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Article: Blood collection under anesthesia, peripheral blood cells, plasma biochemistry, and plasma protein electrophoresis in a living fossil: the Spotted Ratfish (

Morón-Elorza, Pablo / David, Hugo / Batista, Hugo / Quina, Vanessa / Baylina, Nuria / Pereira, Nuno

2024 Volume 10, Page(s) 1305968

Abstract: This report describes the safe and effective handling under anesthesia, blood collection and main clinical pathology values determination for three adult Spotted Ratfish ( ...

Abstract	This report describes the safe and effective handling under anesthesia, blood collection and main clinical pathology values determination for three adult Spotted Ratfish (
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1305968
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Book ; Thesis: Einfluss hyperton-/hyperonkotischer Lösungen auf die posttraumatische kortikale Durchblutung des Gehirns und das sekundäre Nekrosewachstum bei fokaler kortikaler Kälteläsion

Friedrich, David H.

(Medizin)

2007

Author's details	David H. Friedrich
Series title	Medizin
Keywords	Contusio cerebri ; Nekrose ; Hydroxyethylstärke
Subject	HES ; Hydroxyäthylstärke ; HÄS ; HAES ; Tetraspan ; Venofundin ; Vitafusal ; Volulyte ; Voluven ; Gewebstod ; Gewebsuntergang ; Hirnprellung ; Gedecktes Schädel-Hirn-Trauma ; Hirnkontusion
Language	German
Size	137 S.
Publisher	Dr. Hut
Publishing place	München
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., diss., 2007
HBZ-ID	HT015473839
ISBN	978-3-89963-653-6 ; 3-89963-653-8
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2008 A 1955	order for loan	Magazin

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Article: MicroRNA Profile, Putative Diagnostic Biomarkers and RNA-Based Therapies in the Inherited Lipid Storage Disease Niemann-Pick Type C.

Encarnação, Marisa / David, Hugo / Coutinho, Maria Francisca / Moreira, Luciana / Alves, Sandra

Biomedicines

2023 Volume 11, Issue 10

Abstract: Lipids are essential for cellular function and are tightly controlled at the transcriptional and post-transcriptional levels. Dysregulation of these pathways is associated with vascular diseases, diabetes, cancer, and several inherited metabolic ... ...

Abstract	Lipids are essential for cellular function and are tightly controlled at the transcriptional and post-transcriptional levels. Dysregulation of these pathways is associated with vascular diseases, diabetes, cancer, and several inherited metabolic disorders. MicroRNAs (miRNAs), in particular, are a family of post-transcriptional gene repressors associated with the regulation of many genes that encode proteins involved in multiple lipid metabolism pathways, thereby influencing their homeostasis. Thus, this class of non-coding RNAs (ncRNAs) has emerged as a promising therapeutic target for the treatment of lipid-related metabolic alterations. Most of these miRNAs act at an intracellular level, but in the past few years, a role for miRNAs as intercellular signaling molecules has also been uncovered since they can be transported in bodily fluids and used as potential biomarkers of lipid metabolic alterations. In this review, we point out the current knowledge on the miRNA signature in a lysosomal storage disorder associated with lipid dysfunction, Niemann-Pick type C, and discuss the potential use of miRNAs as biomarkers and therapeutic targets for RNA-based therapies.
Language	English
Publishing date	2023-09-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102615
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Article ; Online: Challenges in the Definitive Diagnosis of Niemann-Pick Type C-Leaky Variants and Alternative Transcripts.

Encarnação, Marisa / Ribeiro, Isaura / David, Hugo / Coutinho, Maria Francisca / Quelhas, Dulce / Alves, Sandra

Genes

2023 Volume 14, Issue 11

Abstract: Niemann-Pick type C (NPC, ORPHA: 646) is a neuro-visceral, psychiatric disease caused predominantly by pathogenic variants in ... ...

Abstract	Niemann-Pick type C (NPC, ORPHA: 646) is a neuro-visceral, psychiatric disease caused predominantly by pathogenic variants in the
MeSH term(s)	Humans ; Niemann-Pick Disease, Type C/diagnosis ; Niemann-Pick Disease, Type C/genetics ; DNA, Complementary ; Carrier Proteins/genetics ; Phenotype ; RNA Splicing
Chemical Substances	DNA, Complementary ; Carrier Proteins
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14111990
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Article ; Online: Eficacia del programa ¡Qué importante es tributar! en el desarrollo de cultura tributaria en adolescentes

Samuel Condori Loayza / Oscar Mamani Benito / David Hugo Bernedo Moreira

Apuntes Universitarios, Vol 10, Iss

2020 Volume 1

Abstract: El presente estudio tuvo el objetivo de determinar la eficacia del programa educativo ¡Qué importante es tributar! orientado a desarrollar conocimientos y actitudes favorables sobre cultura tributaria en estudiantes de secundaria de una institución ... ...

Abstract	El presente estudio tuvo el objetivo de determinar la eficacia del programa educativo ¡Qué importante es tributar! orientado a desarrollar conocimientos y actitudes favorables sobre cultura tributaria en estudiantes de secundaria de una institución educativa privada de Juliaca. La investigación se enmarca en un diseño cuasi-experimental con evaluación pre y post intervención, en el cual los participantes fueron distribuidos en dos grupos: experimental (GE = 30) y control (GC = 30). En este caso, fue el GE quien recibió un total de 10 sesiones educativas distribuidas en 3 módulos: conocimientos, percepción y actitudes. Para determinar la eficacia del programa se aplicó un cuestionario que medía la cultura tributaria utilizada en una investigación similar y validada por expertos en educación financiera. Los resultados indican que antes de la intervención seis participantes del GE (20%) demostraron conocimientos sobre cultura tributaria a nivel bajo, 19 a nivel moderado (63.3%) y cinco a nivel alto (16.7%); luego de la intervención, ninguno demostró un nivel bajo, 19 un nivel moderado (63.3%) y 11 un nivel alto. Según la prueba de hipótesis, el estadístico t de student reveló diferencias significativas entre los puntajes hallados antes y después de la intervención (t = -7.509, p < .05), mientras que las diferencias en el grupo control fueron porcentuales mas no significativas (t = .648, p > .05). Se concluye que el programa educativo incrementó positivamente conocimientos, percepciones y actitudes favorables hacia la cultura tributaria en adolescentes, a fin de promover el cumplimiento ético de las obligaciones tributarias.
Keywords	Cultura tributaria ; evasión tributaria ; educación financiera ; economía ; Education (General) ; L7-991 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Dirección General de Investigación, Universidad Peruana Unión
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Neurological Disease Modeling Using Pluripotent and Multipotent Stem Cells: A Key Step towards Understanding and Treating Mucopolysaccharidoses.

Carvalho, Sofia / Santos, Juliana Inês / Moreira, Luciana / Gonçalves, Mariana / David, Hugo / Matos, Liliana / Encarnação, Marisa / Alves, Sandra / Coutinho, Maria Francisca

Biomedicines

2023 Volume 11, Issue 4

Abstract: Despite extensive research, the links between the accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of mucopolysaccharidoses (MPSs) have yet to be further elucidated. This is particularly ... ...

Abstract	Despite extensive research, the links between the accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of mucopolysaccharidoses (MPSs) have yet to be further elucidated. This is particularly true for the neuropathology of these disorders; the neurological symptoms are currently incurable, even in the cases where a disease-specific therapeutic approach does exist. One of the best ways to get insights on the molecular mechanisms driving that pathogenesis is the analysis of patient-derived cells. Yet, not every patient-derived cell recapitulates relevant disease features. For the neuronopathic forms of MPSs, for example, this is particularly evident because of the obvious inability to access live neurons. This scenario changed significantly with the advent of induced pluripotent stem cell (iPSC) technologies. From then on, a series of differentiation protocols to generate neurons from iPSC was developed and extensively used for disease modeling. Currently, human iPSC and iPSC-derived cell models have been generated for several MPSs and numerous lessons were learnt from their analysis. Here we review most of those studies, not only listing the currently available MPS iPSC lines and their derived models, but also summarizing how they were generated and the major information different groups have gathered from their analyses. Finally, and taking into account that iPSC generation is a laborious/expensive protocol that holds significant limitations, we also hypothesize on a tempting alternative to establish MPS patient-derived neuronal cells in a much more expedite way, by taking advantage of the existence of a population of multipotent stem cells in human dental pulp to establish mixed neuronal and glial cultures.
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041234
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Article: Self-efficacy, organizational commitment, workload as predictors of life satisfaction in elementary school teachers: the mediating role of job satisfaction.

Cayupe, Juan C / Bernedo-Moreira, David Hugo / Morales-García, Wilter C / Alcaraz, Fátima López / Peña, Karla Berenice Carrazco / Saintila, Jacksaint / Flores-Paredes, Alcides

Frontiers in psychology

2023 Volume 14, Page(s) 1066321

Abstract: Background: Life satisfaction as well as job satisfaction of teachers has a significant impact on educational outcomes.: Objective: To evaluate a model of factors predicting life satisfaction through the mediating role of job satisfaction.: Methods! ...

Abstract	Background: Life satisfaction as well as job satisfaction of teachers has a significant impact on educational outcomes. Objective: To evaluate a model of factors predicting life satisfaction through the mediating role of job satisfaction. Methods: This was a cross-sectional study, with a sample of 300 primary school teachers of both sexes (68% female, 32% male) and with a mean age of 42.52 years (SD = 10.04). They were administered the General Self-Efficacy Scale, the Satisfaction with Life Scale (SWLS), the Workload Scale (ECT), the Generic Job Satisfaction Scale, and the Organizational Commitment Questionnaire (OCQ). Structural equation modeling (SEM) was used for data analysis. Results: The SEM analysis found significant goodness-of-fit indices: (χ2 = 13.739; df = 5; Conclusion: The results confirm the importance of self-efficacy, organizational commitment, and workload in job satisfaction and overall life satisfaction of elementary education teachers. Job satisfaction acts as a mediator in this relationship. It is important to reduce workload and promote self-efficacy and organizational commitment to improve the well-being and satisfaction of teachers.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1066321
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Article ; Online: Modeling Lysosomal Storage Disorders in an Innovative Way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidosis Type II Patients.

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: Among the many lysosomal storage disorders (LSDs) that would benefit from the establishment of novel cell models, either patient-derived or genetically engineered, is mucopolysaccharidosis type II (MPS II). Here, we present our results on the ... ...

Abstract	Among the many lysosomal storage disorders (LSDs) that would benefit from the establishment of novel cell models, either patient-derived or genetically engineered, is mucopolysaccharidosis type II (MPS II). Here, we present our results on the establishment and characterization of two MPS II patient-derived stem cell line(s) from deciduous baby teeth. To the best of our knowledge, this is the first time a stem cell population has been isolated from LSD patient samples obtained from the dental pulp. Taking into account our results on the molecular and biochemical characterization of those cells and the fact that they exhibit visible and measurable disease phenotypes, we consider these cells may qualify as a valuable disease model, which may be useful for both pathophysiological assessments and in vitro screenings. Ultimately, we believe that patient-derived dental pulp stem cells (DPSCs), particularly those isolated from human exfoliated deciduous teeth (SHEDs), may represent a feasible alternative to induced pluripotent stem cells (iPSCs) in many labs with standard cell culture conditions and limited (human and economic) resources.
MeSH term(s)	Humans ; Mucopolysaccharidosis II ; Stem Cells ; Cell Line ; Lysosomal Storage Diseases ; Tooth, Deciduous ; Lysosomes ; Dental Pulp ; Cell Differentiation/physiology ; Cell Proliferation
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063546
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Article ; Online: Help Comes from Unexpected Places: How a Tiny Fairy and a Tropical Fish may help us Model Mucopolysaccharidoses.

Carvalho, Sofia / Moreira, Luciana / Santos, Juliana Inês / Gaspar, Paulo / Gonçalves, Mariana / Matos, Liliana / David, Hugo / Encarnação, Marisa / Ribeiro, Diogo / Duarte, Ana Joana / Amaral, Olga / Rocha, Hugo / Diogo, Luísa / Ferreira, Sara / Santos, Constança / Martins, Esmeralda / Neuparth, Teresa / Soares, Joana / Ribeiro, Marta /

Ribeiro Pinho, Brígida / Oliveira, Nuno / Ascenção Oliveira, Jorge Miguel / Prata, Maria João / Santos, Miguel / Alves, Sandra / Coutinho, Maria Francisca

Endocrine, metabolic & immune disorders drug targets

2023

Abstract: Introduction: When it comes to disease modeling, countless models are available for Lysosomal Storage Diseases (LSD). Historically, two major approaches are well-established: in vitro assessments are performed in patient fibroblasts, while in vivo pre- ... ...

Abstract	Introduction: When it comes to disease modeling, countless models are available for Lysosomal Storage Diseases (LSD). Historically, two major approaches are well-established: in vitro assessments are performed in patient fibroblasts, while in vivo pre-clinical studies are performed in mouse models. Still, both platforms have a series of drawbacks. Thus, we implemented two alternative and innovative protocols to mimic a particular sub-group of LSDs, the Mucopolysaccharidoses both in vitro and in vivo. Methods: The first one relies on a non-invasive approach using dental pulp stem cells from deciduous teeth (SHEDs). SHEDs are multipotent neuronal precursors that can easily be collected. The second uses a state-of-the-art gene editing technology (CRISPR/Cas9) to generate zebrafish disease models. Results: Even though this is an ongoing project, we have already established and characterized two MPS II and one MPS VI SHED cell models. These cells self-maintain through several passages and can give rise to a variety of cells including neurons. Furthermore, all MPS-associated sub-cellular phenotypes we have assessed so far are easily observable in these cells. Regarding our zebrafish models, we have successfully knocked down both naglu and hgsnat and the first results we got from the behavioral analysis are promising ones, as we can observe altered activity and sleep patterns in the genetically modified fish. For this particular approach we chose MPS III forms as our target disorders, since their neurological features (hyperactivity, seizures and motor impairment) and lifespan decrease would be easily recognizable in zebrafish. Conclusion: Now that these methods are well-established in our lab, their potential is immense. On one hand, the newly developed models will be of ultimate value to understand the mechanisms underlying MPS sub-cellular pathology, which have to be further elucidated. On the other hand, they will constitute an optimal platform for drug testing in house. Also noteworthy, our models will be published as lab resources and made available for the whole LSD community.
Language	English
Publishing date	2023-11-02
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/0118715303277318231024055425
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Article ; Online: Decline in admissions for childhood asthma, a 26-year period population-based study.

Mikalsen, Ingvild Bruun / Skeiseid, Liliane / Tveit, Line Merete / Engelsvold, David Hugo / Øymar, Knut

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2015 Volume 26, Issue 8, Page(s) 750–755

Abstract: Background: The prevalence of childhood asthma has increased, although the rate of hospitalization for asthma seems to decrease. In Norway, the rate of hospital admission for childhood asthma from 1984 to 2000 increased. The aim of this study was to ... ...

Abstract	Background: The prevalence of childhood asthma has increased, although the rate of hospitalization for asthma seems to decrease. In Norway, the rate of hospital admission for childhood asthma from 1984 to 2000 increased. The aim of this study was to assess further trends in hospital admissions for childhood asthma up to 2010. Methods: A population-based study including children 1-13 yrs of age hospitalized for asthma during six periods from 1984/1985 to 2009/2010 in Rogaland, Norway, was performed. Medical records from 1536 admissions (1050 children) were studied; and gender, age, number of admissions, length of hospital stay, medications and symptoms were recorded. Results: For all age groups, the rate of admissions per 10.000 increased from 20.1 in 1984/85 to 33.7 in 1989/90, but declined to 14.4 in 2009/2010. Rates were highest in boys (OR 1.87; 95% CI: 1.69, 2.09), younger age groups (OR 2.51; 2.38, 2.64) and decreased from 1984 to 2010 (OR 0.92; 0.88, 0.94). The rates of readmissions were higher than for primary admissions (OR 1.33; 1.19, 1.47). From 1984 to 2010, there was an increased use of inhaled corticosteroids prior to admission (6 to 51%) and started at discharge (7 to 37%), and systemic steroids given during admission (19 to 83%). Conclusion: There has been a substantial decline in the rate of hospital admissions for childhood asthma after 1989/1990, with major differences between age groups and genders. The decline could be due to improved care of children with asthma or a real reduction in asthma exacerbations.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Asthma/drug therapy ; Asthma/epidemiology ; Child ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Male ; Norway ; Patient Admission/statistics & numerical data ; Population Groups ; Prevalence ; Time Factors
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12372
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