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  1. AU="Dattoli, Anna Ada"
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  1. Article ; Online: Molecular and Serologic Diagnostic Technologies for SARS-CoV-2.

    Rando, Halie M / Brueffer, Christian / Lordan, Ronan / Dattoli, Anna Ada / Manheim, David / Meyer, Jesse G / Mundo, Ariel I / Perrin, Dimitri / Mai, David / Wellhausen, Nils / Gitter, Anthony / Greene, Casey S

    ArXiv

    2022  

    Abstract: The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by ... ...

    Abstract The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological tests make it possible to identify individuals who have mounted an immune response to a virus of interest and therefore facilitate the identification of individuals who have previously encountered the virus. These two categories of tests provide different perspectives valuable to understanding the spread of SARS-CoV-2. Within these categories, different biotechnological approaches offer specific advantages and disadvantages. Here we review the categories of tests developed for the detection of the SARS-CoV-2 virus or antibodies against SARS-CoV-2 and discuss the role of diagnostics in the COVID-19 pandemic.
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Asymmetric assembly of centromeres epigenetically regulates stem cell fate.

    Dattoli, Anna Ada / Carty, Ben L / Kochendoerfer, Antje M / Morgan, Conall / Walshe, Annie E / Dunleavy, Elaine M

    The Journal of cell biology

    2020  Volume 219, Issue 4

    Abstract: Centromeres are epigenetically defined by CENP-A-containing chromatin and are essential for cell division. Previous studies suggest asymmetric inheritance of centromeric proteins upon stem cell division; however, the mechanism and implications of ... ...

    Abstract Centromeres are epigenetically defined by CENP-A-containing chromatin and are essential for cell division. Previous studies suggest asymmetric inheritance of centromeric proteins upon stem cell division; however, the mechanism and implications of selective chromosome segregation remain unexplored. We show that Drosophila female germline stem cells (GSCs) and neuroblasts assemble centromeres after replication and before segregation. Specifically, CENP-A deposition is promoted by CYCLIN A, while excessive CENP-A deposition is prevented by CYCLIN B, through the HASPIN kinase. Furthermore, chromosomes inherited by GSCs incorporate more CENP-A, making stronger kinetochores that capture more spindle microtubules and bias segregation. Importantly, symmetric incorporation of CENP-A on sister chromatids via HASPIN knockdown or overexpression of CENP-A, either alone or together with its assembly factor CAL1, drives stem cell self-renewal. Finally, continued CENP-A assembly in differentiated cells is nonessential for egg development. Our work shows that centromere assembly epigenetically drives GSC maintenance and occurs before oocyte meiosis.
    MeSH term(s) Animals ; Centromere/genetics ; Centromere/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Epigenesis, Genetic/genetics ; Stem Cells/cytology ; Stem Cells/metabolism
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201910084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Online: Molecular and Serologic Diagnostic Technologies for SARS-CoV-2

    Rando, Halie M. / Brueffer, Christian / Lordan, Ronan / Dattoli, Anna Ada / Manheim, David / Meyer, Jesse G. / Mundo, Ariel I. / Perrin, Dimitri / Mai, David / Wellhausen, Nils / Consortium, COVID-19 Review / Gitter, Anthony / Greene, Casey S.

    2022  

    Abstract: The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by ... ...

    Abstract The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological tests make it possible to identify individuals who have mounted an immune response to a virus of interest and therefore facilitate the identification of individuals who have previously encountered the virus. These two categories of tests provide different perspectives valuable to understanding the spread of SARS-CoV-2. Within these categories, different biotechnological approaches offer specific advantages and disadvantages. Here we review the categories of tests developed for the detection of the SARS-CoV-2 virus or antibodies against SARS-CoV-2 and discuss the role of diagnostics in the COVID-19 pandemic.
    Keywords Quantitative Biology - Biomolecules
    Publishing date 2022-04-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Identification and Development of Therapeutics for COVID-19.

    Rando, Halie M / Wellhausen, Nils / Ghosh, Soumita / Lee, Alexandra J / Dattoli, Anna Ada / Hu, Fengling / Byrd, James Brian / Rafizadeh, Diane N / Lordan, Ronan / Qi, Yanjun / Sun, Yuchen / Brueffer, Christian / Field, Jeffrey M / Guebila, Marouen Ben / Jadavji, Nafisa M / Skelly, Ashwin N / Ramsundar, Bharath / Wang, Jinhui / Goel, Rishi Raj /
    Park, YoSon / Boca, Simina M / Gitter, Anthony / Greene, Casey S

    ArXiv

    2021  

    Abstract: After emerging in China in late 2019, the novel coronavirus SARS-CoV-2 spread worldwide and as of mid-2021 remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to ... ...

    Abstract After emerging in China in late 2019, the novel coronavirus SARS-CoV-2 spread worldwide and as of mid-2021 remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2:
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Identification and Development of Therapeutics for COVID-19.

    Rando, Halie M / Wellhausen, Nils / Ghosh, Soumita / Lee, Alexandra J / Dattoli, Anna Ada / Hu, Fengling / Byrd, James Brian / Rafizadeh, Diane N / Lordan, Ronan / Qi, Yanjun / Sun, Yuchen / Brueffer, Christian / Field, Jeffrey M / Ben Guebila, Marouen / Jadavji, Nafisa M / Skelly, Ashwin N / Ramsundar, Bharath / Wang, Jinhui / Goel, Rishi Raj /
    Park, YoSon / Boca, Simina M / Gitter, Anthony / Greene, Casey S

    mSystems

    2021  Volume 6, Issue 6, Page(s) e0023321

    Abstract: After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, ... ...

    Abstract After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2:
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.00233-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book ; Online: Identification and Development of Therapeutics for COVID-19

    Rando, Halie M. / Wellhausen, Nils / Ghosh, Soumita / Lee, Alexandra J. / Dattoli, Anna Ada / Hu, Fengling / Byrd, James Brian / Rafizadeh, Diane N. / Lordan, Ronan / Qi, Yanjun / Sun, Yuchen / Brueffer, Christian / Field, Jeffrey M. / Guebila, Marouen Ben / Jadavji, Nafisa M. / Skelly, Ashwin N. / Ramsundar, Bharath / Wang, Jinhui / Goel, Rishi Raj /
    Park, YoSon / Consortium, the COVID-19 Review / Boca, Simina M. / Gitter, Anthony / Greene, Casey S.

    2021  

    Abstract: After emerging in China in late 2019, the novel Severe acute respiratory syndrome-like coronavirus 2 (SARS-CoV-2) spread worldwide and as of early 2021, continues to significantly impact most countries. Only a small number of coronaviruses are known to ... ...

    Abstract After emerging in China in late 2019, the novel Severe acute respiratory syndrome-like coronavirus 2 (SARS-CoV-2) spread worldwide and as of early 2021, continues to significantly impact most countries. Only a small number of coronaviruses are known to infect humans, and only two are associated with the severe outcomes associated with SARS-CoV-2: Severe acute respiratory syndrome-related coronavirus, a closely related species of SARS-CoV-2 that emerged in 2002, and Middle East respiratory syndrome-related coronavirus, which emerged in 2012. Both of these previous epidemics were controlled fairly rapidly through public health measures, and no vaccines or robust therapeutic interventions were identified. However, previous insights into the immune response to coronaviruses gained during the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) have proved beneficial to identifying approaches to the treatment and prophylaxis of novel coronavirus disease 2019 (COVID-19). A number of potential therapeutics against SARS-CoV-2 and the resultant COVID-19 illness were rapidly identified, leading to a large number of clinical trials investigating a variety of possible therapeutic approaches being initiated early on in the pandemic. As a result, a small number of therapeutics have already been authorized by regulatory agencies such as the Food and Drug Administration (FDA) in the United States, and many other therapeutics remain under investigation. Here, we describe a range of approaches for the treatment of COVID-19, along with their proposed mechanisms of action and the current status of clinical investigation into each candidate. The status of these investigations will continue to evolve, and this review will be updated as progress is made.
    Keywords Quantitative Biology - Quantitative Methods
    Subject code 610
    Publishing date 2021-03-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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