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Article ; Online: Deep brain stimulation of the anterior limb of the internal capsule for treatment of therapy-refractory obsessive compulsive disorder (OCD): a case study highlighting neurocognitive and psychiatric changes.

Choudhury, Tabina K / Davidson, Joyce E / Viswanathan, Ashwin / Strutt, Adriana M

2017 Volume 23, Issue 2, Page(s) 138–145

Abstract: Obsessive compulsive disorder (OCD) is an anxiety disorder characterized by repeated, unwanted thoughts and behaviors. Individuals with this condition often experience significant emotional distress secondary to their symptoms. Additionally, impairments ... ...

Abstract	Obsessive compulsive disorder (OCD) is an anxiety disorder characterized by repeated, unwanted thoughts and behaviors. Individuals with this condition often experience significant emotional distress secondary to their symptoms. Additionally, impairments in attention/concentration, processing speed, and executive functions are typically observed. The exact pathology of OCD remains unknown; consequently, it can be difficult to treat patients with severe symptomatology. Deep brain stimulation (DBS) may be a viable treatment option for individuals who do not respond to medication and/or cognitive behavioral therapy. The following case discusses DBS of the anterior limb of the internal capsule for a patient with severe, therapy-refractory OCD, including pre- to postoperative neurocognitive and psychiatric changes.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1302651-3
ISSN	1465-3656 ; 1355-4794
ISSN (online)	1465-3656
ISSN	1355-4794
DOI	10.1080/13554794.2017.1319958
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Article ; Online: JAK 1/2 Blockade in MDA5 Gain-of-Function.

McLellan, Kirsty E / Martin, Neil / Davidson, Joyce E / Cordeiro, Nuno / Oates, Bridget D / Neven, Bénédicte / Rice, Gillian I / Crow, Yanick J

Journal of clinical immunology

2018 Volume 38, Issue 8, Page(s) 844–846

MeSH term(s)	Alopecia ; Antibodies, Antinuclear/blood ; Child ; Child, Preschool ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Infant ; Infant, Newborn ; Interferon Type I/genetics ; Interferon-Induced Helicase, IFIH1/genetics ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 2/antagonists & inhibitors ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics ; Motor Disorders ; Mutation/genetics ; Neopterin/cerebrospinal fluid ; Nervous System Diseases/diagnosis ; Nervous System Diseases/drug therapy ; Nervous System Diseases/genetics ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Up-Regulation
Chemical Substances	Antibodies, Antinuclear ; Immunosuppressive Agents ; Interferon Type I ; Pyrazoles ; Neopterin (670-65-5) ; ruxolitinib (82S8X8XX8H) ; Janus Kinase 1 (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; IFIH1 protein, human (EC 3.6.1.-) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2018-11-15
Publishing country	Netherlands
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-018-0563-2
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Article ; Online: Chronic non bacterial osteitis- a multicentre study.

Bhat, Chandrika S / Anderson, Catriona / Harbinson, Aoibhinn / McCann, Liza J / Roderick, Marion / Finn, Adam / Davidson, Joyce E / Ramanan, Athimalaipet V

Pediatric rheumatology online journal

2018 Volume 16, Issue 1, Page(s) 74

Abstract: Objective: To understand the demographics, clinical features and treatment outcomes of Chronic Non-bacterial Osteitis (CNO) from three tertiary paediatric rheumatology services in the United Kingdom.: Methods: Children less than 18 years of age ... ...

Abstract	Objective: To understand the demographics, clinical features and treatment outcomes of Chronic Non-bacterial Osteitis (CNO) from three tertiary paediatric rheumatology services in the United Kingdom. Methods: Children less than 18 years of age diagnosed with CNO between 2001 to 2016 from one tertiary service and between 2001 to 2017 from two tertiary services were included. Clinical notes were reviewed and all pertinent data were collected on a pre-defined proforma. One hundred and thirty one patients were included in the study. The Bristol diagnostic criteria were applied retrospectively. Results: Retrospective analysis of the data showed that the disease was more common in girls than boys (2.5:1), median age at onset of symptoms was 9.5 years (IQR 8 to 11 years). Bone pain was the predominant symptom in 118/129 (91.4%) followed by swelling in 50/102 (49.01%). Raised inflammatory markers were present in 39.68% of the patients. Whole body Magnetic Resonance Imaging (MRI) was a useful diagnostic tool. Metaphyses of long bones were most often involved and the distal tibial metaphyses 65/131 (49.6%) was the most common site. Non-steroidal anti-inflammatory drugs were used as first line (81.67%) followed by bisphosphonates (61.79%). Treatment was escalated to a TNF blocker when response to bisphosphonates was suboptimal. The disease was in remission in 82.4% of the patients during the last follow up. Conclusion: Our multicentre study describes features and outcomes of CNO in a large number of patients in the United Kingdom. Significance and innovation: Raised inflammatory markers were present in 39.68% of our patients. Whole body MRI is useful for diagnosis and also determining response to treatment. A greater number of lesions were detected on radiological imaging compared to clinical assessment. Metaphyses of long bones were most often involved and the distal tibial metaphyses (49.6%) were the most common site. Non-steroidal anti-inflammatory drugs were used as first line (81.67%) followed by bisphosphonates (61.79%). There was no difference in number of medications used for management in unifocal versus multifocal disease. TNF blockers were used with good effect in our cohort.
MeSH term(s)	Adolescent ; Bone and Bones/pathology ; Child ; Child, Preschool ; Chronic Disease ; Female ; Humans ; Male ; Osteitis/diagnosis ; Osteitis/drug therapy ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Retrospective Studies ; United Kingdom
Language	English
Publishing date	2018-11-22
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-018-0290-5
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Article: Adolescent development and SLE.

Beresford, Michael W / Davidson, Joyce E

Best practice & research. Clinical rheumatology

2006 Volume 20, Issue 2, Page(s) 353–368

Abstract: Adolescence is a time of profound biological and psychosocial change. The management of a complex chronic condition such as systemic lupus erythematosus (SLE) during this period is a challenging but rewarding task for the clinician. Early diagnosis and ... ...

Abstract	Adolescence is a time of profound biological and psychosocial change. The management of a complex chronic condition such as systemic lupus erythematosus (SLE) during this period is a challenging but rewarding task for the clinician. Early diagnosis and optimal disease control is essential in order to facilitate normal adolescent development and minimize long-term disease sequelae. Current treatment regimens are associated with significant toxicity in young people, and there is a need for new, less toxic regimens. There are currently no controlled therapeutic studies in adolescents with SLE. Those involved in the care of these young people must ensure that they have appropriate access to specialist medical services while ensuring that their specific needs as adolescents in the health-care system are addressed.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Adolescent Development/physiology ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Long-Term Care ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Male ; Patient Compliance ; Prognosis ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2006-04
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2052323-3
ISSN	1521-6942
ISSN	1521-6942
DOI	10.1016/j.berh.2005.11.003
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Article ; Online: Transitional care in clinical networks for young people with juvenile idiopathic arthritis: current situation and challenges.

Cruikshank, Mary / Foster, Helen E / Stewart, Jane / Davidson, Joyce E / Rapley, Tim

Clinical rheumatology

2015 Volume 35, Issue 4, Page(s) 893–899

Abstract: Clinical networks for paediatric and adolescent rheumatology are evolving, and their effect and role in the transition process between paediatric and adult services are unknown. We therefore explored the experiences of those involved to try and ... ...

Abstract	Clinical networks for paediatric and adolescent rheumatology are evolving, and their effect and role in the transition process between paediatric and adult services are unknown. We therefore explored the experiences of those involved to try and understand this further. Health professionals, young people with juvenile idiopathic arthritis and their families were recruited via five national health service paediatric and adolescent rheumatology specialist centres and networks across the UK. Seventy participants took part in focus groups and one-to-one interviews. Data was analysed using coding, memoing and mapping techniques to identify features of transitional services across the sector. Variation and inequities in transitional care exist. Although transition services in networks are evolving, development has lagged behind other areas with network establishment focusing more on access to paediatric rheumatology multidisciplinary teams. Challenges include workforce shortfalls, differences in service priorities, standards and healthcare infrastructures, and managing the legacy of historic encounters. Providing equitable high-quality clinically effective services for transition across the UK has a long way to go. There is a call from within the sector for more protected time, staff and resources to develop transition roles and services, as well as streamlining of local referral pathways between paediatric and adult healthcare services. In addition, there is a need to support professionals in developing their understanding of transitional care in clinical networks, particularly around service design, organisational change and the interpersonal skills required for collaborative working. Key messages • Transitional care in clinical networks requires collaborative working and an effective interface with paediatric and adult rheumatology.• Professional centrism and historic encounters may affect collaborative relationships within clinical networks.• Education programmes need to support the development of interpersonal skills and change management, to facilitate professionals in networks delivering transitional care.
MeSH term(s)	Adolescent ; Arthritis, Juvenile/therapy ; Child ; Focus Groups ; Health Personnel ; Health Services Research ; Humans ; Pediatrics/methods ; Quality of Health Care ; Rheumatology/methods ; Rheumatology/standards ; Transition to Adult Care ; United Kingdom ; Young Adult
Language	English
Publishing date	2015-04-30
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-015-2950-x
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Article ; Online: Foot orthoses in children with juvenile idiopathic arthritis: a randomised controlled trial.

Coda, Andrea / Fowlie, Peter W / Davidson, Joyce E / Walsh, Jo / Carline, Tom / Santos, Derek

Archives of disease in childhood

2014 Volume 99, Issue 7, Page(s) 649–651

Abstract: Introduction: There is limited evidence supporting the podiatric treatment of children with juvenile idiopathic arthritis (JIA). This multicentre randomised controlled trial aimed to determine whether preformed foot orthoses (FOs) impacted on pain and ... ...

Abstract	Introduction: There is limited evidence supporting the podiatric treatment of children with juvenile idiopathic arthritis (JIA). This multicentre randomised controlled trial aimed to determine whether preformed foot orthoses (FOs) impacted on pain and quality of life (QoL) in children with JIA. Methods: Eligible children were randomised to receive either 'fitted' FOs with customised chair-side corrections or 'control' FOs made without corrections. Changes in pain and QoL were measured using a visual analogue scale and Paediatric Quality of Life questionnaire, respectively. JIA children were assessed at baseline, 3 months and 6 months. Results: 60 children were recruited. 179 out of a possible 180 assessments (99.4%) were completed. A statistically significant greater difference in pain reduction (baseline - 6 months) was seen between the two groups favouring fitted FOs (p=0.029). The reduction in pain in the fitted FOs group was clinically important (8 mm). Significant differences in QoL favouring fitted FOs were also identified as measured by the children and independently by their parents/carers. Conclusions: Fitted FOs may reduce pain and improve QoL in selected children with JIA. Trial registration number: NCT02001844.
MeSH term(s)	Adolescent ; Arthritis, Juvenile/psychology ; Arthritis, Juvenile/therapy ; Child ; Female ; Foot Orthoses ; Humans ; Male ; Orthotic Devices ; Pain/psychology ; Pain Management/methods ; Pain Measurement ; Quality of Life/psychology ; Surveys and Questionnaires ; Treatment Outcome
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2013-305166
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Article: "So doctor, what exactly is wrong with my muscles? Glutaric aciduria type II presenting in a teenager".

Beresford, Michael W / Pourfarzam, Morteza / Davidson, Joyce E

Neuromuscular disorders : NMD

2006 Volume 16, Issue 9-10, Page(s) 613

MeSH term(s)	Adolescent ; Confidentiality/ethics ; Confidentiality/standards ; Glutarates/metabolism ; Humans ; Metabolic Diseases/diagnosis ; Metabolic Diseases/genetics ; Metabolic Diseases/metabolism ; Molecular Biology/ethics ; Molecular Biology/standards ; Muscular Diseases/diagnosis ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Mutation/genetics ; Periodicals as Topic/ethics ; Periodicals as Topic/standards
Chemical Substances	Glutarates ; glutaric acid (H849F7N00B)
Language	English
Publishing date	2006-10
Publishing country	England
Document type	Letter
ZDB-ID	1077681-3
ISSN	1873-2364 ; 0960-8966
ISSN (online)	1873-2364
ISSN	0960-8966
DOI	10.1016/j.nmd.2006.07.003
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Article ; Online: Development of a national audit tool for juvenile idiopathic arthritis: a BSPAR project funded by the Health Care Quality Improvement Partnership.

McErlane, Flora / Foster, Helen E / Armitt, Gillian / Bailey, Kathryn / Cobb, Joanna / Davidson, Joyce E / Douglas, Sharon / Fell, Andrew / Friswell, Mark / Pilkington, Clarissa / Strike, Helen / Smith, Nicola / Thomson, Wendy / Cleary, Gavin

Rheumatology (Oxford, England)

2017

Abstract: Objective: Timely access to holistic multidisciplinary care is the core principle underpinning management of juvenile idiopathic arthritis (JIA). Data collected in national clinical audit programmes fundamentally aim to improve health outcomes of ... ...

Abstract	Objective: Timely access to holistic multidisciplinary care is the core principle underpinning management of juvenile idiopathic arthritis (JIA). Data collected in national clinical audit programmes fundamentally aim to improve health outcomes of disease, ensuring clinical care is equitable, safe and patient-centred. The aim of this study was to develop a tool for national audit of JIA in the UK. Methods: A staged and consultative methodology was used across a broad group of relevant stakeholders to develop a national audit tool, with reference to pre-existing standards of care for JIA. The tool comprises key service delivery quality measures assessed against two aspects of impact, namely disease-related outcome measures and patient/carer reported outcome and experience measures. Results: Eleven service-related quality measures were identified, including those that map to current standards for commissioning of JIA clinical services in the UK. The three-variable Juvenile Arthritis Disease Activity Score and presence/absence of sacro-iliitis in patients with enthesitis-related arthritis were identified as the primary disease-related outcome measures, with presence/absence of uveitis a secondary outcome. Novel patient/carer reported outcomes and patient/carer reported experience measures were developed and face validity confirmed by relevant patient/carer groups. Conclusion: A tool for national audit of JIA has been developed with the aim of benchmarking current clinical practice and setting future standards and targets for improvement. Staged implementation of this national audit tool should facilitate investigation of variability in levels of care and drive quality improvement. This will require engagement from patients and carers, clinical teams and commissioners of JIA services.
Language	English
Publishing date	2017-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kex322
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Article ; Online: Patterns of pain over time among children with juvenile idiopathic arthritis.

Rashid, Amir / Cordingley, Lis / Carrasco, Roberto / Foster, Helen E / Baildam, Eileen M / Chieng, Alice / Davidson, Joyce E / Wedderburn, Lucy R / Ioannou, Yiannis / McErlane, Flora / Verstappen, Suzanne M M / Hyrich, Kimme L / Thomson, Wendy

Archives of disease in childhood

2017 Volume 103, Issue 5, Page(s) 437–443

Abstract: Objectives: Pain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the ... ...

Abstract	Objectives: Pain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the different patterns of pain experienced over time in children with JIA and to identify predictors of which children are likely to experience ongoing pain. Methods: This study used longitudinal-data from patients (aged 1-16 years) with new-onset JIA. Baseline and up to 5-year follow-up pain data from the Childhood Arthritis Prospective Study (CAPS) were used. A two-step approach was adopted. First, pain trajectories were modelled using a discrete mixture model. Second, multinomial logistic regression was used to determine the association between variables and trajectories. Results: Data from 851 individuals were included (4 years, median follow-up). A three-group trajectory model was identified: consistently low pain (n=453), improved pain (n=254) and consistently high pain (n=144). Children with improved pain or consistently high pain differed on average at baseline from consistently low pain. Older age at onset, poor function/disability and longer disease duration at baseline were associated with consistently high pain compared with consistently low pain. Early increases in pain and poor function/disability were also associated with consistently high pain compared with consistently low pain. Conclusions: This study has identified routinely collected clinical factors, which may indicate those individuals with JIA at risk of poor pain outcomes earlier in disease. Identifying those at highest risk of poor pain outcomes at disease onset may enable targeted pain management strategies to be implemented early in disease thus reducing the risk of poor pain outcomes.
MeSH term(s)	Adolescent ; Age Factors ; Arthritis, Juvenile/complications ; Child ; Child, Preschool ; Chronic Pain/etiology ; Chronic Pain/therapy ; Disability Evaluation ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Pain/etiology ; Pain Management/methods ; Pain Measurement/methods ; Prognosis ; Risk Factors
Language	English
Publishing date	2017-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2017-313337
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Article ; Online: Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).

McErlane, Flora / Carrasco, Roberto / Kearsley-Fleet, Lianne / Baildam, Eileen M / Wedderburn, Lucy R / Foster, Helen E / Ioannou, Yiannis / Chieng, S E Alice / Davidson, Joyce E / Thomson, Wendy / Hyrich, Kimme L

Seminars in arthritis and rheumatism

2017 Volume 48, Issue 1, Page(s) 53–60

Abstract: Objectives: To investigate early vertical growth patterns and factors associated with poor growth in a modern inception cohort of UK children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis Prospective Study (CAPS).: ... ...

Abstract	Objectives: To investigate early vertical growth patterns and factors associated with poor growth in a modern inception cohort of UK children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis Prospective Study (CAPS). Methods: A study period of 3 years was chosen. Children included in this analysis had a physician diagnosis of JIA and had height measurements available at both baseline and at 3-years of follow-up. Height is presented as z-scores calculated using World Health Organisation growth standards for age and gender. Growth over the 3-year period was assessed using change in z-score and height velocity. Univariable and multivariable linear regressions were used to identify factors associated with height z-score at baseline and change of height z-score at 3 years. Results: 568 patients were included; 65% female, median baseline age 7.4 years [interquartile range (IQR) 3.6, 11.2], median symptom duration at presentation 5.5 months [IQR 3.1, 11.6]. Height z-score decreased significantly from baseline to 3 years (p ≤ 0.0001); baseline median height z-score was -0.02 (IQR -0.71, 0.61), decreasing to -0.47 (IQR -1.12, 0.24) at 3 years. Growth restriction, defined as change of height z-score ≤-0.5, was observed in 39% of patients. At 3 years, higher baseline height z-score was the strongest predictor for a negative change in height z-score [-0.3 per unit of baseline height z-score (95% CI: -0.36, -0.24), p < 0.0001]. Conclusions: Although overall height at 3 years after initial presentation to rheumatology is within the population norm, as a cohort, children with JIA experience a reduction of growth in height over the first 3 years of disease. Late presentation to paediatric rheumatology services is associated with lower height at presentation. However, patients with the lowest height z scores at presentation were also the most likely to see an improvement at 3 years. The impact of JIA on growth patterns is important to children and families and this study provides useful new data to support informed clinical care.
MeSH term(s)	Adolescent ; Adolescent Development/physiology ; Arthritis, Juvenile/physiopathology ; Body Height/physiology ; Child ; Child Development/physiology ; Child, Preschool ; Female ; Humans ; Male ; Prospective Studies
Language	English
Publishing date	2017-11-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2017.11.002
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