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  1. Book: Paediatric respiratory disease / 1

    Davies, Jane C. / Bush, Andrew

    2011  

    Author's details ed. by Andrew Bush
    Collection Paediatric respiratory disease
    Language English
    Size VIII, 109 S. : Ill., graph. Darst.
    Publisher Clinical Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016985525
    ISBN 978-1-904392-97-2 ; 1-904392-97-0 ; 9781846926150 ; 1846926157
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4624 order for loan Magazin

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  2. Book: Paediatric respiratory disease / 2

    Bush, Andrew / Davies, Jane C.

    2011  

    Author's details ed. by Andrew Bush
    Collection Paediatric respiratory disease
    Language English
    Size 86 S. : zahlr. Ill., graph. Darst.
    Publisher Clinical Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016704882
    ISBN 978-1-84692-086-8 ; 1-84692-086-8 ; 9781846926280 ; 1846926289
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3991 order for loan Magazin

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  3. Article ; Online: The life rafts sailed; Now let's take stock and set the course ahead (Commentary).

    Davies, Jane C

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2021  Volume 20 Suppl 3, Page(s) 29–30

    MeSH term(s) COVID-19 ; Cystic Fibrosis ; Humans ; Membrane Microdomains ; Telemedicine
    Language English
    Publishing date 2021-12-20
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2021.08.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6028: Show issues Location:
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    Zs.MO 459: Show issues

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  4. Article ; Online: Trials and tribulations: The highs and lows of running cystic fibrosis drug studies.

    Davies, Jane C

    Paediatric respiratory reviews

    2019  Volume 31, Page(s) 25–27

    Abstract: So many new trials of drugs for CF are being conducted each year it can be difficult to keep up. Yet, almost as numerous are the review articles written about them. I have chosen therefore to use this paper to discuss some of the difficult ethical issues ...

    Abstract So many new trials of drugs for CF are being conducted each year it can be difficult to keep up. Yet, almost as numerous are the review articles written about them. I have chosen therefore to use this paper to discuss some of the difficult ethical issues arising during trials, in particular how to fairly distribute opportunities to participate. Some of these issues may be specific to countries like my own with very limited access to genotype-specific CFTR modulators, others may apply more generally. We have made enormous progress as a community over the recent past, but there is still much more to do before all our patients are reaping health and quality of life benefits.
    MeSH term(s) Clinical Trials as Topic/ethics ; Cystic Fibrosis/drug therapy ; Drug Development/ethics ; Humans ; Patient Selection/ethics
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2019.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5919: Show issues Location:
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  5. Article ; Online: Cystic Fibrosis: From Salty Malediction to Possible Cure.

    Sole, Amparo / Davies, Jane C / Quintana-Gallego, Esther

    Archivos de bronconeumologia

    2023  Volume 60, Issue 3, Page(s) 129–130

    MeSH term(s) Humans ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language Spanish
    Publishing date 2023-10-30
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2655: Show issues Location:
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  6. Article ; Online: What is cystic fibrosis screen positive inconclusive diagnosis? And what is it not?

    Devoy, Emily / Hughes, Dominic / Alharbi, Asma Falah / Francis, Jacqueline / Davies, Jane C

    Archives of disease in childhood. Education and practice edition

    2024  

    Abstract: Since screening for cystic fibrosis (CF) was incorporated into the newborn screening program, the number of recognised variants in ... ...

    Abstract Since screening for cystic fibrosis (CF) was incorporated into the newborn screening program, the number of recognised variants in the
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2023-326767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Lytic Bacteriophage Is a Promising Adjunct to Common Antibiotics across Cystic Fibrosis Clinical Strains and Culture Models of

    Martin, Isaac / Morales, Sandra / Alton, Eric W F W / Davies, Jane C

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Bacteriophages (phages) are antimicrobials with resurgent interest that are being investigated for the treatment of antibiotic refractory infection, including ... ...

    Abstract Bacteriophages (phages) are antimicrobials with resurgent interest that are being investigated for the treatment of antibiotic refractory infection, including for
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Visualising early lung disease in CF: the emergence of MRI.

    Davies, Jane C

    Thorax

    2017  Volume 72, Issue 8, Page(s) 682

    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2017-210297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chronic rhinosinusitis in the era of CFTR modulator therapy.

    Stone, Roy Gavin / Short, Christopher / Davies, Jane C / McNally, Paul

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2023  Volume 23, Issue 2, Page(s) 208–213

    Abstract: Chronic rhinosinusitis is a common manifestation of CF that is associated with impaired quality of life and can be difficult to treat. CFTR modulator therapy has resulted in significant improvements in lower respiratory and nutritional outcomes for ... ...

    Abstract Chronic rhinosinusitis is a common manifestation of CF that is associated with impaired quality of life and can be difficult to treat. CFTR modulator therapy has resulted in significant improvements in lower respiratory and nutritional outcomes for people with CF however their impact on chronic rhinosinusitis has received less attention. We review the literature in relation to chronic rhinosinusitis in CF and examine the impact of CFTR modulator therapy on symptoms, imaging, endoscopic appearances, and olfactory outcomes in the treatment of chronic rhinosinusitis. While an overall improvement in symptoms, imaging and endoscopic appearances is seen in response to treatment, limited impact is documented on olfaction. Outcome measures employed were heterogenous, limiting comparison of findings. There is a need for well powered prospective real-world studies with standardised outcome measures.
    MeSH term(s) Humans ; Sinusitis/drug therapy ; Rhinitis/drug therapy ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/complications ; Chronic Disease ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Chloride Channel Agonists/therapeutic use ; Rhinosinusitis
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2023.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 459: Show issues

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  10. Article: Pseudomonas aeruginosa in the Cystic Fibrosis Lung.

    King, John / Murphy, Ronan / Davies, Jane C

    Advances in experimental medicine and biology

    2022  Volume 1386, Page(s) 347–369

    Abstract: Cystic fibrosis is a common genetically inherited, multisystem disorder caused by loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an apically situated anion channel. In the lung, lack of CFTR leads to airway ... ...

    Abstract Cystic fibrosis is a common genetically inherited, multisystem disorder caused by loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an apically situated anion channel. In the lung, lack of CFTR leads to airway surface dehydration, mucociliary clearance failure and an acidic pH in which innate defence molecules are rendered ineffective. Infection occurs early in life, with P. aeruginosa dominating by adolescence. The characteristic features of the CF airway highlighted above encourage persistence of infection, but P. aeruginosa also possess an array of mechanisms with which they attack host defences and render themselves protected from antimicrobials. Early eradication is usually successful, but this is usually transient. Chronic infection is manifest by biofilm formation which is resistant to treatment. Outcomes for people with CF have improved greatly in the last few decades, but particularly so with the recent advent of small molecule CFTR modulators. However, despite impressive efficacy on lung function and exacerbation frequency, most people with chronic infection remain with their pathogens. There is an active pipeline of new treatments including anti-biofilm and anti-quorum sensing molecules and non-drug approaches such as bacteriophage. Studies are reviewed and challenges for future drug development considered.
    MeSH term(s) Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Cystic Fibrosis/metabolism ; Pseudomonas aeruginosa ; Quorum Sensing ; Lung
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-08491-1_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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