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  1. Article ; Online: Psoriasisarthritis : Klinische Herausforderungen und medikamentöses Management.

    Dauth, Stephanie / Klippstein, Maximilian / Köhm, Michaela

    Zeitschrift fur Rheumatologie

    2023  Volume 82, Issue 3, Page(s) 220–232

    Abstract: Psoriatic arthritis (PsA) is a systemic immune-mediated inflammatory disease of the musculoskeletal system, which is accompanied by a chronic and progressive course. It is characterized by different clinical manifestations and can severely impair the ... ...

    Title translation Psoriatic arthritis : Clinical challenges and pharmaceutical management.
    Abstract Psoriatic arthritis (PsA) is a systemic immune-mediated inflammatory disease of the musculoskeletal system, which is accompanied by a chronic and progressive course. It is characterized by different clinical manifestations and can severely impair the quality of life and function of patients due to the existing heterogeneity of the manifestations. The (early) diagnosis of PsA and individualized therapeutic management in routine clinical practice are difficult due to the enormous clinical variability. In addition to the appearance of arthritis of the peripheral joints, there can be involvement of the axial skeleton, skin psoriasis, nail psoriasis, enthesitis and dactylitis. The clinical appearance, course of the disease, risk factors and pathophysiological mechanisms of PsA have been extensively researched in recent decades. With the associated better understanding of the disease, new treatment options and goals for effective treatment have also been established.
    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Quality of Life ; Psoriasis ; Skin ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language German
    Publishing date 2023-03-01
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-023-01326-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: IL-1 und IL6-inhibierende Therapien reduzieren signifikant die Mortalitätsraten von Patienten mit Hämophagozytischer Lymphohistiozytose als schwere Komplikation von immun-vermittelten Systemerkrankungen

    Dauth, Stephanie / Klippstein, Maximilian / Kunz, Christina / Meier, Florian / Braner, Axel / Behrens, Frank / Köhm, Michaela

    2023  , Page(s) VS.01

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh233
    Database German Medical Science

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  3. Book ; Online ; Thesis: Cathepsin K functions in the mouse central nervous system

    Dauth, Stephanie

    2012  

    Author's details Stephanie Dauth
    Language English
    Size Online-Ressource (Online-Ressource)
    Publisher IRC-Library, Information Resource Center der Jacobs University Bremen
    Publishing place Bremen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Bremen, Jacobs Univ., Diss., 2012
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: Spondyloarthritis

    Holz-Müller, Jana / Dauth, Stephanie / Behrens, Frank / Köhm, Michaela

    Arthritis und Rheuma

    2021  Volume 41, Issue 02, Page(s) 106–122

    Abstract: Der Begriff Spondyloarthritis umfasst mehrere Krankheitsbilder, die sich in der Pathophysiologie und im klinischen Erscheinungsbild ähneln. Zu der Gruppe der Spondyloarthritiden werden die axiale Spondyloarthritis, die Psoriasisarthritis, die reaktive ... ...

    Abstract Der Begriff Spondyloarthritis umfasst mehrere Krankheitsbilder, die sich in der Pathophysiologie und im klinischen Erscheinungsbild ähneln. Zu der Gruppe der Spondyloarthritiden werden die axiale Spondyloarthritis, die Psoriasisarthritis, die reaktive Arthritis, die chronisch entzündliche Darmerkrankung (CED)-assoziierte Spondyloarthritis und die undifferenzierte Spondyloarthritis gezählt. Die Auswahl von geeigneten Therapiestrategien mit hoher klinischer Effektstärke basiert stärker auf der Charakterisierung des klinischen Phänotyps und des Manifestationstyps als auf der indikationsbasierten Zuordnung. Durch die Heterogenität der Erkrankung und durch das Fehlen kontrollierter klinischer Studien, die als Endpunkt die Effektivität auf verschiedene Manifestationsformen vorsieht, ist die Evidenzlage für verschiedene Therapieprinzipien bezogen auf das Manifestationslevel niedrig. Dies beschränkt den In-Label-Einsatz verschiedener Wirkprinzipien. Hier besteht ein hoher Bedarf für die Potenzierung von Evidenz, damit effektive Therapien individualisiert im Patientenkollektiv eingesetzt werden können.

    The term “spondyloarthritis” encompasses several clinical indications that are similar in pathophysiology and clinical appearance. Spondyloarthritis includes axial spondyloarthritis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease (IBD)-associated spondyloarthritis and undifferentiated spondyloarthritis. The selection of suitable therapy strategies with a high clinical effect size is based more on the characterization of the clinical phenotype and the manifestation type than on the indication-based assignment. Due to the heterogeneity of the diseases and the lack of controlled clinical studies, which envisage the effectiveness on various forms of manifestation as an endpoint, the evidence base for various therapeutic principles in relation to the level of manifestation is low. This limits the in-label use of various active principles. There is a high need here for the potentiation of evidence so that effective therapies can be used in an individualized way in this special patient cohort.
    Keywords Axiale Spondyloarthritis ; Psoriasisarthritis ; reaktive Arthritis ; Therapieempfehlungen ; Klassifikation ; Axial spondyloarthritis ; psoriatic arthritis ; reactive arthritis ; treatment recommendations ; classification
    Language German
    Publishing date 2021-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-1352-9692
    Database Thieme publisher's database

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  5. Article: Spondyloarthritis

    Holz-Müller, Jana / Dauth, Stephanie / Behrens, Frank / Köhm, Michaela

    Arthritis + Rheuma

    2021  Volume 41, Issue 2, Page(s) 106

    Language German
    Document type Article
    ZDB-ID 605764-0
    ISSN 0176-5167
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Impact of different classes of immune-modulating treatments on B cell-related and T cell-related immune response before and after COVID-19 booster vaccination in patients with immune-mediated diseases and primary immunodeficiency: a cohort study.

    Koehm, Michaela / Klippstein, Maximilian / Dauth, Stephanie / Hallmann, Konstantin / Kohmer, Niko / Burkhardt, Harald / Ciesek, Sandra / Geisslinger, Gerd / Rabenau, Holger F / Behrens, Frank

    RMD open

    2023  Volume 9, Issue 3

    Abstract: Objectives: To evaluate the potential of immunosuppressed patients to mount B-cell and T-cell responses to COVID-19 booster vaccination (third vaccination).: Methods: Patients with primary immunodeficiency (PID), immune-mediated inflammatory diseases ...

    Abstract Objectives: To evaluate the potential of immunosuppressed patients to mount B-cell and T-cell responses to COVID-19 booster vaccination (third vaccination).
    Methods: Patients with primary immunodeficiency (PID), immune-mediated inflammatory diseases (IMIDs) on CD20-depleting treatment with rituximab (RTX), or IMIDs treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or biological disease-modifying antirheumatic drug (bDMARDs) were included and assessed before (baseline visit (BL)) and 2, 4 and 8 weeks after COVID-19 booster vaccination. Serum B-cell responses were assessed by antibody levels against SARS-CoV-2 spike protein (anti-spike IgG antibody (S-AB)) and a surrogate virus neutralisation test (sVNT). T-cell responses were assessed by an interferon gamma release assay (IGRA).
    Results: Fifty patients with PID (n=6), treated with RTX therapy (n=13), or treated with csDMARDs/bDMARDs (n=31) were included. At BL, anti-S-AB titres in PID and csDMARD/bDMARD-treated patients were low (although significantly higher than RTX patients); measures of B-cell-mediated response increased significantly after booster vaccination. In the RTX cohort, low BL anti-S-AB and sVNT values did not improve after booster vaccination, but patients had significantly elevated IGRA responses post booster vaccination compared with the other groups. csDMARD/bDMARD-treated patients showed the highest BL values in all three assays with greater increases in all parameters after booster vaccination compared with patients with PID.
    Conclusion: Patients with IMID on therapeutic B-cell depletion have low anti-S-AB and sVNT values before and after booster vaccination but show significantly higher levels of IGRA compared with other immunosuppressed patients, suggesting an underlying mechanism attempting to compensate compromised humoral immunity by upregulating T-cell responsiveness. PID appears to have a stronger impact on antiviral immune response than csDMARD/bDMARD treatment.
    MeSH term(s) Humans ; Cohort Studies ; Immunomodulating Agents ; COVID-19/prevention & control ; SARS-CoV-2 ; T-Lymphocytes ; Antirheumatic Agents/therapeutic use
    Chemical Substances spike protein, SARS-CoV-2 ; Immunomodulating Agents ; Antirheumatic Agents
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003094
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  7. Book ; Online ; Thesis: Cathepsin K functions in the mouse central nervous system

    Dauth, Stephanie [Verfasser]

    2012  

    Author's details Stephanie Dauth
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher IRC-Library, Information Resource Center der Jacobs University Bremen
    Publishing place Bremen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: Aufgabenteilung im hausärztlichen Praxisteam bei der Durchführung von Versorgungsstudien. How Do Family Practice Teams Divide up Health Services Research Responsibilities?

    Mergenthal, Karola / Schulz-Rothe, Sylvia / Siebenhofer, Andrea / Gerlach, Ferdinand M. / Dauth, Stephanie / Petersen, Juliana J.

    Zeitschrift für Allgemeinmedizin

    2021  Volume 97, Issue 6, Page(s) 281

    Language German
    Document type Article
    ZDB-ID 522031-2
    ISSN 1433-6251 ; 0937-6801
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.157: Show issues Location:
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  9. Article ; Online: Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

    Yu, D.M.T. / Dauth, Stephanie / Margineanu, M.B. / Snetkova, V. / Rehders, M. / Jordans, S. / Brix, K.

    2022  

    Abstract: The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk-/-) mice have learning and memory impairments. Alterations in cathepsin expression are known to result in ... ...

    Abstract The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk-/-) mice have learning and memory impairments. Alterations in cathepsin expression are known to result in compensatory changes in levels of related cathepsins. To gain insight into the therapeutic usefulness of cathepsin inhibitors in aging individuals with osteoporosis or neurodegenerative diseases, we studied for variations in cathepsin expression and activity in aged (18-20 months) versus young (5-7 months) wild-type (WT) and cathepsin-deficient mice brains. There were age-dependent increases in cathepsin B, D, and L and cystatin C protein levels in various brain regions, mainly of WT and Ctsk-/- mice. This corresponded with changes in activity levels of cathepsins B and L, but not cathepsin D. In contrast, very little age-dependent variation was observed in cathepsin-B-and cathepsin-L-deficient mouse brain, especially at the protein level. The observed alterations in cathepsin protein amounts and activity are likely contributing to changes in important aging-related processes such as autophagy. In addition, the results provide insight into the potential impact of cathepsin inhibitor therapy in aged individuals, as well as in long-term use of cathepsin inhibitor therapy.

    12

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    Keywords Aging disorders ; Aspartic proteases ; Brain ; Cystatin C ; Cysteine peptidases ; Lysosomes ; Protease inhibitor therapy
    Subject code 572
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Potential of FX06 to prevent disease progression in hospitalized non-intubated COVID-19 patients - the randomized, EU-wide, placebo-controlled, phase II study design of IXION.

    Kloka, Jan / Friedrichson, Benjamin / Dauth, Stephanie / Foldenauer, Ann Christina / Bulczak-Schadendorf, Anita / Vehreschild, Maria J G T / Matos, Francisco Maio / Riera-Mestre, Antoni / van Asselt, Antoinette D I / De Robertis, Edoardo / Juskeviciene, Vilma Traskaite / Meybohm, Patrick / Tomescu, Dana / Lacombe, Karine / Stehouwer, Coen D A / Zacharowski, Kai

    Trials

    2022  Volume 23, Issue 1, Page(s) 688

    Abstract: Background: More than 2.7 million hospitalizations of COVID-19-infected patients have occurred in Europe alone since the outbreak of the coronavirus in 2020. Interventions against SARS-CoV-2 are still in high need to prevent admissions to ICUs worldwide. ...

    Abstract Background: More than 2.7 million hospitalizations of COVID-19-infected patients have occurred in Europe alone since the outbreak of the coronavirus in 2020. Interventions against SARS-CoV-2 are still in high need to prevent admissions to ICUs worldwide. FX06, a naturally occurring peptide in humans and other mammals, has the potential to reduce capillary leak by improving endothelial dysfunction and thus preventing the deterioration of patients. With IXION, we want to investigate the potential of FX06 to prevent disease progression in hospitalized, non-intubated COVID-19 patients.
    Methods: IXION is an EU-wide, multicentre, placebo-controlled, double-blinded, parallel, randomized (2:1) phase II clinical study. Patient recruitment will start in September 2022 (to Q2/2023) in Germany, Italy, Lithuania, Spain, Romania, Portugal, and France. A total of 306 hospitalized patients (≥ 18 years and < 75 years) with a positive SARS-CoV-2 PCR test and a COVID-19 severity of 4-6 according to the WHO scale will be enrolled. After randomization to FX06 or placebo, patients will be assessed until day 28 (and followed up until day 60). FX06 (2 × 200 mg per day) or placebo will be administered intravenously for 5 consecutive days. The primary endpoint is to demonstrate a difference in the proportion of patients with progressed/worsened disease state in patients receiving FX06 compared to patients receiving placebo. Secondary endpoints are lung function, oxygen saturation and breathing rate, systemic inflammation, survival, capillary refill time, duration of hospital stay, and drug accountability.
    Discussion: With IXION, the multidisciplinary consortium aims to deliver a new therapy in addition to standard care against SARS-CoV-2 for the clinical management of COVID-19 during mild and moderate stages. Potential limitations might refer to a lack of recruiting and drop-out due to various possible protocol violations. While we controlled for drop-outs in the same size estimation, recruitment problems may be subject to external problems difficult to control for.
    Trial registration: EudraCT 2021-005059-35 . Registered on 12 December 2021. Study Code TMP-2204-2021-47.
    MeSH term(s) COVID-19 ; Disease Progression ; Hospitalization ; Humans ; SARS-CoV-2 ; Spain ; Treatment Outcome
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06609-x
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