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  1. Article ; Online: Management of Solid Pseudopapillary Tumors of the Pancreas: Experience from a Single Institution.

    Kim, Jin K / Dave, Nikita / Chokshi, Ravi J

    The American surgeon

    2020  Volume 86, Issue 2, Page(s) e57–e58

    MeSH term(s) Adenocarcinoma, Papillary/surgery ; Adult ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Pancreatic Neoplasms/surgery ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2020-02-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin.

    Belsham, Hannah R / Alghamdi, Hanan M / Dave, Nikita / Rathbone, Alexandra J / Wickstead, Bill / Friel, Claire T

    Open biology

    2022  Volume 12, Issue 8, Page(s) 220133

    Abstract: The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizing ... ...

    Abstract The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizing kinesins and are vital regulators of microtubule length. Kinesin-13s are critical to spindle assembly and chromosome segregation in both mitotic and meiotic cell division and play crucial roles in cilium length control and neuronal development. To better understand the evolution of microtubule depolymerization activity, we created a synthetic ancestral kinesin-13 motor domain. This phylogenetically inferred ancestral motor domain is the sequence predicted to have existed in the common ancestor of the kinesin-13 family. Here we show that the ancestral kinesin-13 motor depolymerizes stabilized microtubules faster than any previously tested depolymerase. This potent activity is more than an order of magnitude faster than the most highly studied kinesin-13, MCAK and allows the ancestral kinesin-13 to depolymerize doubly stabilized microtubules and cause internal breaks within microtubules. These data suggest that the ancestor of the kinesin-13 family was a 'super depolymerizer' and that members of the kinesin-13 family have evolved away from this extreme depolymerizing activity to provide more controlled microtubule depolymerization activity in extant cells.
    MeSH term(s) Chromosome Segregation ; Kinesins/genetics ; Microtubules
    Chemical Substances Kinesins (EC 3.6.4.4)
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.220133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: K

    Rahman, Mohammad Asikur / Orfali, Razan / Dave, Nikita / Lam, Elyn / Naguib, Nadeen / Nam, Young-Woo / Zhang, Miao

    Journal of neuroscience research

    2023  Volume 101, Issue 11, Page(s) 1699–1710

    Abstract: One group of the ... ...

    Abstract One group of the K
    MeSH term(s) Rats ; Animals ; Potassium Channels/physiology ; Endothelial Cells ; Neurons/physiology ; Membrane Potentials/physiology ; Purkinje Cells
    Chemical Substances Potassium Channels
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Uveal melanoma: epidemiology, etiology, and treatment of primary disease.

    Krantz, Benjamin A / Dave, Nikita / Komatsubara, Kimberly M / Marr, Brian P / Carvajal, Richard D

    Clinical ophthalmology (Auckland, N.Z.)

    2017  Volume 11, Page(s) 279–289

    Abstract: Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of ...

    Abstract Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Genomic analyses have led to the development of gene-expression profiles that effectively predict metastatic progression; unfortunately, no adjuvant therapy has been shown to prolong survival to date. New insights into the molecular biology of UM have found frequent activating mutations in genes encoding for the G-protein α-subunit,
    Language English
    Publishing date 2017-01-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S89591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Incidence and Risk Factors for Isolated Esophageal Cancer Recurrence to the Brain.

    Nobel, Tamar B / Dave, Nikita / Eljalby, Mahmoud / Xing, Xinxin / Barbetta, Arianna / Hsu, Meier / Tan, Kay See / Janjigian, Yelena / Bains, Manjit S / Sihag, Smita / Jones, David R / Molena, Daniela

    The Annals of thoracic surgery

    2019  Volume 109, Issue 2, Page(s) 329–336

    Abstract: Background: Recurrence of esophageal cancer in the brain is rare but associated with a poor prognosis. Identification of risk factors for isolated brain metastasis of esophageal cancer (iBMEC) after surgical treatment may guide surveillance ... ...

    Abstract Background: Recurrence of esophageal cancer in the brain is rare but associated with a poor prognosis. Identification of risk factors for isolated brain metastasis of esophageal cancer (iBMEC) after surgical treatment may guide surveillance recommendations to enable early identification and intervention before widespread metastasis.
    Methods: Patients with iBMEC (n = 38) were identified from a prospective database of patients with esophageal cancer who underwent esophagectomy. Risk factors for iBMEC were identified using competing risk regression analysis.
    Results: In a cohort of 1760 patients, 39% recurred and iBMEC developed in 2% by the end of the study. Survival in patients with iBMEC was similar to survival in patients with distant recurrence (median overall survival, 0.95 years; 95% confidence interval, 0.6-1.5 years). More than half of patients with iBMEC were diagnosed within 1 year postoperatively. All 38 patients with iBMEC had received neoadjuvant therapy before surgery. Pathologic complete response (PCR) to neoadjuvant therapy was associated with improved survival after brain recurrence (median overall survival, 1.56 vs 0.66 years; P = .019).
    Conclusions: In patients with PCR, iBMEC may represent true isolated recurrence, whereas in those with residual nodal disease, iBMEC may actually be the first observed site of widespread metastasis. Patients who receive neoadjuvant therapy, especially with PCR, may benefit from brain imaging, both preoperatively and with routine surveillance.
    MeSH term(s) Adenocarcinoma/mortality ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Adult ; Aged ; Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Cancer Care Facilities ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/secondary ; Carcinoma, Squamous Cell/surgery ; Cause of Death ; Chemoradiotherapy/methods ; Databases, Factual ; Disease-Free Survival ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagectomy/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Neoadjuvant Therapy/methods ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Survival Analysis ; Treatment Outcome ; United States
    Language English
    Publishing date 2019-10-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.09.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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