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  1. Article: Next-Generation Probiotics and Their Metabolites in COVID-19

    Gautier, Thomas / David-Le Gall, Sandrine / Sweidan, Alaa / Tamanai-Shacoori, Zohreh / Jolivet-Gougeon, Anne / Loréal, Olivier / Bousarghin, Latifa

    Microorganisms. 2021 Apr. 27, v. 9, no. 5

    2021  

    Abstract: Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and ... ...

    Abstract Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and gastrointestinal dysfunctions suggesting the spread of the virus to other organs. A dysregulated immune response was also reported. To date, there is no measure to treat or prevent SARS CoV-2 infection. Additionally, as gut microbiota composition is altered in patients with COVID-19, alternative therapies using probiotics can be considered to fight SARS CoV-2 infection. This review aims at summarizing the current knowledge about next-generation probiotics (NGPs) and their benefits in viral respiratory tract infections and in COVID-19. We describe these bacteria, highlighted by studies using metagenomic approaches. In addition, these bacteria generate metabolites such as butyrate, desaminotyrosine, and secondary bile acid, suggested to prevent viral respiratory infections. Gut microbial metabolites transported via the circulation to the lungs could inhibit viral replication or improve the immune response against viruses. The use of probiotics and/or their metabolites may target either the virus itself and/or the immunologic process. However, this review showed that more studies are needed to determine the benefits of probiotics and metabolite products in COVID-19.
    Keywords COVID-19 infection ; Orthocoronavirinae ; bile acids ; butyrates ; gastrointestinal system ; immune response ; intestinal microorganisms ; metabolites ; metagenomics ; pandemic ; probiotics ; respiratory tract diseases ; virus replication ; viruses
    Language English
    Dates of publication 2021-0427
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050941
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Next-Generation Probiotics and Their Metabolites in COVID-19.

    Gautier, Thomas / David-Le Gall, Sandrine / Sweidan, Alaa / Tamanai-Shacoori, Zohreh / Jolivet-Gougeon, Anne / Loréal, Olivier / Bousarghin, Latifa

    Microorganisms

    2021  Volume 9, Issue 5

    Abstract: Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and ... ...

    Abstract Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and gastrointestinal dysfunctions suggesting the spread of the virus to other organs. A dysregulated immune response was also reported. To date, there is no measure to treat or prevent SARS CoV-2 infection. Additionally, as gut microbiota composition is altered in patients with COVID-19, alternative therapies using probiotics can be considered to fight SARS CoV-2 infection. This review aims at summarizing the current knowledge about next-generation probiotics (NGPs) and their benefits in viral respiratory tract infections and in COVID-19. We describe these bacteria, highlighted by studies using metagenomic approaches. In addition, these bacteria generate metabolites such as butyrate, desaminotyrosine, and secondary bile acid, suggested to prevent viral respiratory infections. Gut microbial metabolites transported via the circulation to the lungs could inhibit viral replication or improve the immune response against viruses. The use of probiotics and/or their metabolites may target either the virus itself and/or the immunologic process. However, this review showed that more studies are needed to determine the benefits of probiotics and metabolite products in COVID-19.
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bacteroides fragilis

    Gautier, Thomas / Oliviero, Nolwenn / Ferron, Solenn / Le Pogam, Pierre / David-Le Gall, Sandrine / Sauvager, Aurélie / Leroyer, Patricia / Cannie, Isabelle / Dion, Sarah / Sweidan, Alaa / Loréal, Olivier / Tomasi, Sophie / Bousarghin, Latifa

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1023315

    Abstract: In the gut microbiota, resident bacteria prevent pathogens infection by producing specific metabolites. Among bacteria belonging to ... ...

    Abstract In the gut microbiota, resident bacteria prevent pathogens infection by producing specific metabolites. Among bacteria belonging to phylum
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1023315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.

    Arnaud, Alexis P / Cousin, Ianis / Schmitt, Françoise / Petit, Thierry / Parmentier, Benoit / Levard, Guillaume / Podevin, Guillaume / Guinot, Audrey / DeNapoli, Stéphan / Hervieux, Erik / Flaum, Valérie / De Vries, Philine / Randuineau, Gwénaëlle / David-Le Gall, Sandrine / Buffet-Bataillon, Sylvie / Boudry, Gaëlle

    Frontiers in microbiology

    2022  Volume 13, Page(s) 904758

    Abstract: Background and objectives: Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal ... ...

    Abstract Background and objectives: Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal dysbiosis has been proposed in the last decade. The primary objective of this study was to evaluate in a large cohort if Hirschsprung-associated enterocolitis was associated with alterations of fecal bacterial composition compared with HD without enterocolitis in different age groups.
    Methods: We analyzed the fecal microbiota structure of 103 Hirschsprung patients from 3 months to 16 years of age, all of whom had completed definitive surgery for rectosigmoid Hirschsprung. 16S rRNA gene sequencing allowed us to compare the microbiota composition between Hirschsprung's disease patients with (HAEC group) or without enterocolitis (HD group) in different age groups (0-2, 2-6, 6-12, and 12-16 years).
    Results: Richness and diversity increased with age group but did not differ between HD and HAEC patients, irrespective of the age group. Relative abundance of Actinobacteria was lower in HAEC than in HD patients under 2 years of age (-66%,
    Conclusion: Hirschsprung-associated enterocolitis was associated with features of intestinal dysbiosis in infants (0-2 years) but not in older patients. This could explain the highest rate of enterocolitis in this age group.
    Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT02857205, MICROPRUNG, NCT02857205, 02/08/2016.
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.904758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Post-natal co-development of the microbiota and gut barrier function follows different paths in the small and large intestine in piglets.

    Arnaud, Alexis Pierre / Rome, Véronique / Richard, Marion / Formal, Michèle / David-Le Gall, Sandrine / Boudry, Gaëlle

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2019  Volume 34, Issue 1, Page(s) 1430–1446

    Abstract: Gut microbiota and intestinal barrier co-develop after birth, establishing a homeostatic state whereby mucosal cells cohabit with commensal bacteria. We hypothesized that this post-natal co-development follows different timings depending on the ... ...

    Abstract Gut microbiota and intestinal barrier co-develop after birth, establishing a homeostatic state whereby mucosal cells cohabit with commensal bacteria. We hypothesized that this post-natal co-development follows different timings depending on the intestinal site considered. Jejunal, ileal, and colonic luminal contents and mucosa were sampled in suckling piglets at post-natal day (PND) 0, 2, 7, 14, and 28. Jejunal, ileal, and colonic luminal microbiota (evaluated by 16S DNA sequencing followed by beta-diversity analysis) clustered at PND2 but colonic microbiota diverge afterwards (P < .05). Mucosal permeability, evaluated in Ussing chambers, increased with age in the jejunum and ileum (P < .05) but not the colon. Expression of pattern recognition receptor (PRR) exhibited different patterns (gradual or sharp increase, decrease, or no change with age, P < .05) depending on PRR and intestinal site considered. Principal component analysis of mucosa data revealed clear clustering of colonic samples, irrespective of the age and clustering of jejunal and ileal samples, with gradual changes with age. Correlation analysis highlighted three families correlating with mucosal parameters: Enterobacteriaceae in the jejunum, Peptostreptococcaceae in the ileum, and Micrococcaceae in the colon. In conclusion, small and large intestine display close microbiota composition early in life but distinct mucosal phenotype and follow very different post-natal development.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/growth & development ; Colon/microbiology ; Gastrointestinal Microbiome/physiology ; Ileum/microbiology ; Intestinal Mucosa/microbiology ; Jejunum/microbiology ; Swine
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201902514R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Maternal Linoleic Acid Overconsumption Alters Offspring Gut and Adipose Tissue Homeostasis in Young but Not Older Adult Rats.

    Marchix, Justine / Alain, Charlène / David-Le Gall, Sandrine / Acuña-Amador, Luis Alberto / Druart, Céline / Delzenne, Nathalie M / Barloy-Hubler, Frédérique / Legrand, Philippe / Boudry, Gaëlle

    Nutrients

    2020  Volume 12, Issue 11

    Abstract: ... ...

    Abstract Maternal
    MeSH term(s) Adipose Tissue/metabolism ; Adiposity ; Animals ; Female ; Gastrointestinal Microbiome/physiology ; Homeostasis ; Lactation ; Linoleic Acid/administration & dosage ; Linoleic Acids, Conjugated/metabolism ; Liver/metabolism ; Male ; Maternal Nutritional Physiological Phenomena ; Rats ; Weaning
    Chemical Substances Linoleic Acids, Conjugated ; Linoleic Acid (9KJL21T0QJ)
    Language English
    Publishing date 2020-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12113451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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