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  1. Book: Guidance on Chlamydia control in Europe - 2015

    Davies, Bethan / Ward, Helen / Mårdh, Otilia

    (Scientific advice)

    2016  

    Institution Europäisches Zentrum für die Prävention und die Kontrolle von Krankheiten
    Author's details European Centre for Disease Prevention and Control ; this guidance document was commissioned by the European Centre for Disease Prevention and Control (ECDC) and coordinated by Otilia Mårdh and Andrew J. Amato-Gauci ; this guidance document was written by Bethan Davies and Prof Helen Ward from Imperial College London, United Kingdom, and reviewed by ECDC
    Series title Scientific advice
    Language English
    Size v, 21 Seiten, Diagramme
    Publisher European Centre for Disease Prevention and Control
    Publishing place Stockholm
    Publishing country Sweden
    Document type Book
    HBZ-ID HT018995126
    ISBN 978-92-9193-838-4 ; 92-9193-838-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1345 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: Guidance on chlamydia control in Europe - 2015

    Davies, Bethan / Ward, Helen / Mårdh, Otilia

    (Scientific advice)

    2016  

    Institution Europäisches Zentrum für die Prävention und die Kontrolle von Krankheiten
    Author's details European Centre for Disease Prevention and Control ; this guidance document was commissioned by the European Centre for Disease Prevention and Control (ECDC) and coordinated by Otilia Mårdh and Andrew J. Amato-Gauci ; this guidance document was written by Bethan Davies and Prof Helen Ward from Imperial College London, United Kingdom, and reviewed by ECDC
    Series title Scientific advice
    Language English
    Size 1 Online-Ressource (v, 21 Seiten), Diagramme
    Publisher European Centre for Disease Prevention and Control
    Publishing place Stockholm
    Publishing country Sweden
    Document type Book ; Online
    HBZ-ID HT019057237
    ISBN 978-92-9193-737-0 ; 92-9193-737-1
    DOI 10.2900/667703
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Chlamydia control in Europe

    Ward, Helen / Davies, Bethan / Rönn, Minttu / Sfetcu, Otilia

    qualitative evaluation of the impact of the 2009 ECDC guidance document Chlamydia control in Europe

    (ECDC technical report)

    2015  

    Institution Europäisches Zentrum für die Prävention und die Kontrolle von Krankheiten
    Author's details This report was commissioned by the European Centre for Disease Prevention and Control (ECDC) and coordinated by Otilia Sfetcu and Andrew Amato-Gauci ; this report was produced by Helen Ward, Bethan Davies and Minttu Rönn (Imperial College London, United Kingdom)
    Series title ECDC technical report
    Language English
    Size 1 Online-Ressource (iv, 29 Seiten)
    Publisher ECDC
    Publishing place Stockholm
    Publishing country Sweden
    Document type Book ; Online
    HBZ-ID HT019060988
    ISBN 978-92-9193-617-5 ; 92-9193-617-0
    DOI 10.2900/540203
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The climate and biodiversity crises-impacts and opportunities for older people.

    Davies, Bethan / Harwood, Rowan H

    Age and ageing

    2023  Volume 52, Issue 11

    MeSH term(s) Aged ; Humans ; Biodiversity ; Climate Change
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afad213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 448: Show issues

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  5. Article ; Online: Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis.

    Davies, Bethan / Paul, Richard / Osselton, David / Evers, Richard / Woolley, Timothy

    Drug testing and analysis

    2024  

    Abstract: New psychoactive substances are produced and marketed to mimic the effects of their illicit counterparts and to attempt to evade drug tests and prosecution. Here, we present the optimisation, validation and application of an analytical method using ... ...

    Abstract New psychoactive substances are produced and marketed to mimic the effects of their illicit counterparts and to attempt to evade drug tests and prosecution. Here, we present the optimisation, validation and application of an analytical method using liquid chromatography-time-of-flight mass spectrometry to detect and quantify 37 new psychoactive substances and illicit substances in wastewater from South Wales, UK, using a targeted analysis method. Sample preparation was performed using solid-phase extraction with Oasis HLB cartridges. The LC separation was performed using a YMC-Triart Phenyl 450 bar column (12 nm, 5 μm, 100 × 3 mm) which provided good separation and resolution for all targeted analytes with a run time of 9 min. The method was validated using the following parameters: sensitivity, selectivity, linearity, accuracy, precision, recovery and matrix effects. The method was then applied to influent wastewater samples collected from two wastewater treatment plants in Wales, UK.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Wastewater analysis for new psychoactive substances and cocaine and cannabis in a Northern Ireland Prison.

    Davies, Bethan / Paul, Richard / Osselton, David

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18634

    Abstract: The global drug market has been significantly impacted by the emergence of new psychoactive substances, leading to challenges in creating effective legislative controls and their use within recreational drug consumption. This research explores the ... ...

    Abstract The global drug market has been significantly impacted by the emergence of new psychoactive substances, leading to challenges in creating effective legislative controls and their use within recreational drug consumption. This research explores the prevalence of new psychoactive substances and non-medicinal and medicinal compounds within a prison facility in Northern Ireland. Wastewater samples collected from seven different manholes within the prison were analysed for 37 target compounds including the two most found illicit substances: benzoylecgonine (primary metabolite of cocaine) and cannabis. Using solid phase extraction with Oasis HLB and liquid-chromatography-time-of-flight-mass spectrometry across a gradient of 9 min, our analysis revealed that benzoylecgonine was the sole compound consistently present in all collected samples. Following this finding, our target compound selection was broadened to encompass medicinal compounds and employing qualitative analysis we re-evaluated the samples and discovered the presence of buprenorphine, benzodiazepines, methadone, morphine, and codeine. Finally, the study explored the application of enzymatic beta-glucuronidase hydrolysis to the samples. This final phase yielded significant findings, indicating the presence of codeine and nordiazepam at higher peak intensities, thereby shedding light on the potential implications of this enzymatic process.
    MeSH term(s) Cannabis ; Wastewater ; Northern Ireland/epidemiology ; Prisons ; Cocaine ; Central Nervous System Agents ; Hallucinogens ; Codeine ; Water Pollutants, Chemical/analysis ; Substance Abuse Detection/methods
    Chemical Substances benzoylecgonine (5353I8I6YS) ; Wastewater ; Cocaine (I5Y540LHVR) ; Central Nervous System Agents ; Hallucinogens ; Codeine (UX6OWY2V7J) ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44453-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Geriatric medicine in the era of climate change.

    Davies, Bethan / Bhutta, Mahmood F

    Age and ageing

    2021  Volume 51, Issue 1

    Abstract: Climate change has been termed the greatest threat to human health of the 21st century. Older people and those living with frailty are more vulnerable to the effects of climate change including heatwaves and extreme weather events, and therefore, we have ...

    Abstract Climate change has been termed the greatest threat to human health of the 21st century. Older people and those living with frailty are more vulnerable to the effects of climate change including heatwaves and extreme weather events, and therefore, we have a responsibility to advocate for action on the climate emergency and take steps to reduce the environmental impact of our care provision. The NHS contributes 5.7% to the carbon footprint of the UK, and by reviewing the financial costs associated with frailty, we estimate the carbon footprint of frailty to be 1.7 MtCO2e, or 7% of the total NHS carbon footprint. Resource use also increases with age with particular interventions and medical equipment such as hearing and mobility aids being predominantly associated with the care of older people. The NHS has committed to net zero carbon emissions by 2045 and in order to achieve this we all need to act-balancing the triple bottom line of environmental, social and financial impacts alongside outcomes for patients and populations when making decisions about care. The principles of sustainable healthcare are already embedded in the geriatrician's holisitic approach to the care of older people and those living with frailty, and the imperative to reduce the carbon footprint of healthcare should add weight to the argument for extending the role of the geriatrician into other specialties. It is time to begin our journey to net-zero geriatric medicine.
    MeSH term(s) Aged ; Carbon Footprint ; Climate Change ; Delivery of Health Care ; Frailty ; Geriatrics ; Humans
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afab199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 448: Show issues

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  8. Article ; Online: Health effects of low emission and congestion charging zones: a systematic review.

    Chamberlain, Rosemary C / Fecht, Daniela / Davies, Bethan / Laverty, Anthony A

    The Lancet. Public health

    2023  Volume 8, Issue 7, Page(s) e559–e574

    Abstract: Low emission zones (LEZs) and congestion charging zones (CCZs) have been implemented in several cities globally. We systematically reviewed the evidence on the effects of these air pollution and congestion reduction schemes on a range of physical health ... ...

    Abstract Low emission zones (LEZs) and congestion charging zones (CCZs) have been implemented in several cities globally. We systematically reviewed the evidence on the effects of these air pollution and congestion reduction schemes on a range of physical health outcomes. We searched MEDLINE, Embase, Web of Science, IDEAS, Greenfile, and Transport Research International Documentation databases from database inception to Jan 4, 2023. We included studies that evaluated the effect of implementation of a LEZ or CCZ on air pollution-related health outcomes (cardiovascular and respiratory diseases, birth outcomes, dementia, lung cancer, diabetes, and all-cause) or road traffic injuries (RTIs) using longitudinal study designs and empirical health data. Two authors independently assessed papers for inclusion. Results were narratively synthesised and visualised using harvest plots. Risk of bias was assessed using the Graphic Appraisal Tool for Epidemiological studies. The protocol was registered with PROSPERO (CRD42022311453). Of 2279 studies screened, 16 were included, of which eight assessed LEZs and eight assessed CCZs. Several LEZ studies identified positive effects on air pollution-related outcomes, with reductions in some cardiovascular disease subcategories found in five of six studies investigating this outcome, although results for other health outcomes were less consistent. Six of seven studies on the London CCZ reported reductions in total or car RTIs, although one study reported an increase in cyclist and motorcyclist injuries and one reported an increase in serious or fatal injuries. Current evidence suggests LEZs can reduce air pollution-related health outcomes, with the most consistent effect on cardiovascular disease. Evidence on CCZs is mainly limited to London but suggests that they reduce overall RTIs. Ongoing evaluation of these interventions is necessary to understand longer term health effects.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Longitudinal Studies ; Lung Neoplasms ; Air Pollution/adverse effects ; Cities
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(23)00120-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Impact of daily, oral pre-exposure prophylaxis on the risk of bacterial sexually transmitted infections among cisgender women: a systematic review and narrative synthesis.

    Papageorgiou, Vasiliki / Crittendon, Erica / Coukan, Flavien / Davies, Bethan / Ward, Helen

    Wellcome open research

    2022  Volume 7, Page(s) 108

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Systematic Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.17457.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Modulation of osteoblast differentiation and function by the P2X4 receptor.

    Orriss, Isabel R / Davies, Bethan K / Bourne, Lucie E / Arnett, Timothy R

    Purinergic signalling

    2022  Volume 19, Issue 2, Page(s) 367–378

    Abstract: Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of these. One exception is the P2X4 receptor, which despite strong expression in osteoblasts and osteoclasts, ... ...

    Abstract Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of these. One exception is the P2X4 receptor, which despite strong expression in osteoblasts and osteoclasts, has no defined functional activity. This study used the selective P2X4 receptor antagonists, 5-BDBD and PSB-12062, to investigate the role of this receptor in bone. Both antagonists (≥ 0.1 μM) dose-dependently decreased bone formation by 60-100%. This was accompanied by a ≤ 70% decrease in alkaline phosphatase activity, a ≤ 40% reduction in cell number, and a ≤ 80% increase in the number of adipocytes present in the culture. The analysis of gene expression showed that levels of osteoblast marker genes (e.g. Alpl, Bglap) were decreased in 5-BDBD treated cells. Conversely, expression of the adipogenic transcription factor PPARG was increased 10-fold. In osteoclasts, high doses of both antagonists were associated with a reduction in osteoclast formation and resorptive activity by ≤ 95% and ≤ 90%, respectively. Taken together, these data suggest that the P2X4 receptor plays a role in modulating bone cell function. In particular, it appears to influence osteoblast differentiation favouring the osteogenic lineage over the adipogenic lineage.
    MeSH term(s) Osteogenesis/physiology ; Receptors, Purinergic P2X4/metabolism ; Cell Differentiation/physiology ; Osteoclasts/metabolism ; Osteoblasts/metabolism
    Chemical Substances Receptors, Purinergic P2X4
    Language English
    Publishing date 2022-08-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-022-09887-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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