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  1. Article ; Online: Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury.

    Gagan, Joshuah M / Cao, Khoa / Zhang, Yu-An / Zhang, Jianning / Davidson, Taylor L / Pastor, Johanne V / Moe, Orson W / Hsia, Connie C W

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 321, Issue 4, Page(s) L736–L749

    Abstract: Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of ... ...

    Abstract Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of modest Klotho overexpression on acute lung injury (ALI) and recovery. Transgenic Klotho-overexpressing (
    MeSH term(s) Acute Lung Injury/pathology ; Acute Lung Injury/prevention & control ; Animals ; Cell Line ; Cytoprotection/genetics ; Cytoprotection/physiology ; DNA Breaks, Double-Stranded ; DNA Damage/genetics ; Female ; Glucuronidase/blood ; Glucuronidase/genetics ; Glucuronidase/metabolism ; HEK293 Cells ; Humans ; Hyperoxia ; Klotho Proteins ; L-Lactate Dehydrogenase/analysis ; Lung/metabolism ; Male ; Mice ; Mice, Transgenic ; Smoke/adverse effects
    Chemical Substances Smoke ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Glucuronidase (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00629.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 2749: Show issues Location:
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  2. Article ; Online: Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis.

    Bobulescu, I Alexandru / Park, Sun K / Xu, L H Richie / Blanco, Francisco / Poindexter, John / Adams-Huet, Beverley / Davidson, Taylor L / Sakhaee, Khashayar / Maalouf, Naim M / Moe, Orson W

    Clinical journal of the American Society of Nephrology : CJASN

    2019  Volume 14, Issue 3, Page(s) 411–420

    Abstract: Background and objectives: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in ...

    Abstract Background and objectives: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in part explained by inadequate excretion of the principal urinary buffer ammonium. The role of net acid excretion in the pathogenesis of uric acid nephrolithiasis is incompletely understood.
    Design, setting, participants, & measurements: We compared acid-base parameters of patients with idiopathic uric acid nephrolithiasis with matched control subjects under controlled diets in an inpatient metabolic unit. Measurements included fasting blood and 24-hour urine chemistries and 24-hour urine metabolomic analysis. Comparisons between groups included analysis of covariance models controlling for urine pH or body mass index.
    Results: Subjects with idiopathic uric acid nephrolithiasis had lower urine pH (5.5 versus 5.9;
    Conclusions: Higher acid load to the kidney, resulting in higher urinary net acid excretion, is an important factor in the pathogenesis of idiopathic uric acid nephrolithiasis.
    MeSH term(s) Acid-Base Equilibrium ; Biomarkers/urine ; Body Mass Index ; Case-Control Studies ; Diet/adverse effects ; Female ; Humans ; Hydrogen-Ion Concentration ; Kidney/physiopathology ; Male ; Middle Aged ; Nephrolithiasis/diagnosis ; Nephrolithiasis/etiology ; Nephrolithiasis/physiopathology ; Nephrolithiasis/urine ; Pilot Projects ; Renal Elimination ; Risk Factors ; Uric Acid/urine
    Chemical Substances Biomarkers ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.10420818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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