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Article ; Online: Management and Clinical Outcomes of 37 Patients with Necrotizing Otitis Externa: Retrospective Review of a Standardized 6-Week Treatment Pathway.

Dhariwal, Ankush / Manjaly, Joseph G / Patel, Bhavesh / Morris-Jones, Stephen / David, Kate / Khetarpal, Priya / Beale, Tim / Mehta, Nishchay / Logan, Sarah

The journal of international advanced otology

2023 Volume 19, Issue 3, Page(s) 223–227

Abstract: Background: Necrotizing otitis externa is an invasive infection, affecting older patients, with significant associated morbidity. Despite this, there are no randomized controlled trials that address management, and therefore, treatment approaches may ... ...

Abstract	Background: Necrotizing otitis externa is an invasive infection, affecting older patients, with significant associated morbidity. Despite this, there are no randomized controlled trials that address management, and therefore, treatment approaches may vary considerably. We describe the management and outcomes of 37 patients managed using a multidisciplinary treatment pathway for necrotizing otitis externa over a 5-year period. The pathway is based on a standardized antibiotic regime of 3 weeks of intravenous ceftazidime plus oral ciprofloxacin, followed by a further 3 weeks of ciprofloxacin. Methods: This is a retrospective review of all patients diagnosed with necrotizing otitis externa since the introduction of our pathway in 2016. We include data on patient demographics, comorbidities, microbiology, length of stay, and length of antimicrobial treatment. Outcome data, including mortality, relapse and treatment failure, and adverse effects of treatment, are presented. Results: The median age of our patients was 82 years. About 54% of patients had diabetes mellitus or another cause of immunocompromise. Pseudomonas aeruginosa was isolated in 68%. The median duration of inpatient stay was 9 days, and median treatment duration was 6 weeks. Of 37 patients, 32 were cured (86%), and of the remaining 5 patients, there were 2 mortalities unrelated to necrotizing otitis externa and 3 patients with recurrent infections due to anatomical abnormalities. Conclusion: We note favorable treatment outcomes when using a standardized multidisciplinary pathway and a 6-week course of antibiotic therapy.
MeSH term(s)	Humans ; Aged, 80 and over ; Otitis Externa/drug therapy ; Otitis Externa/microbiology ; Retrospective Studies ; Ciprofloxacin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/complications
Chemical Substances	Ciprofloxacin (5E8K9I0O4U) ; Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2023-06-05
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2561231-1
ISSN	2148-3817 ; 1308-7649 ; 2148-3817
ISSN (online)	2148-3817
ISSN	1308-7649 ; 2148-3817
DOI	10.5152/iao.2023.22637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response to Author Comments on "Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales blood stream infections".

Anton-Vazquez, Vanesa / Evans, Terry John / Fernando, Samitha / Somasunderam, Donald / David, Kate / Melzer, Mark / Hawkins, Lois / Morris-Jones, Stephen / Arias, Mauricio / Drazho, Borana / Dall'Antonia, Martino / Planche, Timothy

Infection prevention in practice

2023 Volume 5, Issue 4, Page(s) 100327

Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ISSN	2590-0889
ISSN (online)	2590-0889
DOI	10.1016/j.infpip.2023.100327
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Article ; Online: Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales bloodstream infections: a multicentre study.

Infection prevention in practice

2023 Volume 5, Issue 3, Page(s) 100298

Abstract: Objectives: To investigate the clinical, microbiological characteristics and outcomes of patients with bloodstream infections (BSI) due to carbapenemase-producing Enterobacterales (CPE).: Methods: A multicentre retrospective observational study of ... ...

Abstract	Objectives: To investigate the clinical, microbiological characteristics and outcomes of patients with bloodstream infections (BSI) due to carbapenemase-producing Enterobacterales (CPE). Methods: A multicentre retrospective observational study of patients with BSIs due to CPE admitted to six UK hospitals was conducted between 2011 and 2021. Multivariate analysis was used to identify factors predicting 30-day case fatality rate (CFR). Results: There were 84 episodes of CPE-BSIs, 37 (44%) due to OXA-48, 35 (42%) to metallo-betalactamases (MBL) and 12 (14%) to KPC. 63% of patients were male with a median age of 64 years. Common organisms included Conclusion: Strategies targeting high-risk patients and adherence to infection prevention bundles for urinary devices and central venous catheters can reduce OXA-48 and KPC-BSIs. Early recognition and management of severe sepsis, prompt initiation of appropriate antimicrobial therapy and development of novel antimicrobials are crucial to mitigate the high CFR associated with CPE-BSIs
Language	English
Publishing date	2023-07-08
Publishing country	England
Document type	Journal Article
ISSN	2590-0889
ISSN (online)	2590-0889
DOI	10.1016/j.infpip.2023.100298
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Article ; Online: Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome.

Cavanna, Andrea E / David, Kate / Orth, Michael / Robertson, Mary M

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2012 Volume 16, Issue 6, Page(s) 605–612

Abstract: Background: Gilles de la Tourette syndrome (GTS) is a chronic neurodevelopmental disorder characterised by multiple motor and phonic tics and behavioural problems. Patients with GTS of all ages often report a poor health-related quality of life (HR-QOL). ...

Abstract	Background: Gilles de la Tourette syndrome (GTS) is a chronic neurodevelopmental disorder characterised by multiple motor and phonic tics and behavioural problems. Patients with GTS of all ages often report a poor health-related quality of life (HR-QOL). The diagnosis of GTS is usually established in childhood but little is known about factors that predict the long-term well-being of patients, especially in the presence of co-morbid behavioural problems. Aim: To investigate the childhood predictors of HR-QOL in a cohort of adult patients with GTS. Methods: Forty-six patients with GTS aged 6-16 years underwent a baseline standardised clinical assessment of both tics and behavioural symptoms at a specialist GTS clinic. The same patients were re-assessed aged 16 years and above, with a mean follow-up period of 13 years (range 3-25 years), when they completed the Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL), a disease-specific measure of HR-QOL. Results: Tic severity, premonitory urges and family history of GTS were identified as predictors during childhood of a poorer HR-QOL in adults with GTS by multiple linear regression analysis. Specifically, tic severity significantly predicted poor outcome across physical, psychological and cognitive domains of the GTS-QOL, reflecting widespread effects on HR-QOL. Conclusion: Young patients with severe tics associated with characteristic premonitory urges and a family history of tic disorders appear to be at higher risk for poorer HR-QOL as adults. Further prospective research into HR-QOL in GTS is required in order to inform long-term strategic resource allocation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Cross-Sectional Studies ; Data Interpretation, Statistical ; Demography ; Female ; Humans ; Interview, Psychological ; Longitudinal Studies ; Male ; Middle Aged ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/psychology ; Prognosis ; Quality of Life/psychology ; Regression Analysis ; Resource Allocation ; Tourette Syndrome/complications ; Tourette Syndrome/psychology ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2012-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2012.02.004
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to 'Impact of immunosuppression on mortality in critically ill COVID-19 patients'.

Fox, Thomas A / Troy-Barnes, Ethan / Kirkwood, Amy A / Chan, Wei Y / Day, James W / Chavda, Selina J / Kumar, Emil A / David, Kate / Tomkins, Oliver / Sanchez, Emilie / Scully, Marie / Khwaja, Asim / Lambert, Jonathan / Singer, Mervyn / Roddie, Claire / Morris, Emma C / Yong, Kwee L / Thomson, Kirsty J / Ardeshna, Kirit M

British journal of haematology

2020 Volume 191, Issue 3, Page(s) 505–506

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-26
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17110
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Article ; Online: Clinical outcomes and risk factors for severe COVID-19 in patients with haematological disorders receiving chemo- or immunotherapy.

Fox, Thomas A / Troy-Barnes, Ethan / Kirkwood, Amy A / Chan, Wei Yee / Day, James W / Chavda, Selina J / Kumar, Emil A / David, Kate / Tomkins, Oliver / Sanchez, Emilie / Scully, Marie / Khwaja, Asim / Lambert, Jonathan / Singer, Mervyn / Roddie, Claire / Morris, Emma C / Yong, Kwee L / Thomson, Kirsty J / Ardeshna, Kirit M

British journal of haematology

2020 Volume 191, Issue 2, Page(s) 194–206

Abstract: Haematology patients receiving chemo- or immunotherapy are considered to be at greater risk of COVID-19-related morbidity and mortality. We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated ... ...

Abstract	Haematology patients receiving chemo- or immunotherapy are considered to be at greater risk of COVID-19-related morbidity and mortality. We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated the treatment of their haematological disorder. A retrospective cohort study was conducted in 55 patients with haematological disorders and COVID-19, including 52 with malignancy, two with bone marrow failure and one immune-mediated thrombotic thrombocytopenic purpura (TTP). COVID-19 diagnosis coincided with a new diagnosis of a haematological malignancy in four patients. Among patients, 82% were on systemic anti-cancer therapy (SACT) at the time of COVID-19 diagnosis. Of hospitalised patients, 37% (19/51) died while all four outpatients recovered. Risk factors for severe disease or mortality were similar to those in other published cohorts. Raised C-reactive protein at diagnosis predicted an aggressive clinical course. The majority of patients recovered from COVID-19, despite receiving recent SACT. This suggests that SACT, where urgent, should be administered despite intercurrent COVID-19 infection, which should be managed according to standard pathways. Delay or modification of therapy should be considered on an individual basis. Long-term follow-up studies in larger patient cohorts are required to assess the efficacy of treatment strategies employed during the pandemic.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Blacks ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Comorbidity ; Cross Infection/complications ; Female ; Hematologic Diseases/complications ; Hematologic Diseases/drug therapy ; Hematologic Diseases/mortality ; Hematologic Diseases/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunotherapy ; Leukemia/complications ; Leukemia/drug therapy ; Leukemia/mortality ; London/epidemiology ; Lymphoma/complications ; Lymphoma/drug therapy ; Lymphoma/mortality ; Male ; Middle Aged ; Respiration, Artificial ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Thrombophilia/drug therapy ; Thrombophilia/etiology ; Treatment Outcome ; Young Adult
Chemical Substances	Antineoplastic Agents
Keywords	covid19
Language	English
Publishing date	2020-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17027
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Article ; Online: Health-related quality of life in Gilles de la Tourette syndrome: a decade of research.

Cavanna, Andrea Eugenio / David, Kate / Bandera, Valentina / Termine, Cristiano / Balottin, Umberto / Schrag, Anette / Selai, Caroline

Behavioural neurology

2012 Volume 27, Issue 1, Page(s) 83–93

Abstract: Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterised by multiple motor and phonic tics and associated behavioural problems, carrying a significant burden on patients' lives. Although the term health related-quality of life ...

Abstract	Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterised by multiple motor and phonic tics and associated behavioural problems, carrying a significant burden on patients' lives. Although the term health related-quality of life (HR-QOL) has only been used in recent years, several studies have long addressed the impact of GTS on physical, psychological and social aspects of wellbeing of both children and adults with GTS. We set out to answer the question "Is HR-QOL affected by GTS and, if so, in what domains?" by conducting a systematic literature review of published original studies addressing HR-QOL in both children and adult patients with GTS. This review focuses on the current evidence on the impact of GTS on patients' lives, mainly informed by studies using generic functional impairment and HR-QOL measures from the last decade, and expands on the new opportunities introduced by the recently developed GTS-specific HR-QOL scales (GTS-QOL and GTS-QOL-C&A). Analysis of the first decade of studies specifically addressing HR-QOL in GTS suggests that co-morbid conditions are key factors in determining HR-QOL in young patients, whilst the picture is more complex in adults with GTS. These findings offer some general directions for both current clinical practice and future research.
MeSH term(s)	Comorbidity ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Quality of Life/psychology ; Tourette Syndrome/epidemiology ; Tourette Syndrome/psychology
Language	English
Publishing date	2012-11-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	1001896-7
ISSN	1875-8584 ; 0953-4180
ISSN (online)	1875-8584
ISSN	0953-4180
DOI	10.3233/BEN-120296
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Article: Survey of Pediatricians and Early Hearing Detection and Identification Programs at a Precise Local Level: An Academic Medical Center

Danhauer, Jeffrey L / David, Kate B / Johnson, Carole E / Meyer, Dianne H

Seminars in Hearing

2009 Volume 30, Issue 03, Page(s) 165–183

Abstract: Pediatricians (Peds) are vital to early hearing detection and intervention programs (EHDIPs). Peds should educate families about programs and encourage them to comply with professionals' recommendations. Surveying Peds at local levels is important for ... ...

Abstract	Pediatricians (Peds) are vital to early hearing detection and intervention programs (EHDIPs). Peds should educate families about programs and encourage them to comply with professionals' recommendations. Surveying Peds at local levels is important for ensuring that they meet benchmarks. This study used a revised questionnaire to assess Peds at Rush University Medical Center (RUMC) about EHDIPs. Of all 115 Peds at RUMC, 21 responded = 18.6% response rate; 57% (12) were residents and 42.9% (9) were attending physicians. Most had knowledge about, experience with, and positive attitudes toward EHDIPs, but could use additional information. Results expanded on earlier surveys by using an updated questionnaire relevant to latest EHDIPs goals and Peds at a precise hospital and provided information for audiologists conducting physician outreach programs to help Peds prevent children from being lost to follow up.
Keywords	Benchmarks ; continuing medical education ; early hearing detection and intervention programs ; newborn hearing screening programs ; pediatricians ; physicians' impressions ; questionnaire
Language	English
Publishing date	2009-08-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	604961-8
ISSN	1098-8955 ; 0734-0451
ISSN (online)	1098-8955
ISSN	0734-0451
DOI	10.1055/s-0029-1225402
Database	Thieme publisher's database

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Zs.MO 115: Show issues

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Article: Response to 'Impact of immunosuppression on mortality in critically ill COVID-19 patients'

Br J Haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #889708
Database	COVID19

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Article: Clinical outcomes and risk factors for severe COVID-19 in patients with haematological disorders receiving chemo- or immunotherapy

Br. j. haematol

Abstract	Haematology patients receiving chemo- or immunotherapy are considered to be at greater risk of COVID-19-related morbidity and mortality. We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated the treatment of their haematological disorder. A retrospective cohort study was conducted in 55 patients with haematological disorders and COVID-19, including 52 with malignancy, two with bone marrow failure and one immune-mediated thrombotic thrombocytopenic purpura (TTP). COVID-19 diagnosis coincided with a new diagnosis of a haematological malignancy in four patients. Among patients, 82% were on systemic anti-cancer therapy (SACT) at the time of COVID-19 diagnosis. Of hospitalised patients, 37% (19/51) died while all four outpatients recovered. Risk factors for severe disease or mortality were similar to those in other published cohorts. Raised C-reactive protein at diagnosis predicted an aggressive clinical course. The majority of patients recovered from COVID-19, despite receiving recent SACT. This suggests that SACT, where urgent, should be administered despite intercurrent COVID-19 infection, which should be managed according to standard pathways. Delay or modification of therapy should be considered on an individual basis. Long-term follow-up studies in larger patient cohorts are required to assess the efficacy of treatment strategies employed during the pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #650898
Database	COVID19

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