Article ; Online: Genome Replication Is Associated With Release of Immunogenic DNA Waste.
2022 Volume 13, Page(s) 880413
Abstract: Innate DNA sensors detect foreign and endogenous DNA to induce responses to infection and cellular stress or damage. Inappropriate activation by self-DNA triggers severe autoinflammatory conditions, including Aicardi-Goutières syndrome (AGS) that can be ... ...
| Abstract | Innate DNA sensors detect foreign and endogenous DNA to induce responses to infection and cellular stress or damage. Inappropriate activation by self-DNA triggers severe autoinflammatory conditions, including Aicardi-Goutières syndrome (AGS) that can be caused by defects of the cytosolic DNase 3'repair exonuclease 1 (TREX1). |
|---|---|
| MeSH term(s) | Animals ; Autoimmune Diseases of the Nervous System ; Mice ; Nervous System Malformations/pathology ; Nucleotidyltransferases/metabolism ; Retroelements ; Virus Replication |
| Chemical Substances | Retroelements ; Nucleotidyltransferases (EC 2.7.7.-) |
| Language | English |
| Publishing date | 2022-05-11 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2022.880413 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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