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  1. Book: Interesting, very interesting - the autobiography

    Davies, Barry

    2008  

    Author's details Barry Davies
    Size XII, 435 Seiten: Illustrationen
    Edition 1. ed.
    Publisher Headline; London
    Document type Book
    HBZ-ID HT015677515
    ISBN 0-7553-1423-9 ; 978-0-7553-1423-2
    Database Central Library of Sport Science of the German Sport University Cologne

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  2. Article ; Online: Expression of Concern: Mechanisms underlying p53 regulation of

    Astanehe, Arezoo / Arenillas, David / Wasserman, Wyeth W / Leung, Peter C K / Dunn, Sandra E / Davies, Barry R / Mills, Gordon B / Auersperg, Nelly

    Journal of cell science

    2020  Volume 133, Issue 17

    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article ; Expression of Concern
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.253260
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 14: Show issues

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  3. Article ; Online: Deploying continuous improvement across the drug discovery value chain.

    Walker, Stephen M / Davies, Barry J

    Drug discovery today

    2011  Volume 16, Issue 11-12, Page(s) 467–471

    Abstract: In addressing the challenges facing pharmaceutical R&D one question is frequently asked: how can continuous improvement (CI), delivered through a Lean Sigma approach, be applied in a research environment to deliver overall benefit? We show that taking a ... ...

    Abstract In addressing the challenges facing pharmaceutical R&D one question is frequently asked: how can continuous improvement (CI), delivered through a Lean Sigma approach, be applied in a research environment to deliver overall benefit? We show that taking a value chain approach to improvement projects in a discovery research organization, initially focusing on the drug discovery project delivery level (i.e. middle layer of the value chain), provides the foundation for an effective CI programme. The adaptation of Lean Sigma principles and methodology, combined with the tenacity and creativity of scientists, enabled the delivery of significant improvements in challenging areas, including target selection, project decision making and the compound design-make-test-analyse (DMTA) cycle.
    MeSH term(s) Decision Support Techniques ; Decision Trees ; Drug Discovery/methods ; Drug Discovery/trends ; Drug Industry/trends
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2011.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The impact of mood on decision-making process

    Gear, Tony / Davies, Barry J / Fets, Nagah Abdlelaziz / Shi, Hong

    EuroMed journal of business Vol. 12, No. 3 , p. 242-257

    2017  Volume 12, Issue 3, Page(s) 242–257

    Author's details Tony Gear, Hong Shi, Barry J. Davies and Nagah Abdlelaziz Fets
    Keywords Emotion ; Rationality ; Intuition ; Strategy-as-practice ; Mood ; Strategic process
    Language English
    Publisher Emerald
    Publishing place Bingley
    Document type Article
    ZDB-ID 2509205-4 ; 2455829-1
    ISSN 1450-2194
    ISSN 1450-2194
    Database ECONomics Information System

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  5. Article ; Online: Nonlinear Wavefront Control with All-Dielectric Metasurfaces.

    Wang, Lei / Kruk, Sergey / Koshelev, Kirill / Kravchenko, Ivan / Luther-Davies, Barry / Kivshar, Yuri

    Nano letters

    2018  Volume 18, Issue 6, Page(s) 3978–3984

    Abstract: Metasurfaces, two-dimensional lattices of nanoscale resonators, offer unique opportunities for functional flat optics and allow the control of the transmission, reflection, and polarization of a wavefront of light. Recently, all-dielectric metasurfaces ... ...

    Abstract Metasurfaces, two-dimensional lattices of nanoscale resonators, offer unique opportunities for functional flat optics and allow the control of the transmission, reflection, and polarization of a wavefront of light. Recently, all-dielectric metasurfaces reached remarkable efficiencies, often matching or out-performing conventional optical elements. The exploitation of the nonlinear optical response of metasurfaces offers a paradigm shift in nonlinear optics, and dielectric nonlinear metasurfaces are expected to enrich subwavelength photonics by enhancing substantially nonlinear response of natural materials combined with the efficient control of the phase of nonlinear waves. Here, we suggest a novel and rather general approach for engineering the wavefront of parametric waves of arbitrary complexity generated by a nonlinear metasurface. We design all-dielectric nonlinear metasurfaces, achieve a highly efficient wavefront control of a third-harmonic field, and demonstrate the generation of nonlinear beams at a designed angle and the generation of nonlinear focusing vortex beams. Our nonlinear metasurfaces produce phase gradients over a full 0-2π phase range with a 92% diffraction efficiency.
    Language English
    Publishing date 2018-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.8b01460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Negligible nonlinear absorption in hydrogenated amorphous silicon at 1.55 μm for ultra-fast nonlinear signal processing.

    Gai, Xin / Choi, Duk-Yong / Luther-Davies, Barry

    Optics express

    2014  Volume 22, Issue 8, Page(s) 9948–9958

    Abstract: Three-photon absorption (3PA) has been observed as the dominant mechanism for nonlinear absorption in wide-bandgap hydrogenated amorphous silicon (a-Si:H-W) at 1.55 μm. The nonlinear index n2 and 3PA coefficient were measured to be 22 × 10(-17)m(2)/W and ...

    Abstract Three-photon absorption (3PA) has been observed as the dominant mechanism for nonlinear absorption in wide-bandgap hydrogenated amorphous silicon (a-Si:H-W) at 1.55 μm. The nonlinear index n2 and 3PA coefficient were measured to be 22 × 10(-17)m(2)/W and 5.0 × 10(-26) m(3)/W(2) respectively at 1.55 μm by using the z-scan method. This indicates that the figure of merit (FOM) of this material is intensity dependent. A value FOM>60 is predicted at intensities below 0.5 GW/cm(2) which is the maximum practical intensity for high-bit-rate (>160 GB/s) alloptical signal processing. The nonlinear phase change in a-Si:H-W has been compared with other common nonlinear materials (c-Si, As(2)S(3), Ge(11.5)As(24)Se(64.5)) for a 2 cm long waveguide with a-Si:H-W showing the greatest potential for integrated devices for all-optical processing with a high nonlinear index and negligible nonlinear absorption at intensities < 0.5 GW/cm(2).
    Language English
    Publishing date 2014-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.22.009948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Terrorism

    Davies, Barry

    inside a world phenomenon

    2003  

    Author's details Barry Davies
    Language English
    Size VIII, 280 S, Ill
    Publisher Virgin Books
    Publishing place London
    Document type Book
    ISBN 0753508788 ; 1852279648 ; 9780753508787 ; 9781852279646
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells.

    Zelceski, Anabel / Francica, Paola / Lingg, Lea / Mutlu, Merve / Stok, Colin / Liptay, Martin / Alexander, John / Baxter, Joseph S / Brough, Rachel / Gulati, Aditi / Haider, Syed / Raghunandan, Maya / Song, Feifei / Sridhar, Sandhya / Forment, Josep V / O'Connor, Mark J / Davies, Barry R / van Vugt, Marcel A T M / Krastev, Dragomir B /
    Pettitt, Stephen J / Tutt, Andrew N J / Rottenberg, Sven / Lord, Christopher J

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112484

    Abstract: The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose) polymerase ... ...

    Abstract The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose) polymerase inhibitors (PARPi) used in cancer treatment. PSMC3IP or MND1 depletion also causes ionizing radiation sensitivity. These effects are independent of PSMC3IP/MND1's role in mitotic alternative lengthening of telomeres. PSMC3IP- or MND1-depleted cells accumulate toxic RAD51 foci in response to DNA damage, show impaired homology-directed DNA repair, and become PARPi sensitive, even in cells lacking both BRCA1 and TP53BP1. Epistasis between PSMC3IP-MND1 and BRCA1/BRCA2 defects suggest that abrogated D loop formation is the cause of PARPi sensitivity. Wild-type PSMC3IP reverses PARPi sensitivity, whereas a PSMC3IP p.Glu201del mutant associated with D loop defects and ovarian dysgenesis does not. These observations suggest that meiotic proteins such as MND1 and PSMC3IP have a greater role in mitotic DNA repair.
    MeSH term(s) Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Antineoplastic Agents ; DNA Repair ; DNA Damage ; BRCA1 Protein/genetics ; Recombinational DNA Repair ; Cell Line, Tumor
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Antineoplastic Agents ; BRCA1 Protein
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CMOS compatible fabrication of micro, nano convex silicon lens arrays by conformal chemical vapor deposition.

    Zuo, Haijie / Choi, Duk-Yong / Gai, Xin / Luther-Davies, Barry / Zhang, Baoping

    Optics express

    2017  Volume 25, Issue 4, Page(s) 3069–3076

    Abstract: We present a novel CMOS-compatible fabrication technique for convex micro-nano lens arrays (MNLAs) with high packing density on the wafer scale. By means of conformal chemical vapor deposition (CVD) of hydrogenated amorphous silicon (a-Si:H) following ... ...

    Abstract We present a novel CMOS-compatible fabrication technique for convex micro-nano lens arrays (MNLAs) with high packing density on the wafer scale. By means of conformal chemical vapor deposition (CVD) of hydrogenated amorphous silicon (a-Si:H) following patterning of silicon pillars via electron beam lithography (EBL) and plasma etching, large areas of a close packed silicon lens array with the diameter from a few micrometers down to a few hundred nanometers was fabricated. The resulting structure shows excellent surface roughness and high uniformity. The optical focusing properties of the lenses at infrared wavelengths were verified by experimental measurements and numerical simulation. This approach provides a feasible solution for fabricating silicon MNLAs compatible for next generation large scale, miniaturized optical imaging detectors and related optical devices.
    Language English
    Publishing date 2017-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.25.003069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8

    Goldberg, Frederick W / Ting, Attilla K T / Beattie, David / Lamont, Gillian M / Fallan, Charlene / Finlay, M Raymond V / Williamson, Beth / Schimpl, Marianne / Harmer, Alexander R / Adeyemi, Oladipupo B / Nordell, Pär / Cronin, Anna S / Vazquez-Chantada, Mercedes / Barratt, Derek / Ramos-Montoya, Antonio / Cadogan, Elaine B / Davies, Barry R

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 8, Page(s) 1295–1301

    Abstract: The DNA-PK complex is activated by double-strand DNA breaks and regulates the non-homologous end-joining repair pathway; thus, targeting DNA-PK by inhibiting the DNA-PK catalytic subunit (DNA-PKcs) is potentially a useful therapeutic approach for ... ...

    Abstract The DNA-PK complex is activated by double-strand DNA breaks and regulates the non-homologous end-joining repair pathway; thus, targeting DNA-PK by inhibiting the DNA-PK catalytic subunit (DNA-PKcs) is potentially a useful therapeutic approach for oncology. A previously reported series of neutral DNA-PKcs inhibitors were modified to incorporate a basic group, with the rationale that increasing the volume of distribution while maintaining good metabolic stability should increase the half-life. However, adding a basic group introduced hERG activity, and basic compounds with modest hERG activity (IC
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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