts ; Metals, Heavy ; Cobalt (3G0H8C9362) ; Solid Waste
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120580
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Article ; Online: Sustainable utilization of incineration bottom ash in pavement construction: Environmental impacts and life cycle assessment.

Bansal, Deepesh / Ramana, G V / Datta, Manoj

The Science of the total environment

2024 , Page(s) 172890

Abstract: The global drive towards sustainable development has prompted a notable shift in civil engineering practices towards utilizing secondary materials, such as incineration bottom ash (IBA). The literature review underscores the relevance of waste ... ...

Abstract	The global drive towards sustainable development has prompted a notable shift in civil engineering practices towards utilizing secondary materials, such as incineration bottom ash (IBA). The literature review underscores the relevance of waste incineration and the crucial need for effective IBA management strategies. Existing studies, however, reveal a dearth of studies within the life cycle assessment (LCA) framework focusing on understanding IBA characteristics and field conditions. The study addresses this gap by proposing an LCA to assess the environmental implications of substituting natural aggregates with IBA in pavement layers. A comparative LCA was carried out, where different scenarios of reuse of IBA (as produced, treated, or with restrictions) were assessed against a baseline scenario that represents the conventional use of aggregates in roads and landfilling of IBA. The ReCiPe technique, incorporating a hierarchist perspective, was employed to assess impacts across different problem-oriented categories. Additionally, this study also explores the impact of data variability on LCA outcomes, considering changes in landfill height, pavement infiltration rate, time duration, and IBA transportation distance. The analysis indicates that incorporating IBA in road layers can significantly reduce impacts on non-toxic categories like global warming by over 35 %. However, the leaching properties of untreated IBA contribute to a >28 % increase in human carcinogenic toxicity, rendering it environmentally unsuitable for road layer reuse. The comparative study illustrated that reusing treated IBA is the most sustainable approach, remaining effective up to a distance of d + 15 km. In cases where treatment is not feasible, utilizing IBA with restrictions is recommended up to a distance of d + 5 km (d represents the transportation distance for natural materials). This research fills a critical gap in the literature by providing a framework to assess IBA reuse in road construction, thereby advancing the discourse on sustainable materials management in the construction industry.
Language	English
Publishing date	2024-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172890
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Article: Immunoglobulin Gene Sequence as an Inherited and Acquired Risk Factor for Chronic Lymphocytic Leukemia.

Datta, Moumita / Jumaa, Hassan

Cancers

2022 Volume 14, Issue 13

Abstract: Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease characterized by the accumulation of ... ...

Abstract	Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease characterized by the accumulation of CD5
Language	English
Publishing date	2022-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14133045
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Article: Revaccination with Bacille Calmette-Guérin: Some issues to consider.

Datta, Manjula / Radhamani, M P

The Indian journal of medical research

2022 Volume 157, Issue 2&3, Page(s) 160–162

MeSH term(s)	Humans ; Immunization, Secondary ; BCG Vaccine/adverse effects
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2022-12-19
Publishing country	India
Document type	Journal Article ; Comment
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.ijmr_2106_22
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Article ; Online: H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes.

Kumar, Amit / Datta, Malabika

Molecular medicine (Cambridge, Mass.)

2022 Volume 28, Issue 1, Page(s) 81

Abstract: Background: Histone deacetylases (HDACs) that catalyze removal of acetyl groups from histone proteins, are strongly associated with several diseases including diabetes, yet the precise regulatory events that control the levels and activity of the HDACs ... ...

Abstract	Background: Histone deacetylases (HDACs) that catalyze removal of acetyl groups from histone proteins, are strongly associated with several diseases including diabetes, yet the precise regulatory events that control the levels and activity of the HDACs are not yet well elucidated. Methods: Levels of H19 and HDACs were evaluated in skeletal muscles of normal and diabetic db/db mice by Western Blot analysis. C2C12 cells were differentiated and transfected with either the scramble or H19 siRNA and the levels of HDACs and Prkab2, Pfkfb3, Srebf1, Socs2, Irs1 and Ppp2r5b were assessed by Western Blot analysis and qRT-PCR, respectively. Levels of H9, HDAC6 and IRS1 were evaluated in skeletal muscles of scramble/ H19 siRNA injected mice and chow/HFD-fed mice. Results: Our data show that the lncRNA H19 and HDAC6 exhibit inverse patterns of expression in the skeletal muscle of diabetic db/db mice and in C2C12 cells, H19 inhibition led to significant increase in HDAC activity and in the levels of HDAC6, both at the transcript and protein levels. This was associated with downregulation of IRS1 levels that were prevented in the presence of the HDAC inhibitor, SAHA, and HDAC6 siRNA suggesting the lncRNA H19-HDAC6 axis possibly regulates cellular IRS1 levels. Such patterns of H19, HDAC6 and IRS1 expression were also validated and confirmed in high fat diet-fed mice where as compared to normal chow-fed mice, H19 levels were significantly inhibited in the skeletal muscle of these mice and this was accompanied with elevated HDAC6 levels and decreased IRS1 levels. In-vivo inhibition of H19 led to significant increase in HDAC6 levels and this was associated with a decrease in IRS1 levels in the skeletal muscle. Conclusions: Our results suggest a critical role for the lncRNA H19-HDAC6 axis in regulating IRS1 levels in the skeletal muscle during diabetes and therefore restoring normal H19 levels might hold a therapeutic potential for the management of aberrant skeletal muscle physiology during insulin resistance and type 2 diabetes.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Histone Deacetylase 6/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Small Interfering
Chemical Substances	H19 long non-coding RNA ; Insulin ; Insulin Receptor Substrate Proteins ; Irs1 protein, mouse ; RNA, Long Noncoding ; RNA, Small Interfering ; Hdac6 protein, mouse (EC 3.5.1.98) ; Histone Deacetylase 6 (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2022-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-022-00507-3
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Article ; Online: Management of Adult Traumatic Brachial Plexus Injury.

Datta, N K / Das, K P / Islam, M A / Aish, P K / Datta, M

Mymensingh medical journal : MMJ

2023 Volume 32, Issue 2, Page(s) 437–447

Abstract: Brachial plexus injury is not uncommon in our country like Bangladesh and it causes functional damage and physical disability of the upper limbs. Most of the cases were caused by motor vehicle accident. We have conducted a prospective study for the ... ...

Abstract	Brachial plexus injury is not uncommon in our country like Bangladesh and it causes functional damage and physical disability of the upper limbs. Most of the cases were caused by motor vehicle accident. We have conducted a prospective study for the operative treatment of 105 adult traumatic brachial plexus injury cases in Hand unit in the department of Orthopaedics, Bangabandhu Sheikh Mujib Medial University (BSMMU) during January 2012 to July 2019. The main surgical options for brachial plexus injury include primary reconstructive surgery such as neurolysis, direct repair, nerve graft, nerve transfer (neurotization) and possibly free functioning (gracilis) muscle transfer and secondary reconstructive procedure such as tendon transfer, arthrodesis, FFMT and bony procedure. Each of these procedures is used either alone or in combination for particular clinical scenarios. Aims and objectives of this study was to restoration of shoulder abduction and external rotation, elbow flexion and hand function are goal of treatment of adult traumatic brachial plexus injury. Age range was from 14 years to 55 years (mean age 26 years). Male were 95 and female were 10 cases. Time from trauma to surgery was valid 3 months to 9 months. Motor cycle accident was most common mechanism of injury. Upper plexus (C5, C6) injury was 52 cases, extended upper plexus (C5, C6 & C7) injury was 19 cases and global brachial plexus injury was 34 cases. When there is high suspicion of root avulsions, early exploration and reconstruction is indicated. Operate these patients 2-3 months after their injury. In other patients without high suspicion of root avulsion, we routinely perform exploration between 3 to 6 months after injury when no adequate sign of recovery are present. Common reconstructive options are any injury with neuroma in continuity with conductive nerve action potential (NAP): only neurolysis or any injury with nerve rupture or postganglionic neuroma not conducting nerve Action potential (NAP) and good proximal nerve: Direct repair or repair with nerve graft or nerve transfer if possible. Follow up period from 6 months to 6 years. The best results were obtained in C5, C6 and C5, C6 & C7 brachial plexus injury cases. SAN to SSN, Oberlin II and long head triceps motor branch to anterior division of axillary nerve transfer for C5 & C6 injury or upper plexus injury and in addition intercostals nerve to anterior division of axillary nerve and AIN branch of median nerve to ECRB for C5, C6 & C7 (extended upper plexus injury). Extra-plexus and intra-plexus neurotization was done in global brachial plexus injury cases and 5 cases by contra-lateral C7 to median nerve by vascularised ulnar nerve graft and only 2 cases contra-lateral C7 to lower trunk through pre spinal or pre tracheal route were done and only one case by FFMT. Few cases gain shoulder abduction and elbow flexion but no improvement of hand function and most cases even by FFMT still in follow up. Results of surgical treatment of upper and extended upper brachial plexus injury cases were satisfactory on the other hand recovery of shoulder abduction and elbow flexion was acceptable and comparable to other study in global brachial plexus injury and recovery of hand function were poor.
MeSH term(s)	Humans ; Adult ; Male ; Female ; Adolescent ; Prospective Studies ; Brachial Plexus/surgery ; Elbow/innervation ; Elbow Joint/surgery ; Elbow Joint/innervation ; Nerve Transfer/methods ; Treatment Outcome ; Range of Motion, Articular
Language	English
Publishing date	2023-04-01
Publishing country	Bangladesh
Document type	Journal Article
ZDB-ID	2435083-7
ISSN	2408-8757 ; 1022-4742
ISSN (online)	2408-8757
ISSN	1022-4742
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Article: Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response.

Burchett, Alice / Siri, Saeed / Li, Jun / Lu, Xin / Datta, Meenal

bioRxiv : the preprint server for biology

2024

Abstract: Purpose: In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how macrophages ... ...

Abstract	Purpose: In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how macrophages themselves contribute to mechanical forces in their microenvironment. Methods: Raw 264.7 murine macrophages were embedded in a confining agarose gel, where they proliferated to form spheroids over time. Gels were synthesized at various concentrations to tune the stiffness and treated with various growth supplements to promote macrophage polarization. The spheroids were then analyzed by immunofluorescent staining and qPCR for markers of proliferation, mechanosensory channels, and polarization. Finally, spheroid geometries were used to computationally model the strain generated in the agarose by macrophage spheroid growth. Results: Macrophages form spheroids and generate growth-induced mechanical forces (i.e., solid stress) within confining agarose gels, which can be maintained for at least 16 days in culture. Increasing agarose concentration restricts spheroid expansion, promotes discoid geometries, limits gel deformation, and induces an increase in iNOS expression. LPS stimulation increases spheroid growth, though this effect is reversed with the addition of IFN-γ. Ki67 expression decreases with increasing agarose concentration, in line with the growth measurements. Conclusions: Macrophages alone both respond to and generate solid stress. Understanding how macrophage generation of growth-induced solid stress responds to different environmental conditions will help to inform treatment strategies for the plethora of diseases that involve macrophage accumulation.
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.14.580327
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