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  1. AU="Daubenberger, Claudia A."
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  1. Article ; Online: First-generation malaria vaccine successfully implemented in three African countries.

    Daubenberger, Claudia A / Silva, Joana C

    Lancet (London, England)

    2024  Volume 403, Issue 10437, Page(s) 1607–1609

    MeSH term(s) Humans ; Malaria Vaccines ; Malaria/prevention & control ; Africa/epidemiology
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article ; News
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02892-1
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    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  2. Article ; Online: Towards protective immune responses against malaria in pregnant women.

    Daubenberger, Claudia A

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 5, Page(s) 517–519

    MeSH term(s) Aluminum Hydroxide ; Double-Blind Method ; Female ; Humans ; Malaria ; Pregnancy ; Pregnant Women
    Chemical Substances Aluminum Hydroxide (5QB0T2IUN0)
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30002-5
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    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Next-generation malaria subunit vaccines to reduce disease burden in African children.

    Daubenberger, Claudia A / Moncunill, Gemma

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 12, Page(s) 1655–1656

    MeSH term(s) Child ; Humans ; Malaria Vaccines ; Malaria/epidemiology ; Malaria/prevention & control ; Malaria, Falciparum/prevention & control ; Vaccines, Subunit ; Cost of Illness
    Chemical Substances Malaria Vaccines ; Vaccines, Subunit
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00523-0
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    Zs.A 5743: Show issues Location:
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  4. Article ; Online: Monoclonal antibodies for reducing malaria transmission.

    Daubenberger, Claudia A / Gupta, Rajesh

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 11, Page(s) 1519–1520

    MeSH term(s) Animals ; Humans ; Antibodies, Monoclonal/therapeutic use ; Malaria ; Anopheles ; Antibodies, Protozoan ; Plasmodium falciparum ; Malaria Vaccines ; Protozoan Proteins ; Malaria, Falciparum
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Protozoan ; Malaria Vaccines ; Protozoan Proteins
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00413-3
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  5. Article ; Online: Anti-tick Vaccines for the Control of Ticks Affecting Livestock

    Olds, Cassandra / Bishop, Richard P. / Daubenberger, Claudia A.

    Molecular Vaccines

    2023  

    Keywords livestock ; vaccines ; ticks
    Publishing date 2023-03-10T14:33:19Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A paradigm for Africa-centric vaccine development in Equatorial Guinea.

    Billingsley, Peter F / Richie, Thomas L / Abdulla, Salim / Ondo'o Ayekaba, Mitoha / Daubenberger, Claudia A / Garcia, Guíllermo A / Hoffman, Stephen L

    Trends in parasitology

    2024  Volume 40, Issue 5, Page(s) 362–366

    Abstract: The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review ... ...

    Abstract The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).
    MeSH term(s) Equatorial Guinea ; Malaria Vaccines/immunology ; Humans ; Vaccine Development ; Malaria/prevention & control ; Public-Private Sector Partnerships ; Africa
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2024.03.005
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    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  7. Article ; Online: First clinical trial of purified, irradiated malaria sporozoites in humans.

    Daubenberger, Claudia A

    Expert review of vaccines

    2012  Volume 11, Issue 1, Page(s) 31–33

    Abstract: Purified, irradiated, metabolically active sporozoites of Plasmodium falciparum (PfSPZ) have been administered to 80 volunteers through subcutaneous or intradermal routes. This PfSPZ vaccine has been shown to be safe but of low immunogenicity and hence ... ...

    Abstract Purified, irradiated, metabolically active sporozoites of Plasmodium falciparum (PfSPZ) have been administered to 80 volunteers through subcutaneous or intradermal routes. This PfSPZ vaccine has been shown to be safe but of low immunogenicity and hence protective efficacy as shown after challenge with infected mosquitoes. Intravenous delivery of PfSPZ in nonhuman primates induced memory CD8(+) and CD4(+) T cells specific for PfSPZ that reside in the liver. Further studies using PfSPZ and the intravenous route in humans are warranted to fully explore the potential of purified, attenuated sporozoites for malaria vaccine development.
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.11.161
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    Zs.A 6077: Show issues Location:
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  8. Article ; Online: Predicting hosts and cross-species transmission of Streptococcus agalactiae by interpretable machine learning.

    Ren, Yunxiao / Li, Carmen / Nanayakkara Sapugahawatte, Dulmini / Zhu, Chendi / Spänig, Sebastian / Jamrozy, Dorota / Rothen, Julian / Daubenberger, Claudia A / Bentley, Stephen D / Ip, Margaret / Heider, Dominik

    Computers in biology and medicine

    2024  Volume 171, Page(s) 108185

    Abstract: Background: Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), exhibits a broad host range, manifesting as both a beneficial commensal and an opportunistic pathogen across various species. In humans, it poses significant risks, ... ...

    Abstract Background: Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), exhibits a broad host range, manifesting as both a beneficial commensal and an opportunistic pathogen across various species. In humans, it poses significant risks, causing neonatal sepsis and meningitis, along with severe infections in adults. Additionally, it impacts livestock by inducing mastitis in bovines and contributing to epidemic mortality in fish populations. Despite its wide host spectrum, the mechanisms enabling GBS to adapt to specific hosts remain inadequately elucidated. Therefore, the development of a rapid and accurate method differentiates GBS strains associated with particular animal hosts based on genome-wide information holds immense potential. Such a tool would not only bolster the identification and containment efforts during GBS outbreaks but also deepen our comprehension of the bacteria's host adaptations spanning humans, livestock, and other natural animal reservoirs.
    Methods and results: Here, we developed three machine learning models-random forest (RF), logistic regression (LR), and support vector machine (SVM) based on genome-wide mutation data. These models enabled precise prediction of the host origin of GBS, accurately distinguishing between human, bovine, fish, and pig hosts. Moreover, we conducted an interpretable machine learning using SHapley Additive exPlanations (SHAP) and variant annotation to uncover the most influential genomic features and associated genes for each host. Additionally, by meticulously examining misclassified samples, we gained valuable insights into the dynamics of host transmission and the potential for zoonotic infections.
    Conclusions: Our study underscores the effectiveness of random forest (RF) and logistic regression (LR) models based on mutation data for accurately predicting GBS host origins. Additionally, we identify the key features associated with each GBS host, thereby enhancing our understanding of the bacteria's host-specific adaptations.
    MeSH term(s) Female ; Adult ; Animals ; Humans ; Cattle ; Swine ; Streptococcus agalactiae/genetics ; Streptococcal Infections/veterinary ; Genomics ; Fishes ; Machine Learning
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108185
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    Zs.A 653: Show issues Location:
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  9. Article ; Online: Gene-expression analysis for prediction of RTS,S-induced protection in humans.

    Daubenberger, Claudia A

    Expert review of vaccines

    2010  Volume 9, Issue 5, Page(s) 465–469

    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.10.35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6077: Show issues Location:
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  10. Article ; Online: Draft Genome Sequences of Seven Streptococcus agalactiae Strains Isolated from Camelus dromedarius at the Horn of Africa

    Rothen, Julian / Schindler, Tobias / Pothier, Joël F. / Younan, Mario / Certa, Ulrich / Daubenberger, Claudia A. / Pflüger, Valentin / Jores, Joerg

    Genome Announcements

    2023  

    Abstract: We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the ... ...

    Abstract We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the underlying mechanisms of pathogenicity and antibiotic resistance of camel GBS.
    Keywords africa ; strains ; camelus dromedarius ; streptococcus
    Publishing date 2023-03-10T14:33:15Z
    Publisher American Society for Microbiology
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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