Article ; Online: Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic.
Advanced drug delivery reviews
2021 Volume 181, Page(s) 114033
Abstract: Neurosurgery as one of the most technologically demanding medical fields rapidly adapts the newest developments from multiple scientific disciplines for treating brain tumors. Despite half a century of clinical trials, survival for brain primary tumors ... ...
Abstract | Neurosurgery as one of the most technologically demanding medical fields rapidly adapts the newest developments from multiple scientific disciplines for treating brain tumors. Despite half a century of clinical trials, survival for brain primary tumors such as glioblastoma (GBM), the most common primary brain cancer, or rare ones including primary central nervous system lymphoma (PCNSL), is dismal. Cancer therapy and research have currently shifted toward targeted approaches, and personalized therapies. The orchestration of novel and effective blood-brain barrier (BBB) drug delivery approaches, targeting of cancer cells and regulating tumor microenvironment including the immune system are the key themes of this review. As the global pandemic due to SARS-CoV-2 virus continues, neurosurgery and neuro-oncology must wrestle with the issues related to treatment-related immune dysfunction. The selection of chemotherapeutic treatments, even rare cases of hypersensitivity reactions (HSRs) that occur among immunocompromised people, and number of vaccinations they have to get are emerging as a new chapter for modern Nano neurosurgery. |
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MeSH term(s) | Animals ; Blood-Brain Barrier/surgery ; Brain Neoplasms/surgery ; COVID-19/surgery ; Glioblastoma/surgery ; Humans ; Nanotechnology/methods ; Neurosurgery/methods ; Pandemics/statistics & numerical data ; Tumor Microenvironment/physiology |
Language | English |
Publishing date | 2021-11-20 |
Publishing country | Netherlands |
Document type | Journal Article ; Review |
ZDB-ID | 639113-8 |
ISSN | 1872-8294 ; 0169-409X |
ISSN (online) | 1872-8294 |
ISSN | 0169-409X |
DOI | 10.1016/j.addr.2021.114033 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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