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  1. AU="David Lukacsovich"
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  1. Article ; Online: Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus

    Lin Que / David Lukacsovich / Wenshu Luo / Csaba Földy

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: The relationship between gene expression and morphology to classify PV interneurons is unclear. Here, the authors show transcriptional continuity of morphologically distinct mouse hippocampal PV interneurons subtypes, combining single-cell RNA sequencing ...

    Abstract The relationship between gene expression and morphology to classify PV interneurons is unclear. Here, the authors show transcriptional continuity of morphologically distinct mouse hippocampal PV interneurons subtypes, combining single-cell RNA sequencing and electrophysiology.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Single-Cell RNA-Seq Reveals Developmental Origins and Ontogenetic Stability of Neurexin Alternative Splicing Profiles

    David Lukacsovich / Jochen Winterer / Lin Que / Wenshu Luo / Tamas Lukacsovich / Csaba Földy

    Cell Reports, Vol 27, Iss 13, Pp 3752-3759.e

    2019  Volume 4

    Abstract: Summary: Neurexins are key synaptic organizers that are expressed in thousands of alternatively spliced isoforms. Because transsynaptic neurexin interactions with different postsynaptic molecules are largely isoform dependent, a cell type-level census of ...

    Abstract Summary: Neurexins are key synaptic organizers that are expressed in thousands of alternatively spliced isoforms. Because transsynaptic neurexin interactions with different postsynaptic molecules are largely isoform dependent, a cell type-level census of different neurexin isoforms could predict molecular interactions relating to synapse identity and function. Using single-cell transcriptomics to study the origin of neurexin diversity in multiple murine mature and embryonic cell types, we have discovered shared neurexin expression patterns in developmentally related cells. By comparing neurexin profiles in immature embryonic neurons, we show that neurexin profiles are specified during early development and remain unchanged throughout neuronal maturation. Thus, our findings reveal ontogenetic stability and provide a cell type-level census of neurexin isoform expression in the cortex. : Neurexins are key presynaptic molecules that are expressed in thousands of alternatively spliced isoforms. Lukacsovich et al. investigated neurexin exon usage in mature and embryonic neurons and find shared neurexin splicing patterns in developmentally related cells. Keywords: neurexin, single-cell RNA-seq, alternative splicing, isoforms, secreted neurexin ligand, developmental origin, ontogenetic stability, MGE, CGE, Prox1, Lhx6, Cajal-Retzius, embryonic neuron
    Keywords Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits

    Viktor János Oláh / David Lukacsovich / Jochen Winterer / Antónia Arszovszki / Andrea Lőrincz / Zoltan Nusser / Csaba Földy / János Szabadics

    eLife, Vol

    2020  Volume 9

    Abstract: CCK-expressing interneurons (CCK+INs) are crucial for controlling hippocampal activity. We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing ...

    Abstract CCK-expressing interneurons (CCK+INs) are crucial for controlling hippocampal activity. We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing phenotype, due to different low-voltage-activated potassium currents. These different excitability properties destine the two types for distinct functions, because the former is essentially silenced during realistic 8–15 Hz oscillations. By contrast, the general intrinsic excitability, morphology and gene-profiles of the two types were surprisingly similar. Even the expression of Kv4.3 channels were comparable, despite evidences showing that Kv4.3-mediated currents underlie the distinct firing properties. Instead, the firing phenotypes were correlated with the presence of distinct isoforms of Kv4 auxiliary subunits (KChIP1 vs. KChIP4e and DPP6S). Our results reveal the underlying mechanisms of two previously unknown types of CCK+INs and demonstrate that alternative splicing of few genes, which may be viewed as a minor change in the cells’ whole transcriptome, can determine cell-type identity.
    Keywords hippocampus ; GABAergic neurons ; membrane excitability ; ionic channels ; oscillations ; splicing isoforms ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids

    Gyöngyi Cinege / Lilla B. Magyar / Attila L. Kovács / Zita Lerner / Gábor Juhász / David Lukacsovich / Jochen Winterer / Tamás Lukacsovich / Zoltán Hegedűs / Éva Kurucz / Dan Hultmark / Csaba Földy / István Andó

    Journal of Innate Immunity, Pp 1-

    2021  Volume 20

    Abstract: Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating ... ...

    Abstract Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating MGHs have high motility and the interaction with the parasitoid rapidly triggers encapsulation. However, structural and molecular mechanisms behind these processes remained elusive. Here, we used detailed ultrastructural analysis and live cell imaging of MGHs to study encapsulation in Drosophila ananassae after parasitoid wasp infection. We found dynamic structural changes, mainly driven by the formation of diverse vesicular systems and newly developed complex intracytoplasmic membrane structures, and abundant generation of giant cell exosomes in MGHs. In addition, we used RNA sequencing to study the transcriptomic profile of MGHs and activated plasmatocytes 72 h after infection, as well as the uninduced blood cells. This revealed that differentiation of MGHs was accompanied by broad changes in gene expression. Consistent with the observed structural changes, transcripts related to vesicular function, cytoskeletal organization, and adhesion were enriched in MGHs. In addition, several orphan genes encoding for hemolysin-like proteins, pore-forming toxins of prokaryotic origin, were expressed at high level, which may be important for parasitoid elimination. Our results reveal coordinated molecular and structural changes in the course of MGH differentiation and parasitoid encapsulation, providing a mechanistic model for a powerful innate immune response.
    Keywords multinucleated giant hemocyte ; encapsulation ; drosophila ; transcriptome ; innate immunity ; Medicine ; R ; Internal medicine ; RC31-1245
    Subject code 572
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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